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P31423

- GRM4_RAT

UniProt

P31423 - GRM4_RAT

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Protein
Metabotropic glutamate receptor 4
Gene
Grm4, Gprc1d, Mglur4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591Glutamate By similarity
Binding sitei230 – 2301Glutamate By similarity
Binding sitei312 – 3121Glutamate By similarity
Binding sitei405 – 4051Glutamate By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. calcium-dependent protein binding Source: RGD
  3. calmodulin binding Source: RGD
  4. glutamate receptor activity Source: UniProtKB
  5. group III metabotropic glutamate receptor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  3. gamma-aminobutyric acid secretion Source: UniProtKB
  4. learning Source: Ensembl
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of cell proliferation Source: UniProtKB
  7. negative regulation of synaptic transmission Source: UniProtKB
  8. neuron projection development Source: UniProtKB
  9. regulation of neuron apoptotic process Source: UniProtKB
  10. regulation of synaptic transmission, glutamatergic Source: RefGenome
  11. synaptic transmission, GABAergic Source: UniProtKB
  12. synaptic transmission, glutamatergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 4
Short name:
mGluR4
Gene namesi
Name:Grm4
Synonyms:Gprc1d, Mglur4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2745. Grm4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 587555Extracellular Reviewed prediction
Add
BLAST
Transmembranei588 – 61023Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini611 – 62414Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei625 – 64521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini646 – 65611Extracellular Reviewed prediction
Add
BLAST
Transmembranei657 – 67519Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini676 – 69924Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei700 – 72021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini721 – 75030Extracellular Reviewed prediction
Add
BLAST
Transmembranei751 – 77222Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini773 – 78513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei786 – 80823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini809 – 82113Extracellular Reviewed prediction
Add
BLAST
Transmembranei822 – 84726Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini848 – 91265Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. dendritic shaft Source: UniProtKB
  3. integral component of plasma membrane Source: RefGenome
  4. presynaptic active zone membrane Source: UniProtKB
  5. terminal bouton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 912880Metabotropic glutamate receptor 4
PRO_0000012931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 109 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi249 ↔ 538 By similarity
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi372 ↔ 388 By similarity
Disulfide bondi428 ↔ 435 By similarity
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi520 ↔ 539 By similarity
Disulfide bondi524 ↔ 542 By similarity
Disulfide bondi545 ↔ 557 By similarity
Disulfide bondi560 ↔ 573 By similarity
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31423.
PRIDEiP31423.

PTM databases

PhosphoSiteiP31423.

Expressioni

Tissue specificityi

Is widely distributed in the CNS. Predominant expression is seen in the granule cells of the cerebellum.

Gene expression databases

GenevestigatoriP31423.

Interactioni

Subunit structurei

Interacts with PICK1.1 Publication

Protein-protein interaction databases

BioGridi246582. 6 interactions.
DIPiDIP-41144N.
IntActiP31423. 4 interactions.
MINTiMINT-235145.

Structurei

3D structure databases

ProteinModelPortaliP31423.
SMRiP31423. Positions 38-508.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
HOVERGENiHBG107965.
KOiK04607.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001786. GPCR_3_mtglu_rcpt_4.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01054. MTABOTROPC4R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31423-1 [UniParc]FASTAAdd to Basket

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MSGKGGWAWW WARLPLCLLL SLYAPWVPSS LGKPKGHPHM NSIRIDGDIT    50
LGGLFPVHGR GSEGKACGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT 100
LGARILDTCS RDTHALEQSL TFVQALIEKD GTEVRCGSGG PPIITKPERV 150
VGVIGASGSS VSIMVANILR LFKIPQISYA STAPDLSDNS RYDFFSRVVP 200
SDTYQAQAMV DIVRALKWNY VSTLASEGSY GESGVEAFIQ KSRENGGVCI 250
AQSVKIPREP KTGEFDKIIK RLLETSNARG IIIFANEDDI RRVLEAARRA 300
NQTGHFFWMG SDSWGSKSAP VLRLEEVAEG AVTILPKRMS VRGFDRYFSS 350
RTLDNNRRNI WFAEFWEDNF HCKLSRHALK KGSHIKKCTN RERIGQDSAY 400
EQEGKVQFVI DAVYAMGHAL HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI 450
RNVNFSGIAG NPVTFNENGD APGRYDIYQY QLRNGSAEYK VIGSWTDHLH 500
LRIERMQWPG SGQQLPRSIC SLPCQPGERK KTVKGMACCW HCEPCTGYQY 550
QVDRYTCKTC PYDMRPTENR TSCQPIPIVK LEWDSPWAVL PLFLAVVGIA 600
ATLFVVVTFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG 650
TCSLRRIFLG LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL 700
AITFILISLQ LLGICVWFVV DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD 750
LSLICLLGYS MLLMVTCTVY AIKTRGVPET FNEAKPIGFT MYTTCIVWLA 800
FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP KVYIILFHPE 850
QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLETPALAT 900
KQTYVTYTNH AI 912
Length:912
Mass (Da):101,819
Last modified:July 1, 1993 - v1
Checksum:i336430EF19B4B577
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241Q → R in AAA93190. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92077 mRNA. No translation available.
M90518 mRNA. Translation: AAA93190.1.
PIRiJH0563.
RefSeqiNP_073157.1. NM_022666.1.
UniGeneiRn.89046.

Genome annotation databases

GeneIDi24417.
KEGGirno:24417.
UCSCiRGD:2745. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92077 mRNA. No translation available.
M90518 mRNA. Translation: AAA93190.1 .
PIRi JH0563.
RefSeqi NP_073157.1. NM_022666.1.
UniGenei Rn.89046.

3D structure databases

ProteinModelPortali P31423.
SMRi P31423. Positions 38-508.
ModBasei Search...

Protein-protein interaction databases

BioGridi 246582. 6 interactions.
DIPi DIP-41144N.
IntActi P31423. 4 interactions.
MINTi MINT-235145.

Chemistry

BindingDBi P31423.
ChEMBLi CHEMBL2787.
GuidetoPHARMACOLOGYi 292.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P31423.

Proteomic databases

PaxDbi P31423.
PRIDEi P31423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24417.
KEGGi rno:24417.
UCSCi RGD:2745. rat.

Organism-specific databases

CTDi 2914.
RGDi 2745. Grm4.

Phylogenomic databases

eggNOGi NOG295200.
HOVERGENi HBG107965.
KOi K04607.

Miscellaneous databases

NextBioi 603263.

Gene expression databases

Genevestigatori P31423.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001786. GPCR_3_mtglu_rcpt_4.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01054. MTABOTROPC4R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of metabotropic glutamate receptors."
    Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S.
    Neuron 8:169-179(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins."
    O'Hara P.J., Sheppard P.O., Thoegersen H., Venezia D., Haldeman B.A., McGrane V., Houamed K.M., Thomsen C., Gilbert T.L., Mulvihill E.R.
    Neuron 11:41-52(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 347-357 AND 686-692, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1."
    El Far O., Airas J., Wischmeyer E., Nehring R.B., Karschin A., Betz H.
    Eur. J. Neurosci. 12:4215-4221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PICK1.

Entry informationi

Entry nameiGRM4_RAT
AccessioniPrimary (citable) accession number: P31423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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