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Protein

2-dehydro-3-deoxygalactonokinase

Gene

dgoK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate.

Pathwayi: D-galactonate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-galactonate dehydratase (dgoD)
  2. 2-dehydro-3-deoxygalactonokinase (dgoK)
  3. 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (dgoA)
This subpathway is part of the pathway D-galactonate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate, the pathway D-galactonate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

  • 2-dehydro-3-deoxygalactonokinase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • D-galactonate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:DEHYDDEOXGALACTKIN-MONOMER.
ECOL316407:JW3670-MONOMER.
MetaCyc:DEHYDDEOXGALACTKIN-MONOMER.
RETL1328306-WGS:GSTH-867-MONOMER.
UniPathwayiUPA00081; UER00519.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxygalactonokinase (EC:2.7.1.58)
Alternative name(s):
2-keto-3-deoxy-galactonokinase
2-oxo-3-deoxygalactonate kinase
Gene namesi
Name:dgoK
Synonyms:yidV
Ordered Locus Names:b3693, JW3670
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11717. dgoK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2922922-dehydro-3-deoxygalactonokinasePRO_0000079881Add
BLAST

Proteomic databases

PaxDbiP31459.

Interactioni

Protein-protein interaction databases

BioGridi4263413. 153 interactions.
IntActiP31459. 3 interactions.
STRINGi511145.b3693.

Structurei

3D structure databases

ProteinModelPortaliP31459.
SMRiP31459. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DgoK family.Curated

Phylogenomic databases

eggNOGiENOG4105EI3. Bacteria.
COG3734. LUCA.
HOGENOMiHOG000256078.
InParanoidiP31459.
KOiK00883.
OMAiVGWKIAP.
OrthoDBiEOG6D5G3C.
PhylomeDBiP31459.

Family and domain databases

InterProiIPR007729. DGOK.
[Graphical view]
PfamiPF05035. DGOK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARYIAIDW GSTNLRAWLY QGDHCLESRQ SEAGVTRLNG KSPAAVLAEV
60 70 80 90 100
TTDWREEKTP VVMAGMVGSN VGWKVAPYLS VPACFSSIGE QLTSVGDNIW
110 120 130 140 150
IIPGLCVSHD DNHNVMRGEE TQLIGARALA PSSLYVMPGT HCKWVQADSQ
160 170 180 190 200
QINDFRTVMT GELHHLLLNH SLIGAGLPPQ ENSADAFTAG LERGLNTPAI
210 220 230 240 250
LPQLFEVRAS HVLGTLPREQ VSEFLSGLLI GAEVASMRDY VAHQHAITLV
260 270 280 290
AGTSLTARYQ QAFQAMGCDV TAVAGDTAFQ AGIRSIAHAV AN
Length:292
Mass (Da):31,374
Last modified:July 1, 1993 - v1
Checksum:iBBF5219EE27F35F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62045.1.
U00096 Genomic DNA. Translation: AAC76716.1.
AP009048 Genomic DNA. Translation: BAE77600.1.
PIRiF65171.
RefSeqiNP_418148.1. NC_000913.3.
WP_000127091.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76716; AAC76716; b3693.
BAE77600; BAE77600; BAE77600.
GeneIDi948207.
KEGGiecj:JW3670.
eco:b3693.
PATRICi32122883. VBIEscCol129921_3817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62045.1.
U00096 Genomic DNA. Translation: AAC76716.1.
AP009048 Genomic DNA. Translation: BAE77600.1.
PIRiF65171.
RefSeqiNP_418148.1. NC_000913.3.
WP_000127091.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31459.
SMRiP31459. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263413. 153 interactions.
IntActiP31459. 3 interactions.
STRINGi511145.b3693.

Proteomic databases

PaxDbiP31459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76716; AAC76716; b3693.
BAE77600; BAE77600; BAE77600.
GeneIDi948207.
KEGGiecj:JW3670.
eco:b3693.
PATRICi32122883. VBIEscCol129921_3817.

Organism-specific databases

EchoBASEiEB1668.
EcoGeneiEG11717. dgoK.

Phylogenomic databases

eggNOGiENOG4105EI3. Bacteria.
COG3734. LUCA.
HOGENOMiHOG000256078.
InParanoidiP31459.
KOiK00883.
OMAiVGWKIAP.
OrthoDBiEOG6D5G3C.
PhylomeDBiP31459.

Enzyme and pathway databases

UniPathwayiUPA00081; UER00519.
BioCyciEcoCyc:DEHYDDEOXGALACTKIN-MONOMER.
ECOL316407:JW3670-MONOMER.
MetaCyc:DEHYDDEOXGALACTKIN-MONOMER.
RETL1328306-WGS:GSTH-867-MONOMER.

Miscellaneous databases

PROiP31459.

Family and domain databases

InterProiIPR007729. DGOK.
[Graphical view]
PfamiPF05035. DGOK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiDGOK_ECOLI
AccessioniPrimary (citable) accession number: P31459
Secondary accession number(s): Q2M806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.