P31460 (DGOR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactonate operon transcriptional repressor

Gene names

Name:	dgoR
Synonyms:	yidW
Ordered Locus Names:	b4479, JW5627

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer.
Sequence similarities	Contains 1 HTH gntR-type DNA-binding domain.
Sequence caution	The sequence AAA62046.1 differs from that shown. Reason: Frameshift at position 174.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Galactonate operon transcriptional repressor		PRO_0000050621
Regions
	Domain	1 – 71	71	HTH gntR-type
	DNA binding	31 – 50	20	H-T-H motif Potential
Experimental info
	Sequence conflict	111 – 112	2	RW → VA in AAA62046. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P31460 [UniParc]. Last modified October 11, 2004. Version 4. Checksum: EE41742299285B8F	FASTA	229	26,080
	10 20 30 40 50 60 MTLNKTDRIV ITLGKQIVHG KYVPGSPLPA EAELCEEFAT SRNIIREVFR SLMAKRLIEM 70 80 90 100 110 120 KRYRGAFVAP RNQWNYLDTD VLQWVLENDY DPRLISAMSE VRNLVEPAIA RWAAERATSS 130 140 150 160 170 180 DLAQIESALN EMIANNQDRE AFNEADIRYH EAVLQSVHNP VLQQLSIAIS SLQRAVFERT 190 200 210 220 WMGDEANMPQ TLQEHKALFD AIRHQDGDAA EQAALTMIAS STRRLKEIT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R. Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005." Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L. Nucleic Acids Res. 34:1-9(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L10328 Genomic DNA. Translation: AAA62046.1. Frameshift. U00096 Genomic DNA. Translation: AAT48199.1. AP009048 Genomic DNA. Translation: BAE77599.1.
RefSeq	YP_026239.1. NC_000913.2. YP_491740.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P31460.
SMR	P31460. Positions 4-150.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9435N.
STRING	511145.b4479.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT48199; AAT48199; b4479. BAE77599; BAE77599; BAE77599.
GeneID	12934379. 2847767.
KEGG	ecj:Y75_p3478. eco:b4479.
PATRIC	32122885. VBIEscCol129921_3818.
Organism-specific databases
EchoBASE	EB1669.
EcoGene	EG11718. dgoR.
Phylogenomic databases
eggNOG	COG2186.
HOGENOM	HOG000273996.
OMA	NRDAFNE.
ProtClustDB	CLSK894832.
Enzyme and pathway databases
BioCyc	EcoCyc:G7790-MONOMER. ECOL316407:JW5627-MONOMER.
Gene expression databases
Genevestigator	P31460.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011711. GntR_C. IPR000524. Tscrpt_reg_HTH_GntR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF07729. FCD. 1 hit. PF00392. GntR. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SMART	SM00895. FCD. 1 hit. SM00345. HTH_GNTR. 1 hit. [Graphical view]
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DGOR_ECOLI

Accession

Primary (citable) accession number: P31460
Secondary accession number(s): O32529 , P76735, Q2M807, Q6BF15

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 103 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program