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P31388

- 5HT6R_RAT

UniProt

P31388 - 5HT6R_RAT

Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

    GO - Molecular functioni

    1. serotonin receptor activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
    3. learning Source: RGD
    4. long-term synaptic potentiation Source: RGD
    5. negative regulation of acetylcholine secretion, neurotransmission Source: RGD
    6. negative regulation of gamma-aminobutyric acid secretion Source: RGD
    7. negative regulation of glutamate secretion Source: RGD
    8. positive regulation of dopamine secretion Source: RGD
    9. positive regulation of gamma-aminobutyric acid secretion Source: RGD
    10. response to drug Source: RGD
    11. response to estradiol Source: RGD
    12. serotonin receptor signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 6
    Short name:
    5-HT-6
    Short name:
    5-HT6
    Alternative name(s):
    ST-B17
    Serotonin receptor 6
    Gene namesi
    Name:Htr6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi62044. Htr6.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: Ensembl
    2. dendrite Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4364365-hydroxytryptamine receptor 6PRO_0000068977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP31388.

    PTM databases

    PhosphoSiteiP31388.

    Expressioni

    Tissue specificityi

    Localized exclusively in the central nervous system, predominantly in the corpus striatum but also in various limbic and cortical regions.

    Gene expression databases

    GenevestigatoriP31388.

    Interactioni

    Protein-protein interaction databases

    BioGridi249039. 1 interaction.
    MINTiMINT-7214733.

    Structurei

    3D structure databases

    ProteinModelPortaliP31388.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularBy similarityAdd
    BLAST
    Topological domaini58 – 647CytoplasmicBy similarity
    Topological domaini86 – 10015ExtracellularBy similarityAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicBy similarityAdd
    BLAST
    Topological domaini167 – 18418ExtracellularBy similarityAdd
    BLAST
    Topological domaini209 – 26557CytoplasmicBy similarityAdd
    BLAST
    Topological domaini291 – 2955ExtracellularBy similarity
    Topological domaini321 – 436116CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5723Helical; Name=1By similarityAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2By similarityAdd
    BLAST
    Transmembranei101 – 12222Helical; Name=3By similarityAdd
    BLAST
    Transmembranei145 – 16622Helical; Name=4By similarityAdd
    BLAST
    Transmembranei185 – 20824Helical; Name=5By similarityAdd
    BLAST
    Transmembranei266 – 29025Helical; Name=6By similarityAdd
    BLAST
    Transmembranei296 – 32025Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG106962.
    KOiK04162.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31388-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL    50
    ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL 100
    LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA 150
    WSLAALASFL PLLLGWHELG KARTPAPGQC RLLASLPFVL VASGVTFFLP 200
    SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP RTPRPGMESA 250
    DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG 300
    LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP 350
    PPCGPLTAVP DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE 400
    RPPGTPRHPP GPPLWSTSLS QTLWSLRYGR IHSVPP 436
    Length:436
    Mass (Da):46,923
    Last modified:November 1, 1995 - v2
    Checksum:i6BC00F6A3CBA5FB4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571L → V in AAA40618. (PubMed:7680751)Curated
    Sequence conflicti336 – 436101PCVHC…HSVPP → HASTVPRSTGQPCLPLHVDL SQRCQTRPQLQQVLALPLPP NSDSDSASGGTSGLQLTAQL LLPGEATRDPPPPTRATTVV NFFVTDSVEPEIRPHPLSSP VN in AAA40618. (PubMed:7680751)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03202 mRNA. Translation: AAA40618.1.
    S62043 mRNA. Translation: AAB26908.1.
    L19656 mRNA. Translation: AAA40611.1.
    PIRiI57942.
    JN0591.
    RefSeqiNP_077341.1. NM_024365.1.
    UniGeneiRn.10552.

    Genome annotation databases

    GeneIDi64354.
    KEGGirno:64354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03202 mRNA. Translation: AAA40618.1 .
    S62043 mRNA. Translation: AAB26908.1 .
    L19656 mRNA. Translation: AAA40611.1 .
    PIRi I57942.
    JN0591.
    RefSeqi NP_077341.1. NM_024365.1.
    UniGenei Rn.10552.

    3D structure databases

    ProteinModelPortali P31388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249039. 1 interaction.
    MINTi MINT-7214733.

    Chemistry

    BindingDBi P31388.
    ChEMBLi CHEMBL3372.
    GuidetoPHARMACOLOGYi 11.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P31388.

    Proteomic databases

    PRIDEi P31388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 64354.
    KEGGi rno:64354.

    Organism-specific databases

    CTDi 3362.
    RGDi 62044. Htr6.

    Phylogenomic databases

    HOVERGENi HBG106962.
    KOi K04162.

    Miscellaneous databases

    NextBioi 613040.
    PROi P31388.

    Gene expression databases

    Genevestigatori P31388.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs."
      Monsma F.J. Jr., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R.
      Mol. Pharmacol. 43:320-327(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Corpus striatum.
    2. "A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation."
      Ruat M., Traiffort E., Arrang J.-M., Tardivel-Lacombe J., Diaz J., Leurs R., Schwartz J.-C.
      Biochem. Biophys. Res. Commun. 193:268-276(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "A novel rat serotonin (5HT6) receptor."
      Martial R.
      Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei5HT6R_RAT
    AccessioniPrimary (citable) accession number: P31388
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3