Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside transporter FUN26

Gene

FUN26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.

GO - Molecular functioni

  • nicotinamide riboside transmembrane transporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: SGD
  • nucleoside transmembrane transporter activity Source: SGD

GO - Biological processi

  • nicotinamide riboside transport Source: SGD
  • nucleobase transport Source: SGD
  • nucleoside transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28834-MONOMER.

Protein family/group databases

TCDBi2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside transporter FUN26
Gene namesi
Name:FUN26
Ordered Locus Names:YAL022C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL022C.
SGDiS000000020. FUN26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: SGD
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093461 – 517Nucleoside transporter FUN26Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31381.
PRIDEiP31381.

PTM databases

iPTMnetiP31381.

Interactioni

Protein-protein interaction databases

BioGridi31744. 11 interactors.
DIPiDIP-5495N.
IntActiP31381. 5 interactors.
MINTiMINT-518779.

Structurei

3D structure databases

ProteinModelPortaliP31381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000190304.
InParanoidiP31381.
KOiK15014.
OMAiWPWNCIL.
OrthoDBiEOG092C2CLW.

Family and domain databases

InterProiIPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequencei

Sequence statusi: Complete.

P31381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD
60 70 80 90 100
NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ
110 120 130 140 150
YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING
160 170 180 190 200
LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA
210 220 230 240 250
IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF
260 270 280 290 300
TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI
310 320 330 340 350
VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT
360 370 380 390 400
TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM
410 420 430 440 450
FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC
460 470 480 490 500
YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL
510
GSIISYVFVF IIDFIIR
Length:517
Mass (Da):58,317
Last modified:July 1, 1993 - v1
Checksum:i43C92A3E9A3D8D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04935.1.
BK006935 Genomic DNA. Translation: DAA06966.1.
PIRiS36712.
RefSeqiNP_009380.1. NM_001178167.1.

Genome annotation databases

EnsemblFungiiYAL022C; YAL022C; YAL022C.
GeneIDi851211.
KEGGisce:YAL022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04935.1.
BK006935 Genomic DNA. Translation: DAA06966.1.
PIRiS36712.
RefSeqiNP_009380.1. NM_001178167.1.

3D structure databases

ProteinModelPortaliP31381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31744. 11 interactors.
DIPiDIP-5495N.
IntActiP31381. 5 interactors.
MINTiMINT-518779.

Protein family/group databases

TCDBi2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

PTM databases

iPTMnetiP31381.

Proteomic databases

MaxQBiP31381.
PRIDEiP31381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL022C; YAL022C; YAL022C.
GeneIDi851211.
KEGGisce:YAL022C.

Organism-specific databases

EuPathDBiFungiDB:YAL022C.
SGDiS000000020. FUN26.

Phylogenomic databases

HOGENOMiHOG000190304.
InParanoidiP31381.
KOiK15014.
OMAiWPWNCIL.
OrthoDBiEOG092C2CLW.

Enzyme and pathway databases

BioCyciYEAST:G3O-28834-MONOMER.

Miscellaneous databases

PROiP31381.

Family and domain databases

InterProiIPR002259. Eqnu_transpt.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 2 hits.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUN26_YEAST
AccessioniPrimary (citable) accession number: P31381
Secondary accession number(s): D6VPJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.