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P31376 (SWC3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SWR1-complex protein 3
Gene names
Name:SWC3
Synonyms:FUN36, SWC1
Ordered Locus Names:YAL011W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability. Ref.4 Ref.8 Ref.9

Subunit structure

Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Ref.4 Ref.8 Ref.9

Subcellular location

Nucleus Ref.6.

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the SWC3 family.

Sequence caution

The sequence AAC04946.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 625625SWR1-complex protein 3
PRO_0000072344

Regions

Compositional bias34 – 5623Asp-rich
Compositional bias175 – 26288Lys-rich

Sequences

Sequence LengthMass (Da)Tools
P31376 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: A4F13DB85B657D59

FASTA62572,514
        10         20         30         40         50         60 
MPAVLRTRSK ESSIEQKPAS RTRTRSRRGK RGRDDDDDDD DEESDDAYDE VGNDYDEYAS 

        70         80         90        100        110        120 
RAKLATNRPF EIVAGLPASV ELPNYNSSLT HPQSIKNSGV LYDSLVSSRR TWVQGEMFEL 

       130        140        150        160        170        180 
YWRRPKKIVS ESTPAATESP TSGTIPLIRD KMQKMCDCVM SGGPHTFKVR LFILKNDKIE 

       190        200        210        220        230        240 
QKWQDEQELK KKEKELKRKN DAEAKRLRME ERKRQQMQKK IAKEQKLQLQ KENKAKQKLE 

       250        260        270        280        290        300 
QEALKLKRKE EMKKLKEQNK NKQGSPSSSM HDPRMIMNLN LMAQEDPKLN TLMETVAKGL 

       310        320        330        340        350        360 
ANNSQLEEFK KFIEIAKKRS LEENPVNKRP SVTTTRPAPP SKAKDVAEDH RLNSITLVKS 

       370        380        390        400        410        420 
SKTAATEPEP KKADDENAEK QQSKEAKTTA ESTQVDVKKE EEDVKEKGVK SEDTQKKEDN 

       430        440        450        460        470        480 
QVVPKRKRRK NAIKEDKDMQ LTAFQQKYVQ GAEIILEYLE FTHSRYYLPK KSVVEFLEDT 

       490        500        510        520        530        540 
DEIIISWIVI HNSKEIEKFK TKKIKAKLKA DQKLNKEDAK PGSDVEKEVS FNPLFEADCP 

       550        560        570        580        590        600 
TPLYTPMTMK LSGIHKRFNQ IIRNSVSPME EVVKEMEKIL QIGTRLSGYN LWYQLDGYDD 

       610        620 
EALSESLRFE LNEWEHAMRS RRHKR 

« Hide

References

« Hide 'large scale' references
[1]"Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes."
Ouellette B.F.F., Clark M.W., Keng T., Storms R.K., Zhong W.-W., Zeng B., Fortin N., Delaney S., Barton A.B., Kaback D.B., Bussey H.
Genome 36:32-42(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1."
Krogan N.J., Keogh M.-C., Datta N., Sawa C., Ryan O.W., Ding H., Haw R.A., Pootoolal J., Tong A., Canadien V., Richards D.P., Wu X., Emili A., Hughes T.R., Buratowski S., Greenblatt J.F.
Mol. Cell 12:1565-1576(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, MASS SPECTROMETRY.
[5]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin."
Kobor M.S., Venkatasubrahmanyam S., Meneghini M.D., Gin J.W., Jennings J.L., Link A.J., Madhani H.D., Rine J.
PLoS Biol. 2:587-599(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, MASS SPECTROMETRY.
[9]"ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex."
Mizuguchi G., Shen X., Landry J., Wu W.-H., Sen S., Wu C.
Science 303:343-348(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE SWR1 COMPLEX, FUNCTION OF THE SWR1 COMPLEX, MASS SPECTROMETRY.
[10]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05146 Genomic DNA. Translation: AAC04946.1. Different initiation.
BK006935 Genomic DNA. Translation: DAA06977.1.
PIRS36723.
RefSeqNP_009391.2. NM_001178156.1.

3D structure databases

ProteinModelPortalP31376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31755. 321 interactions.
DIPDIP-2986N.
IntActP31376. 21 interactions.
MINTMINT-437491.
STRING4932.YAL011W.

Proteomic databases

PaxDbP31376.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL011W; YAL011W; YAL011W.
GeneID851222.
KEGGsce:YAL011W.

Organism-specific databases

CYGDYAL011w.
SGDS000000009. SWC3.

Phylogenomic databases

eggNOGNOG47360.
HOGENOMHOG000001103.
KOK11682.
OMANLWYQLD.
OrthoDBEOG72891W.

Enzyme and pathway databases

BioCycYEAST:G3O-28824-MONOMER.

Gene expression databases

GenevestigatorP31376.

Family and domain databases

ProtoNetSearch...

Other

NextBio968121.

Entry information

Entry nameSWC3_YEAST
AccessionPrimary (citable) accession number: P31376
Secondary accession number(s): D6VPK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 16, 2004
Last modified: February 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families