Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31376

- SWC3_YEAST

UniProt

P31376 - SWC3_YEAST

Protein

SWR1-complex protein 3

Gene

SWC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.3 Publications

    GO - Biological processi

    1. chromatin remodeling Source: SGD
    2. endoplasmic reticulum organization Source: SGD
    3. histone exchange Source: SGD
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28824-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWR1-complex protein 3
    Gene namesi
    Name:SWC3
    Synonyms:FUN36, SWC1
    Ordered Locus Names:YAL011W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL011w.
    SGDiS000000009. SWC3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Swr1 complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 625625SWR1-complex protein 3PRO_0000072344Add
    BLAST

    Proteomic databases

    MaxQBiP31376.
    PaxDbiP31376.

    Expressioni

    Gene expression databases

    GenevestigatoriP31376.

    Interactioni

    Subunit structurei

    Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.3 Publications

    Protein-protein interaction databases

    BioGridi31755. 323 interactions.
    DIPiDIP-2986N.
    IntActiP31376. 21 interactions.
    MINTiMINT-437491.
    STRINGi4932.YAL011W.

    Structurei

    3D structure databases

    ProteinModelPortaliP31376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 5623Asp-richAdd
    BLAST
    Compositional biasi175 – 26288Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SWC3 family.Curated

    Phylogenomic databases

    eggNOGiNOG47360.
    HOGENOMiHOG000001103.
    KOiK11682.
    OMAiKESSIEQ.
    OrthoDBiEOG72891W.

    Sequencei

    Sequence statusi: Complete.

    P31376-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE    50
    VGNDYDEYAS RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV 100
    LYDSLVSSRR TWVQGEMFEL YWRRPKKIVS ESTPAATESP TSGTIPLIRD 150
    KMQKMCDCVM SGGPHTFKVR LFILKNDKIE QKWQDEQELK KKEKELKRKN 200
    DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE QEALKLKRKE 250
    EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL 300
    ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH 350
    RLNSITLVKS SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE 400
    EEDVKEKGVK SEDTQKKEDN QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ 450
    GAEIILEYLE FTHSRYYLPK KSVVEFLEDT DEIIISWIVI HNSKEIEKFK 500
    TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP TPLYTPMTMK 550
    LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD 600
    EALSESLRFE LNEWEHAMRS RRHKR 625
    Length:625
    Mass (Da):72,514
    Last modified:January 16, 2004 - v2
    Checksum:iA4F13DB85B657D59
    GO

    Sequence cautioni

    The sequence AAC04946.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05146 Genomic DNA. Translation: AAC04946.1. Different initiation.
    BK006935 Genomic DNA. Translation: DAA06977.1.
    PIRiS36723.
    RefSeqiNP_009391.2. NM_001178156.1.

    Genome annotation databases

    EnsemblFungiiYAL011W; YAL011W; YAL011W.
    GeneIDi851222.
    KEGGisce:YAL011W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05146 Genomic DNA. Translation: AAC04946.1 . Different initiation.
    BK006935 Genomic DNA. Translation: DAA06977.1 .
    PIRi S36723.
    RefSeqi NP_009391.2. NM_001178156.1.

    3D structure databases

    ProteinModelPortali P31376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31755. 323 interactions.
    DIPi DIP-2986N.
    IntActi P31376. 21 interactions.
    MINTi MINT-437491.
    STRINGi 4932.YAL011W.

    Proteomic databases

    MaxQBi P31376.
    PaxDbi P31376.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL011W ; YAL011W ; YAL011W .
    GeneIDi 851222.
    KEGGi sce:YAL011W.

    Organism-specific databases

    CYGDi YAL011w.
    SGDi S000000009. SWC3.

    Phylogenomic databases

    eggNOGi NOG47360.
    HOGENOMi HOG000001103.
    KOi K11682.
    OMAi KESSIEQ.
    OrthoDBi EOG72891W.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28824-MONOMER.

    Miscellaneous databases

    NextBioi 968121.

    Gene expression databases

    Genevestigatori P31376.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
      Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
      Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
      Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
      PLoS Biol. 2:587-599(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex."
      Mizuguchi G., Shen X., Landry J., Wu W.-H., Sen S., Wu C.
      Science 303:343-348(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSWC3_YEAST
    AccessioniPrimary (citable) accession number: P31376
    Secondary accession number(s): D6VPK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1380 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3