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Protein

ATP synthase subunit d, mitochondrial

Gene

Atp5h

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

  • hydrogen ion transmembrane transporter activity Source: RGD

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.
R-RNO-8949613. Cristae formation.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Short name:
ATPase subunit d
Gene namesi
Name:Atp5h
Synonyms:Atp5jd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620083. Atp5h.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000716752 – 161ATP synthase subunit d, mitochondrialAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei85N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei117N6-acetyllysineBy similarity1
Modified residuei149N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP31399.
PRIDEiP31399.

2D gel databases

World-2DPAGEi0004:P31399.

PTM databases

iPTMnetiP31399.
PhosphoSitePlusiP31399.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003626.
GenevisibleiP31399. RN.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

BioGridi566012. 1 interactor.
CORUMiP31399.
IntActiP31399. 1 interactor.
STRINGi10116.ENSRNOP00000004836.

Structurei

3D structure databases

ProteinModelPortaliP31399.
SMRiP31399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

eggNOGiKOG3366. Eukaryota.
ENOG4111IHJ. LUCA.
GeneTreeiENSGT00390000003582.
HOVERGENiHBG050612.
InParanoidiP31399.
KOiK02138.
OMAiRIQNYQK.
OrthoDBiEOG091G0MQA.
PhylomeDBiP31399.

Family and domain databases

InterProiView protein in InterPro
IPR008689. ATP_synth_F0_dsu_mt.
IPR036228. ATP_synth_F0_dsu_sf_mt.
PANTHERiPTHR12700. PTHR12700. 1 hit.
PfamiView protein in Pfam
PF05873. Mt_ATP-synt_D. 1 hit.
PIRSFiPIRSF005514. ATPase_F0_D_mt. 1 hit.
SUPFAMiSSF161065. SSF161065. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRKLALKT IDWVSFVEIM PQNQKAIGNA LKSWNETFHT RLASLSEKPP
60 70 80 90 100
AIDWAYYRAN VDKPGLVDDF KNKYNALKIP VPEDKYTALV DAEEKEDVKN
110 120 130 140 150
CAQFVTGSQA RVREYEKQLE KIKNMIPFDQ MTIDDLNEVF PETKLDKRKY
160
PYWPHQPIEN L
Length:161
Mass (Da):18,763
Last modified:January 23, 2007 - v3
Checksum:i285F075DE5641261
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79I → D in BAA00911 (PubMed:1531750).Curated1
Sequence conflicti141P → L in BAA00911 (PubMed:1531750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10021 mRNA. Translation: BAA00911.1.
D13120 mRNA. Translation: BAA02422.1.
BC059139 mRNA. Translation: AAH59139.1.
BC078846 mRNA. Translation: AAH78846.1.
PIRiJS0739.
RefSeqiNP_062256.1. NM_019383.2.
UniGeneiRn.224479.
Rn.80.

Genome annotation databases

EnsembliENSRNOT00000004836; ENSRNOP00000004836; ENSRNOG00000003626.
GeneIDi641434.
KEGGirno:641434.

Similar proteinsi

Entry informationi

Entry nameiATP5H_RAT
AccessioniPrimary (citable) accession number: P31399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families