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Protein

Multidrug resistance protein MdtL

Gene

mdtL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers resistance to chloramphenicol.1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIDY-MONOMER

Protein family/group databases

TCDBi2.A.1.2.22 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtL
Gene namesi
Name:mdtL
Synonyms:yidY
Ordered Locus Names:b3710, JW3688
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11720 mdtL

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 41PeriplasmicSequence analysisAdd BLAST17
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 68CytoplasmicSequence analysis6
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 92PeriplasmicSequence analysis3
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 130CytoplasmicSequence analysisAdd BLAST17
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 157PeriplasmicSequence analysis6
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 202CytoplasmicSequence analysisAdd BLAST24
Transmembranei203 – 222HelicalSequence analysisAdd BLAST20
Topological domaini223 – 244PeriplasmicSequence analysisAdd BLAST22
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 268CytoplasmicSequence analysis3
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 292PeriplasmicSequence analysis3
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 330CytoplasmicSequence analysisAdd BLAST17
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 355PeriplasmicSequence analysis4
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 391CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733541 – 391Multidrug resistance protein MdtLAdd BLAST391

Proteomic databases

PaxDbiP31462
PRIDEiP31462

Interactioni

Protein-protein interaction databases

BioGridi4262213, 171 interactors
DIPiDIP-12457N
IntActiP31462, 1 interactor
STRINGi316385.ECDH10B_3897

Structurei

3D structure databases

ProteinModelPortaliP31462
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNH Bacteria
ENOG410YI0P LUCA
HOGENOMiHOG000277663
InParanoidiP31462
KOiK08163
OMAiMFQFGWI
PhylomeDBiP31462

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01530 MFS_MdtL, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR023697 Multidrug-R_MdtL
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P31462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII ASVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WAMAMMGIAV LMLSLFILKE TRPAAPAASD KPRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLAVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
IGAWNMLIGI LIACSIVSLL LIMFVAPGRP VAAHEEIHHH A
Length:391
Mass (Da):41,490
Last modified:November 1, 1997 - v2
Checksum:iF1CD02E113AA94B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62061.1
U00096 Genomic DNA Translation: AAC76733.1
AP009048 Genomic DNA Translation: BAE77580.1
PIRiG65173
RefSeqiNP_418166.1, NC_000913.3
WP_000085982.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76733; AAC76733; b3710
BAE77580; BAE77580; BAE77580
GeneIDi948219
KEGGiecj:JW3688
eco:b3710
PATRICifig|1411691.4.peg.2991

Similar proteinsi

Entry informationi

Entry nameiMDTL_ECOLI
AccessioniPrimary (citable) accession number: P31462
Secondary accession number(s): P76739, Q2M826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health