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P31411

- VATB_SCHPO

UniProt

P31411 - VATB_SCHPO

Protein

V-type proton ATPase subunit B

Gene

vma2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. proton-transporting ATPase activity, rotational mechanism Source: PomBase

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: PomBase
    2. vacuolar acidification Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit B
    Short name:
    V-ATPase subunit B
    Alternative name(s):
    V-ATPase 57 kDa subunit
    Vacuolar proton pump subunit B
    Gene namesi
    Name:vma2
    ORF Names:SPAC637.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC637.05c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. vacuolar proton-transporting V-type ATPase, V1 domain Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503V-type proton ATPase subunit BPRO_0000144647Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei491 – 4911Phosphoserine1 Publication
    Modified residuei492 – 4921Phosphoserine1 Publication
    Modified residuei502 – 5021Phosphoserine1 Publication
    Modified residuei503 – 5031Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP31411.
    PaxDbiP31411.
    PRIDEiP31411.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein). Interacts with rav1.1 Publication

    Protein-protein interaction databases

    BioGridi279830. 6 interactions.
    MINTiMINT-4688355.
    STRINGi4896.SPAC637.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP31411.
    SMRiP31411. Positions 32-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1156.
    HOGENOMiHOG000165320.
    KOiK02147.
    OMAiTVCEFTG.
    OrthoDBiEOG7H79BK.
    PhylomeDBiP31411.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00310. ATP_synth_B_arch.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR005723. ATPase_V1-cplx_bsu.
    IPR027417. P-loop_NTPase.
    IPR022879. V-ATPase_su_B/beta.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01040. V-ATPase_V1_B. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31411-1 [UniParc]FASTAAdd to Basket

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    MASLFDINAA AAVKDYSIKP RLSYNTVNSI TGPLVILDNI RRPQYNEIVN    50
    LNLPDGSVRS GQVLEVAGHK AIVQVFEGTS GVDVRKTTID FTGHSMRIPV 100
    SEDMLGRVFN GSGLPIDKGP NLLAEDYLDI NGSPINPYAR IYPEEMIQTG 150
    ISSIDGLNSI ARGQKIPIFS AAGLPHNEIA AQICRQAGLV KRPTKDVHDG 200
    HEDNFSIVFA AMGVNLETAR FFQRDFEENG SFERVTLFLN LANDPTIERI 250
    ITPRLALSAS EFLAYQTEKH VLTILTDMTS YADALREVSA AREEVPGRRG 300
    YPGYMYTDLS TIYERAGRVE GRNGSITQIP ILTMPNDDIT HPIPDLTGYI 350
    TEGQIFVDRQ LHNNAIYPPI NVLPSLSRLM KSAIGEGMTR NDHGDVSNQL 400
    YAMYAIGRDA ASMKSVVGEE ALSQEDRLAL EFLGKFEKTF ISQGAYENRT 450
    IFETLDLAWS LLRIFPREML TRIPKKILDQ YYSRSSAYTE SSKDVIDNTP 500
    ESS 503
    Length:503
    Mass (Da):55,841
    Last modified:November 1, 1995 - v2
    Checksum:iBC1C15C7E915920F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69638 Genomic DNA. Translation: CAA49339.1.
    CU329670 Genomic DNA. Translation: CAA22584.1.
    PIRiS25335.
    T38997.
    RefSeqiNP_594623.1. NM_001020051.2.

    Genome annotation databases

    EnsemblFungiiSPAC637.05c.1; SPAC637.05c.1:pep; SPAC637.05c.
    GeneIDi2543408.
    KEGGispo:SPAC637.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69638 Genomic DNA. Translation: CAA49339.1 .
    CU329670 Genomic DNA. Translation: CAA22584.1 .
    PIRi S25335.
    T38997.
    RefSeqi NP_594623.1. NM_001020051.2.

    3D structure databases

    ProteinModelPortali P31411.
    SMRi P31411. Positions 32-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279830. 6 interactions.
    MINTi MINT-4688355.
    STRINGi 4896.SPAC637.05c-1.

    Proteomic databases

    MaxQBi P31411.
    PaxDbi P31411.
    PRIDEi P31411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC637.05c.1 ; SPAC637.05c.1:pep ; SPAC637.05c .
    GeneIDi 2543408.
    KEGGi spo:SPAC637.05c.

    Organism-specific databases

    PomBasei SPAC637.05c.

    Phylogenomic databases

    eggNOGi COG1156.
    HOGENOMi HOG000165320.
    KOi K02147.
    OMAi TVCEFTG.
    OrthoDBi EOG7H79BK.
    PhylomeDBi P31411.

    Miscellaneous databases

    NextBioi 20804423.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00310. ATP_synth_B_arch.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR005723. ATPase_V1-cplx_bsu.
    IPR027417. P-loop_NTPase.
    IPR022879. V-ATPase_su_B/beta.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01040. V-ATPase_V1_B. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the genes encoding subunits A and B of the vacuolar H(+)-ATPase of Schizosaccharomyces pombe."
      Ghislain M., Bowman E.J.
      Yeast 8:791-799(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe."
      Dawson K., Toone W.M., Jones N., Wilkinson C.R.
      Eukaryot. Cell 7:926-937(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAV1.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491; SER-492; SER-502 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiVATB_SCHPO
    AccessioniPrimary (citable) accession number: P31411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3