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P31388

- 5HT6R_RAT

UniProt

P31388 - 5HT6R_RAT

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Protein

5-hydroxytryptamine receptor 6

Gene

Htr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

GO - Molecular functioni

  1. serotonin receptor activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
  3. learning Source: RGD
  4. long-term synaptic potentiation Source: RGD
  5. negative regulation of acetylcholine secretion, neurotransmission Source: RGD
  6. negative regulation of gamma-aminobutyric acid secretion Source: RGD
  7. negative regulation of glutamate secretion Source: RGD
  8. positive regulation of dopamine secretion Source: RGD
  9. positive regulation of gamma-aminobutyric acid secretion Source: RGD
  10. response to drug Source: RGD
  11. response to estradiol Source: RGD
  12. serotonin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 6
Short name:
5-HT-6
Short name:
5-HT6
Alternative name(s):
ST-B17
Serotonin receptor 6
Gene namesi
Name:Htr6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi62044. Htr6.

Subcellular locationi

GO - Cellular componenti

  1. cilium Source: Ensembl
  2. dendrite Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4364365-hydroxytryptamine receptor 6PRO_0000068977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP31388.

PTM databases

PhosphoSiteiP31388.

Expressioni

Tissue specificityi

Localized exclusively in the central nervous system, predominantly in the corpus striatum but also in various limbic and cortical regions.

Gene expression databases

GenevestigatoriP31388.

Interactioni

Protein-protein interaction databases

BioGridi249039. 1 interaction.
MINTiMINT-7214733.

Structurei

3D structure databases

ProteinModelPortaliP31388.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Topological domaini58 – 647CytoplasmicBy similarity
Topological domaini86 – 10015ExtracellularBy similarityAdd
BLAST
Topological domaini123 – 14422CytoplasmicBy similarityAdd
BLAST
Topological domaini167 – 18418ExtracellularBy similarityAdd
BLAST
Topological domaini209 – 26557CytoplasmicBy similarityAdd
BLAST
Topological domaini291 – 2955ExtracellularBy similarity
Topological domaini321 – 436116CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5723Helical; Name=1By similarityAdd
BLAST
Transmembranei65 – 8521Helical; Name=2By similarityAdd
BLAST
Transmembranei101 – 12222Helical; Name=3By similarityAdd
BLAST
Transmembranei145 – 16622Helical; Name=4By similarityAdd
BLAST
Transmembranei185 – 20824Helical; Name=5By similarityAdd
BLAST
Transmembranei266 – 29025Helical; Name=6By similarityAdd
BLAST
Transmembranei296 – 32025Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiP31388.
KOiK04162.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL
60 70 80 90 100
ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL
110 120 130 140 150
LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTA PRALALILGA
160 170 180 190 200
WSLAALASFL PLLLGWHELG KARTPAPGQC RLLASLPFVL VASGVTFFLP
210 220 230 240 250
SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP RTPRPGMESA
260 270 280 290 300
DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG
310 320 330 340 350
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP
360 370 380 390 400
PPCGPLTAVP DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE
410 420 430
RPPGTPRHPP GPPLWSTSLS QTLWSLRYGR IHSVPP
Length:436
Mass (Da):46,923
Last modified:November 1, 1995 - v2
Checksum:i6BC00F6A3CBA5FB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571L → V in AAA40618. (PubMed:7680751)Curated
Sequence conflicti336 – 436101PCVHC…HSVPP → HASTVPRSTGQPCLPLHVDL SQRCQTRPQLQQVLALPLPP NSDSDSASGGTSGLQLTAQL LLPGEATRDPPPPTRATTVV NFFVTDSVEPEIRPHPLSSP VN in AAA40618. (PubMed:7680751)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03202 mRNA. Translation: AAA40618.1.
S62043 mRNA. Translation: AAB26908.1.
L19656 mRNA. Translation: AAA40611.1.
PIRiI57942.
JN0591.
RefSeqiNP_077341.1. NM_024365.1.
UniGeneiRn.10552.

Genome annotation databases

GeneIDi64354.
KEGGirno:64354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L03202 mRNA. Translation: AAA40618.1 .
S62043 mRNA. Translation: AAB26908.1 .
L19656 mRNA. Translation: AAA40611.1 .
PIRi I57942.
JN0591.
RefSeqi NP_077341.1. NM_024365.1.
UniGenei Rn.10552.

3D structure databases

ProteinModelPortali P31388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249039. 1 interaction.
MINTi MINT-7214733.

Chemistry

BindingDBi P31388.
ChEMBLi CHEMBL2094123.
GuidetoPHARMACOLOGYi 11.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P31388.

Proteomic databases

PRIDEi P31388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 64354.
KEGGi rno:64354.

Organism-specific databases

CTDi 3362.
RGDi 62044. Htr6.

Phylogenomic databases

HOVERGENi HBG106962.
InParanoidi P31388.
KOi K04162.

Miscellaneous databases

NextBioi 613040.
PROi P31388.

Gene expression databases

Genevestigatori P31388.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs."
    Monsma F.J. Jr., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R.
    Mol. Pharmacol. 43:320-327(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Corpus striatum.
  2. "A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation."
    Ruat M., Traiffort E., Arrang J.-M., Tardivel-Lacombe J., Diaz J., Leurs R., Schwartz J.-C.
    Biochem. Biophys. Res. Commun. 193:268-276(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A novel rat serotonin (5HT6) receptor."
    Martial R.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei5HT6R_RAT
AccessioniPrimary (citable) accession number: P31388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3