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P31391

- SSR4_HUMAN

UniProt

P31391 - SSR4_HUMAN

Protein

Somatostatin receptor type 4

Gene

SSTR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

    GO - Molecular functioni

    1. somatostatin receptor activity Source: ProtInc

    GO - Biological processi

    1. arachidonic acid metabolic process Source: Ensembl
    2. cell migration Source: Ensembl
    3. cellular response to glucocorticoid stimulus Source: Ensembl
    4. forebrain development Source: Ensembl
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    7. negative regulation of cAMP metabolic process Source: Ensembl
    8. negative regulation of cell proliferation Source: ProtInc
    9. positive regulation of MAPK cascade Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 4
    Short name:
    SS-4-R
    Short name:
    SS4-R
    Short name:
    SS4R
    Gene namesi
    Name:SSTR4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11333. SSTR4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36157.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Somatostatin receptor type 4PRO_0000070127Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi119 ↔ 198PROSITE-ProRule annotation
    Lipidationi327 – 3271S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP31391.
    PRIDEiP31391.

    PTM databases

    PhosphoSiteiP31391.

    Expressioni

    Tissue specificityi

    Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

    Gene expression databases

    BgeeiP31391.
    CleanExiHS_SSTR4.
    GenevestigatoriP31391.

    Interactioni

    Protein-protein interaction databases

    BioGridi112632. 1 interaction.
    STRINGi9606.ENSP00000255008.

    Structurei

    3D structure databases

    ProteinModelPortaliP31391.
    SMRiP31391. Positions 30-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 8310CytoplasmicSequence Analysis
    Topological domaini105 – 12016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 16119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 20823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 26028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini315 – 38874CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 7327Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 14222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei162 – 18524Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei261 – 28020Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31423Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235424.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP31391.
    KOiK04220.
    OMAiWPHPAWS.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP31391.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001512. Somatstn_rcpt_4.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00590. SOMATOSTTN4R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI    50
    QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV 100
    PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH 150
    PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL 200
    QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR 250
    RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS 300
    YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA 350
    LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF 388
    Length:388
    Mass (Da):42,003
    Last modified:September 23, 2008 - v2
    Checksum:iDFCD9393620EDFC9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti365 – 3651P → K in AAA60565. (PubMed:8483934)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831N → T.1 Publication
    Corresponds to variant rs1065191 [ dbSNP | Ensembl ].
    VAR_011703
    Natural varianti236 – 2361G → D.
    Corresponds to variant rs35601930 [ dbSNP | Ensembl ].
    VAR_049441
    Natural varianti284 – 2841F → V.4 Publications
    Corresponds to variant rs3746726 [ dbSNP | Ensembl ].
    VAR_021560
    Natural varianti321 – 3211F → S.4 Publications
    Corresponds to variant rs2567608 [ dbSNP | Ensembl ].
    VAR_021561

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16826 Genomic DNA. Translation: BAA04106.1.
    L14856 Genomic DNA. Translation: AAA36623.1.
    L07833 Genomic DNA. Translation: AAA60565.1.
    L07061 Genomic DNA. No translation available.
    AY548169 Genomic DNA. Translation: AAS55648.1.
    AL049651 Genomic DNA. Translation: CAB51953.1.
    CH471133 Genomic DNA. Translation: EAX10170.1.
    BC069063 mRNA. Translation: AAH69063.1.
    BC117270 mRNA. Translation: AAI17271.1.
    BC117272 mRNA. Translation: AAI17273.1.
    CCDSiCCDS42856.1.
    PIRiJN0605.
    RefSeqiNP_001043.2. NM_001052.2.
    UniGeneiHs.673846.

    Genome annotation databases

    EnsembliENST00000255008; ENSP00000255008; ENSG00000132671.
    GeneIDi6754.
    KEGGihsa:6754.
    UCSCiuc002wsr.2. human.

    Polymorphism databases

    DMDMi206729897.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16826 Genomic DNA. Translation: BAA04106.1 .
    L14856 Genomic DNA. Translation: AAA36623.1 .
    L07833 Genomic DNA. Translation: AAA60565.1 .
    L07061 Genomic DNA. No translation available.
    AY548169 Genomic DNA. Translation: AAS55648.1 .
    AL049651 Genomic DNA. Translation: CAB51953.1 .
    CH471133 Genomic DNA. Translation: EAX10170.1 .
    BC069063 mRNA. Translation: AAH69063.1 .
    BC117270 mRNA. Translation: AAI17271.1 .
    BC117272 mRNA. Translation: AAI17273.1 .
    CCDSi CCDS42856.1.
    PIRi JN0605.
    RefSeqi NP_001043.2. NM_001052.2.
    UniGenei Hs.673846.

    3D structure databases

    ProteinModelPortali P31391.
    SMRi P31391. Positions 30-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112632. 1 interaction.
    STRINGi 9606.ENSP00000255008.

    Chemistry

    BindingDBi P31391.
    ChEMBLi CHEMBL1853.
    GuidetoPHARMACOLOGYi 358.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P31391.

    Polymorphism databases

    DMDMi 206729897.

    Proteomic databases

    PaxDbi P31391.
    PRIDEi P31391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255008 ; ENSP00000255008 ; ENSG00000132671 .
    GeneIDi 6754.
    KEGGi hsa:6754.
    UCSCi uc002wsr.2. human.

    Organism-specific databases

    CTDi 6754.
    GeneCardsi GC20P022964.
    H-InvDB HIX0040596.
    HGNCi HGNC:11333. SSTR4.
    MIMi 182454. gene.
    neXtProti NX_P31391.
    PharmGKBi PA36157.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235424.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P31391.
    KOi K04220.
    OMAi WPHPAWS.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P31391.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Somatostatin_receptor_4.
    GenomeRNAii 6754.
    NextBioi 26348.
    PROi P31391.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31391.
    CleanExi HS_SSTR4.
    Genevestigatori P31391.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001512. Somatstn_rcpt_4.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00590. SOMATOSTTN4R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4."
      Xu Y., Song J., Bruno J.F., Berelowitz M.
      Biochem. Biophys. Res. Commun. 193:648-652(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-284 AND SER-321.
    2. "Cloning and characterization of a fourth human somatostatin receptor."
      Rohrer L., Raulf F., Bruns C., Buettner R., Hofstaedter F., Schuele R.
      Proc. Natl. Acad. Sci. U.S.A. 90:4196-4200(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-83; VAL-284 AND SER-321.
    3. "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype."
      Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y.
      Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20."
      Demchyshyn L.L., Srikant C.B., Sunahara R.K., Kent G., Seeman P., van Tol H.H.M., Panetta R., Patel Y.C., Niznik H.B.
      Mol. Pharmacol. 43:894-901(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
    6. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.

    Entry informationi

    Entry nameiSSR4_HUMAN
    AccessioniPrimary (citable) accession number: P31391
    Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3