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Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.1 Publication

GO - Molecular functioni

  • histamine binding Source: RGD
  • histamine receptor activity Source: UniProtKB

GO - Biological processi

  • cellular response to histamine Source: UniProtKB
  • chemical synaptic transmission Source: RGD
  • eosinophil chemotaxis Source: InterPro
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RGD
  • inflammatory response Source: GO_Central
  • modulation of synaptic transmission Source: GO_Central
  • negative regulation of steroid biosynthetic process Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of nitric oxide biosynthetic process Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • regulation of vascular permeability Source: InterPro
  • response to gravity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:Hrh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2830. Hrh1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 52Helical; Name=1By similarityAdd BLAST23
Topological domaini53 – 62CytoplasmicBy similarity10
Transmembranei63 – 83Helical; Name=2By similarityAdd BLAST21
Topological domaini84 – 101ExtracellularBy similarityAdd BLAST18
Transmembranei102 – 123Helical; Name=3By similarityAdd BLAST22
Topological domaini124 – 143CytoplasmicBy similarityAdd BLAST20
Transmembranei144 – 164Helical; Name=4By similarityAdd BLAST21
Topological domaini165 – 189ExtracellularBy similarityAdd BLAST25
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 415CytoplasmicBy similarityAdd BLAST205
Transmembranei416 – 437Helical; Name=6By similarityAdd BLAST22
Topological domaini438 – 449ExtracellularBy similarityAdd BLAST12
Transmembranei450 – 469Helical; Name=7By similarityAdd BLAST20
Topological domaini470 – 486CytoplasmicBy similarityAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696801 – 486Histamine H1 receptorAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
Modified residuei140PhosphothreonineBy similarity1
Modified residuei142PhosphothreonineBy similarity1
Modified residuei230PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei397PhosphoserineBy similarity1
Disulfide bondi440 ↔ 443PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31390.
PRIDEiP31390.

PTM databases

PhosphoSitePlusiP31390.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009775.

Chemistry databases

BindingDBiP31390.

Structurei

3D structure databases

ProteinModelPortaliP31390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 112Important for agonist bindingBy similarity6
Regioni423 – 427Important for agonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
HOVERGENiHBG101103.
InParanoidiP31390.
KOiK04149.
PhylomeDBiP31390.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFANTSSTF EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY
60 70 80 90 100
AVHSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG
160 170 180 190 200
AWFFSFLWVI PILGWHHFMP PAPELREDKC ETDFYNVTWF KIMTAIINFY
210 220 230 240 250
LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPSFSELKLR SDDTKEGAKK
260 270 280 290 300
PGRESPWGVL KRPSRDPSVG LDQKSTSEDP KMTSPTVFSQ EGERETRPCF
310 320 330 340 350
RLDIMQKQSV AEGDVRGSKA NDQALSQPKM DEQSLNTCRR ISETSEDQTL
360 370 380 390 400
VDQQSFSRTT DSDTSIEPGP GRVKSRSGSN SGLDYIKITW KRLRSHSRQY
410 420 430 440 450
VSGLHLNRER KAAKQLGFIM AAFILCWIPY FIFFMVIAFC KSCCSEPMHM
460 470 480
FTIWLGYINS TLNPLIYPLC NENFKKTFKK ILHIRS
Length:486
Mass (Da):55,693
Last modified:July 1, 1993 - v1
Checksum:iE44C02A743A95E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12800 Genomic DNA. Translation: BAA02245.1.
PIRiJC1415.
RefSeqiNP_058714.1. NM_017018.1.
UniGeneiRn.81032.

Genome annotation databases

GeneIDi24448.
KEGGirno:24448.
UCSCiRGD:2830. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12800 Genomic DNA. Translation: BAA02245.1.
PIRiJC1415.
RefSeqiNP_058714.1. NM_017018.1.
UniGeneiRn.81032.

3D structure databases

ProteinModelPortaliP31390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009775.

Chemistry databases

BindingDBiP31390.
ChEMBLiCHEMBL4701.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP31390.

Proteomic databases

PaxDbiP31390.
PRIDEiP31390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24448.
KEGGirno:24448.
UCSCiRGD:2830. rat.

Organism-specific databases

CTDi3269.
RGDi2830. Hrh1.

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
HOVERGENiHBG101103.
InParanoidiP31390.
KOiK04149.
PhylomeDBiP31390.

Miscellaneous databases

PROiP31390.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRH1_RAT
AccessioniPrimary (citable) accession number: P31390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.