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Protein

Stathmin

Gene

STMN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Gene namesi
Name:STMN1
Synonyms:LAP18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001823931 – 148StathminAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Phosphoserine; by PKABy similarity1
Modified residuei38Phosphoserine; by CDK1By similarity1
Modified residuei63Phosphoserine; by PKABy similarity1

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP31395.
PRIDEiP31395.

PTM databases

iPTMnetiP31395.

Expressioni

Gene expression databases

BgeeiENSGALG00000001475.

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1636998,EBI-1635766

GO - Molecular functioni

Protein-protein interaction databases

BioGridi676325. 1 interactor.
IntActiP31395. 1 interactor.
STRINGi9031.ENSGALP00000040254.

Structurei

3D structure databases

ProteinModelPortaliP31395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 145SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 140Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IN6S. Eukaryota.
ENOG4111KFP. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP31395.
KOiK04381.
OMAiDAKSEFP.
OrthoDBiEOG091G0Y2U.
PhylomeDBiP31395.
TreeFamiTF326935.

Family and domain databases

InterProiIPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKEGK DPGEAETN
Length:148
Mass (Da):17,082
Last modified:July 1, 1993 - v1
Checksum:iEDD5BF82A415D5E9
GO

Sequence cautioni

The sequence CAA46450 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67840 mRNA. Translation: CAA48035.1.
X65458 mRNA. Translation: CAA46450.1. Different initiation.
PIRiS31791.
RefSeqiNP_001001858.1. NM_001001858.2.
XP_015153089.1. XM_015297603.1.
XP_015153090.1. XM_015297604.1.
XP_015153091.1. XM_015297605.1.
XP_015153092.1. XM_015297606.1.
UniGeneiGga.2844.

Genome annotation databases

EnsembliENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
ENSGALT00000063239; ENSGALP00000050128; ENSGALG00000001475.
ENSGALT00000068150; ENSGALP00000050542; ENSGALG00000001475.
ENSGALT00000068880; ENSGALP00000048802; ENSGALG00000001475.
GeneIDi396057.
KEGGigga:396057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67840 mRNA. Translation: CAA48035.1.
X65458 mRNA. Translation: CAA46450.1. Different initiation.
PIRiS31791.
RefSeqiNP_001001858.1. NM_001001858.2.
XP_015153089.1. XM_015297603.1.
XP_015153090.1. XM_015297604.1.
XP_015153091.1. XM_015297605.1.
XP_015153092.1. XM_015297606.1.
UniGeneiGga.2844.

3D structure databases

ProteinModelPortaliP31395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676325. 1 interactor.
IntActiP31395. 1 interactor.
STRINGi9031.ENSGALP00000040254.

PTM databases

iPTMnetiP31395.

Proteomic databases

PaxDbiP31395.
PRIDEiP31395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
ENSGALT00000063239; ENSGALP00000050128; ENSGALG00000001475.
ENSGALT00000068150; ENSGALP00000050542; ENSGALG00000001475.
ENSGALT00000068880; ENSGALP00000048802; ENSGALG00000001475.
GeneIDi396057.
KEGGigga:396057.

Organism-specific databases

CTDi3925.

Phylogenomic databases

eggNOGiENOG410IN6S. Eukaryota.
ENOG4111KFP. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP31395.
KOiK04381.
OMAiDAKSEFP.
OrthoDBiEOG091G0Y2U.
PhylomeDBiP31395.
TreeFamiTF326935.

Miscellaneous databases

PROiP31395.

Gene expression databases

BgeeiENSGALG00000001475.

Family and domain databases

InterProiIPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN1_CHICK
AccessioniPrimary (citable) accession number: P31395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.