Reviewed, UniProtKB/Swiss-Prot P31459 (DGOK_ECOLI)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxygalactonokinase
    EC=2.7.1.58
Alternative name(s):
    2-keto-3-deoxy-galactonokinase
    2-oxo-3-deoxygalactonate kinase

Gene names

Name:	dgoK
Synonyms:	yidV
Ordered Locus Names:	b3693, JW3670

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate.
Pathway	Carbohydrate acid metabolism; D-galactonic acid degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonic acid: step 2/3.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	2-dehydro-3-deoxygalactonokinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	2-dehydro-3-deoxygalactonokinase		PRO_0000079881

Sequences

	Sequence		Length	Mass (Da)
	P31459-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: BBF5219EE27F35F9	FASTA	292	31,374
	10 20 30 40 50 60 MTARYIAIDW GSTNLRAWLY QGDHCLESRQ SEAGVTRLNG KSPAAVLAEV TTDWREEKTP 70 80 90 100 110 120 VVMAGMVGSN VGWKVAPYLS VPACFSSIGE QLTSVGDNIW IIPGLCVSHD DNHNVMRGEE 130 140 150 160 170 180 TQLIGARALA PSSLYVMPGT HCKWVQADSQ QINDFRTVMT GELHHLLLNH SLIGAGLPPQ 190 200 210 220 230 240 ENSADAFTAG LERGLNTPAI LPQLFEVRAS HVLGTLPREQ VSEFLSGLLI GAEVASMRDY 250 260 270 280 290 VAHQHAITLV AGTSLTARYQ QAFQAMGCDV TAVAGDTAFQ AGIRSIAHAV AN

References

[1]	"DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R. Genomics 16:551-561(1993) [PubMed: 7686882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L10328 Genomic DNA. Translation: AAA62045.1. U00096 Genomic DNA. Translation: AAC76716.1. AP009048 Genomic DNA. Translation: BAE77600.1.
PIR	F65171.
RefSeq	AP_004099.1. NP_418148.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	948207.
GenomeReviews	Gene locus JW3670 in contig AP009048_GR. Gene locus b3693 in contig U00096_GR.
KEGG	ecj:JW3670. eco:b3693.
Organism-specific databases
EchoBASE	EB1668.
EcoGene	EG11717. dgoK.
CMR	Search...
Phylogenomic databases
HOGENOM	P31459.
OMA	P31459. EASGDAY.
Enzyme and pathway databases
BioCyc	EcoCyc:DEHYDDEOXGALACTKIN-MON. MetaCyc:DEHYDDEOXGALACTKIN-MON.
Family and domain databases
InterPro	IPR007729. DGOK. [Graphical view]
Pfam	PF05035. DGOK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DGOK_ECOLI

Accession

Primary (citable) accession number: P31459
Secondary accession number(s): Q2M806

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)