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P31424

- GRM5_RAT

UniProt

P31424 - GRM5_RAT

Protein

Metabotropic glutamate receptor 5

Gene

Grm5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641GlutamateBy similarity
    Binding sitei151 – 1511GlutamateBy similarity
    Binding sitei222 – 2221GlutamateBy similarity
    Binding sitei304 – 3041GlutamateBy similarity
    Binding sitei395 – 3951GlutamateBy similarity

    GO - Molecular functioni

    1. A2A adenosine receptor binding Source: RGD
    2. calmodulin binding Source: UniProtKB
    3. glutamate receptor activity Source: UniProtKB
    4. G-protein coupled receptor activity Source: UniProtKB
    5. PDZ domain binding Source: UniProtKB
    6. PLC activating G-protein coupled glutamate receptor activity Source: UniProtKB
    7. protein binding Source: IntAct

    GO - Biological processi

    1. activation of MAPKKK activity Source: UniProtKB
    2. desensitization of G-protein coupled receptor protein signaling pathway Source: UniProtKB
    3. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    4. learning Source: Ensembl
    5. locomotory behavior Source: Ensembl
    6. negative regulation of locomotion Source: RGD
    7. phosphatidylinositol-mediated signaling Source: UniProtKB
    8. phospholipase C-activating G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    9. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
    10. positive regulation of long-term neuronal synaptic plasticity Source: RGD
    11. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    12. protein phosphorylation Source: UniProtKB
    13. regulation of synaptic transmission, glutamatergic Source: RefGenome
    14. regulation of transcription, DNA-templated Source: RGD
    15. synaptic transmission Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 5
    Short name:
    mGluR5
    Gene namesi
    Name:Grm5
    Synonyms:Gprc1e, Mglur5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2746. Grm5.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. astrocyte projection Source: RGD
    2. cytoplasm Source: Ensembl
    3. dendritic shaft Source: RGD
    4. dendritic spine Source: RGD
    5. integral component of plasma membrane Source: UniProtKB
    6. membrane Source: RGD
    7. postsynaptic density Source: RGD
    8. postsynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1154 – 11541L → V: Normal binding to HOMER1. 1 Publication
    Mutagenesisi1156 – 11561P → K: Disrupts binding to HOMER1. 1 Publication
    Mutagenesisi1157 – 11571P → E: Disrupts binding to HOMER1. 1 Publication
    Mutagenesisi1157 – 11571P → L: Disrupts binding to HOMER1. 1 Publication
    Mutagenesisi1158 – 11581S → F: Normal binding to HOMER1. 1 Publication
    Mutagenesisi1159 – 11591P → A: Normal binding to HOMER1. 1 Publication
    Mutagenesisi1160 – 11601F → R: Disrupts binding to HOMER1.
    Mutagenesisi1161 – 11611R → T: Normal binding to HOMER1. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 12031183Metabotropic glutamate receptor 5PRO_0000012933Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 99By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi240 ↔ 529By similarity
    Disulfide bondi275 ↔ 277By similarity
    Disulfide bondi364 ↔ 380By similarity
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi418 ↔ 425By similarity
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi510 ↔ 530By similarity
    Disulfide bondi514 ↔ 533By similarity
    Disulfide bondi536 ↔ 548By similarity
    Disulfide bondi551 ↔ 564By similarity
    Disulfide bondi643 ↔ 732By similarity
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP31424.
    PRIDEiP31424.

    PTM databases

    PhosphoSiteiP31424.

    Expressioni

    Tissue specificityi

    Widely distributed in neuronal cells of the central nervous system.2 Publications

    Gene expression databases

    GenevestigatoriP31424.

    Interactioni

    Subunit structurei

    Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1 and GRASP. Interacts with NCDN.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ADORA2AP292743EBI-2902778,EBI-2902702From a different organism.
    FYNP062412EBI-8830305,EBI-515315From a different organism.
    GraspQ8R4T55EBI-2902734,EBI-7361884
    PIN1Q135263EBI-8830305,EBI-714158From a different organism.
    Ppp1ccP6308819EBI-2902734,EBI-80049
    PRNPP041564EBI-8830305,EBI-8830282From a different organism.

    Protein-protein interaction databases

    BioGridi246583. 7 interactions.
    DIPiDIP-41263N.
    IntActiP31424. 10 interactions.
    MINTiMINT-235173.

