P31395 (STMN1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stathmin

Gene names

Name:	STMN1
Synonyms:	LAP18

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules By similarity.
Subunit structure	Binds to two alpha/beta-tubulin heterodimers By similarity.
Subcellular location	Cytoplasm › cytoskeleton.
Post-translational modification	Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF By similarity.
Sequence similarities	Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain.
Sequence caution	The sequence CAA46450.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from electronic annotation. Source: Compara microtubule depolymerization Inferred from electronic annotation. Source: Compara mitotic spindle organization Inferred from electronic annotation. Source: Compara negative regulation of microtubule polymerization Inferred from electronic annotation. Source: Compara positive regulation of cellular component movement Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KCNMA1	Q8AYS8	3	EBI-1636998,EBI-1635766

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Stathmin		PRO_0000182393
Regions
	Domain	4 – 145	142	SLD
	Coiled coil	41 – 140	100	Potential
Amino acid modifications
	Modified residue	16	1	Phosphoserine; by PKA By similarity
	Modified residue	38	1	Phosphoserine; by CDK1 By similarity
	Modified residue	63	1	Phosphoserine; by PKA By similarity

Sequences

	Sequence		Length	Mass (Da)
	P31395 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: EDD5BF82A415D5E9	FASTA	148	17,082
	10 20 30 40 50 60 MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI QKKLEAAEER 70 80 90 100 110 120 RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 130 140 ERLREKDKHI EEVRKNKEGK DPGEAETN

References

[1]	"Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina." Godbout R. Exp. Eye Res. 56:95-106(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67840 mRNA. Translation: CAA48035.1. X65458 mRNA. Translation: CAA46450.1. Different initiation.
IPI	IPI00603631.
PIR	S31791.
RefSeq	NP_001001858.1. NM_001001858.2.
UniGene	Gga.2844.
3D structure databases
ProteinModelPortal	P31395.
SMR	P31395. Positions 6-141.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31395. 1 interaction.
STRING	9031.ENSGALP00000002235.
Proteomic databases
PaxDb	P31395.
PRIDE	P31395.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475. ENSGALT00000041049; ENSGALP00000040254; ENSGALG00000001475.
GeneID	396057.
KEGG	gga:396057.
Organism-specific databases
CTD	3925.
Phylogenomic databases
eggNOG	NOG75290.
GeneTree	ENSGT00390000003691.
HOGENOM	HOG000013197.
HOVERGEN	HBG054037.
InParanoid	P31395.
KO	K04381.
OMA	KEAVPEF.
OrthoDB	EOG46MBKT.
Gene expression databases
ArrayExpress	P31395.
Family and domain databases
InterPro	IPR000956. Stathmin_fam. [Graphical view]
PANTHER	PTHR10104. PTHR10104. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
SUPFAM	SSF101494. Stathmin. 1 hit.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. PS51663. STATHMIN_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816117.

Entry information

Entry name

STMN1_CHICK

Accession

Primary (citable) accession number: P31395

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program