P31391 (SSR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 4
Short name=SS-4-R
Short name=SS4-R
Short name=SS4R

Gene names

Name:

SSTR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement PubMed 8405411. Source: ProtInc arachidonic acid metabolic process Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara negative regulation of cAMP metabolic process Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Traceable author statement PubMed 9892014. Source: ProtInc positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.4. Source: ProtInc
Molecular_function	somatostatin receptor activity Traceable author statement PubMed 9892014. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Somatostatin receptor type 4		PRO_0000070127
Regions
	Topological domain	1 – 46	46	Extracellular Potential
	Transmembrane	47 – 73	27	Helical; Name=1; Potential
	Topological domain	74 – 83	10	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Helical; Name=2; Potential
	Topological domain	105 – 120	16	Extracellular Potential
	Transmembrane	121 – 142	22	Helical; Name=3; Potential
	Topological domain	143 – 161	19	Cytoplasmic Potential
	Transmembrane	162 – 185	24	Helical; Name=4; Potential
	Topological domain	186 – 208	23	Extracellular Potential
	Transmembrane	209 – 232	24	Helical; Name=5; Potential
	Topological domain	233 – 260	28	Cytoplasmic Potential
	Transmembrane	261 – 280	20	Helical; Name=6; Potential
	Topological domain	281 – 291	11	Extracellular Potential
	Transmembrane	292 – 314	23	Helical; Name=7; Potential
	Topological domain	315 – 388	74	Cytoplasmic Potential
Amino acid modifications
	Lipidation	327	1	S-palmitoyl cysteine Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Disulfide bond	119 ↔ 198		By similarity
Natural variations
	Natural variant	83	1	N → T. Ref.2 Corresponds to variant rs1065191 [ dbSNP | Ensembl ].		VAR_011703
	Natural variant	236	1	G → D. Corresponds to variant rs35601930 [ dbSNP | Ensembl ].		VAR_049441
	Natural variant	284	1	F → V. Ref.1 Ref.2 Ref.5 Ref.8 Corresponds to variant rs3746726 [ dbSNP | Ensembl ].		VAR_021560
	Natural variant	321	1	F → S. Ref.1 Ref.2 Ref.5 Ref.8 Corresponds to variant rs2567608 [ dbSNP | Ensembl ].		VAR_021561
Experimental info
	Sequence conflict	365	1	P → K in AAA60565. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P31391 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: DFCD9393620EDFC9	FASTA	388	42,003
	10 20 30 40 50 60 MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI QCIYALVCLV 70 80 90 100 110 120 GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV PFVASSAALR HWPFGSVLCR 130 140 150 160 170 180 AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH PLRAATYRRP SVAKLINLGV WLASLLVTLP 190 200 210 220 230 240 IAIFADTRPA RGGQAVACNL QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA 250 260 270 280 290 300 VALRAGWQQR RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS 310 320 330 340 350 360 YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA LKSKGGAGCM 370 380 CPPLPCQQEA LQPEPGRKRI PLTRTTTF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4." Xu Y., Song J., Bruno J.F., Berelowitz M. Biochem. Biophys. Res. Commun. 193:648-652(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-284 AND SER-321.
[2]	"Cloning and characterization of a fourth human somatostatin receptor." Rohrer L., Raulf F., Bruns C., Buettner R., Hofstaedter F., Schuele R. Proc. Natl. Acad. Sci. U.S.A. 90:4196-4200(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-83; VAL-284 AND SER-321.
[3]	"Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype." Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y. Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20." Demchyshyn L.L., Srikant C.B., Sunahara R.K., Kent G., Seeman P., van Tol H.H.M., Panetta R., Patel Y.C., Niznik H.B. Mol. Pharmacol. 43:894-901(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16826 Genomic DNA. Translation: BAA04106.1. L14856 Genomic DNA. Translation: AAA36623.1. L07833 Genomic DNA. Translation: AAA60565.1. L07061 Genomic DNA. No translation available. AY548169 Genomic DNA. Translation: AAS55648.1. AL049651 Genomic DNA. Translation: CAB51953.1. CH471133 Genomic DNA. Translation: EAX10170.1. BC069063 mRNA. Translation: AAH69063.1. BC117270 mRNA. Translation: AAI17271.1. BC117272 mRNA. Translation: AAI17273.1.
IPI	IPI00306173.
PIR	JN0605.
RefSeq	NP_001043.2. NM_001052.2.
UniGene	Hs.673846.
3D structure databases
ProteinModelPortal	P31391.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000255008.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P31391.
Polymorphism databases
DMDM	206729897.
Proteomic databases
PaxDb	P31391.
PRIDE	P31391.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255008; ENSP00000255008; ENSG00000132671.
GeneID	6754.
KEGG	hsa:6754.
UCSC	uc002wsr.2. human.
Organism-specific databases
CTD	6754.
GeneCards	GC20P022964.
H-InvDB	HIX0040596.
HGNC	HGNC:11333. SSTR4.
MIM	182454. gene.
neXtProt	NX_P31391.
PharmGKB	PA36157.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG235424.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	P31391.
KO	K04220.
OMA	FYVVQLL.
OrthoDB	EOG44J2J9.
PhylomeDB	P31391.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P31391.
CleanEx	HS_SSTR4.
Genevestigator	P31391.
GermOnline	ENSG00000132671. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001512. Somatstn_rcpt_4. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00590. SOMATOSTTN4R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P31391.
ChEMBL	CHEMBL1853.
GenomeRNAi	6754.
NextBio	26348.
SOURCE	Search...

Entry information

Entry name

SSR4_HUMAN

Accession

Primary (citable) accession number: P31391
Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 128 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.