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Protein

Inner membrane protein CbrB

Gene

cbrB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG11726-MONOMER.
ECOL316407:JW3694-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein CbrB
Alternative name(s):
CreB-regulated gene B protein
Gene namesi
Name:cbrB
Synonyms:yieI
Ordered Locus Names:b3716, JW3694
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11726. cbrB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 364PeriplasmicSequence analysis
Transmembranei37 – 5721HelicalSequence analysisAdd
BLAST
Topological domaini58 – 8124CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11311PeriplasmicSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 15521CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Inner membrane protein CbrBPRO_0000169639Add
BLAST

Proteomic databases

PaxDbiP31468.

Expressioni

Inductioni

Induced by the two-component regulatory system CreC/CreB.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263199. 6 interactions.
STRINGi511145.b3716.

Structurei

3D structure databases

ProteinModelPortaliP31468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbrB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106HGK. Bacteria.
ENOG410Y18Y. LUCA.
HOGENOMiHOG000050898.
OMAiIPTENAQ.
OrthoDBiEOG6SFPBG.

Family and domain databases

InterProiIPR020222. IMCbrB.
[Graphical view]
ProDomiPD092472. IM_protein_CbrB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P31468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSRRVIHH GLYFAVLGPL IGVLFLVLYI FFAKEPLVLW VIIHPIFLLL
60 70 80 90 100
SITTGAIPAL LTGVMVACLP EKIGSQKRYR CLAGGIGGVV ITEIYCAVIV
110 120 130 140 150
HIKGMASSEL FENILSGDSL VVRIIPALLA GVVMSRIITR LPGLDISCPE

TDSLS
Length:155
Mass (Da):16,683
Last modified:July 1, 1993 - v1
Checksum:i779FDA7162CF501D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62067.1.
U00096 Genomic DNA. Translation: AAC76739.1.
AP009048 Genomic DNA. Translation: BAE77572.1.
PIRiE65174.
RefSeqiNP_418172.1. NC_000913.3.
WP_000116777.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiAAC76739; AAC76739; b3716.
BAE77572; BAE77572; BAE77572.
GeneIDi948231.
KEGGiecj:JW3694.
eco:b3716.
PATRICi32122927. VBIEscCol129921_3839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62067.1.
U00096 Genomic DNA. Translation: AAC76739.1.
AP009048 Genomic DNA. Translation: BAE77572.1.
PIRiE65174.
RefSeqiNP_418172.1. NC_000913.3.
WP_000116777.1. NZ_CP014272.1.

3D structure databases

ProteinModelPortaliP31468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263199. 6 interactions.
STRINGi511145.b3716.

Proteomic databases

PaxDbiP31468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76739; AAC76739; b3716.
BAE77572; BAE77572; BAE77572.
GeneIDi948231.
KEGGiecj:JW3694.
eco:b3716.
PATRICi32122927. VBIEscCol129921_3839.

Organism-specific databases

EchoBASEiEB1677.
EcoGeneiEG11726. cbrB.

Phylogenomic databases

eggNOGiENOG4106HGK. Bacteria.
ENOG410Y18Y. LUCA.
HOGENOMiHOG000050898.
OMAiIPTENAQ.
OrthoDBiEOG6SFPBG.

Enzyme and pathway databases

BioCyciEcoCyc:EG11726-MONOMER.
ECOL316407:JW3694-MONOMER.

Miscellaneous databases

PROiP31468.

Family and domain databases

InterProiIPR020222. IMCbrB.
[Graphical view]
ProDomiPD092472. IM_protein_CbrB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli CreBC is a global regulator of gene expression that responds to growth in minimal media."
    Avison M.B., Horton R.E., Walsh T.R., Bennett P.M.
    J. Biol. Chem. 276:26955-26961(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY CREBC.
  5. "Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems."
    Zhou L., Lei X.-H., Bochner B.R., Wanner B.L.
    J. Bacteriol. 185:4956-4972(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTANT STUDIES.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCBRB_ECOLI
AccessioniPrimary (citable) accession number: P31468
Secondary accession number(s): Q2M834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Disruption of this gene leads to hypersensibility to nitrofurazone.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.