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Protein

V-type proton ATPase subunit B, brain isoform

Gene

ATP6V1B2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-1222556. ROS, RNS production in response to bacteria.
R-BTA-77387. Insulin receptor recycling.
R-BTA-917977. Transferrin endocytosis and recycling.
R-BTA-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit B, brain isoform
Short name:
V-ATPase subunit B 2
Alternative name(s):
Endomembrane proton pump 58 kDa subunit
Vacuolar proton pump subunit B 2
Gene namesi
Name:ATP6V1B2
Synonyms:ATP6B2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511V-type proton ATPase subunit B, brain isoformPRO_0000144625Add
BLAST

Proteomic databases

PaxDbiP31408.
PeptideAtlasiP31408.
PRIDEiP31408.

Expressioni

Tissue specificityi

In all tissues tested, but highest in brain and in adrenal medulla.

Gene expression databases

BgeeiENSBTAG00000018646.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024812.

Structurei

3D structure databases

ProteinModelPortaliP31408.
SMRiP31408. Positions 55-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351. Eukaryota.
COG1156. LUCA.
GeneTreeiENSGT00550000074724.
HOGENOMiHOG000165320.
HOVERGENiHBG002176.
InParanoidiP31408.
KOiK02147.
OMAiWRERRYL.
OrthoDBiEOG091G04TR.
TreeFamiTF300313.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR005723. ATPase_V1-cplx_bsu.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01040. V-ATPase_V1_B. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAMRGIV NGAAPELPVP TSGPLAGSRE QALAVSRNYL SQPRLTYKTV
60 70 80 90 100
SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE
110 120 130 140 150
GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF
160 170 180 190 200
LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN
210 220 230 240 250
EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE
260 270 280 290 300
NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM
310 320 330 340 350
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ
360 370 380 390 400
IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR
410 420 430 440 450
LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL
460 470 480 490 500
YLEFLQKFER NFIAQGPYEN RTVYETLDIG WQLLRIFPKE MLKRIPQSTL
510
SEFYPRDSAK H
Length:511
Mass (Da):56,577
Last modified:June 26, 2007 - v3
Checksum:iE8DC915692F25E99
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241Missing in AAA30400 (PubMed:1373501).Curated
Sequence conflicti83 – 831S → T in AAA30391 (PubMed:1371275).Curated
Sequence conflicti161 – 1622QC → HF in AAA30400 (PubMed:1373501).Curated
Sequence conflicti250 – 2501E → Q in CAA41275 (PubMed:1835703).Curated
Sequence conflicti460 – 4601R → K in AAA30400 (PubMed:1373501).Curated
Sequence conflicti464 – 4641A → T in AAA30400 (PubMed:1373501).Curated
Sequence conflicti510 – 5112KH → NS in AAA30391 (PubMed:1371275).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88690 mRNA. Translation: AAA30400.1.
M83131 mRNA. Translation: AAA30391.1.
X58385 mRNA. Translation: CAA41275.1.
BC123404 mRNA. Translation: AAI23405.1.
PIRiS32614.
RefSeqiNP_001001146.1. NM_001001146.1.
NP_788844.2. NM_176671.3.
UniGeneiBt.4086.

Genome annotation databases

EnsembliENSBTAT00000024812; ENSBTAP00000024812; ENSBTAG00000018646.
GeneIDi338082.
KEGGibta:338082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88690 mRNA. Translation: AAA30400.1.
M83131 mRNA. Translation: AAA30391.1.
X58385 mRNA. Translation: CAA41275.1.
BC123404 mRNA. Translation: AAI23405.1.
PIRiS32614.
RefSeqiNP_001001146.1. NM_001001146.1.
NP_788844.2. NM_176671.3.
UniGeneiBt.4086.

3D structure databases

ProteinModelPortaliP31408.
SMRiP31408. Positions 55-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024812.

Chemistry

ChEMBLiCHEMBL4798.

Proteomic databases

PaxDbiP31408.
PeptideAtlasiP31408.
PRIDEiP31408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024812; ENSBTAP00000024812; ENSBTAG00000018646.
GeneIDi338082.
KEGGibta:338082.

Organism-specific databases

CTDi526.

Phylogenomic databases

eggNOGiKOG1351. Eukaryota.
COG1156. LUCA.
GeneTreeiENSGT00550000074724.
HOGENOMiHOG000165320.
HOVERGENiHBG002176.
InParanoidiP31408.
KOiK02147.
OMAiWRERRYL.
OrthoDBiEOG091G04TR.
TreeFamiTF300313.

Enzyme and pathway databases

ReactomeiR-BTA-1222556. ROS, RNS production in response to bacteria.
R-BTA-77387. Insulin receptor recycling.
R-BTA-917977. Transferrin endocytosis and recycling.
R-BTA-983712. Ion channel transport.

Gene expression databases

BgeeiENSBTAG00000018646.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR005723. ATPase_V1-cplx_bsu.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01040. V-ATPase_V1_B. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATB2_BOVIN
AccessioniPrimary (citable) accession number: P31408
Secondary accession number(s): A4FUX5, Q28058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.