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Protein

Uncharacterized inner membrane transporter YicL

Gene

yicL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11688-MONOMER.
ECOL316407:JW3634-MONOMER.

Protein family/group databases

TCDBi2.A.7.3.12. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized inner membrane transporter YicL
Gene namesi
Name:yicL
Ordered Locus Names:b3660, JW3634
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11688. yicL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77PeriplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 4517CytoplasmicSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Topological domaini67 – 715PeriplasmicSequence analysis
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Topological domaini93 – 997CytoplasmicSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 1244PeriplasmicSequence analysis
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 1516CytoplasmicSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 18412PeriplasmicSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 21611CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 26326PeriplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Topological domaini285 – 30723CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Uncharacterized inner membrane transporter YicLPRO_0000108173Add
BLAST

Proteomic databases

PaxDbiP31437.

Interactioni

Protein-protein interaction databases

BioGridi4259627. 15 interactions.
STRINGi511145.b3660.

Structurei

3D structure databases

ProteinModelPortaliP31437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 145130EamA 1Add
BLAST
Domaini167 – 291125EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the EamA transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108UZ3. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000083322.
InParanoidiP31437.
OMAiGTMLAYL.
OrthoDBiEOG6742TN.
PhylomeDBiP31437.

Family and domain databases

InterProiIPR004779. CO/AA/NH_transpt.
IPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00950. 2A78. 1 hit.

Sequencei

Sequence statusi: Complete.

P31437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTRKGMLN VLIAAVLWGS SGVCAQYIME QSQMSSQFLT MTRLIFAGLI
60 70 80 90 100
LLTLSFVHGD KIFSIINNHK DAISLLIFSV VGALTVQLTF LLTIEKSNAA
110 120 130 140 150
TATVLQFLSP TIIVAWFSLV RKSRPGILVF CAILTSLVGT FLLVTHGNPT
160 170 180 190 200
SLSISPAALF WGIASAFAAA FYTTYPSTLI ARYGTLPVVG WSMLIGGLIL
210 220 230 240 250
LPFYARQGTN FVVNGSLILA FFYLVVIGTS LTFSLYLKGA QLIGGPKASI
260 270 280 290 300
LSCAEPLSSA LLSLLLLGIT FTLPDWLGTL LILSSVILIS MDSRRRARKI

NRPARHK
Length:307
Mass (Da):33,113
Last modified:July 1, 1993 - v1
Checksum:i9EEAF9067FFCABD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62012.1.
U00096 Genomic DNA. Translation: AAC76683.1.
AP009048 Genomic DNA. Translation: BAE77634.1.
PIRiE65167.
RefSeqiNP_418116.1. NC_000913.3.
WP_000535961.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76683; AAC76683; b3660.
BAE77634; BAE77634; BAE77634.
GeneIDi948176.
KEGGiecj:JW3634.
eco:b3660.
PATRICi32122809. VBIEscCol129921_3780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62012.1.
U00096 Genomic DNA. Translation: AAC76683.1.
AP009048 Genomic DNA. Translation: BAE77634.1.
PIRiE65167.
RefSeqiNP_418116.1. NC_000913.3.
WP_000535961.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259627. 15 interactions.
STRINGi511145.b3660.

Protein family/group databases

TCDBi2.A.7.3.12. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP31437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76683; AAC76683; b3660.
BAE77634; BAE77634; BAE77634.
GeneIDi948176.
KEGGiecj:JW3634.
eco:b3660.
PATRICi32122809. VBIEscCol129921_3780.

Organism-specific databases

EchoBASEiEB1639.
EcoGeneiEG11688. yicL.

Phylogenomic databases

eggNOGiENOG4108UZ3. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000083322.
InParanoidiP31437.
OMAiGTMLAYL.
OrthoDBiEOG6742TN.
PhylomeDBiP31437.

Enzyme and pathway databases

BioCyciEcoCyc:EG11688-MONOMER.
ECOL316407:JW3634-MONOMER.

Miscellaneous databases

PROiP31437.

Family and domain databases

InterProiIPR004779. CO/AA/NH_transpt.
IPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00950. 2A78. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYICL_ECOLI
AccessioniPrimary (citable) accession number: P31437
Secondary accession number(s): Q2M7X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 20, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.