    Structurei

    Secondary structure

    1
    1203
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni1158 – 11592

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DDVX-ray1.90B1155-1160[»]
    ProteinModelPortaliP31424.
    SMRiP31424. Positions 25-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP31424.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 579559ExtracellularBy similarityAdd
    BLAST
    Topological domaini603 – 61210CytoplasmicBy similarity
    Topological domaini636 – 6438ExtracellularBy similarity
    Topological domaini667 – 69226CytoplasmicBy similarityAdd
    BLAST
    Topological domaini714 – 73623ExtracellularBy similarityAdd
    BLAST
    Topological domaini759 – 77113CytoplasmicBy similarityAdd
    BLAST
    Topological domaini795 – 7973ExtracellularBy similarity
    Topological domaini820 – 1203384CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei580 – 60223Helical; Name=1By similarityAdd
    BLAST
    Transmembranei613 – 63523Helical; Name=2By similarityAdd
    BLAST
    Transmembranei644 – 66623Helical; Name=3By similarityAdd
    BLAST
    Transmembranei693 – 71321Helical; Name=4By similarityAdd
    BLAST
    Transmembranei737 – 75822Helical; Name=5By similarityAdd
    BLAST
    Transmembranei772 – 79423Helical; Name=6By similarityAdd
    BLAST
    Transmembranei798 – 81922Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 1743Glutamate bindingBy similarity
    Regioni804 – 8085Allosteric effector bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    GeneTreeiENSGT00750000117484.
    HOGENOMiHOG000218636.
    HOVERGENiHBG107965.
    InParanoidiP31424.
    KOiK04604.
    OMAiAPLCSSY.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiP31424.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000202. GPCR_3_mtglu_rcpt_5.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01055. MTABOTROPC5R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: P31424-1) [UniParc]FASTAAdd to Basket

    Also known as: 5b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD     50
    KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW 100
    HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSFRSKK PIVGVIGPGS 150
    SSVAIQVQNL LQLFNIPQIA YSATSMDLSD KTLFKYFMRV VPSDAQQARA 200
    MVDIVKRYNW TYVSAVHTEG NYGESGMEAF KDMSAKEGIC IAHSYKIYSN 250
    AGEQSFDKLL KKLRSHLPKA RVVACFCEGM TVRGLLMAMR RLGLAGEFLL 300
    LGSDGWADRY DVTDGYQREA VGGITIKLQS PDVKWFDDYY LKLRPETNLR 350
    NPWFQEFWQH RFQCRLEGFA QENSKYNKTC NSSLTLRTHH VQDSKMGFVI 400
    NAIYSMAYGL HNMQMSLCPG YAGLCDAMKP IDGRKLLDSL MKTNFTGVSG 450
    DMILFDENGD SPGRYEIMNF KEMGKDYFDY INVGSWDNGE LKMDDDEVWS 500
    KKNNIIRSVC SEPCEKGQIK VIRKGEVSCC WTCTPCKENE YVFDEYTCKA 550
    CQLGSWPTDD LTGCDLIPVQ YLRWGDPEPI AAVVFACLGL LATLFVTVIF 600
    IIYRDTPVVK SSSRELCYII LAGICLGYLC TFCLIAKPKQ IYCYLQRIGI 650
    GLSPAMSYSA LVTKTNRIAR ILAGSKKKIC TKKPRFMSAC AQLVIAFILI 700
    CIQLGIIVAL FIMEPPDIMH DYPSIREVYL ICNTTNLGVV TPLGYNGLLI 750
    LSCTFYAFKT RNVPANFNEA KYIAFTMYTT CIIWLAFVPI YFGSNYKIIT 800
    MCFSVSLSAT VALGCMFVPK VYIILAKPER NVRSAFTTST VVRMHVGDGK 850
    SSSAASRSSS LVNLWKRRGS SGETLRYKDR RLAQHKSEIE CFTPKGSMGN 900
    GGRATMSSSN GKSVTWAQNE KSTRGQHLWQ RLSVHINKKE NPNQTAVIKP 950
    FPKSTENRGP GAAAGGGSGP GVAGAGNAGC TATGGPEPPD AGPKALYDVA 1000
    EAEESFPAAA RPRSPSPIST LSHLAGSAGR TDDDAPSLHS ETAARSSSSQ 1050
    GSLMEQISSV VTRFTANISE LNSMMLSTAA TPGPPGTPIC SSYLIPKEIQ 1100
    LPTTMTTFAE IQPLPAIEVT GGAQGATGVS PAQETPTGAE SAPGKPDLEE 1150
    LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT LIIRDYTQSS 1200
    SSL 1203
    Length:1,203
    Mass (Da):131,885
    Last modified:November 1, 1995 - v2
    Checksum:i99CA51E9E11C1EA4
    GO
    Isoform 1 (identifier: P31424-2) [UniParc]FASTAAdd to Basket

    Also known as: 5a

    The sequence of this isoform differs from the canonical sequence as follows:
         876-907: Missing.

    Show »
    Length:1,171
    Mass (Da):128,290
    Checksum:i8B43A7D33497C3AC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei876 – 90732Missing in isoform 1. 1 PublicationVSP_002031Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10891 mRNA. Translation: BAA01711.1.
    S64315 mRNA. Translation: AAB27666.1.
    PIRiA42916.
    PN0549.
    RefSeqiNP_058708.1. NM_017012.1. [P31424-2]
    XP_006229717.1. XM_006229655.1. [P31424-1]
    XP_006229718.1. XM_006229656.1. [P31424-1]
    XP_006229719.1. XM_006229657.1. [P31424-1]
    XP_006229720.1. XM_006229658.1. [P31424-1]
    XP_006229721.1. XM_006229659.1. [P31424-1]
    XP_006229722.1. XM_006229660.1. [P31424-2]
    UniGeneiRn.29972.

