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P31381

- FUN26_YEAST

UniProt

P31381 - FUN26_YEAST

Protein

Nucleoside transporter FUN26

Gene

FUN26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.

    GO - Molecular functioni

    1. nicotinamide riboside transmembrane transporter activity Source: SGD
    2. nucleoside transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. nicotinamide riboside transport Source: SGD
    2. nucleoside transmembrane transport Source: GOC
    3. nucleoside transport Source: SGD
    4. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28834-MONOMER.

    Protein family/group databases

    TCDBi2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoside transporter FUN26
    Gene namesi
    Name:FUN26
    Ordered Locus Names:YAL022C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL022c.
    SGDiS000000020. FUN26.

    Subcellular locationi

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular Source: SGD
    4. membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Nucleoside transporter FUN26PRO_0000209346Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Phosphoserine1 Publication
    Modified residuei58 – 581Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP31381.
    PaxDbiP31381.

    Expressioni

    Gene expression databases

    GenevestigatoriP31381.

    Interactioni

    Protein-protein interaction databases

    BioGridi31744. 12 interactions.
    DIPiDIP-5495N.
    IntActiP31381. 5 interactions.
    MINTiMINT-518779.
    STRINGi4932.YAL022C.

    Structurei

    3D structure databases

    ProteinModelPortaliP31381.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei492 – 51221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299983.
    HOGENOMiHOG000190304.
    KOiK15014.
    OMAiHESENNE.
    OrthoDBiEOG7966T3.

    Family and domain databases

    InterProiIPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10332. PTHR10332. 1 hit.
    PfamiPF01733. Nucleoside_tran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016379. ENT. 1 hit.
    PRINTSiPR01130. DERENTRNSPRT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00939. 2a57. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P31381-1 [UniParc]FASTAAdd to Basket

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    MSTSADTDTI KKPILAVPEP ALADTHSEEI SRSGEEHESE NNEHSDEEGD    50
    NYSEREQSVS TEPLDTLPLR KKLKNLSYIT FFAIGIGLLW PWNCILSASQ 100
    YFKHDIFKDT SIWAKIFTSS MMSFSTISSM LFNIYLAKRQ YKYSRRVING 150
    LVWEIIVFTV MCFFTILHFL LPKWFNFMFI MMLVVISSMG TAMTQNGIMA 200
    IANVFGSEYS QGVMVGQAVA GVLPSLVLFA LAFIENSSVS TTGGILLYFF 250
    TTTLVVTICV VMFSVSKISR KVNENWNVED GHITDVLLGS LRSNEEEIRI 300
    VGRIDQMEDE DHRRTNGTRD DNDEGEELQL KVPFEVLFAK LKYLVLSIFT 350
    TFVVTLVFPV FASATYVTGL PLSNAQYIPL IFTLWNLGDL YGRVIADWPM 400
    FRDQKFTPRK TFIYSLLRVA AIPLFLMFTA ITSSSSGDEE HNGSVIVDLC 450
    YMLLQFLFGV TNGHVISMSF MKVPEQLDND DEKEAAGGFT NIFVSTGLAL 500
    GSIISYVFVF IIDFIIR 517
    Length:517
    Mass (Da):58,317
    Last modified:July 1, 1993 - v1
    Checksum:i43C92A3E9A3D8D50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05146 Genomic DNA. Translation: AAC04935.1.
    BK006935 Genomic DNA. Translation: DAA06966.1.
    PIRiS36712.
    RefSeqiNP_009380.1. NM_001178167.1.

    Genome annotation databases

    EnsemblFungiiYAL022C; YAL022C; YAL022C.
    GeneIDi851211.
    KEGGisce:YAL022C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05146 Genomic DNA. Translation: AAC04935.1 .
    BK006935 Genomic DNA. Translation: DAA06966.1 .
    PIRi S36712.
    RefSeqi NP_009380.1. NM_001178167.1.

    3D structure databases

    ProteinModelPortali P31381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31744. 12 interactions.
    DIPi DIP-5495N.
    IntActi P31381. 5 interactions.
    MINTi MINT-518779.
    STRINGi 4932.YAL022C.

    Protein family/group databases

    TCDBi 2.A.57.3.1. the equilibrative nucleoside transporter (ent) family.

    Proteomic databases

    MaxQBi P31381.
    PaxDbi P31381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL022C ; YAL022C ; YAL022C .
    GeneIDi 851211.
    KEGGi sce:YAL022C.

    Organism-specific databases

    CYGDi YAL022c.
    SGDi S000000020. FUN26.

    Phylogenomic databases

    eggNOGi NOG299983.
    HOGENOMi HOG000190304.
    KOi K15014.
    OMAi HESENNE.
    OrthoDBi EOG7966T3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28834-MONOMER.

    Miscellaneous databases

    NextBioi 968088.
    PROi P31381.

    Gene expression databases

    Genevestigatori P31381.

    Family and domain databases

    InterProi IPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10332. PTHR10332. 1 hit.
    Pfami PF01733. Nucleoside_tran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016379. ENT. 1 hit.
    PRINTSi PR01130. DERENTRNSPRT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00939. 2a57. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
      Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
      Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
      Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
      J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFUN26_YEAST
    AccessioniPrimary (citable) accession number: P31381
    Secondary accession number(s): D6VPJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 217 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3