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Protein

Multidrug resistance protein MdtL

Gene

mdtL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers resistance to chloramphenicol.1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIDY-MONOMER.
ECOL316407:JW3688-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtL
Gene namesi
Name:mdtL
Synonyms:yidY
Ordered Locus Names:b3710, JW3688
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11720. mdtL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 4117PeriplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 686CytoplasmicSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 923PeriplasmicSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 13017CytoplasmicSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1576PeriplasmicSequence analysis
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 20224CytoplasmicSequence analysisAdd
BLAST
Transmembranei203 – 22220HelicalSequence analysisAdd
BLAST
Topological domaini223 – 24422PeriplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 2683CytoplasmicSequence analysis
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 2923PeriplasmicSequence analysis
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Topological domaini314 – 33017CytoplasmicSequence analysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Topological domaini352 – 3554PeriplasmicSequence analysis
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Topological domaini377 – 39115CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Multidrug resistance protein MdtLPRO_0000173354Add
BLAST

Proteomic databases

PaxDbiP31462.

Interactioni

Protein-protein interaction databases

BioGridi4262213. 171 interactions.
DIPiDIP-12457N.
IntActiP31462. 1 interaction.
MINTiMINT-1316334.
STRINGi511145.b3710.

Structurei

3D structure databases

ProteinModelPortaliP31462.
SMRiP31462. Positions 21-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNH. Bacteria.
ENOG410YI0P. LUCA.
HOGENOMiHOG000277663.
InParanoidiP31462.
KOiK08163.
OMAiSAVGFFY.
PhylomeDBiP31462.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01530. MFS_MdtL. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023697. Multidrug-R_MdtL.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFLICSFA LVLLYPAGID MYLVGLPRIA ADLNASEAQL HIAFSVYLAG
60 70 80 90 100
MAAAMLFAGK VADRSGRKPV AIPGAALFII ASVFCSLAET STLFLAGRFL
110 120 130 140 150
QGLGAGCCYV VAFAILRDTL DDRRRAKVLS LLNGITCIIP VLAPVLGHLI
160 170 180 190 200
MLKFPWQSLF WAMAMMGIAV LMLSLFILKE TRPAAPAASD KPRENSESLL
210 220 230 240 250
NRFFLSRVVI TTLSVSVILT FVNTSPVLLM EIMGFERGEY ATIMALTAGV
260 270 280 290 300
SMTVSFSTPF ALGIFKPRTL MITSQVLFLA AGITLAVSPS HAVSLFGITL
310 320 330 340 350
ICAGFSVGFG VAMSQALGPF SLRAGVASST LGIAQVCGSS LWIWLAAVVG
360 370 380 390
IGAWNMLIGI LIACSIVSLL LIMFVAPGRP VAAHEEIHHH A
Length:391
Mass (Da):41,490
Last modified:November 1, 1997 - v2
Checksum:iF1CD02E113AA94B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62061.1.
U00096 Genomic DNA. Translation: AAC76733.1.
AP009048 Genomic DNA. Translation: BAE77580.1.
PIRiG65173.
RefSeqiNP_418166.1. NC_000913.3.
WP_000085982.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76733; AAC76733; b3710.
BAE77580; BAE77580; BAE77580.
GeneIDi948219.
KEGGiecj:JW3688.
eco:b3710.
PATRICi32122915. VBIEscCol129921_3833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62061.1.
U00096 Genomic DNA. Translation: AAC76733.1.
AP009048 Genomic DNA. Translation: BAE77580.1.
PIRiG65173.
RefSeqiNP_418166.1. NC_000913.3.
WP_000085982.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31462.
SMRiP31462. Positions 21-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262213. 171 interactions.
DIPiDIP-12457N.
IntActiP31462. 1 interaction.
MINTiMINT-1316334.
STRINGi511145.b3710.

Protein family/group databases

TCDBi2.A.1.2.22. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76733; AAC76733; b3710.
BAE77580; BAE77580; BAE77580.
GeneIDi948219.
KEGGiecj:JW3688.
eco:b3710.
PATRICi32122915. VBIEscCol129921_3833.

Organism-specific databases

EchoBASEiEB1671.
EcoGeneiEG11720. mdtL.

Phylogenomic databases

eggNOGiENOG4105CNH. Bacteria.
ENOG410YI0P. LUCA.
HOGENOMiHOG000277663.
InParanoidiP31462.
KOiK08163.
OMAiSAVGFFY.
PhylomeDBiP31462.

Enzyme and pathway databases

BioCyciEcoCyc:YIDY-MONOMER.
ECOL316407:JW3688-MONOMER.

Miscellaneous databases

PROiP31462.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01530. MFS_MdtL. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023697. Multidrug-R_MdtL.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTL_ECOLI
AccessioniPrimary (citable) accession number: P31462
Secondary accession number(s): P76739, Q2M826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.