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Protein

Protein ATS1

Gene

ATS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in regulatory interactions between microtubules and the cell cycle.

GO - Biological processi

  • budding cell bud growth Source: SGD
  • microtubule-based process Source: SGD
  • microtubule cytoskeleton organization Source: SGD
  • tRNA wobble uridine modification Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28832-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATS1
Alternative name(s):
Alpha-tubulin suppressor 1
Gene namesi
Name:ATS1
Ordered Locus Names:YAL020C
ORF Names:FUN28, YAL006
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome I

Organism-specific databases

CYGDiYAL020c.
EuPathDBiFungiDB:YAL020C.
SGDiS000000018. ATS1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Protein ATS1PRO_0000206648Add
BLAST

Proteomic databases

MaxQBiP31386.
PaxDbiP31386.
PeptideAtlasiP31386.

Interactioni

Protein-protein interaction databases

BioGridi31746. 90 interactions.
IntActiP31386. 2 interactions.
MINTiMINT-2786397.

Structurei

Secondary structure

1
333
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Beta strandi16 – 194Combined sources
Beta strandi23 – 297Combined sources
Beta strandi32 – 343Combined sources
Beta strandi38 – 436Combined sources
Beta strandi45 – 528Combined sources
Beta strandi57 – 626Combined sources
Beta strandi66 – 683Combined sources
Beta strandi76 – 827Combined sources
Beta strandi89 – 946Combined sources
Beta strandi96 – 1038Combined sources
Beta strandi108 – 1125Combined sources
Beta strandi115 – 1217Combined sources
Beta strandi127 – 1293Combined sources
Beta strandi132 – 1376Combined sources
Beta strandi140 – 1456Combined sources
Beta strandi148 – 1558Combined sources
Beta strandi158 – 1636Combined sources
Beta strandi165 – 17612Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi182 – 1876Combined sources
Beta strandi189 – 1968Combined sources
Beta strandi201 – 2077Combined sources
Helixi214 – 2163Combined sources
Beta strandi217 – 2193Combined sources
Beta strandi224 – 2285Combined sources
Beta strandi231 – 2366Combined sources
Turni237 – 2404Combined sources
Beta strandi241 – 2466Combined sources
Beta strandi263 – 2686Combined sources
Beta strandi270 – 2789Combined sources
Beta strandi281 – 2844Combined sources
Beta strandi287 – 2937Combined sources
Beta strandi296 – 3005Combined sources
Beta strandi311 – 3188Combined sources
Beta strandi321 – 3244Combined sources
Beta strandi326 – 3338Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D4OX-ray2.90A/B/C1-333[»]
4D4PX-ray3.00A/B/C/E/G/H1-333[»]
4D4QX-ray2.40A/B1-333[»]
4X33X-ray1.45B1-333[»]
ProteinModelPortaliP31386.
SMRiP31386. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 5353RCC1 1Add
BLAST
Repeati55 – 10450RCC1 2Add
BLAST
Repeati146 – 19752RCC1 3Add
BLAST
Repeati286 – 33348RCC1 4Add
BLAST

Sequence similaritiesi

Contains 4 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5184.
HOGENOMiHOG000163478.
InParanoidiP31386.
KOiK15462.
OMAiGAGFCYA.
OrthoDBiEOG757D8X.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCVYAFGSN GQRQLGLGHD EDMDTPQRSV PGDDGAIVRK IACGGNHSVM
60 70 80 90 100
LTNDGNLVGC GDNRRGELDS AQALRQVHDW RPVEVPAPVV DVACGWDTTV
110 120 130 140 150
IVDADGRVWQ RGGGCYEFTQ QHVPLNSNDE RIAVYGCFQN FVVVQGTRVY
160 170 180 190 200
GWGSNTKCQL QEPKSRSLKE PVLVYDTGSV AVDYVAMGKD FMVIVDEGGR
210 220 230 240 250
IVHASGRLPT GFELKQQQKR HNLVVLCMWT SIHLWNARLN TVESFGRGTH
260 270 280 290 300
SQLFPQERLD FPIVGVATGS EHGILTTANQ EGKSHCYNVY CWGWGEHGNC
310 320 330
GPQKGSQPGL QLVGQYSGKP RVFGGCATTW IVL
Length:333
Mass (Da):36,467
Last modified:July 27, 2011 - v2
Checksum:i3C6F4BE180479096
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051G → A no nucleotide entry (PubMed:8458570).Curated
Sequence conflicti305 – 3051G → A no nucleotide entry (PubMed:8144453).Curated
Sequence conflicti305 – 3051G → A in AAC04937 (PubMed:7731988).Curated
Sequence conflicti305 – 3051G → A no nucleotide entry (PubMed:1561836).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04937.1.
BK006935 Genomic DNA. Translation: DAA06968.2.
PIRiS36714.
RefSeqiNP_009382.2. NM_001178165.2.

Genome annotation databases

EnsemblFungiiYAL020C; YAL020C; YAL020C.
GeneIDi851213.
KEGGisce:YAL020C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04937.1.
BK006935 Genomic DNA. Translation: DAA06968.2.
PIRiS36714.
RefSeqiNP_009382.2. NM_001178165.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D4OX-ray2.90A/B/C1-333[»]
4D4PX-ray3.00A/B/C/E/G/H1-333[»]
4D4QX-ray2.40A/B1-333[»]
4X33X-ray1.45B1-333[»]
ProteinModelPortaliP31386.
SMRiP31386. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31746. 90 interactions.
IntActiP31386. 2 interactions.
MINTiMINT-2786397.

Proteomic databases

MaxQBiP31386.
PaxDbiP31386.
PeptideAtlasiP31386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL020C; YAL020C; YAL020C.
GeneIDi851213.
KEGGisce:YAL020C.

Organism-specific databases

CYGDiYAL020c.
EuPathDBiFungiDB:YAL020C.
SGDiS000000018. ATS1.

Phylogenomic databases

eggNOGiCOG5184.
HOGENOMiHOG000163478.
InParanoidiP31386.
KOiK15462.
OMAiGAGFCYA.
OrthoDBiEOG757D8X.

Enzyme and pathway databases

BioCyciYEAST:G3O-28832-MONOMER.

Miscellaneous databases

NextBioi968094.
PROiP31386.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 1 hit.
PS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
    Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
    Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region."
    Barton A.B., Kaback D.B.
    J. Bacteriol. 176:1872-1880(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 305.
    Strain: ATCC 204508 / S288c.
  5. "Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I."
    Clark M.W., Zhong W.-W., Keng T., Storms R.K., Barton A.B., Kaback D.B., Bussey H.
    Yeast 8:133-145(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  6. "Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules."
    Kirkpatrick D., Solomon F.
    Genetics 137:381-392(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiATS1_YEAST
AccessioniPrimary (citable) accession number: P31386
Secondary accession number(s): D6VPJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.