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P31421

- GRM2_RAT

UniProt

P31421 - GRM2_RAT

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Protein

Metabotropic glutamate receptor 2

Gene

Grm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451GlutamateBy similarity
Binding sitei216 – 2161GlutamateBy similarity
Binding sitei295 – 2951GlutamateBy similarity
Binding sitei377 – 3771GlutamateBy similarity

GO - Molecular functioni

  1. calcium channel regulator activity Source: RefGenome
  2. group II metabotropic glutamate receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: GOC
  2. glutamate secretion Source: UniProtKB
  3. regulation of neurotransmitter secretion Source: UniProtKB
  4. regulation of synaptic transmission, glutamatergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 2
Short name:
mGluR2
Gene namesi
Name:Grm2
Synonyms:Gprc1b, Mglur2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2743. Grm2.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. integral component of plasma membrane Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. presynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 872854Metabotropic glutamate receptor 2PRO_0000012926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 92By similarity
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi234 ↔ 518By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi355 ↔ 362By similarity
Disulfide bondi400 ↔ 407By similarity
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi500 ↔ 519By similarity
Disulfide bondi504 ↔ 522By similarity
Disulfide bondi525 ↔ 537By similarity
Disulfide bondi540 ↔ 553By similarity
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP31421.

PTM databases

PhosphoSiteiP31421.

Expressioni

Tissue specificityi

Is widely distributed in the CNS and prominent expression is seen in Golgi cells of the cerebellum and some particular neuronal cells in other brain regions.

Gene expression databases

GenevestigatoriP31421.

Interactioni

Subunit structurei

Interacts with HTR2A (By similarity). Interacts with GRASP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Htr2aP148423EBI-7090147,EBI-7090176
RANBP9Q96S594EBI-7090147,EBI-636085From a different organism.

Protein-protein interaction databases

BioGridi246580. 2 interactions.
IntActiP31421. 2 interactions.
MINTiMINT-146442.
STRINGi10116.ENSRNOP00000017607.

Structurei

3D structure databases

ProteinModelPortaliP31421.
SMRiP31421. Positions 23-558.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 567549ExtracellularSequence AnalysisAdd
BLAST
Topological domaini591 – 60414CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini626 – 63611ExtracellularSequence AnalysisAdd
BLAST
Topological domaini656 – 67924CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini701 – 72525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini748 – 76013CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini784 – 79310ExtracellularSequence Analysis
Topological domaini820 – 87253CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei568 – 59023Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei605 – 62521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei637 – 65519Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei680 – 70021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei726 – 74722Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei761 – 78323Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei794 – 81926Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 1683Glutamate bindingBy similarity
Regioni677 – 6859Important for interaction with HTR2ABy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiP31421.
KOiK04605.
OMAiVTLKCNN.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP31421.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001458. GPCR_3_mtglu_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01052. MTABOTROPC2R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31421-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLLGFLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEEC
60 70 80 90 100
GPVNEHRGIQ RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE
110 120 130 140 150
QALDFVRASL SRGADGSRHI CPDGSYATHS DAPTAVTGVI GGSYSDVSIQ
160 170 180 190 200
VANLLRLFQI PQISYASTSA KLSDKSRYDY FARTVPPDFF QAKAMAEILR
210 220 230 240 250
FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK VGRAMSRAAF
260 270 280 290 300
EGVVRALLQK PSARVAVLFT RSEDARELLA ATQRLNASFT WVASDGWGAL
310 320 330 340 350
ESVVAGSERA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE
360 370 380 390 400
ERFHCSFRQR DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC
410 420 430 440 450
PNTTHLCDAM RPVNGRRLYK DFVLNVKFDA PFRPADTDDE VRFDRFGDGI
460 470 480 490 500
GRYNIFTYLR AGSGRYRYQK VGYWAEGLTL DTSFIPWASP SAGPLPASRC
510 520 530 540 550
SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC GLGYWPNASL
560 570 580 590 600
TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA
610 620 630 640 650
SGRELCYILL GGVFLCYCMT FVFIAKPSTA VCTLRRLGLG TAFSVCYSAL
660 670 680 690 700
LTKTNRIARI FGGAREGAQR PRFISPASQV AICLALISGQ LLIVAAWLVV
710 720 730 740 750
EAPGTGKETA PERREVVTLR CNHRDASMLG SLAYNVLLIA LCTLYAFKTR
760 770 780 790 800
KCPENFNEAK FIGFTMYTTC IIWLAFLPIF YVTSSDYRVQ TTTMCVSVSL
810 820 830 840 850
SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAP RASANLGQGS
860 870
GSQFVPTVCN GREVVDSTTS SL
Length:872
Mass (Da):95,774
Last modified:July 1, 1993 - v1
Checksum:i1E74CABD6AD4BED9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92075 mRNA. No translation available.
PIRiJH0561.
RefSeqiNP_001099181.1. NM_001105711.1.
UniGeneiRn.9681.

Genome annotation databases

EnsembliENSRNOT00000017607; ENSRNOP00000017607; ENSRNOG00000013171.
GeneIDi24415.
KEGGirno:24415.
UCSCiRGD:2743. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92075 mRNA. No translation available.
PIRi JH0561.
RefSeqi NP_001099181.1. NM_001105711.1.
UniGenei Rn.9681.

3D structure databases

ProteinModelPortali P31421.
SMRi P31421. Positions 23-558.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246580. 2 interactions.
IntActi P31421. 2 interactions.
MINTi MINT-146442.
STRINGi 10116.ENSRNOP00000017607.

Chemistry

BindingDBi P31421.
ChEMBLi CHEMBL2111335.
GuidetoPHARMACOLOGYi 290.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P31421.

Proteomic databases

PRIDEi P31421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017607 ; ENSRNOP00000017607 ; ENSRNOG00000013171 .
GeneIDi 24415.
KEGGi rno:24415.
UCSCi RGD:2743. rat.

Organism-specific databases

CTDi 2912.
RGDi 2743. Grm2.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi P31421.
KOi K04605.
OMAi VTLKCNN.
OrthoDBi EOG7Z0JXG.
PhylomeDBi P31421.
TreeFami TF313240.

Miscellaneous databases

NextBioi 603251.
PROi P31421.

Gene expression databases

Genevestigatori P31421.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001458. GPCR_3_mtglu_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01052. MTABOTROPC2R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A family of metabotropic glutamate receptors."
    Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S.
    Neuron 8:169-179(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRASP.

Entry informationi

Entry nameiGRM2_RAT
AccessioniPrimary (citable) accession number: P31421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3