P31459 (DGOK_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxygalactonokinase
EC=2.7.1.58

Alternative name(s):
2-keto-3-deoxy-galactonokinase
2-oxo-3-deoxygalactonate kinase

Gene names

Name:	dgoK
Synonyms:	yidV
Ordered Locus Names:	b3693, JW3670

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate.
Pathway	Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 2/3.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-galactonate catabolic process Inferred from mutant phenotype PubMed 211976. Source: EcoCyc
Molecular_function	2-dehydro-3-deoxygalactonokinase activity Inferred from direct assay PubMed 324806. Source: EcoCyc ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	2-dehydro-3-deoxygalactonokinase		PRO_0000079881

Sequences

	Sequence		Length	Mass (Da)
	P31459 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: BBF5219EE27F35F9	FASTA	292	31,374
	10 20 30 40 50 60 MTARYIAIDW GSTNLRAWLY QGDHCLESRQ SEAGVTRLNG KSPAAVLAEV TTDWREEKTP 70 80 90 100 110 120 VVMAGMVGSN VGWKVAPYLS VPACFSSIGE QLTSVGDNIW IIPGLCVSHD DNHNVMRGEE 130 140 150 160 170 180 TQLIGARALA PSSLYVMPGT HCKWVQADSQ QINDFRTVMT GELHHLLLNH SLIGAGLPPQ 190 200 210 220 230 240 ENSADAFTAG LERGLNTPAI LPQLFEVRAS HVLGTLPREQ VSEFLSGLLI GAEVASMRDY 250 260 270 280 290 VAHQHAITLV AGTSLTARYQ QAFQAMGCDV TAVAGDTAFQ AGIRSIAHAV AN

References

[1]	"DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R. Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L10328 Genomic DNA. Translation: AAA62045.1. U00096 Genomic DNA. Translation: AAC76716.1. AP009048 Genomic DNA. Translation: BAE77600.1.
PIR	F65171.
RefSeq	NP_418148.1. NC_000913.2. YP_491741.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P31459.
SMR	P31459. Positions 1-292.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31459. 3 interactions.
STRING	511145.b3693.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76716; AAC76716; b3693. BAE77600; BAE77600; BAE77600.
GeneID	12934419. 948207.
KEGG	ecj:Y75_p3479. eco:b3693.
PATRIC	32122883. VBIEscCol129921_3817.
Organism-specific databases
EchoBASE	EB1668.
EcoGene	EG11717. dgoK.
Phylogenomic databases
eggNOG	COG3734.
HOGENOM	HOG000256078.
KO	K00883.
OMA	YIMPGTH.
ProtClustDB	CLSK891817.
Enzyme and pathway databases
BioCyc	EcoCyc:DEHYDDEOXGALACTKIN-MONOMER. ECOL316407:JW3670-MONOMER. MetaCyc:DEHYDDEOXGALACTKIN-MONOMER.
UniPathway	UPA00081; UER00519.
Gene expression databases
Genevestigator	P31459.
Family and domain databases
InterPro	IPR007729. DGOK. [Graphical view]
Pfam	PF05035. DGOK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DGOK_ECOLI

Accession

Primary (citable) accession number: P31459
Secondary accession number(s): Q2M806

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program