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Protein

Somatostatin receptor type 4

Gene

SSTR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132671-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP31391.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:SSTR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11333. SSTR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 73Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini74 – 83CytoplasmicSequence analysis10
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 120ExtracellularSequence analysisAdd BLAST16
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 161CytoplasmicSequence analysisAdd BLAST19
Transmembranei162 – 185Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini186 – 208ExtracellularSequence analysisAdd BLAST23
Transmembranei209 – 232Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini233 – 260CytoplasmicSequence analysisAdd BLAST28
Transmembranei261 – 280Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini281 – 291ExtracellularSequence analysisAdd BLAST11
Transmembranei292 – 314Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini315 – 388CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6754.
OpenTargetsiENSG00000132671.
PharmGKBiPA36157.

Chemistry databases

ChEMBLiCHEMBL1853.
GuidetoPHARMACOLOGYi358.

Polymorphism and mutation databases

BioMutaiSSTR4.
DMDMi206729897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701271 – 388Somatostatin receptor type 4Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation
Lipidationi327S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP31391.
PRIDEiP31391.

PTM databases

iPTMnetiP31391.
PhosphoSitePlusiP31391.

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Gene expression databases

BgeeiENSG00000132671.
CleanExiHS_SSTR4.
GenevisibleiP31391. HS.

Organism-specific databases

HPAiHPA064252.

Interactioni

Protein-protein interaction databases

BioGridi112632. 1 interactor.
STRINGi9606.ENSP00000255008.

Chemistry databases

BindingDBiP31391.

Structurei

3D structure databases

ProteinModelPortaliP31391.
SMRiP31391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP31391.
KOiK04220.
OMAiLIVGKMR.
OrthoDBiEOG091G0HEN.
PhylomeDBiP31391.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI
60 70 80 90 100
QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV
110 120 130 140 150
PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH
160 170 180 190 200
PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL
210 220 230 240 250
QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR
260 270 280 290 300
RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS
310 320 330 340 350
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA
360 370 380
LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF
Length:388
Mass (Da):42,003
Last modified:September 23, 2008 - v2
Checksum:iDFCD9393620EDFC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365P → K in AAA60565 (PubMed:8483934).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01170383N → T.1 PublicationCorresponds to variant rs1065191dbSNPEnsembl.1
Natural variantiVAR_049441236G → D.Corresponds to variant rs35601930dbSNPEnsembl.1
Natural variantiVAR_021560284F → V.4 PublicationsCorresponds to variant rs3746726dbSNPEnsembl.1
Natural variantiVAR_021561321F → S.4 PublicationsCorresponds to variant rs2567608dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16826 Genomic DNA. Translation: BAA04106.1.
L14856 Genomic DNA. Translation: AAA36623.1.
L07833 Genomic DNA. Translation: AAA60565.1.
L07061 Genomic DNA. No translation available.
AY548169 Genomic DNA. Translation: AAS55648.1.
AL049651 Genomic DNA. Translation: CAB51953.1.
CH471133 Genomic DNA. Translation: EAX10170.1.
BC069063 mRNA. Translation: AAH69063.1.
BC117270 mRNA. Translation: AAI17271.1.
BC117272 mRNA. Translation: AAI17273.1.
CCDSiCCDS42856.1.
PIRiJN0605.
RefSeqiNP_001043.2. NM_001052.2.
UniGeneiHs.673846.

Genome annotation databases

EnsembliENST00000255008; ENSP00000255008; ENSG00000132671.
GeneIDi6754.
KEGGihsa:6754.
UCSCiuc002wsr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16826 Genomic DNA. Translation: BAA04106.1.
L14856 Genomic DNA. Translation: AAA36623.1.
L07833 Genomic DNA. Translation: AAA60565.1.
L07061 Genomic DNA. No translation available.
AY548169 Genomic DNA. Translation: AAS55648.1.
AL049651 Genomic DNA. Translation: CAB51953.1.
CH471133 Genomic DNA. Translation: EAX10170.1.
BC069063 mRNA. Translation: AAH69063.1.
BC117270 mRNA. Translation: AAI17271.1.
BC117272 mRNA. Translation: AAI17273.1.
CCDSiCCDS42856.1.
PIRiJN0605.
RefSeqiNP_001043.2. NM_001052.2.
UniGeneiHs.673846.

3D structure databases

ProteinModelPortaliP31391.
SMRiP31391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112632. 1 interactor.
STRINGi9606.ENSP00000255008.

Chemistry databases

BindingDBiP31391.
ChEMBLiCHEMBL1853.
GuidetoPHARMACOLOGYi358.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP31391.
PhosphoSitePlusiP31391.

Polymorphism and mutation databases

BioMutaiSSTR4.
DMDMi206729897.

Proteomic databases

PaxDbiP31391.
PRIDEiP31391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255008; ENSP00000255008; ENSG00000132671.
GeneIDi6754.
KEGGihsa:6754.
UCSCiuc002wsr.3. human.

Organism-specific databases

CTDi6754.
DisGeNETi6754.
GeneCardsiSSTR4.
H-InvDBHIX0040596.
HGNCiHGNC:11333. SSTR4.
HPAiHPA064252.
MIMi182454. gene.
neXtProtiNX_P31391.
OpenTargetsiENSG00000132671.
PharmGKBiPA36157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP31391.
KOiK04220.
OMAiLIVGKMR.
OrthoDBiEOG091G0HEN.
PhylomeDBiP31391.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132671-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP31391.

Miscellaneous databases

GeneWikiiSomatostatin_receptor_4.
GenomeRNAii6754.
PROiP31391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132671.
CleanExiHS_SSTR4.
GenevisibleiP31391. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR4_HUMAN
AccessioniPrimary (citable) accession number: P31391
Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.