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P31411 (VATB_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit B

Short name=V-ATPase subunit B
Alternative name(s):
V-ATPase 57 kDa subunit
Vacuolar proton pump subunit B
Gene names
Name:vma2
ORF Names:SPAC637.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. HAMAP-Rule MF_00310

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein). Interacts with rav1. Ref.3

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503V-type proton ATPase subunit B HAMAP-Rule MF_00310
PRO_0000144647

Amino acid modifications

Modified residue4911Phosphoserine Ref.4
Modified residue4921Phosphoserine Ref.4
Modified residue5021Phosphoserine Ref.4
Modified residue5031Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P31411 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: BC1C15C7E915920F

FASTA50355,841
        10         20         30         40         50         60 
MASLFDINAA AAVKDYSIKP RLSYNTVNSI TGPLVILDNI RRPQYNEIVN LNLPDGSVRS 

        70         80         90        100        110        120 
GQVLEVAGHK AIVQVFEGTS GVDVRKTTID FTGHSMRIPV SEDMLGRVFN GSGLPIDKGP 

       130        140        150        160        170        180 
NLLAEDYLDI NGSPINPYAR IYPEEMIQTG ISSIDGLNSI ARGQKIPIFS AAGLPHNEIA 

       190        200        210        220        230        240 
AQICRQAGLV KRPTKDVHDG HEDNFSIVFA AMGVNLETAR FFQRDFEENG SFERVTLFLN 

       250        260        270        280        290        300 
LANDPTIERI ITPRLALSAS EFLAYQTEKH VLTILTDMTS YADALREVSA AREEVPGRRG 

       310        320        330        340        350        360 
YPGYMYTDLS TIYERAGRVE GRNGSITQIP ILTMPNDDIT HPIPDLTGYI TEGQIFVDRQ 

       370        380        390        400        410        420 
LHNNAIYPPI NVLPSLSRLM KSAIGEGMTR NDHGDVSNQL YAMYAIGRDA ASMKSVVGEE 

       430        440        450        460        470        480 
ALSQEDRLAL EFLGKFEKTF ISQGAYENRT IFETLDLAWS LLRIFPREML TRIPKKILDQ 

       490        500 
YYSRSSAYTE SSKDVIDNTP ESS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of the genes encoding subunits A and B of the vacuolar H(+)-ATPase of Schizosaccharomyces pombe."
Ghislain M., Bowman E.J.
Yeast 8:791-799(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe."
Dawson K., Toone W.M., Jones N., Wilkinson C.R.
Eukaryot. Cell 7:926-937(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAV1.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491; SER-492; SER-502 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69638 Genomic DNA. Translation: CAA49339.1.
CU329670 Genomic DNA. Translation: CAA22584.1.
PIRS25335.
T38997.
RefSeqNP_594623.1. NM_001020051.2.

3D structure databases

ProteinModelPortalP31411.
SMRP31411. Positions 32-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279830. 6 interactions.
MINTMINT-4688355.
STRING4896.SPAC637.05c-1.

Proteomic databases

PaxDbP31411.
PRIDEP31411.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC637.05c.1; SPAC637.05c.1:pep; SPAC637.05c.
GeneID2543408.
KEGGspo:SPAC637.05c.

Organism-specific databases

PomBaseSPAC637.05c.

Phylogenomic databases

eggNOGCOG1156.
HOGENOMHOG000165320.
KOK02147.
OMAETMKMPV.
OrthoDBEOG7H79BK.
PhylomeDBP31411.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00310. ATP_synth_B_arch.
InterProIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR005723. ATPase_V1-cplx_bsu.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01040. V-ATPase_V1_B. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804423.

Entry information

Entry nameVATB_SCHPO
AccessionPrimary (citable) accession number: P31411
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names