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Protein

Protein CbrA

Gene

cbrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Disruption of this gene leads to greater resistance to hydroxylamine and hypersensitivity to ofloxacin, 5,7-dichloro-8-hydroxyquinaldine (a lipophilic chelator) and 18-crown-6 ether (an ionophore).

GO - Molecular functioni

  • FAD binding Source: InterPro
  • flavin adenine dinucleotide binding Source: EcoCyc

GO - Biological processi

  • bacteriocin immunity Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11714-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CbrA
Alternative name(s):
CreB-regulated gene A protein
Gene namesi
Name:cbrA
Synonyms:yidS
Ordered Locus Names:b3690, JW5631
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11714 cbrA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000139291 – 354Protein CbrAAdd BLAST354

Proteomic databases

PaxDbiP31456
PRIDEiP31456

Expressioni

Inductioni

Induced by the two-component regulatory system CreC/CreB and by the signal autoinducer AI-2.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4261311, 15 interactors
DIPiDIP-12455N
IntActiP31456, 1 interactor
STRINGi316407.85676354

Structurei

3D structure databases

ProteinModelPortaliP31456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbrA family.Curated

Phylogenomic databases

eggNOGiENOG4107WAP Bacteria
COG0644 LUCA
HOGENOMiHOG000277521
InParanoidiP31456
OMAiSEKMEHF
PhylomeDBiP31456

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01494 FAD_binding_3, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P31456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHFDVAIIG LGPAGSALAR KLAGKMQVIA LDKKHQCGTE GFSKPCGGLL
60 70 80 90 100
APDAQRSFIR DGLTLPVDVI ANPQIFSVKT VDVAASLTRN YQRSYININR
110 120 130 140 150
HAFDLWMKSL IPASVEVYHD SLCRKIWRED DKWHVIFRAD GWEQHITARY
160 170 180 190 200
LVGADGANSM VRRHLYPDHQ IRKYVAIQQW FAEKHPVPFY SCIFDNSITN
210 220 230 240 250
CYSWSISKDG YFIFGGAYPM KDGQTRFTTL KEKMSAFQFQ FGKTVKSEKC
260 270 280 290 300
TVLFPSRWQD FVCGKDNAFL IGEAAGFISA SSLEGISYAL DSTDILRSVL
310 320 330 340 350
LKQPEKLNTA YWRATRKLRL KLFGKIVKSR CLTAPALRKW IMRSGVAHIP

QLKD
Length:354
Mass (Da):40,142
Last modified:December 4, 2007 - v2
Checksum:i3A58C8A91F7B65FB
GO

Sequence cautioni

The sequence AAA62042 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62042.1 Different initiation.
U00096 Genomic DNA Translation: AAC76713.2
AP009048 Genomic DNA Translation: BAE77604.1
PIRiC65171
RefSeqiNP_418145.2, NC_000913.3
WP_001340434.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76713; AAC76713; b3690
BAE77604; BAE77604; BAE77604
GeneIDi948197
KEGGiecj:JW5631
eco:b3690
PATRICifig|511145.12.peg.3813

Similar proteinsi

Entry informationi

Entry nameiCBRA_ECOLI
AccessioniPrimary (citable) accession number: P31456
Secondary accession number(s): Q2M802
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health