P31386 (ATS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ATS1

Alternative name(s):
Alpha-tubulin suppressor 1

Gene names

Name:	ATS1
Ordered Locus Names:	YAL020C
ORF Names:	YAL006, FUN28

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in regulatory interactions between microtubules and the cell cycle.
Sequence similarities	Contains 4 RCC1 repeats.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	budding cell bud growth Inferred from genetic interaction. Source: SGD microtubule cytoskeleton organization Inferred from mutant phenotype. Source: SGD tRNA wobble uridine modification Inferred from mutant phenotype. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Protein ATS1		PRO_0000206648
Regions
	Repeat	1 – 53	53	RCC1 1
	Repeat	55 – 104	50	RCC1 2
	Repeat	146 – 197	52	RCC1 3
	Repeat	286 – 333	48	RCC1 4
Experimental info
	Sequence conflict	305	1	G → A no nucleotide entry Ref.1
	Sequence conflict	305	1	G → A no nucleotide entry Ref.2
	Sequence conflict	305	1	G → A in AAC04937. Ref.3
	Sequence conflict	305	1	G → A no nucleotide entry Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P31386 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 3C6F4BE180479096	FASTA	333	36,467
	10 20 30 40 50 60 MSCVYAFGSN GQRQLGLGHD EDMDTPQRSV PGDDGAIVRK IACGGNHSVM LTNDGNLVGC 70 80 90 100 110 120 GDNRRGELDS AQALRQVHDW RPVEVPAPVV DVACGWDTTV IVDADGRVWQ RGGGCYEFTQ 130 140 150 160 170 180 QHVPLNSNDE RIAVYGCFQN FVVVQGTRVY GWGSNTKCQL QEPKSRSLKE PVLVYDTGSV 190 200 210 220 230 240 AVDYVAMGKD FMVIVDEGGR IVHASGRLPT GFELKQQQKR HNLVVLCMWT SIHLWNARLN 250 260 270 280 290 300 TVESFGRGTH SQLFPQERLD FPIVGVATGS EHGILTTANQ EGKSHCYNVY CWGWGEHGNC 310 320 330 GPQKGSQPGL QLVGQYSGKP RVFGGCATTW IVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes." Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H. Genome 36:32-42(1993) [PubMed: 8458570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region." Barton A.B., Kaback D.B. J. Bacteriol. 176:1872-1880(1994) [PubMed: 8144453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 305. Strain: ATCC 204508 / S288c.
[5]	"Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I." Clark M.W., Zhong W.-W., Keng T., Storms R.K., Barton A.B., Kaback D.B., Bussey H. Yeast 8:133-145(1992) [PubMed: 1561836] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[6]	"Overexpression of yeast homologs of the mammalian checkpoint gene RCC1 suppresses the class of alpha-tubulin mutations that arrest with excess microtubules." Kirkpatrick D., Solomon F. Genetics 137:381-392(1994) [PubMed: 8070652] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05146 Genomic DNA. Translation: AAC04937.1. BK006935 Genomic DNA. Translation: DAA06968.2.
PIR	S36714.
RefSeq	NP_009382.2. NM_001178165.2.
3D structure databases
ProteinModelPortal	P31386.
SMR	P31386. Positions 3-209.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31386. 3 interactions.
MINT	MINT-2786397.
STRING	P31386.
Proteomic databases
PeptideAtlas	P31386.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	851213.
KEGG	sce:YAL020C.
NMPDR	fig|4932.3.peg.63.
Organism-specific databases
CYGD	YAL020c.
SGD	S000000018. ATS1.
Phylogenomic databases
eggNOG	fuNOG06510.
GeneTree	EFGT00050000001855.
HOGENOM	HBG398181.
OMA	VTFDYLN.
OrthoDB	EOG4H75MP.
Gene expression databases
ArrayExpress	P31386.
Genevestigator	P31386.
GermOnline	YAL020C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000408. Reg_chr_condens. IPR009091. Reg_csome_cond/b-lactamase_inh. [Graphical view]
Gene3D	G3DSA:2.130.10.30. Reg_csome_cond/b-lactamase_inh. 1 hit.
KO	K15462.
Pfam	PF00415. RCC1. 2 hits. [Graphical view]
PRINTS	PR00633. RCCNDNSATION.
SUPFAM	SSF50985. RCC1/BLIP-II. 1 hit.
PROSITE	PS00625. RCC1_1. False negative. PS00626. RCC1_2. 1 hit. PS50012. RCC1_3. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	968094.

Entry information

Entry name

ATS1_YEAST

Accession

Primary (citable) accession number: P31386
Secondary accession number(s): D6VPJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program