Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative permease IIC component GlvC

Gene

glvC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: EcoliWiki
  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLVC-MONOMER.
ECOL316407:JW3660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative permease IIC component GlvC
Alternative name(s):
PTS system EIIC component
Gene namesi
Name:glvC
Ordered Locus Names:b3683, JW3660
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11710. glvC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11PeriplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini33 – 59CytoplasmicSequence analysisAdd BLAST27
Transmembranei60 – 80HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini81 – 86PeriplasmicSequence analysis6
Transmembranei87 – 107HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini108 – 129CytoplasmicSequence analysisAdd BLAST22
Transmembranei130 – 150HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini151 – 173PeriplasmicSequence analysisAdd BLAST23
Transmembranei174 – 194HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini195 – 198CytoplasmicSequence analysis4
Transmembranei199 – 221HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini222 – 224PeriplasmicSequence analysis3
Transmembranei225 – 245HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini246 – 276CytoplasmicSequence analysisAdd BLAST31
Transmembranei277 – 297HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini298 – 306PeriplasmicSequence analysis9
Transmembranei307 – 327HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini328CytoplasmicSequence analysis1
Transmembranei329 – 349HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini350 – 368PeriplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001865791 – 368Putative permease IIC component GlvCAdd BLAST368

Proteomic databases

PRIDEiP31452.

Interactioni

Protein-protein interaction databases

BioGridi4260807. 9 interactors.
STRINGi316407.85676361.

Structurei

3D structure databases

ProteinModelPortaliP31452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 368PTS EIIC type-1PROSITE-ProRule annotationAdd BLAST368

Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIC type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1263. LUCA.
HOGENOMiHOG000250994.
InParanoidiP31452.
KOiK02750.
OMAiKQNARAS.
PhylomeDBiP31452.

Family and domain databases

InterProiIPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR010975. PTS_IIBC_a_glc.
IPR004719. PTS_maltose/Glc_sub_IIC.
[Graphical view]
PfamiPF02378. PTS_EIIC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00852. pts-Glc. 1 hit.
TIGR02005. PTS-IIBC-alpha. 1 hit.
PROSITEiPS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQIQRFGG AMFTPVLLFP FAGIVVGLAI LLQNPMFVGE SLTDPNSLFA
60 70 80 90 100
QIVHIIEEGG WTVFRNMPLI FAVGLPIGLA KQAQGRACLA VMVSFLTWNY
110 120 130 140 150
FINAMGMTWG SYFGVDFTQD AVAGSGLTMM AGIKTLDTSI IGAIIISGIV
160 170 180 190 200
TALHNRLFDK KLPVFLGIFQ GTSYVVIIAF LVMIPCAWLT LLGWPKVQMG
210 220 230 240 250
IESLQAFLRS AGALGVWVYT FLERILIPTG LHHFIYGQFI FGPAAVEGGI
260 270 280 290 300
QMYWAQHLQE FSLSAEPLKS LFPEGGFALH GNSKIFGAVG ISLAMYFTAA
310 320 330 340 350
PENRVKVAGL LIPATLTAML VGITEPLEFT FLFISPLLFA VHAVLAASMS
360
TVMYLFGVVG NMGGGLID
Length:368
Mass (Da):39,692
Last modified:October 1, 1993 - v2
Checksum:iD6E858D618D3EB90
GO

Sequence cautioni

The sequence AAA62035 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62035.1. Different initiation.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77611.1.
PIRiD65170.
RefSeqiWP_000952140.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiBAE77611; BAE77611; BAE77611.
KEGGiecj:JW3660.
PATRICi48666694. VBIEscCol107702_3617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62035.1. Different initiation.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77611.1.
PIRiD65170.
RefSeqiWP_000952140.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260807. 9 interactors.
STRINGi316407.85676361.

Proteomic databases

PRIDEiP31452.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE77611; BAE77611; BAE77611.
KEGGiecj:JW3660.
PATRICi48666694. VBIEscCol107702_3617.

Organism-specific databases

EchoBASEiEB1661.
EcoGeneiEG11710. glvC.

Phylogenomic databases

eggNOGiCOG1263. LUCA.
HOGENOMiHOG000250994.
InParanoidiP31452.
KOiK02750.
OMAiKQNARAS.
PhylomeDBiP31452.

Enzyme and pathway databases

BioCyciEcoCyc:GLVC-MONOMER.
ECOL316407:JW3660-MONOMER.

Family and domain databases

InterProiIPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR010975. PTS_IIBC_a_glc.
IPR004719. PTS_maltose/Glc_sub_IIC.
[Graphical view]
PfamiPF02378. PTS_EIIC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00852. pts-Glc. 1 hit.
TIGR02005. PTS-IIBC-alpha. 1 hit.
PROSITEiPS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTXC_ECOLI
AccessioniPrimary (citable) accession number: P31452
Secondary accession number(s): P76731, Q2M7Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.