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Protein

Transcriptional regulatory protein DEP1

Gene

DEP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.1 Publication

GO - Molecular functioni

GO - Biological processi

  • histone deacetylation Source: SGD
  • negative regulation of chromatin silencing at rDNA Source: SGD
  • negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  • negative regulation of chromatin silencing at telomere Source: SGD
  • negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • regulation of transcription from RNA polymerase II promoter Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein DEP1
Gene namesi
Name:DEP1
Synonyms:FUN54
Ordered Locus Names:YAL013W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL013W.
SGDiS000000011. DEP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • Rpd3L complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Transcriptional regulatory protein DEP1PRO_0000079864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei370 – 3701PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31385.

PTM databases

iPTMnetiP31385.

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31753. 465 interactions.
DIPiDIP-5922N.
IntActiP31385. 7 interactions.
MINTiMINT-641697.

Structurei

3D structure databases

ProteinModelPortaliP31385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 17797Glu-richAdd
BLAST

Phylogenomic databases

InParanoidiP31385.
OrthoDBiEOG092C3LCX.

Family and domain databases

InterProiIPR033487. Dep1.
IPR013907. Sds3.
[Graphical view]
PANTHERiPTHR21964:SF7. PTHR21964:SF7. 2 hits.
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQTPQESE QTTAKEQDLD QESVLSNIDF NTDLNHNLNL SEYCISSDAG
60 70 80 90 100
TEKMDSDEEK SLANLPELKY APKLSSLVKQ ETLTESLKRP HEDEKEAIDE
110 120 130 140 150
AKKMKVPGEN EDESKEEEKS QELEEAIDSK EKSTDARDEQ GDEGDNEEEN
160 170 180 190 200
NEEDNENENE HTAPPALVMP SPIEMEEQRM TALKEITDIE YKFAQLRQKL
210 220 230 240 250
YDNQLVRLQT ELQMCLEGSH PELQVYYSKI AAIRDYKLHR AYQRQKYELS
260 270 280 290 300
CINTETIATR TFIHQDFHKK VTDLRARLLN RTTQTWYDIN KERRDMDIVI
310 320 330 340 350
PDVNYHVPIK LDNKTLSCIT GYASAAQLCY PGEPVAEDLA CESIEYRYRA
360 370 380 390 400
NPVDKLEVIV DRMRLNNEIS DLEGLRKYFH SFPGAPELNP LRDSEINDDF

HQWAQ
Length:405
Mass (Da):46,978
Last modified:July 27, 2011 - v3
Checksum:i3A67F052C3920A22
GO

Sequence cautioni

The sequence AAC04944 differs from that shown. Reason: Frameshift at position 405. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04944.2. Frameshift.
AY260888 Genomic DNA. Translation: AAP21756.1.
BK006935 Genomic DNA. Translation: DAA06975.2.
PIRiS36721.
RefSeqiNP_009389.3. NM_001178158.2.

Genome annotation databases

EnsemblFungiiYAL013W; YAL013W; YAL013W.
GeneIDi851220.
KEGGisce:YAL013W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04944.2. Frameshift.
AY260888 Genomic DNA. Translation: AAP21756.1.
BK006935 Genomic DNA. Translation: DAA06975.2.
PIRiS36721.
RefSeqiNP_009389.3. NM_001178158.2.

3D structure databases

ProteinModelPortaliP31385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31753. 465 interactions.
DIPiDIP-5922N.
IntActiP31385. 7 interactions.
MINTiMINT-641697.

PTM databases

iPTMnetiP31385.

Proteomic databases

MaxQBiP31385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL013W; YAL013W; YAL013W.
GeneIDi851220.
KEGGisce:YAL013W.

Organism-specific databases

EuPathDBiFungiDB:YAL013W.
SGDiS000000011. DEP1.

Phylogenomic databases

InParanoidiP31385.
OrthoDBiEOG092C3LCX.

Enzyme and pathway databases

BioCyciYEAST:G3O-28825-MONOMER.

Miscellaneous databases

PROiP31385.

Family and domain databases

InterProiIPR033487. Dep1.
IPR013907. Sds3.
[Graphical view]
PANTHERiPTHR21964:SF7. PTHR21964:SF7. 2 hits.
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEP1_YEAST
AccessioniPrimary (citable) accession number: P31385
Secondary accession number(s): D6VPK5, Q86ZS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.