Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance protein MdtL

Gene

mdtL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers resistance to chloramphenicol.1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIDY-MONOMER.
ECOL316407:JW3688-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtL
Gene namesi
Name:mdtL
Synonyms:yidY
Ordered Locus Names:b3710, JW3688
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11720. mdtL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 41PeriplasmicSequence analysisAdd BLAST17
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 68CytoplasmicSequence analysis6
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 92PeriplasmicSequence analysis3
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 130CytoplasmicSequence analysisAdd BLAST17
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 157PeriplasmicSequence analysis6
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 202CytoplasmicSequence analysisAdd BLAST24
Transmembranei203 – 222HelicalSequence analysisAdd BLAST20
Topological domaini223 – 244PeriplasmicSequence analysisAdd BLAST22
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 268CytoplasmicSequence analysis3
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 292PeriplasmicSequence analysis3
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 330CytoplasmicSequence analysisAdd BLAST17
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 355PeriplasmicSequence analysis4
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 391CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733541 – 391Multidrug resistance protein MdtLAdd BLAST391

Proteomic databases

PaxDbiP31462.
PRIDEiP31462.

Interactioni

Protein-protein interaction databases

BioGridi4262213. 171 interactors.
DIPiDIP-12457N.
IntActiP31462. 1 interactor.
MINTiMINT-1316334.
STRINGi511145.b3710.

Structurei

3D structure databases

ProteinModelPortaliP31462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNH. Bacteria.
ENOG410YI0P. LUCA.
HOGENOMiHOG000277663.
InParanoidiP31462.
KOiK08163.
OMAiSAVGFFY.
PhylomeDBiP31462.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01530. MFS_MdtL. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023697. Multidrug-R_MdtL.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII ASVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WAMAMMGIAV LMLSLFILKE TRPAAPAASD KPRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLAVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
IGAWNMLIGI LIACSIVSLL LIMFVAPGRP VAAHEEIHHH A
Length:391
Mass (Da):41,490
Last modified:November 1, 1997 - v2
Checksum:iF1CD02E113AA94B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62061.1.
U00096 Genomic DNA. Translation: AAC76733.1.
AP009048 Genomic DNA. Translation: BAE77580.1.
PIRiG65173.
RefSeqiNP_418166.1. NC_000913.3.
WP_000085982.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76733; AAC76733; b3710.
BAE77580; BAE77580; BAE77580.
GeneIDi948219.
KEGGiecj:JW3688.
eco:b3710.
PATRICi32122915. VBIEscCol129921_3833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62061.1.
U00096 Genomic DNA. Translation: AAC76733.1.
AP009048 Genomic DNA. Translation: BAE77580.1.
PIRiG65173.
RefSeqiNP_418166.1. NC_000913.3.
WP_000085982.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262213. 171 interactors.
DIPiDIP-12457N.
IntActiP31462. 1 interactor.
MINTiMINT-1316334.
STRINGi511145.b3710.

Protein family/group databases

TCDBi2.A.1.2.22. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31462.
PRIDEiP31462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76733; AAC76733; b3710.
BAE77580; BAE77580; BAE77580.
GeneIDi948219.
KEGGiecj:JW3688.
eco:b3710.
PATRICi32122915. VBIEscCol129921_3833.

Organism-specific databases

EchoBASEiEB1671.
EcoGeneiEG11720. mdtL.

Phylogenomic databases

eggNOGiENOG4105CNH. Bacteria.
ENOG410YI0P. LUCA.
HOGENOMiHOG000277663.
InParanoidiP31462.
KOiK08163.
OMAiSAVGFFY.
PhylomeDBiP31462.

Enzyme and pathway databases

BioCyciEcoCyc:YIDY-MONOMER.
ECOL316407:JW3688-MONOMER.

Miscellaneous databases

PROiP31462.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01530. MFS_MdtL. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023697. Multidrug-R_MdtL.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTL_ECOLI
AccessioniPrimary (citable) accession number: P31462
Secondary accession number(s): P76739, Q2M826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.