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Protein

SWR1-complex protein 3

Gene

SWC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.3 Publications

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin remodeling Source: SGD
  • endoplasmic reticulum organization Source: SGD
  • histone exchange Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 3
Gene namesi
Name:SWC3
Synonyms:FUN36, SWC1
Ordered Locus Names:YAL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL011W.
SGDiS000000009. SWC3.

Subcellular locationi

GO - Cellular componenti

  • Swr1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723441 – 625SWR1-complex protein 3Add BLAST625

Proteomic databases

MaxQBiP31376.
PRIDEiP31376.

PTM databases

iPTMnetiP31376.

Interactioni

Subunit structurei

Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.3 Publications

Protein-protein interaction databases

BioGridi31755. 327 interactors.
DIPiDIP-2986N.
IntActiP31376. 21 interactors.
MINTiMINT-437491.

Structurei

3D structure databases

ProteinModelPortaliP31376.
SMRiP31376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 56Asp-richAdd BLAST23
Compositional biasi175 – 262Lys-richAdd BLAST88

Sequence similaritiesi

Belongs to the SWC3 family.Curated

Phylogenomic databases

HOGENOMiHOG000001103.
InParanoidiP31376.
KOiK11682.
OMAiRDKMQKM.
OrthoDBiEOG092C1EM8.

Sequencei

Sequence statusi: Complete.

P31376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE
60 70 80 90 100
VGNDYDEYAS RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV
110 120 130 140 150
LYDSLVSSRR TWVQGEMFEL YWRRPKKIVS ESTPAATESP TSGTIPLIRD
160 170 180 190 200
KMQKMCDCVM SGGPHTFKVR LFILKNDKIE QKWQDEQELK KKEKELKRKN
210 220 230 240 250
DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE QEALKLKRKE
260 270 280 290 300
EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL
310 320 330 340 350
ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH
360 370 380 390 400
RLNSITLVKS SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE
410 420 430 440 450
EEDVKEKGVK SEDTQKKEDN QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ
460 470 480 490 500
GAEIILEYLE FTHSRYYLPK KSVVEFLEDT DEIIISWIVI HNSKEIEKFK
510 520 530 540 550
TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP TPLYTPMTMK
560 570 580 590 600
LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD
610 620
EALSESLRFE LNEWEHAMRS RRHKR
Length:625
Mass (Da):72,514
Last modified:January 16, 2004 - v2
Checksum:iA4F13DB85B657D59
GO

Sequence cautioni

The sequence AAC04946 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04946.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06977.1.
PIRiS36723.
RefSeqiNP_009391.2. NM_001178156.1.

Genome annotation databases

EnsemblFungiiYAL011W; YAL011W; YAL011W.
GeneIDi851222.
KEGGisce:YAL011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05146 Genomic DNA. Translation: AAC04946.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06977.1.
PIRiS36723.
RefSeqiNP_009391.2. NM_001178156.1.

3D structure databases

ProteinModelPortaliP31376.
SMRiP31376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31755. 327 interactors.
DIPiDIP-2986N.
IntActiP31376. 21 interactors.
MINTiMINT-437491.

PTM databases

iPTMnetiP31376.

Proteomic databases

MaxQBiP31376.
PRIDEiP31376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL011W; YAL011W; YAL011W.
GeneIDi851222.
KEGGisce:YAL011W.

Organism-specific databases

EuPathDBiFungiDB:YAL011W.
SGDiS000000009. SWC3.

Phylogenomic databases

HOGENOMiHOG000001103.
InParanoidiP31376.
KOiK11682.
OMAiRDKMQKM.
OrthoDBiEOG092C1EM8.

Enzyme and pathway databases

BioCyciYEAST:G3O-28824-MONOMER.

Miscellaneous databases

PROiP31376.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSWC3_YEAST
AccessioniPrimary (citable) accession number: P31376
Secondary accession number(s): D6VPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 16, 2004
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.