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Protein

Adenine permease AdeQ

Gene

adeQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity transporter for adenine.1 Publication

Kineticsi

  1. KM=6.5 µM for adenine1 Publication
  1. Vmax=11.0 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • adenine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • adenine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11691-MONOMER.
ECOL316407:JW5636-MONOMER.
MetaCyc:EG11691-MONOMER.

Protein family/group databases

TCDBi2.A.40.7.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine permease AdeQ
Gene namesi
Name:adeQ
Synonyms:yicO
Ordered Locus Names:b3664, JW5636
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11691. adeQ.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 53HelicalSequence analysisAdd BLAST24
Topological domaini54 – 63PeriplasmicSequence analysis10
Transmembranei64 – 82HelicalSequence analysisAdd BLAST19
Topological domaini83 – 84CytoplasmicSequence analysis2
Transmembranei85 – 101Discontinuously helicalSequence analysisAdd BLAST17
Topological domaini102 – 113PeriplasmicSequence analysisAdd BLAST12
Transmembranei114 – 133HelicalSequence analysisAdd BLAST20
Topological domaini134 – 145CytoplasmicSequence analysisAdd BLAST12
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 182PeriplasmicSequence analysisAdd BLAST16
Transmembranei183 – 200HelicalSequence analysisAdd BLAST18
Topological domaini201 – 204CytoplasmicSequence analysis4
Transmembranei205 – 223HelicalSequence analysisAdd BLAST19
Topological domaini224 – 251PeriplasmicSequence analysisAdd BLAST28
Transmembranei252 – 280HelicalSequence analysisAdd BLAST29
Topological domaini281 – 293CytoplasmicSequence analysisAdd BLAST13
Transmembranei294 – 309HelicalSequence analysisAdd BLAST16
Topological domaini310 – 311PeriplasmicSequence analysis2
Transmembranei312 – 327Discontinuously helicalSequence analysisAdd BLAST16
Topological domaini328 – 331CytoplasmicSequence analysis4
Transmembranei332 – 346HelicalSequence analysisAdd BLAST15
Topological domaini347 – 357PeriplasmicSequence analysisAdd BLAST11
Transmembranei358 – 377HelicalSequence analysisAdd BLAST20
Topological domaini378 – 382CytoplasmicSequence analysis5
Intramembranei383 – 418Discontinuously helicalSequence analysisAdd BLAST36
Topological domaini419 – 444CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001696211 – 444Adenine permease AdeQAdd BLAST444

Proteomic databases

PaxDbiP31440.
PRIDEiP31440.

Interactioni

Protein-protein interaction databases

BioGridi4260893. 111 interactors.
STRINGi511145.b3664.

Structurei

3D structure databases

ProteinModelPortaliP31440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C7N. Bacteria.
COG2252. LUCA.
HOGENOMiHOG000244363.
InParanoidiP31440.
KOiK06901.
OMAiWMALFAN.
PhylomeDBiP31440.

Family and domain databases

InterProiIPR029940. AzgA.
IPR026033. Pur_Permease_PbuG-like.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF9. PTHR11119:SF9. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF005353. PbuG. 1 hit.

Sequencei

Sequence statusi: Complete.

P31440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNDNTDYVS NESGTLSRLF KLPQHGTTVR TELIAGMTTF LTMVYIVFVN
60 70 80 90 100
PQILGAAQMD PKVVFVTTCL IAGIGSIAMG IFANLPVALA PAMGLNAFFA
110 120 130 140 150
FVVVGAMGIS WQTGMGAIFW GAVGLFLLTL FRIRYWMISN IPLSLRIGIT
160 170 180 190 200
SGIGLFIALM GLKNTGVIVA NKDTLVMIGD LSSHGVLLGI LGFFIITVLS
210 220 230 240 250
SRHFHAAVLV SIVVTSCCGL FFGDVHFSGV YSIPPDISGV IGEVDLSGAL
260 270 280 290 300
TLELAGIIFS FMLINLFDSS GTLIGVTDKA GLIDGNGKFP NMNKALYVDS
310 320 330 340 350
VSSVAGAFIG TSSVTAYIES TSGVAVGGRT GLTAVVVGVM FLLVMFFSPL
360 370 380 390 400
VAIVPPYATA GALIFVGVLM TSSLARVNWD DFTESVPAFI TTVMMPFTFS
410 420 430 440
ITEGIALGFM SYCIMKVCTG RWRDLNLCVV VVAALFALKI ILVD
Length:444
Mass (Da):46,934
Last modified:December 4, 2007 - v3
Checksum:i555CECFDB53324B6
GO

Sequence cautioni

The sequence AAA62016 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62016.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76687.2.
AP009048 Genomic DNA. Translation: BAE77629.1.
PIRiA65168.
RefSeqiNP_418120.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76687; AAC76687; b3664.
BAE77629; BAE77629; BAE77629.
GeneIDi948174.
KEGGiecj:JW5636.
eco:b3664.
PATRICi32122821. VBIEscCol129921_3786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62016.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76687.2.
AP009048 Genomic DNA. Translation: BAE77629.1.
PIRiA65168.
RefSeqiNP_418120.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP31440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260893. 111 interactors.
STRINGi511145.b3664.

Protein family/group databases

TCDBi2.A.40.7.4. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Proteomic databases

PaxDbiP31440.
PRIDEiP31440.

Protocols and materials databases

DNASUi948174.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76687; AAC76687; b3664.
BAE77629; BAE77629; BAE77629.
GeneIDi948174.
KEGGiecj:JW5636.
eco:b3664.
PATRICi32122821. VBIEscCol129921_3786.

Organism-specific databases

EchoBASEiEB1642.
EcoGeneiEG11691. adeQ.

Phylogenomic databases

eggNOGiENOG4105C7N. Bacteria.
COG2252. LUCA.
HOGENOMiHOG000244363.
InParanoidiP31440.
KOiK06901.
OMAiWMALFAN.
PhylomeDBiP31440.

Enzyme and pathway databases

BioCyciEcoCyc:EG11691-MONOMER.
ECOL316407:JW5636-MONOMER.
MetaCyc:EG11691-MONOMER.

Miscellaneous databases

PROiP31440.

Family and domain databases

InterProiIPR029940. AzgA.
IPR026033. Pur_Permease_PbuG-like.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF9. PTHR11119:SF9. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF005353. PbuG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADEQ_ECOLI
AccessioniPrimary (citable) accession number: P31440
Secondary accession number(s): P76726, Q2M7X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.