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Protein

Galactonate operon transcriptional repressor

Gene

dgoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7790-MONOMER.
ECOL316407:JW5627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactonate operon transcriptional repressor
Gene namesi
Name:dgoR
Synonyms:yidW
Ordered Locus Names:b4479, JW5627
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11718. dgoR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Galactonate operon transcriptional repressorPRO_0000050621Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP31460.

Interactioni

Protein-protein interaction databases

DIPiDIP-9435N.
STRINGi511145.b4479.

Structurei

3D structure databases

ProteinModelPortaliP31460.
SMRiP31460. Positions 4-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7171HTH gntR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2186.
HOGENOMiHOG000273996.
InParanoidiP31460.
OMAiIHEDIVI.
OrthoDBiEOG6JQH1G.
PhylomeDBiP31460.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNKTDRIV ITLGKQIVHG KYVPGSPLPA EAELCEEFAT SRNIIREVFR
60 70 80 90 100
SLMAKRLIEM KRYRGAFVAP RNQWNYLDTD VLQWVLENDY DPRLISAMSE
110 120 130 140 150
VRNLVEPAIA RWAAERATSS DLAQIESALN EMIANNQDRE AFNEADIRYH
160 170 180 190 200
EAVLQSVHNP VLQQLSIAIS SLQRAVFERT WMGDEANMPQ TLQEHKALFD
210 220
AIRHQDGDAA EQAALTMIAS STRRLKEIT
Length:229
Mass (Da):26,080
Last modified:October 11, 2004 - v4
Checksum:iEE41742299285B8F
GO

Sequence cautioni

The sequence AAA62046.1 differs from that shown. Reason: Frameshift at position 174. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1122RW → VA in AAA62046 (PubMed:7686882).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62046.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48199.1.
AP009048 Genomic DNA. Translation: BAE77599.1.
RefSeqiYP_026239.1. NC_000913.3.
YP_491740.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAT48199; AAT48199; b4479.
BAE77599; BAE77599; BAE77599.
GeneIDi12934379.
2847767.
KEGGiecj:Y75_p3478.
eco:b4479.
PATRICi32122885. VBIEscCol129921_3818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62046.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48199.1.
AP009048 Genomic DNA. Translation: BAE77599.1.
RefSeqiYP_026239.1. NC_000913.3.
YP_491740.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP31460.
SMRiP31460. Positions 4-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9435N.
STRINGi511145.b4479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48199; AAT48199; b4479.
BAE77599; BAE77599; BAE77599.
GeneIDi12934379.
2847767.
KEGGiecj:Y75_p3478.
eco:b4479.
PATRICi32122885. VBIEscCol129921_3818.

Organism-specific databases

EchoBASEiEB1669.
EcoGeneiEG11718. dgoR.

Phylogenomic databases

eggNOGiCOG2186.
HOGENOMiHOG000273996.
InParanoidiP31460.
OMAiIHEDIVI.
OrthoDBiEOG6JQH1G.
PhylomeDBiP31460.

Enzyme and pathway databases

BioCyciEcoCyc:G7790-MONOMER.
ECOL316407:JW5627-MONOMER.

Miscellaneous databases

PROiP31460.

Gene expression databases

GenevestigatoriP31460.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: SEQUENCE REVISION.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiDGOR_ECOLI
AccessioniPrimary (citable) accession number: P31460
Secondary accession number(s): O32529
, P76735, Q2M807, Q6BF15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.