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Protein

Metabotropic glutamate receptor 5

Gene

Grm5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641GlutamateBy similarity
Binding sitei151 – 1511GlutamateBy similarity
Binding sitei222 – 2221GlutamateBy similarity
Binding sitei304 – 3041GlutamateBy similarity
Binding sitei395 – 3951GlutamateBy similarity

GO - Molecular functioni

  • A2A adenosine receptor binding Source: RGD
  • calmodulin binding Source: UniProtKB
  • glutamate receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • PLC activating G-protein coupled glutamate receptor activity Source: UniProtKB

GO - Biological processi

  • activation of MAPKKK activity Source: UniProtKB
  • desensitization of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  • G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • learning Source: Ensembl
  • locomotory behavior Source: Ensembl
  • negative regulation of locomotion Source: RGD
  • phosphatidylinositol-mediated signaling Source: UniProtKB
  • phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • positive regulation of long-term neuronal synaptic plasticity Source: RGD
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of synaptic transmission, glutamatergic Source: GO_Central
  • regulation of transcription, DNA-templated Source: RGD
  • synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_345363. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 5
Short name:
mGluR5
Gene namesi
Name:Grm5
Synonyms:Gprc1e, Mglur5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2746. Grm5.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 579559ExtracellularBy similarityAdd
BLAST
Transmembranei580 – 60223Helical; Name=1By similarityAdd
BLAST
Topological domaini603 – 61210CytoplasmicBy similarity
Transmembranei613 – 63523Helical; Name=2By similarityAdd
BLAST
Topological domaini636 – 6438ExtracellularBy similarity
Transmembranei644 – 66623Helical; Name=3By similarityAdd
BLAST
Topological domaini667 – 69226CytoplasmicBy similarityAdd
BLAST
Transmembranei693 – 71321Helical; Name=4By similarityAdd
BLAST
Topological domaini714 – 73623ExtracellularBy similarityAdd
BLAST
Transmembranei737 – 75822Helical; Name=5By similarityAdd
BLAST
Topological domaini759 – 77113CytoplasmicBy similarityAdd
BLAST
Transmembranei772 – 79423Helical; Name=6By similarityAdd
BLAST
Topological domaini795 – 7973ExtracellularBy similarity
Transmembranei798 – 81922Helical; Name=7By similarityAdd
BLAST
Topological domaini820 – 1203384CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • astrocyte projection Source: RGD
  • cytosol Source: GOC
  • dendritic shaft Source: RGD
  • dendritic spine Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: RGD
  • postsynaptic density Source: RGD
  • postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1154 – 11541L → V: Normal binding to HOMER1. 1 Publication
Mutagenesisi1156 – 11561P → K: Disrupts binding to HOMER1. 1 Publication
Mutagenesisi1157 – 11571P → E: Disrupts binding to HOMER1. 1 Publication
Mutagenesisi1157 – 11571P → L: Disrupts binding to HOMER1. 1 Publication
Mutagenesisi1158 – 11581S → F: Normal binding to HOMER1. 1 Publication
Mutagenesisi1159 – 11591P → A: Normal binding to HOMER1. 1 Publication
Mutagenesisi1160 – 11601F → R: Disrupts binding to HOMER1.
Mutagenesisi1161 – 11611R → T: Normal binding to HOMER1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 12031183Metabotropic glutamate receptor 5PRO_0000012933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 99By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi240 ↔ 529By similarity
Disulfide bondi275 ↔ 277By similarity
Disulfide bondi364 ↔ 380By similarity
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi418 ↔ 425By similarity
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi510 ↔ 530By similarity
Disulfide bondi514 ↔ 533By similarity
Disulfide bondi536 ↔ 548By similarity
Disulfide bondi551 ↔ 564By similarity
Disulfide bondi643 ↔ 732By similarity
Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31424.
PRIDEiP31424.

PTM databases

PhosphoSiteiP31424.

Expressioni

Tissue specificityi

Widely distributed in neuronal cells of the central nervous system.2 Publications

Gene expression databases

ExpressionAtlasiP31424. baseline.
GenevisibleiP31424. RN.

Interactioni

Subunit structurei

Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1 and GRASP. Interacts with NCDN.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADORA2AP292743EBI-2902778,EBI-2902702From a different organism.
FYNP062412EBI-8830305,EBI-515315From a different organism.
GraspQ8R4T55EBI-2902734,EBI-7361884
PIN1Q135263EBI-8830305,EBI-714158From a different organism.
Ppp1ccP6308819EBI-2902734,EBI-80049
PRNPP041564EBI-8830305,EBI-8830282From a different organism.

Protein-protein interaction databases

BioGridi246583. 6 interactions.
DIPiDIP-41263N.
IntActiP31424. 10 interactions.
MINTiMINT-235173.
STRINGi10116.ENSRNOP00000022059.

Structurei

Secondary structure

1
1203
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1158 – 11592

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DDVX-ray1.90B1155-1160[»]
ProteinModelPortaliP31424.
SMRiP31424. Positions 25-498.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31424.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Glutamate bindingBy similarity
Regioni804 – 8085Allosteric effector bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP31424.
KOiK04604.
OMAiLRPETNH.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP31424.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000202. GPCR_3_mtglu_rcpt_5.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01055. MTABOTROPC5R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P31424-1) [UniParc]FASTAAdd to basket

