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Protein

Sugar efflux transporter C

Gene

setC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B3659-MONOMER.
ECOL316407:JW3633-MONOMER.

Protein family/group databases

TCDBi2.A.1.20.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter C
Gene namesi
Name:setC
Synonyms:yicK
Ordered Locus Names:b3659, JW3633
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11687. setC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10PeriplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 49CytoplasmicSequence analysisAdd BLAST18
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 80PeriplasmicSequence analysis10
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 104CytoplasmicSequence analysis3
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 150PeriplasmicSequence analysisAdd BLAST25
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172CytoplasmicSequence analysis1
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 224PeriplasmicSequence analysisAdd BLAST31
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 253CytoplasmicSequence analysis8
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 283PeriplasmicSequence analysis9
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 310CytoplasmicSequence analysis6
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 370PeriplasmicSequence analysisAdd BLAST39
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 394CytoplasmicSequence analysis3

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093621 – 394Sugar efflux transporter CAdd BLAST394

Proteomic databases

PaxDbiP31436.
PRIDEiP31436.

Interactioni

Protein-protein interaction databases

BioGridi4259628. 13 interactors.
STRINGi511145.b3659.

Structurei

3D structure databases

ProteinModelPortaliP31436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31436.
KOiK03291.
OMAiEMGGRHA.
PhylomeDBiP31436.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTATTPSK ILDLTAAAFL LVAFLTGIAG ALQTPTLSIF LADELKARPI
60 70 80 90 100
MVGFFFTGSA IMGILVSQFL ARHSDKQGDR KLLILLCCLF GVLACTLFAW
110 120 130 140 150
NRNYFILLST GVLLSSFAST ANPQMFALAR EHADRTGRET VMFSTFLRAQ
160 170 180 190 200
ISLAWVIGPP LAYELAMGFS FKVMYLTAAI AFVVCGLIVW LFLPSIQRNI
210 220 230 240 250
PVVTQPVEIL PSTHRKRDTR LLFVVCSMMW AANNLYMINM PLFIIDELHL
260 270 280 290 300
TDKLTGEMIG IAAGLEIPMM LIAGYYMKRI GKRLLMLIAI VSGMCFYASV
310 320 330 340 350
LMATTPAVEL ELQILNAIFL GILCGIGMLY FQDLMPEKIG SATTLYANTS
360 370 380 390
RVGWIIAGSV DGIMVEIWSY HALFWLAIGM LGIAMICLLF IKDI
Length:394
Mass (Da):43,493
Last modified:July 1, 1993 - v1
Checksum:i310838BDFD04F92F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62011.1.
U00096 Genomic DNA. Translation: AAC76682.1.
AP009048 Genomic DNA. Translation: BAE77635.1.
PIRiD65167.
RefSeqiNP_418115.1. NC_000913.3.
WP_001172878.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76682; AAC76682; b3659.
BAE77635; BAE77635; BAE77635.
GeneIDi948177.
KEGGiecj:JW3633.
eco:b3659.
PATRICi32122807. VBIEscCol129921_3779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62011.1.
U00096 Genomic DNA. Translation: AAC76682.1.
AP009048 Genomic DNA. Translation: BAE77635.1.
PIRiD65167.
RefSeqiNP_418115.1. NC_000913.3.
WP_001172878.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259628. 13 interactors.
STRINGi511145.b3659.

Protein family/group databases

TCDBi2.A.1.20.3. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31436.
PRIDEiP31436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76682; AAC76682; b3659.
BAE77635; BAE77635; BAE77635.
GeneIDi948177.
KEGGiecj:JW3633.
eco:b3659.
PATRICi32122807. VBIEscCol129921_3779.

Organism-specific databases

EchoBASEiEB1638.
EcoGeneiEG11687. setC.

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31436.
KOiK03291.
OMAiEMGGRHA.
PhylomeDBiP31436.

Enzyme and pathway databases

BioCyciEcoCyc:B3659-MONOMER.
ECOL316407:JW3633-MONOMER.

Miscellaneous databases

PROiP31436.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETC_ECOLI
AccessioniPrimary (citable) accession number: P31436
Secondary accession number(s): Q2M7X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.