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P31381 (FUN26_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoside transporter FUN26
Gene names
Name:FUN26
Ordered Locus Names:YAL022C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Nucleoside transporter FUN26
PRO_0000209346

Regions

Transmembrane76 – 9621Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane344 – 36421Helical; Potential
Transmembrane367 – 38721Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane446 – 46621Helical; Potential
Transmembrane492 – 51221Helical; Potential

Amino acid modifications

Modified residue451Phosphoserine Ref.7
Modified residue581Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P31381 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 43C92A3E9A3D8D50

FASTA51758,317
        10         20         30         40         50         60 
MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD NYSEREQSVS 

        70         80         90        100        110        120 
TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ YFKHDIFKDT SIWAKIFTSS 

       130        140        150        160        170        180 
MMSFSTISSM LFNIYLAKRQ YKYSRRVING LVWEIIVFTV MCFFTILHFL LPKWFNFMFI 

       190        200        210        220        230        240 
MMLVVISSMG TAMTQNGIMA IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS 

       250        260        270        280        290        300 
TTGGILLYFF TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI 

       310        320        330        340        350        360 
VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT TFVVTLVFPV 

       370        380        390        400        410        420 
FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM FRDQKFTPRK TFIYSLLRVA 

       430        440        450        460        470        480 
AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC YMLLQFLFGV TNGHVISMSF MKVPEQLDND 

       490        500        510 
DEKEAAGGFT NIFVSTGLAL GSIISYVFVF IIDFIIR 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05146 Genomic DNA. Translation: AAC04935.1.
BK006935 Genomic DNA. Translation: DAA06966.1.
PIRS36712.
RefSeqNP_009380.1. NM_001178167.1.

3D structure databases

ProteinModelPortalP31381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31744. 12 interactions.
DIPDIP-5495N.
IntActP31381. 5 interactions.
MINTMINT-518779.
STRING4932.YAL022C.

Protein family/group databases

TCDB2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

Proteomic databases

MaxQBP31381.
PaxDbP31381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL022C; YAL022C; YAL022C.
GeneID851211.
KEGGsce:YAL022C.

Organism-specific databases

CYGDYAL022c.
SGDS000000020. FUN26.

Phylogenomic databases

eggNOGNOG299983.
HOGENOMHOG000190304.
KOK15014.
OMAHESENNE.
OrthoDBEOG7966T3.

Enzyme and pathway databases

BioCycYEAST:G3O-28834-MONOMER.

Gene expression databases

GenevestigatorP31381.

Family and domain databases

InterProIPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERPTHR10332. PTHR10332. 1 hit.
PfamPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFPIRSF016379. ENT. 1 hit.
PRINTSPR01130. DERENTRNSPRT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00939. 2a57. 1 hit.
ProtoNetSearch...

Other

NextBio968088.
PROP31381.

Entry information

Entry nameFUN26_YEAST
AccessionPrimary (citable) accession number: P31381
Secondary accession number(s): D6VPJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 14, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families