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Protein

Transcriptional regulatory protein DEP1

Gene

DEP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.1 Publication

GO - Molecular functioni

GO - Biological processi

  • histone deacetylation Source: SGD
  • negative regulation of chromatin silencing at rDNA Source: SGD
  • negative regulation of chromatin silencing at silent mating-type cassette Source: SGD
  • negative regulation of chromatin silencing at telomere Source: SGD
  • negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  • regulation of DNA-dependent DNA replication initiation Source: SGD
  • regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28825-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein DEP1
Gene namesi
Name:DEP1
Synonyms:FUN54
Ordered Locus Names:YAL013W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL013W
SGDiS000000011 DEP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798641 – 405Transcriptional regulatory protein DEP1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31385
PaxDbiP31385
PRIDEiP31385

PTM databases

iPTMnetiP31385

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31753, 880 interactors
DIPiDIP-5922N
IntActiP31385, 9 interactors
MINTiP31385
STRINGi4932.YAL013W

Structurei

3D structure databases

ProteinModelPortaliP31385
SMRiP31385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 177Glu-richAdd BLAST97

Phylogenomic databases

InParanoidiP31385
OrthoDBiEOG092C3LCX

Family and domain databases

InterProiView protein in InterPro
IPR033487 Dep1
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 2 hits
PTHR21964:SF25 PTHR21964:SF25, 2 hits
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequencei

Sequence statusi: Complete.

P31385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQTPQESE QTTAKEQDLD QESVLSNIDF NTDLNHNLNL SEYCISSDAG
60 70 80 90 100
TEKMDSDEEK SLANLPELKY APKLSSLVKQ ETLTESLKRP HEDEKEAIDE
110 120 130 140 150
AKKMKVPGEN EDESKEEEKS QELEEAIDSK EKSTDARDEQ GDEGDNEEEN
160 170 180 190 200
NEEDNENENE HTAPPALVMP SPIEMEEQRM TALKEITDIE YKFAQLRQKL
210 220 230 240 250
YDNQLVRLQT ELQMCLEGSH PELQVYYSKI AAIRDYKLHR AYQRQKYELS
260 270 280 290 300
CINTETIATR TFIHQDFHKK VTDLRARLLN RTTQTWYDIN KERRDMDIVI
310 320 330 340 350
PDVNYHVPIK LDNKTLSCIT GYASAAQLCY PGEPVAEDLA CESIEYRYRA
360 370 380 390 400
NPVDKLEVIV DRMRLNNEIS DLEGLRKYFH SFPGAPELNP LRDSEINDDF

HQWAQ
Length:405
Mass (Da):46,978
Last modified:July 27, 2011 - v3
Checksum:i3A67F052C3920A22
GO

Sequence cautioni

The sequence AAC04944 differs from that shown. Reason: Frameshift at position 405.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA Translation: AAC04944.2 Frameshift.
AY260888 Genomic DNA Translation: AAP21756.1
BK006935 Genomic DNA Translation: DAA06975.2
PIRiS36721
RefSeqiNP_009389.3, NM_001178158.2

Genome annotation databases

EnsemblFungiiYAL013W; YAL013W; YAL013W
GeneIDi851220
KEGGisce:YAL013W

Similar proteinsi

Entry informationi

Entry nameiDEP1_YEAST
AccessioniPrimary (citable) accession number: P31385
Secondary accession number(s): D6VPK5, Q86ZS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health