    Genome annotation databases

    EnsembliENSRNOT00000022060; ENSRNOP00000022059; ENSRNOG00000016429. [P31424-1]
    ENSRNOT00000050639; ENSRNOP00000040016; ENSRNOG00000016429. [P31424-2]
    GeneIDi24418.
    KEGGirno:24418.
    UCSCiRGD:2746. rat. [P31424-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10891 mRNA. Translation: BAA01711.1 .
    S64315 mRNA. Translation: AAB27666.1 .
    PIRi A42916.
    PN0549.
    RefSeqi NP_058708.1. NM_017012.1. [P31424-2 ]
    XP_006229717.1. XM_006229655.1. [P31424-1 ]
    XP_006229718.1. XM_006229656.1. [P31424-1 ]
    XP_006229719.1. XM_006229657.1. [P31424-1 ]
    XP_006229720.1. XM_006229658.1. [P31424-1 ]
    XP_006229721.1. XM_006229659.1. [P31424-1 ]
    XP_006229722.1. XM_006229660.1. [P31424-2 ]
    UniGenei Rn.29972.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DDV X-ray 1.90 B 1155-1160 [» ]
    ProteinModelPortali P31424.
    SMRi P31424. Positions 25-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246583. 7 interactions.
    DIPi DIP-41263N.
    IntActi P31424. 10 interactions.
    MINTi MINT-235173.

    Chemistry

    BindingDBi P31424.
    ChEMBLi CHEMBL2111335.
    GuidetoPHARMACOLOGYi 293.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P31424.

    Proteomic databases

    PaxDbi P31424.
    PRIDEi P31424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022060 ; ENSRNOP00000022059 ; ENSRNOG00000016429 . [P31424-1 ]
    ENSRNOT00000050639 ; ENSRNOP00000040016 ; ENSRNOG00000016429 . [P31424-2 ]
    GeneIDi 24418.
    KEGGi rno:24418.
    UCSCi RGD:2746. rat. [P31424-1 ]

    Organism-specific databases

    CTDi 2915.
    RGDi 2746. Grm5.

    Phylogenomic databases

    eggNOGi NOG295200.
    GeneTreei ENSGT00750000117484.
    HOGENOMi HOG000218636.
    HOVERGENi HBG107965.
    InParanoidi P31424.
    KOi K04604.
    OMAi APLCSSY.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi P31424.
    TreeFami TF313240.

    Miscellaneous databases

    EvolutionaryTracei P31424.
    NextBioi 603267.
    PROi P31424.

    Gene expression databases

    Genevestigatori P31424.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000202. GPCR_3_mtglu_rcpt_5.
    IPR019588. Metabotropic_Glu_rcpt_Homer-bd.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF10606. GluR_Homer-bdg. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01055. MTABOTROPC5R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction."
      Abe T., Sugihara H., Nawa H., Shigemoto R., Mizuno N., Nakanishi S.
      J. Biol. Chem. 267:13361-13368(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon."
      Minakami R., Katsuki F., Sugiyama H.
      Biochem. Biophys. Res. Commun. 194:622-627(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 859-923, ALTERNATIVE SPLICING.
      Tissue: Brain.
    3. "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors."
      Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., Worley P.F.
      Neuron 21:717-726(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HOMER1; HOMER2 AND HOMER3, MUTAGENESIS OF LEU-1154; PRO-1156; PRO-1157; SER-1158; PRO-1159 AND ARG-1161.
    4. "Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors."
      Ishikawa K., Nash S.R., Nishimune A., Neki A., Kaneko S., Nakanishi S.
      Genes Cells 4:381-390(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIAH1.
    5. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
      Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
      J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRASP.
    6. "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling."
      Wang H., Westin L., Nong Y., Birnbaum S., Bendor J., Brismar H., Nestler E., Aperia A., Flajolet M., Greengard P.
      Science 326:1554-1557(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCDN.
    7. "Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses."
      Verpelli C., Dvoretskova E., Vicidomini C., Rossi F., Chiappalone M., Schoen M., Di Stefano B., Mantegazza R., Broccoli V., Boeckers T.M., Dityatev A., Sala C.
      J. Biol. Chem. 286:34839-34850(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SYNAPTIC ACTIVITY, TISSUE SPECIFICITY.
    8. "Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition."
      Beneken J., Tu J.C., Xiao B., Nuriya M., Yuan J.P., Worley P.F., Leahy D.J.
      Neuron 26:143-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1155-1160 IN COMPLEX WITH HOMER1.

    Entry informationi

    Entry nameiGRM5_RAT
    AccessioniPrimary (citable) accession number: P31424
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3