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Protein

Adenine permease AdeQ

Gene

adeQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity transporter for adenine.1 Publication

Kineticsi

  1. KM=6.5 µM for adenine1 Publication
  1. Vmax=11.0 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • adenine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • adenine transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG11691-MONOMER
MetaCyc:EG11691-MONOMER

Protein family/group databases

TCDBi2.A.40.7.4 the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine permease AdeQ
Gene namesi
Name:adeQ
Synonyms:yicO
Ordered Locus Names:b3664, JW5636
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11691 adeQ

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 53HelicalSequence analysisAdd BLAST24
Topological domaini54 – 63PeriplasmicSequence analysis10
Transmembranei64 – 82HelicalSequence analysisAdd BLAST19
Topological domaini83 – 84CytoplasmicSequence analysis2
Transmembranei85 – 101Discontinuously helicalSequence analysisAdd BLAST17
Topological domaini102 – 113PeriplasmicSequence analysisAdd BLAST12
Transmembranei114 – 133HelicalSequence analysisAdd BLAST20
Topological domaini134 – 145CytoplasmicSequence analysisAdd BLAST12
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 182PeriplasmicSequence analysisAdd BLAST16
Transmembranei183 – 200HelicalSequence analysisAdd BLAST18
Topological domaini201 – 204CytoplasmicSequence analysis4
Transmembranei205 – 223HelicalSequence analysisAdd BLAST19
Topological domaini224 – 251PeriplasmicSequence analysisAdd BLAST28
Transmembranei252 – 280HelicalSequence analysisAdd BLAST29
Topological domaini281 – 293CytoplasmicSequence analysisAdd BLAST13
Transmembranei294 – 309HelicalSequence analysisAdd BLAST16
Topological domaini310 – 311PeriplasmicSequence analysis2
Transmembranei312 – 327Discontinuously helicalSequence analysisAdd BLAST16
Topological domaini328 – 331CytoplasmicSequence analysis4
Transmembranei332 – 346HelicalSequence analysisAdd BLAST15
Topological domaini347 – 357PeriplasmicSequence analysisAdd BLAST11
Transmembranei358 – 377HelicalSequence analysisAdd BLAST20
Topological domaini378 – 382CytoplasmicSequence analysis5
Intramembranei383 – 418Discontinuously helicalSequence analysisAdd BLAST36
Topological domaini419 – 444CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001696211 – 444Adenine permease AdeQAdd BLAST444

Proteomic databases

PaxDbiP31440
PRIDEiP31440

Interactioni

Protein-protein interaction databases

BioGridi4260893, 115 interactors
STRINGi316385.ECDH10B_3847

Structurei

3D structure databases

ProteinModelPortaliP31440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C7N Bacteria
COG2252 LUCA
HOGENOMiHOG000244363
InParanoidiP31440
KOiK06901
OMAiGCMMIRQ
PhylomeDBiP31440

Family and domain databases

InterProiView protein in InterPro
IPR026033 Pur_Permease_PbuG-like
IPR006043 Xant/urac/vitC
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
PIRSFiPIRSF005353 PbuG, 1 hit

Sequencei

Sequence statusi: Complete.

P31440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNDNTDYVS NESGTLSRLF KLPQHGTTVR TELIAGMTTF LTMVYIVFVN
60 70 80 90 100
PQILGAAQMD PKVVFVTTCL IAGIGSIAMG IFANLPVALA PAMGLNAFFA
110 120 130 140 150
FVVVGAMGIS WQTGMGAIFW GAVGLFLLTL FRIRYWMISN IPLSLRIGIT
160 170 180 190 200
SGIGLFIALM GLKNTGVIVA NKDTLVMIGD LSSHGVLLGI LGFFIITVLS
210 220 230 240 250
SRHFHAAVLV SIVVTSCCGL FFGDVHFSGV YSIPPDISGV IGEVDLSGAL
260 270 280 290 300
TLELAGIIFS FMLINLFDSS GTLIGVTDKA GLIDGNGKFP NMNKALYVDS
310 320 330 340 350
VSSVAGAFIG TSSVTAYIES TSGVAVGGRT GLTAVVVGVM FLLVMFFSPL
360 370 380 390 400
VAIVPPYATA GALIFVGVLM TSSLARVNWD DFTESVPAFI TTVMMPFTFS
410 420 430 440
ITEGIALGFM SYCIMKVCTG RWRDLNLCVV VVAALFALKI ILVD
Length:444
Mass (Da):46,934
Last modified:December 4, 2007 - v3
Checksum:i555CECFDB53324B6
GO

Sequence cautioni

The sequence AAA62016 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62016.1 Different initiation.
U00096 Genomic DNA Translation: AAC76687.2
AP009048 Genomic DNA Translation: BAE77629.1
PIRiA65168
RefSeqiNP_418120.2, NC_000913.3
WP_001403836.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76687; AAC76687; b3664
BAE77629; BAE77629; BAE77629
GeneIDi948174
KEGGiecj:JW5636
eco:b3664
PATRICifig|511145.12.peg.3786

Similar proteinsi

Entry informationi

Entry nameiADEQ_ECOLI
AccessioniPrimary (citable) accession number: P31440
Secondary accession number(s): P76726, Q2M7X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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