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P31381

- FUN26_YEAST

UniProt

P31381 - FUN26_YEAST

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Protein

Nucleoside transporter FUN26

Gene

FUN26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.

GO - Molecular functioni

  1. nicotinamide riboside transmembrane transporter activity Source: SGD
  2. nucleobase transmembrane transporter activity Source: SGD
  3. nucleoside transmembrane transporter activity Source: SGD

GO - Biological processi

  1. nicotinamide riboside transport Source: SGD
  2. nucleobase transport Source: SGD
  3. nucleoside transmembrane transport Source: GOC
  4. nucleoside transport Source: SGD
  5. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28834-MONOMER.
ReactomeiREACT_244559. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside transporter FUN26
Gene namesi
Name:FUN26
Ordered Locus Names:YAL022C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL022c.
SGDiS000000020. FUN26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST
Transmembranei492 – 51221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular Source: SGD
  4. membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Nucleoside transporter FUN26PRO_0000209346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine1 Publication
Modified residuei58 – 581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31381.
PaxDbiP31381.

Expressioni

Gene expression databases

GenevestigatoriP31381.

Interactioni

Protein-protein interaction databases

BioGridi31744. 12 interactions.
DIPiDIP-5495N.
IntActiP31381. 5 interactions.
MINTiMINT-518779.
STRINGi4932.YAL022C.

Structurei

3D structure databases

ProteinModelPortaliP31381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299983.
HOGENOMiHOG000190304.
InParanoidiP31381.
KOiK15014.
OMAiHESENNE.
OrthoDBiEOG7966T3.

Family and domain databases

InterProiIPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequencei

Sequence statusi: Complete.

P31381-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD
60 70 80 90 100
NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ
110 120 130 140 150
YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING
160 170 180 190 200
LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA
210 220 230 240 250
IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF
260 270 280 290 300
TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI
310 320 330 340 350
VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT
360 370 380 390 400
TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM
410 420 430 440 450
FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC
460 470 480 490 500
YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL
510
GSIISYVFVF IIDFIIR
Length:517
Mass (Da):58,317
Last modified:July 1, 1993 - v1
Checksum:i43C92A3E9A3D8D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04935.1.
BK006935 Genomic DNA. Translation: DAA06966.1.
PIRiS36712.
RefSeqiNP_009380.1. NM_001178167.1.

Genome annotation databases

EnsemblFungiiYAL022C; YAL022C; YAL022C.
GeneIDi851211.
KEGGisce:YAL022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04935.1 .
BK006935 Genomic DNA. Translation: DAA06966.1 .
PIRi S36712.
RefSeqi NP_009380.1. NM_001178167.1.

3D structure databases

ProteinModelPortali P31381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31744. 12 interactions.
DIPi DIP-5495N.
IntActi P31381. 5 interactions.
MINTi MINT-518779.
STRINGi 4932.YAL022C.

Protein family/group databases

TCDBi 2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

Proteomic databases

MaxQBi P31381.
PaxDbi P31381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL022C ; YAL022C ; YAL022C .
GeneIDi 851211.
KEGGi sce:YAL022C.

Organism-specific databases

CYGDi YAL022c.
SGDi S000000020. FUN26.

Phylogenomic databases

eggNOGi NOG299983.
HOGENOMi HOG000190304.
InParanoidi P31381.
KOi K15014.
OMAi HESENNE.
OrthoDBi EOG7966T3.

Enzyme and pathway databases

BioCyci YEAST:G3O-28834-MONOMER.
Reactomei REACT_244559. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

NextBioi 968088.
PROi P31381.

Gene expression databases

Genevestigatori P31381.

Family and domain databases

InterProi IPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR10332. PTHR10332. 1 hit.
Pfami PF01733. Nucleoside_tran. 1 hit.
[Graphical view ]
PIRSFi PIRSF016379. ENT. 1 hit.
PRINTSi PR01130. DERENTRNSPRT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00939. 2a57. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
    Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
    Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
    Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
    J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFUN26_YEAST
AccessioniPrimary (citable) accession number: P31381
Secondary accession number(s): D6VPJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3