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P31395 (STMN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stathmin
Gene names
Name:STMN1
Synonyms:LAP18
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules By similarity.

Subunit structure

Binds to two alpha/beta-tubulin heterodimers By similarity.

Subcellular location

Cytoplasmcytoskeleton.

Post-translational modification

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF By similarity.

Sequence similarities

Belongs to the stathmin family.

Contains 1 SLD (stathmin-like) domain.

Sequence caution

The sequence CAA46450.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KCNMA1Q8AYS83EBI-1636998,EBI-1635766

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148Stathmin
PRO_0000182393

Regions

Domain4 – 145142SLD
Coiled coil41 – 140100 Potential

Amino acid modifications

Modified residue161Phosphoserine; by PKA By similarity
Modified residue381Phosphoserine; by CDK1 By similarity
Modified residue631Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
P31395 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: EDD5BF82A415D5E9

FASTA14817,082
        10         20         30         40         50         60 
MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI QKKLEAAEER 

        70         80         90        100        110        120 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 

       130        140 
ERLREKDKHI EEVRKNKEGK DPGEAETN 

« Hide

References

[1]"Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina."
Godbout R.
Exp. Eye Res. 56:95-106(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67840 mRNA. Translation: CAA48035.1.
X65458 mRNA. Translation: CAA46450.1. Different initiation.
PIRS31791.
RefSeqNP_001001858.1. NM_001001858.2.
UniGeneGga.2844.

3D structure databases

ProteinModelPortalP31395.
SMRP31395. Positions 6-141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid676325. 1 interaction.
IntActP31395. 1 interaction.
STRING9031.ENSGALP00000002235.

Proteomic databases

PaxDbP31395.
PRIDEP31395.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
GeneID396057.
KEGGgga:396057.

Organism-specific databases

CTD3925.

Phylogenomic databases

eggNOGNOG75290.
GeneTreeENSGT00390000003691.
HOGENOMHOG000013197.
HOVERGENHBG054037.
InParanoidP31395.
KOK04381.
OMAREKDKHM.
OrthoDBEOG744TBN.
PhylomeDBP31395.
TreeFamTF326935.

Family and domain databases

InterProIPR000956. Stathmin_fam.
[Graphical view]
PANTHERPTHR10104. PTHR10104. 1 hit.
PfamPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFPIRSF002285. Stathmin. 1 hit.
PRINTSPR00345. STATHMIN.
SUPFAMSSF101494. SSF101494. 1 hit.
PROSITEPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816117.
PROP31395.

Entry information

Entry nameSTMN1_CHICK
AccessionPrimary (citable) accession number: P31395
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families