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P31391

- SSR4_HUMAN

UniProt

P31391 - SSR4_HUMAN

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Protein

Somatostatin receptor type 4

Gene

SSTR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

GO - Molecular functioni

  1. somatostatin receptor activity Source: ProtInc

GO - Biological processi

  1. arachidonic acid metabolic process Source: Ensembl
  2. cell migration Source: Ensembl
  3. cellular response to glucocorticoid stimulus Source: Ensembl
  4. forebrain development Source: Ensembl
  5. G-protein coupled receptor signaling pathway Source: ProtInc
  6. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  7. negative regulation of cAMP metabolic process Source: Ensembl
  8. negative regulation of cell proliferation Source: ProtInc
  9. positive regulation of MAPK cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 4
Short name:
SS-4-R
Short name:
SS4-R
Short name:
SS4R
Gene namesi
Name:SSTR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:11333. SSTR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 7327Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini74 – 8310CytoplasmicSequence Analysis
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 12016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei121 – 14222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini143 – 16119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18524Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini186 – 20823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini233 – 26028CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei261 – 28020Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 29111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei292 – 31423Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini315 – 38874CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Somatostatin receptor type 4PRO_0000070127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi119 ↔ 198PROSITE-ProRule annotation
Lipidationi327 – 3271S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP31391.
PRIDEiP31391.

PTM databases

PhosphoSiteiP31391.

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Gene expression databases

BgeeiP31391.
CleanExiHS_SSTR4.
GenevestigatoriP31391.

Interactioni

Protein-protein interaction databases

BioGridi112632. 1 interaction.
STRINGi9606.ENSP00000255008.

Structurei

3D structure databases

ProteinModelPortaliP31391.
SMRiP31391. Positions 30-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235424.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP31391.
KOiK04220.
OMAiWPHPAWS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP31391.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI
60 70 80 90 100
QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV
110 120 130 140 150
PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH
160 170 180 190 200
PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL
210 220 230 240 250
QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR
260 270 280 290 300
RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS
310 320 330 340 350
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA
360 370 380
LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF
Length:388
Mass (Da):42,003
Last modified:September 23, 2008 - v2
Checksum:iDFCD9393620EDFC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti365 – 3651P → K in AAA60565. (PubMed:8483934)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831N → T.1 Publication
Corresponds to variant rs1065191 [ dbSNP | Ensembl ].
VAR_011703
Natural varianti236 – 2361G → D.
Corresponds to variant rs35601930 [ dbSNP | Ensembl ].
VAR_049441
Natural varianti284 – 2841F → V.4 Publications
Corresponds to variant rs3746726 [ dbSNP | Ensembl ].
VAR_021560
Natural varianti321 – 3211F → S.4 Publications
Corresponds to variant rs2567608 [ dbSNP | Ensembl ].
VAR_021561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16826 Genomic DNA. Translation: BAA04106.1.
L14856 Genomic DNA. Translation: AAA36623.1.
L07833 Genomic DNA. Translation: AAA60565.1.
L07061 Genomic DNA. No translation available.
AY548169 Genomic DNA. Translation: AAS55648.1.
AL049651 Genomic DNA. Translation: CAB51953.1.
CH471133 Genomic DNA. Translation: EAX10170.1.
BC069063 mRNA. Translation: AAH69063.1.
BC117270 mRNA. Translation: AAI17271.1.
BC117272 mRNA. Translation: AAI17273.1.
CCDSiCCDS42856.1.
PIRiJN0605.
RefSeqiNP_001043.2. NM_001052.2.
UniGeneiHs.673846.

Genome annotation databases

EnsembliENST00000255008; ENSP00000255008; ENSG00000132671.
GeneIDi6754.
KEGGihsa:6754.
UCSCiuc002wsr.2. human.

Polymorphism databases

DMDMi206729897.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16826 Genomic DNA. Translation: BAA04106.1 .
L14856 Genomic DNA. Translation: AAA36623.1 .
L07833 Genomic DNA. Translation: AAA60565.1 .
L07061 Genomic DNA. No translation available.
AY548169 Genomic DNA. Translation: AAS55648.1 .
AL049651 Genomic DNA. Translation: CAB51953.1 .
CH471133 Genomic DNA. Translation: EAX10170.1 .
BC069063 mRNA. Translation: AAH69063.1 .
BC117270 mRNA. Translation: AAI17271.1 .
BC117272 mRNA. Translation: AAI17273.1 .
CCDSi CCDS42856.1.
PIRi JN0605.
RefSeqi NP_001043.2. NM_001052.2.
UniGenei Hs.673846.

3D structure databases

ProteinModelPortali P31391.
SMRi P31391. Positions 30-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112632. 1 interaction.
STRINGi 9606.ENSP00000255008.

Chemistry

BindingDBi P31391.
ChEMBLi CHEMBL2111436.
GuidetoPHARMACOLOGYi 358.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P31391.

Polymorphism databases

DMDMi 206729897.

Proteomic databases

PaxDbi P31391.
PRIDEi P31391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255008 ; ENSP00000255008 ; ENSG00000132671 .
GeneIDi 6754.
KEGGi hsa:6754.
UCSCi uc002wsr.2. human.

Organism-specific databases

CTDi 6754.
GeneCardsi GC20P022964.
H-InvDB HIX0040596.
HGNCi HGNC:11333. SSTR4.
MIMi 182454. gene.
neXtProti NX_P31391.
PharmGKBi PA36157.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235424.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230485.
HOVERGENi HBG106919.
InParanoidi P31391.
KOi K04220.
OMAi WPHPAWS.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P31391.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Somatostatin_receptor_4.
GenomeRNAii 6754.
NextBioi 26348.
PROi P31391.
SOURCEi Search...

Gene expression databases

Bgeei P31391.
CleanExi HS_SSTR4.
Genevestigatori P31391.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001512. Somatstn_rcpt_4.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00590. SOMATOSTTN4R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4."
    Xu Y., Song J., Bruno J.F., Berelowitz M.
    Biochem. Biophys. Res. Commun. 193:648-652(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-284 AND SER-321.
  2. "Cloning and characterization of a fourth human somatostatin receptor."
    Rohrer L., Raulf F., Bruns C., Buettner R., Hofstaedter F., Schuele R.
    Proc. Natl. Acad. Sci. U.S.A. 90:4196-4200(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-83; VAL-284 AND SER-321.
  3. "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype."
    Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y.
    Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20."
    Demchyshyn L.L., Srikant C.B., Sunahara R.K., Kent G., Seeman P., van Tol H.H.M., Panetta R., Patel Y.C., Niznik H.B.
    Mol. Pharmacol. 43:894-901(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.
  6. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-284 AND SER-321.

Entry informationi

Entry nameiSSR4_HUMAN
AccessioniPrimary (citable) accession number: P31391
Secondary accession number(s): Q17RM1, Q17RM3, Q9UIY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3