Also known as: 5b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD
60 70 80 90 100
KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW
110 120 130 140 150
HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS
160 170 180 190 200
SSVAIQVQNL LQLFNIPQIA YSATSMDLSD KTLFKYFMRV VPSDAQQARA
210 220 230 240 250
MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC IAHSYKIYSN
260 270 280 290 300
AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL
310 320 330 340 350
LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR
360 370 380 390 400
NPWFQEFWQH RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI
410 420 430 440 450
NAIYSMAYGL HNMQMSLCPG YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG
460 470 480 490 500
DMILFDENGD SPGRYEIMNF KEMGKDYFDY INVGSWDNGE LKMDDDEVWS
510 520 530 540 550
KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE YVFDEYTCKA
560 570 580 590 600
CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF
610 620 630 640 650
IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI
660 670 680 690 700
GLSPAMSYSA LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI
710 720 730 740 750
CIQLGIIVAL FIMEPPDIMH DYPSIREVYL ICNTTNLGVV TPLGYNGLLI
760 770 780 790 800
LSCTFYAFKT RNVPANFNEA KYIAFTMYTT CIIWLAFVPI YFGSNYKIIT
810 820 830 840 850
MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST VVRMHVGDGK
860 870 880 890 900
SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN
910 920 930 940 950
GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP
960 970 980 990 1000
FPKSTENRGP GAAAGGGSGP GVAGAGNAGC TATGGPEPPD AGPKALYDVA
1010 1020 1030 1040 1050
EAEESFPAAA RPRSPSPIST LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ
1060 1070 1080 1090 1100
GSLMEQISSV VTRFTANISE LNSMMLSTAA TPGPPGTPIC SSYLIPKEIQ
1110 1120 1130 1140 1150
LPTTMTTFAE IQPLPAIEVT GGAQGATGVS PAQETPTGAE SAPGKPDLEE
1160 1170 1180 1190 1200
LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS

SSL
Length:1,203
Mass (Da):131,885
Last modified:November 1, 1995 - v2
Checksum:i99CA51E9E11C1EA4
GO
Isoform 1 (identifier: P31424-2) [UniParc]FASTAAdd to basket

Also known as: 5a

The sequence of this isoform differs from the canonical sequence as follows:
     876-907: Missing.

Show »
Length:1,171
Mass (Da):128,290
Checksum:i8B43A7D33497C3AC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei876 – 90732Missing in isoform 1. 1 PublicationVSP_002031Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10891 mRNA. Translation: BAA01711.1.
S64315 mRNA. Translation: AAB27666.1.
PIRiA42916.
PN0549.
RefSeqiNP_058708.1. NM_017012.1. [P31424-2]
XP_006229721.1. XM_006229659.2. [P31424-1]
UniGeneiRn.29972.

Genome annotation databases

GeneIDi24418.
KEGGirno:24418.
UCSCiRGD:2746. rat. [P31424-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10891 mRNA. Translation: BAA01711.1.
S64315 mRNA. Translation: AAB27666.1.
PIRiA42916.
PN0549.
RefSeqiNP_058708.1. NM_017012.1. [P31424-2]
XP_006229721.1. XM_006229659.2. [P31424-1]
UniGeneiRn.29972.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DDVX-ray1.90B1155-1160[»]
ProteinModelPortaliP31424.
SMRiP31424. Positions 25-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246583. 6 interactions.
DIPiDIP-41263N.
IntActiP31424. 10 interactions.
MINTiMINT-235173.
STRINGi10116.ENSRNOP00000022059.

Chemistry

BindingDBiP31424.
ChEMBLiCHEMBL2111335.
GuidetoPHARMACOLOGYi293.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP31424.

Proteomic databases

PaxDbiP31424.
PRIDEiP31424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24418.
KEGGirno:24418.
UCSCiRGD:2746. rat. [P31424-1]

Organism-specific databases

CTDi2915.
RGDi2746. Grm5.

Phylogenomic databases

eggNOGiNOG295200.
HOGENOMiHOG000218636.
HOVERGENiHBG107965.
InParanoidiP31424.
KOiK04604.
OMAiLRPETNH.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP31424.
TreeFamiTF313240.

Enzyme and pathway databases

ReactomeiREACT_345363. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTraceiP31424.
NextBioi603267.
PROiP31424.

Gene expression databases

ExpressionAtlasiP31424. baseline.
GenevisibleiP31424. RN.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000202. GPCR_3_mtglu_rcpt_5.
IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF10606. GluR_Homer-bdg. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01055. MTABOTROPC5R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction."
    Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S.
    J. Biol. Chem. 267:13361-13368(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon."
    Minakami R., Katsuki F., Sugiyama H.
    Biochem. Biophys. Res. Commun. 194:622-627(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 859-923, ALTERNATIVE SPLICING.
    Tissue: Brain.
  3. "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
    Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
    Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HOMER1; HOMER2 AND HOMER3, MUTAGENESIS OF LEU-1154; PRO-1156; PRO-1157; SER-1158; PRO-1159 AND ARG-1161.
  4. "Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors."
    Ishikawa K., Nash S.R., Nishimune A., Neki A., Kaneko S., Nakanishi S.
    Genes Cells 4:381-390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIAH1.
  5. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRASP.
  6. "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling."
    Wang H., Westin L., Nong Y., Birnbaum S., Bendor J., Brismar H., Nestler E., Aperia A., Flajolet M., Greengard P.
    Science 326:1554-1557(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCDN.
  7. "Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses."
    Verpelli C., Dvoretskova E., Vicidomini C., Rossi F., Chiappalone M., Schoen M., Di Stefano B., Mantegazza R., Broccoli V., Boeckers T.M., Dityatev A., Sala C.
    J. Biol. Chem. 286:34839-34850(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SYNAPTIC ACTIVITY, TISSUE SPECIFICITY.
  8. "Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition."
    Beneken J., Tu J.C., Xiao B., Nuriya M., Yuan J.P., Worley P.F., Leahy D.J.
    Neuron 26:143-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1155-1160 IN COMPLEX WITH HOMER1.

Entry informationi

Entry nameiGRM5_RAT
AccessioniPrimary (citable) accession number: P31424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: July 22, 2015
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.