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Protein

5-hydroxytryptamine receptor 5B

Gene

Htr5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

GO - Molecular functioni

  • G-protein coupled serotonin receptor activity Source: MGI

GO - Biological processi

  • serotonin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5B
Short name:
5-HT-5B
Short name:
5-HT5B
Alternative name(s):
Serotonin receptor 5B
Gene namesi
Name:Htr5b
Synonyms:5ht5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96284. Htr5b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularBy similarityAdd
BLAST
Transmembranei53 – 7523Helical; Name=1By similarityAdd
BLAST
Topological domaini76 – 9015CytoplasmicBy similarityAdd
BLAST
Transmembranei91 – 11121Helical; Name=2By similarityAdd
BLAST
Topological domaini112 – 12817ExtracellularBy similarityAdd
BLAST
Transmembranei129 – 15022Helical; Name=3By similarityAdd
BLAST
Topological domaini151 – 17121CytoplasmicBy similarityAdd
BLAST
Transmembranei172 – 19423Helical; Name=4By similarityAdd
BLAST
Topological domaini195 – 21117ExtracellularBy similarityAdd
BLAST
Transmembranei212 – 23221Helical; Name=5By similarityAdd
BLAST
Topological domaini233 – 29563CytoplasmicBy similarityAdd
BLAST
Transmembranei296 – 31621Helical; Name=6By similarityAdd
BLAST
Topological domaini317 – 33317ExtracellularBy similarityAdd
BLAST
Transmembranei334 – 35421Helical; Name=7By similarityAdd
BLAST
Topological domaini355 – 37016CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi648.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3703705-hydroxytryptamine receptor 5BPRO_0000068972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31387.
PRIDEiP31387.

PTM databases

iPTMnetiP31387.
PhosphoSiteiP31387.

Expressioni

Tissue specificityi

Expressed predominantly in the central nervous system; in the hippocampus, habenula, and the doral raphe.

Gene expression databases

CleanExiMM_HTR5B.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057212.

Chemistry

BindingDBiP31387.

Structurei

3D structure databases

ProteinModelPortaliP31387.
SMRiP31387. Positions 51-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP31387.
PhylomeDBiP31387.

Family and domain databases

InterProiIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSNLSGAT PGLAFPPGPE SCSDSPSSGR SMGSTPGGLI LPGREPPFSA
60 70 80 90 100
FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL
110 120 130 140 150
VAVLVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL
160 170 180 190 200
DRYWTITRHL QYTLRTRSRA SALMIAITWA LSALIALAPL LFGWGEAYDA
210 220 230 240 250
RLQRCQVSQE PSYAVFSTCG AFYLPLAVVL FVYWKIYKAA KFRFGRRRRA
260 270 280 290 300
VVPLPATTQA KEAPPESEMV FTARRRATVT FQTSGDSWRE QKEKRAAMMV
310 320 330 340 350
GILIGVFVLC WIPFFLTELI SPLCACSLPP IWKSIFLWLG YSNSFFNPLI
360 370
YTAFNKNYNN AFKSLFTKQR
Length:370
Mass (Da):41,201
Last modified:July 1, 1993 - v1
Checksum:i0553C62B12DAAD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69867 mRNA. Translation: CAA49501.1.
BC114988 mRNA. Translation: AAI14989.1.
BC115825 mRNA. Translation: AAI15826.1.
CCDSiCCDS15239.1.
PIRiI48231.
UniGeneiMm.4833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69867 mRNA. Translation: CAA49501.1.
BC114988 mRNA. Translation: AAI14989.1.
BC115825 mRNA. Translation: AAI15826.1.
CCDSiCCDS15239.1.
PIRiI48231.
UniGeneiMm.4833.

3D structure databases

ProteinModelPortaliP31387.
SMRiP31387. Positions 51-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057212.

Chemistry

BindingDBiP31387.
GuidetoPHARMACOLOGYi648.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP31387.
PhosphoSiteiP31387.

Proteomic databases

PaxDbiP31387.
PRIDEiP31387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96284. Htr5b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP31387.
PhylomeDBiP31387.

Miscellaneous databases

PROiP31387.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HTR5B.

Family and domain databases

InterProiIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization."
    Matthes H., Boschert U., Amlaiky N., Grailhe R., Plassat J.-L., Muscatelli F., Mattei M.-G., Hen R.
    Mol. Pharmacol. 43:313-319(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry namei5HT5B_MOUSE
AccessioniPrimary (citable) accession number: P31387
Secondary accession number(s): Q1RME2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.