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P31376

- SWC3_YEAST

UniProt

P31376 - SWC3_YEAST

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Protein

SWR1-complex protein 3

Gene

SWC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.3 Publications

GO - Biological processi

  1. chromatin remodeling Source: SGD
  2. endoplasmic reticulum organization Source: SGD
  3. histone exchange Source: SGD
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 3
Gene namesi
Name:SWC3
Synonyms:FUN36, SWC1
Ordered Locus Names:YAL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL011w.
SGDiS000000009. SWC3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Swr1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625SWR1-complex protein 3PRO_0000072344Add
BLAST

Proteomic databases

MaxQBiP31376.
PaxDbiP31376.

Expressioni

Gene expression databases

GenevestigatoriP31376.

Interactioni

Subunit structurei

Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.3 Publications

Protein-protein interaction databases

BioGridi31755. 323 interactions.
DIPiDIP-2986N.
IntActiP31376. 21 interactions.
MINTiMINT-437491.
STRINGi4932.YAL011W.

Structurei

3D structure databases

ProteinModelPortaliP31376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 5623Asp-richAdd
BLAST
Compositional biasi175 – 26288Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the SWC3 family.Curated

Phylogenomic databases

eggNOGiNOG47360.
HOGENOMiHOG000001103.
InParanoidiP31376.
KOiK11682.
OMAiKESSIEQ.
OrthoDBiEOG72891W.

Sequencei

Sequence statusi: Complete.

P31376-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE
60 70 80 90 100
VGNDYDEYAS RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV
110 120 130 140 150
LYDSLVSSRR TWVQGEMFEL YWRRPKKIVS ESTPAATESP TSGTIPLIRD
160 170 180 190 200
KMQKMCDCVM SGGPHTFKVR LFILKNDKIE QKWQDEQELK KKEKELKRKN
210 220 230 240 250
DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE QEALKLKRKE
260 270 280 290 300
EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL
310 320 330 340 350
ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH
360 370 380 390 400
RLNSITLVKS SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE
410 420 430 440 450
EEDVKEKGVK SEDTQKKEDN QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ
460 470 480 490 500
GAEIILEYLE FTHSRYYLPK KSVVEFLEDT DEIIISWIVI HNSKEIEKFK
510 520 530 540 550
TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP TPLYTPMTMK
560 570 580 590 600
LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD
610 620
EALSESLRFE LNEWEHAMRS RRHKR
Length:625
Mass (Da):72,514
Last modified:January 16, 2004 - v2
Checksum:iA4F13DB85B657D59
GO

Sequence cautioni

The sequence AAC04946.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05146 Genomic DNA. Translation: AAC04946.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06977.1.
PIRiS36723.
RefSeqiNP_009391.2. NM_001178156.1.

Genome annotation databases

EnsemblFungiiYAL011W; YAL011W; YAL011W.
GeneIDi851222.
KEGGisce:YAL011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05146 Genomic DNA. Translation: AAC04946.1 . Different initiation.
BK006935 Genomic DNA. Translation: DAA06977.1 .
PIRi S36723.
RefSeqi NP_009391.2. NM_001178156.1.

3D structure databases

ProteinModelPortali P31376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31755. 323 interactions.
DIPi DIP-2986N.
IntActi P31376. 21 interactions.
MINTi MINT-437491.
STRINGi 4932.YAL011W.

Proteomic databases

MaxQBi P31376.
PaxDbi P31376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL011W ; YAL011W ; YAL011W .
GeneIDi 851222.
KEGGi sce:YAL011W.

Organism-specific databases

CYGDi YAL011w.
SGDi S000000009. SWC3.

Phylogenomic databases

eggNOGi NOG47360.
HOGENOMi HOG000001103.
InParanoidi P31376.
KOi K11682.
OMAi KESSIEQ.
OrthoDBi EOG72891W.

Enzyme and pathway databases

BioCyci YEAST:G3O-28824-MONOMER.

Miscellaneous databases

NextBioi 968121.

Gene expression databases

Genevestigatori P31376.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
    Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
    Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
    Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
    PLoS Biol. 2:587-599(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex."
    Mizuguchi G., Shen X., Landry J., Wu W.-H., Sen S., Wu C.
    Science 303:343-348(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSWC3_YEAST
AccessioniPrimary (citable) accession number: P31376
Secondary accession number(s): D6VPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3