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P31380 (FUN30_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uncharacterized ATP-dependent helicase FUN30

EC=3.6.4.-
Gene names
Name:FUN30
Ordered Locus Names:YAL019W
ORF Names:YAL001
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1131 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a negative regulatory element in the process of UV damage repair.

Subcellular location

Nucleus Potential.

Miscellaneous

Present with 6800 molecules/cell in log phase SD medium. Ref.6

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11311131Uncharacterized ATP-dependent helicase FUN30
PRO_0000074384

Regions

Domain584 – 752169Helicase ATP-binding
Domain953 – 1108156Helicase C-terminal
Nucleotide binding597 – 6048ATP Potential
Motif703 – 7064DEGH box

Amino acid modifications

Modified residue261Phosphoserine Ref.8 Ref.9
Modified residue271Phosphoserine Ref.9
Modified residue281Phosphoserine Ref.7 Ref.8 Ref.9
Modified residue331Phosphothreonine Ref.9
Modified residue341Phosphoserine Ref.7 Ref.9
Modified residue881Phosphothreonine Ref.9
Modified residue961Phosphoserine Ref.9
Modified residue981Phosphoserine Ref.9
Modified residue1311Phosphothreonine Ref.9
Modified residue2261Phosphoserine Ref.9
Modified residue2321Phosphoserine Ref.9
Modified residue3691Phosphoserine Ref.9
Modified residue3831Phosphoserine Ref.9
Modified residue4511Phosphoserine Ref.7 Ref.9

Sequences

Sequence LengthMass (Da)Tools
P31380 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7E61B9ABB3A42ED2

FASTA1,131128,507
        10         20         30         40         50         60 
MSGSHSNDED DVVQVPETSS PTKVASSSPL KPTSPTVPDA SVASLRSRFT FKPSDPSEGA 

        70         80         90        100        110        120 
HTSKPLPSGS PEVALVNLAR EFPDFSQTLV QAVFKSNSFN LQSARERLTR LRQQRQNWTW 

       130        140        150        160        170        180 
NKNASPKKSE TPPPVKKSLP LANTGRLSSI HGNINNKSSK ITVAKQKTSI FDRYSNVINQ 

       190        200        210        220        230        240 
KQYTFELPTN LNIDSEALSK LPVNYNKKRR LVRADQHPIG KSYESSATQL GSAREKLLAN 

       250        260        270        280        290        300 
RKYGRHANDN DEEEEESMMT DDDDASGDDY TESTPQINLD EQVLQFINDS DIVDLSDLSD 

       310        320        330        340        350        360 
TTMHKAQLIA SHRPYSSLNA FVNTNFNDKD TEENASNKRK RRAAASANES ERLLDKITQS 

       370        380        390        400        410        420 
IRGYNAIESV IKKCSSYGDL VTSQMKKWGV QVEGDNSELD LMNLGEDDDD DNDDGNNDNN 

       430        440        450        460        470        480 
NSNNNNTAGA DATSKEKEDT KAVVEGFDET SAEPTPAPAP APVERETKRI RNTTKPKVVE 

       490        500        510        520        530        540 
DEDDDVDLEA IDDELPQSEH EDDDYEEEDE DYNDEEEDVE YDDGDDDDDD DDEFVATRKN 

       550        560        570        580        590        600 
THVISTTSRN GRKPIVKFFK GKPRLLSPEI SLKDYQQTGI NWLNLLYQNK MSCILADDMG 

       610        620        630        640        650        660 
LGKTCQVISF FAYLKQINEP GPHLVVVPSS TLENWLREFQ KFAPALKIEP YYGSLQEREE 

       670        680        690        700        710        720 
LRDILERNAG KYDVIVTTYN LAAGNKYDVS FLKNRNFNVV VYDEGHMLKN STSERFAKLM 

       730        740        750        760        770        780 
KIRANFRLLL TGTPLQNNLK ELMSLLEFIM PNLFISKKES FDAIFKQRAK TTDDNKNHNP 

       790        800        810        820        830        840 
LLAQEAITRA KTMMKPFILR RRKDQVLKHL PPKHTHIQYC ELNAIQKKIY DKEIQIVLEH 

       850        860        870        880        890        900 
KRMIKDGELP KDAKEKSKLQ SSSSKNLIMA LRKASLHPLL FRNIYNDKII TKMSDAILDE 

       910        920        930        940        950        960 
PAYAENGNKE YIKEDMSYMT DFELHKLCCN FPNTLSKYQL HNDEWMQSGK IDALKKLLKT 

       970        980        990       1000       1010       1020 
IIVDKQEKVL IFSLFTQVLD ILEMVLSTLD YKFLRLDGST QVNDRQLLID KFYEDKDIPI 

      1030       1040       1050       1060       1070       1080 
FILSTKAGGF GINLVCANNV IIFDQSFNPH DDRQAADRAH RVGQTKEVNI TTLITKDSIE 

      1090       1100       1110       1120       1130 
EKIHQLAKNK LALDSYISED KKSQDVLESK VSDMLEDIIY DENSKPKGTK E 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I."
Clark M.W., Zhong W.-W., Keng T., Storms R.K., Barton A.B., Kaback D.B., Bussey H.
Yeast 8:133-145(1992) [PubMed: 1561836] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
Genome 36:32-42(1993) [PubMed: 8458570] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region."
Barton A.B., Kaback D.B.
J. Bacteriol. 176:1872-1880(1994) [PubMed: 8144453] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed: 7731988] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[5]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-34 AND SER-451, MASS SPECTROMETRY.
Strain: YAL6B.
[8]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-28, MASS SPECTROMETRY.
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-27; SER-28; THR-33; SER-34; THR-88; SER-96; SER-98; THR-131; SER-226; SER-232; SER-369; SER-383 AND SER-451, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05146 Genomic DNA. Translation: AAC04938.1.
BK006935 Genomic DNA. Translation: DAA06969.1.
PIRS22266.
RefSeqNP_009383.1. NM_001178164.1.

3D structure databases

ProteinModelPortalP31380.
SMRP31380. Positions 559-1106.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2541N.
IntActP31380. 12 interactions.
MINTMINT-425278.
STRINGP31380.

Proteomic databases

PeptideAtlasP31380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL019W; YAL019W; YAL019W.
GeneID851214.
KEGGsce:YAL019W.
NMPDRfig|4932.3.peg.65.

Organism-specific databases

CYGDYAL019w.
SGDS000000017. FUN30.

Phylogenomic databases

eggNOGfuNOG04339.
GeneTreeEFGT00050000000148.
HOGENOMHBG398150.
OMAKIEPYYG.
OrthoDBEOG4BCHW4.

Gene expression databases

ArrayExpressP31380.
GenevestigatorP31380.
GermOnlineYAL019W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR014001. DEAD-like_helicase.
IPR001650. Helicase_C.
IPR000330. SNF2_N.
[Graphical view]
KOK14439.
PfamPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968097.

Entry information

Entry nameFUN30_YEAST
AccessionPrimary (citable) accession number: P31380
Secondary accession number(s): D6VPJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

SIMILARITY comments

Index of protein domains and families