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P31391 (SSR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 4

Short name=SS-4-R
Short name=SS4-R
Short name=SS4R
Gene names
Name:SSTR4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 9892014. Source: ProtInc

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement PubMed 8405411. Source: ProtInc

arachidonic acid metabolic process

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from electronic annotation. Source: Ensembl

cellular response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Ensembl

forebrain development

Inferred from electronic annotation. Source: Ensembl

negative regulation of cAMP metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Traceable author statement PubMed 9892014. Source: ProtInc

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.4. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionsomatostatin receptor activity

Traceable author statement PubMed 9892014. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Somatostatin receptor type 4
PRO_0000070127

Regions

Topological domain1 – 4646Extracellular Potential
Transmembrane47 – 7327Helical; Name=1; Potential
Topological domain74 – 8310Cytoplasmic Potential
Transmembrane84 – 10421Helical; Name=2; Potential
Topological domain105 – 12016Extracellular Potential
Transmembrane121 – 14222Helical; Name=3; Potential
Topological domain143 – 16119Cytoplasmic Potential
Transmembrane162 – 18524Helical; Name=4; Potential
Topological domain186 – 20823Extracellular Potential
Transmembrane209 – 23224Helical; Name=5; Potential
Topological domain233 – 26028Cytoplasmic Potential
Transmembrane261 – 28020Helical; Name=6; Potential
Topological domain281 – 29111Extracellular Potential
Transmembrane292 – 31423Helical; Name=7; Potential
Topological domain315 – 38874Cytoplasmic Potential

Amino acid modifications

Lipidation3271S-palmitoyl cysteine Potential
Glycosylation241N-linked (GlcNAc...) Potential
Disulfide bond119 ↔ 198 By similarity

Natural variations

Natural variant831N → T. Ref.2
Corresponds to variant rs1065191 [ dbSNP | Ensembl ].
VAR_011703
Natural variant2361G → D.
Corresponds to variant rs35601930 [ dbSNP | Ensembl ].
VAR_049441
Natural variant2841F → V. Ref.1 Ref.2 Ref.5 Ref.8
Corresponds to variant rs3746726 [ dbSNP | Ensembl ].
VAR_021560
Natural variant3211F → S. Ref.1 Ref.2 Ref.5 Ref.8
Corresponds to variant rs2567608 [ dbSNP | Ensembl ].
VAR_021561

Experimental info

Sequence conflict3651P → K in AAA60565. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P31391 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: DFCD9393620EDFC9

FASTA38842,003
        10         20         30         40         50         60 
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI QCIYALVCLV 

        70         80         90        100        110        120 
GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV PFVASSAALR HWPFGSVLCR 

       130        140        150        160        170        180 
AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH PLRAATYRRP SVAKLINLGV WLASLLVTLP 

       190        200        210        220        230        240 
IAIFADTRPA RGGQAVACNL QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA 

       250        260        270        280        290        300 
VALRAGWQQR RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS 

       310        320        330        340        350        360 
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA LKSKGGAGCM 

       370        380 
CPPLPCQQEA LQPEPGRKRI PLTRTTTF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4."
Xu Y., Song J., Bruno J.F., Berelowitz M.
Biochem. Biophys. Res. Commun. 193:648-652(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-284 AND SER-321.
[2]"Cloning and characterization of a fourth human somatostatin receptor."
Rohrer L., Raulf F., Bruns C., Buettner R., Hofstaedter F., Schuele R.
Proc. Natl. Acad. Sci. U.S.A. 90:4196-4200(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-83; VAL-284 AND SER-321.
[3]"Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype."
Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y.
Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20."
Demchyshyn L.L., Srikant C.B., Sunahara R.K., Kent G., Seeman P., van Tol H.H.M., Panetta R., Patel Y.C., Niznik H.B.
Mol. Pharmacol. 43:894-901(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
[6]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16826 Genomic DNA. Translation: BAA04106.1.
L14856 Genomic DNA. Translation: AAA36623.1.
L07833 Genomic DNA. Translation: AAA60565.1.
L07061 Genomic DNA. No translation available.
AY548169 Genomic DNA. Translation: AAS55648.1.
AL049651 Genomic DNA. Translation: CAB51953.1.
CH471133 Genomic DNA. Translation: EAX10170.1.
BC069063 mRNA. Translation: AAH69063.1.
BC117270 mRNA. Translation: AAI17271.1.
BC117272 mRNA. Translation: AAI17273.1.
PIRJN0605.
RefSeqNP_001043.2. NM_001052.2.
UniGeneHs.673846.

3D structure databases

ProteinModelPortalP31391.
SMRP31391. Positions 22-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112632. 1 interaction.
STRING9606.ENSP00000255008.

Chemistry

BindingDBP31391.
ChEMBLCHEMBL2111436.
GuidetoPHARMACOLOGY358.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP31391.

Polymorphism databases

DMDM206729897.

Proteomic databases

PaxDbP31391.
PRIDEP31391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255008; ENSP00000255008; ENSG00000132671.
GeneID6754.
KEGGhsa:6754.
UCSCuc002wsr.2. human.

Organism-specific databases

CTD6754.
GeneCardsGC20P022964.
H-InvDBHIX0040596.
HGNCHGNC:11333. SSTR4.
MIM182454. gene.
neXtProtNX_P31391.
PharmGKBPA36157.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235424.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP31391.
KOK04220.
OMAFYVVQLL.
OrthoDBEOG7BKCVQ.
PhylomeDBP31391.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP31391.
CleanExHS_SSTR4.
GenevestigatorP31391.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSomatostatin_receptor_4.
GenomeRNAi6754.
NextBio26348.
PROP31391.
SOURCESearch...

Entry information

Entry nameSSR4_HUMAN
AccessionPrimary (citable) accession number: P31391
Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries