P31419 (OBP2_MANSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
General odorant-binding protein 2
Short name=GOBP 2

Gene names

Name:

GOBP2

Organism

Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

Taxonomic identifier

7130 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Amphiesmenoptera › Lepidoptera › Glossata › Neolepidoptera › Heteroneura › Ditrysia › Obtectomera › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Subunit structure	Homodimer Probable.
Tissue specificity	Olfactory tissue; expressed by the glia-like support cells that ensheathe the sensory neurons and line the base of the sensillum lumen.
Sequence similarities	Belongs to the PBP/GOBP family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction Transport
Domain	Signal
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	odorant binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.2
	Chain	21 – 161	141	General odorant-binding protein 2		PRO_0000012585
Amino acid modifications
	Disulfide bond	39 ↔ 74		By similarity
	Disulfide bond	70 ↔ 128		By similarity
	Disulfide bond	117 ↔ 137		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P31419 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 3CA2BB78E88C0CA2	FASTA	161	18,504
	10 20 30 40 50 60 MVNRLILMVV VVFITDSVMG TAEVMSHVTA HFGKALEECR EESGLPVEVM DEFKHFWRED 70 80 90 100 110 120 FEVVHRELGC AIICMSNKFE LLQDDTRIHH VKMHDYIKSF PNGQVLSEKM VQLIHNCEKQ 130 140 150 160 YDDIADDCDR VVKVAACFKK DAKKEGIAPE VAMIEAVIEK Y

References

[1]	"Molecular cloning and sequencing of general odorant-binding proteins GOBP1 and GOBP2 from the tobacco hawk moth Manduca sexta: comparisons with other insect OBPs and their signal peptides." Vogt R.G., Rybczynski R., Lerner M.R. J. Neurosci. 11:2972-2984(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects." Vogt R.G., Prestwich G.D., Lerner M.R. J. Neurobiol. 22:74-84(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-38.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73798 mRNA. Translation: AAA29316.1.
PIR	A44821.
3D structure databases
ProteinModelPortal	P31419.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.238.20. 1 hit.
InterPro	IPR006072. Odorant/phero-bd_Lep. IPR006170. PBP_GOBP. IPR023316. PBP_GOBP_dom. [Graphical view]
Pfam	PF01395. PBP_GOBP. 1 hit. [Graphical view]
PIRSF	PIRSF015604. Odorant/phero_bd. 1 hit.
PRINTS	PR00484. PBPGOBP.
SMART	SM00708. PhBP. 1 hit. [Graphical view]
SUPFAM	SSF47565. PBP_GOBP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OBP2_MANSE

Accession

Primary (citable) accession number: P31419

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)