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P31395

- STMN1_CHICK

UniProt

P31395 - STMN1_CHICK

Protein

Stathmin

Gene

STMN1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. microtubule depolymerization Source: Ensembl
    3. mitotic spindle organization Source: Ensembl
    4. negative regulation of microtubule polymerization Source: Ensembl
    5. positive regulation of cellular component movement Source: Ensembl
    6. response to virus Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stathmin
    Gene namesi
    Name:STMN1
    Synonyms:LAP18
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 23

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. membrane Source: Ensembl
    3. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148StathminPRO_0000182393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine; by PKABy similarity
    Modified residuei38 – 381Phosphoserine; by CDK1By similarity
    Modified residuei63 – 631Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP31395.
    PRIDEiP31395.

    Interactioni

    Subunit structurei

    Binds to two alpha/beta-tubulin heterodimers.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KCNMA1Q8AYS83EBI-1636998,EBI-1635766

    Protein-protein interaction databases

    BioGridi676325. 1 interaction.
    IntActiP31395. 1 interaction.
    STRINGi9031.ENSGALP00000002235.

    Structurei

    3D structure databases

    ProteinModelPortaliP31395.
    SMRiP31395. Positions 6-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 145142SLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 140100Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the stathmin family.Curated
    Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG75290.
    GeneTreeiENSGT00390000003691.
    HOGENOMiHOG000013197.
    HOVERGENiHBG054037.
    InParanoidiP31395.
    KOiK04381.
    OMAiREKDKHM.
    OrthoDBiEOG744TBN.
    PhylomeDBiP31395.
    TreeFamiTF326935.

    Family and domain databases

    InterProiIPR000956. Stathmin_fam.
    [Graphical view]
    PANTHERiPTHR10104. PTHR10104. 1 hit.
    PfamiPF00836. Stathmin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002285. Stathmin. 1 hit.
    PRINTSiPR00345. STATHMIN.
    SUPFAMiSSF101494. SSF101494. 1 hit.
    PROSITEiPS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31395-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI    50
    QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK 100
    LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKEGK DPGEAETN 148
    Length:148
    Mass (Da):17,082
    Last modified:July 1, 1993 - v1
    Checksum:iEDD5BF82A415D5E9
    GO

    Sequence cautioni

    The sequence CAA46450.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67840 mRNA. Translation: CAA48035.1.
    X65458 mRNA. Translation: CAA46450.1. Different initiation.
    PIRiS31791.
    RefSeqiNP_001001858.1. NM_001001858.2.
    UniGeneiGga.2844.

    Genome annotation databases

    EnsembliENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
    GeneIDi396057.
    KEGGigga:396057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67840 mRNA. Translation: CAA48035.1 .
    X65458 mRNA. Translation: CAA46450.1 . Different initiation.
    PIRi S31791.
    RefSeqi NP_001001858.1. NM_001001858.2.
    UniGenei Gga.2844.

    3D structure databases

    ProteinModelPortali P31395.
    SMRi P31395. Positions 6-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676325. 1 interaction.
    IntActi P31395. 1 interaction.
    STRINGi 9031.ENSGALP00000002235.

    Proteomic databases

    PaxDbi P31395.
    PRIDEi P31395.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000002237 ; ENSGALP00000002235 ; ENSGALG00000001475 .
    GeneIDi 396057.
    KEGGi gga:396057.

    Organism-specific databases

    CTDi 3925.

    Phylogenomic databases

    eggNOGi NOG75290.
    GeneTreei ENSGT00390000003691.
    HOGENOMi HOG000013197.
    HOVERGENi HBG054037.
    InParanoidi P31395.
    KOi K04381.
    OMAi REKDKHM.
    OrthoDBi EOG744TBN.
    PhylomeDBi P31395.
    TreeFami TF326935.

    Miscellaneous databases

    NextBioi 20816117.
    PROi P31395.

    Family and domain databases

    InterProi IPR000956. Stathmin_fam.
    [Graphical view ]
    PANTHERi PTHR10104. PTHR10104. 1 hit.
    Pfami PF00836. Stathmin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002285. Stathmin. 1 hit.
    PRINTSi PR00345. STATHMIN.
    SUPFAMi SSF101494. SSF101494. 1 hit.
    PROSITEi PS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of transcripts present at elevated levels in the undifferentiated chick retina."
      Godbout R.
      Exp. Eye Res. 56:95-106(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiSTMN1_CHICK
    AccessioniPrimary (citable) accession number: P31395
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3