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P31395

- STMN1_CHICK

UniProt

P31395 - STMN1_CHICK

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Protein

Stathmin

Gene

STMN1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).By similarity

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. microtubule depolymerization Source: Ensembl
  3. mitotic spindle organization Source: Ensembl
  4. negative regulation of microtubule polymerization Source: Ensembl
  5. positive regulation of cellular component movement Source: Ensembl
  6. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Gene namesi
Name:STMN1
Synonyms:LAP18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 23

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. membrane Source: Ensembl
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148StathminPRO_0000182393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKABy similarity
Modified residuei38 – 381Phosphoserine; by CDK1By similarity
Modified residuei63 – 631Phosphoserine; by PKABy similarity

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP31395.
PRIDEiP31395.

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1636998,EBI-1635766

Protein-protein interaction databases

BioGridi676325. 1 interaction.
IntActiP31395. 1 interaction.
STRINGi9031.ENSGALP00000002235.

Structurei

3D structure databases

ProteinModelPortaliP31395.
SMRiP31395. Positions 6-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 145142SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 140100Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG75290.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP31395.
KOiK04381.
OMAiREKDKHM.
OrthoDBiEOG744TBN.
PhylomeDBiP31395.
TreeFamiTF326935.

Family and domain databases

InterProiIPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31395-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKEGK DPGEAETN
Length:148
Mass (Da):17,082
Last modified:July 1, 1993 - v1
Checksum:iEDD5BF82A415D5E9
GO

Sequence cautioni

The sequence CAA46450.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67840 mRNA. Translation: CAA48035.1.
X65458 mRNA. Translation: CAA46450.1. Different initiation.
PIRiS31791.
RefSeqiNP_001001858.1. NM_001001858.2.
UniGeneiGga.2844.

Genome annotation databases

EnsembliENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
GeneIDi396057.
KEGGigga:396057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67840 mRNA. Translation: CAA48035.1 .
X65458 mRNA. Translation: CAA46450.1 . Different initiation.
PIRi S31791.
RefSeqi NP_001001858.1. NM_001001858.2.
UniGenei Gga.2844.

3D structure databases

ProteinModelPortali P31395.
SMRi P31395. Positions 6-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676325. 1 interaction.
IntActi P31395. 1 interaction.
STRINGi 9031.ENSGALP00000002235.

Proteomic databases

PaxDbi P31395.
PRIDEi P31395.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000002237 ; ENSGALP00000002235 ; ENSGALG00000001475 .
GeneIDi 396057.
KEGGi gga:396057.

Organism-specific databases

CTDi 3925.

Phylogenomic databases

eggNOGi NOG75290.
GeneTreei ENSGT00390000003691.
HOGENOMi HOG000013197.
HOVERGENi HBG054037.
InParanoidi P31395.
KOi K04381.
OMAi REKDKHM.
OrthoDBi EOG744TBN.
PhylomeDBi P31395.
TreeFami TF326935.

Miscellaneous databases

NextBioi 20816117.
PROi P31395.

Family and domain databases

InterProi IPR000956. Stathmin_fam.
[Graphical view ]
PANTHERi PTHR10104. PTHR10104. 1 hit.
Pfami PF00836. Stathmin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002285. Stathmin. 1 hit.
PRINTSi PR00345. STATHMIN.
SUPFAMi SSF101494. SSF101494. 1 hit.
PROSITEi PS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina."
    Godbout R.
    Exp. Eye Res. 56:95-106(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiSTMN1_CHICK
AccessioniPrimary (citable) accession number: P31395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3