Reviewed,
UniProtKB/Swiss-Prot P31371 (FGF9_HUMAN)
Last modified
January 19, 2010.
Version 110.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glia-activating factor Short name=GAF Alternative name(s): Fibroblast growth factor 9 Short name=FGF-9 HBGF-9 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. |
| Subunit structure | Monomer. |
| Subcellular location | |
| Tissue specificity | Glial cells. |
| Post-translational modification | Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step. N-glycosylated. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation |
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Ligand | Heparin-binding |
| Molecular function | Developmental protein Growth factor Mitogen |
| PTM | Glycoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cell-cell signaling Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathwayInferred from genetic interaction. Source: MGI positive regulation of cell divisionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular space Ref.1 Inferred from direct assay. Source: MGI |
| Molecular function | growth factor activity Ref.1 Traceable author statement. Source: ProtInc heparin bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 3 | 3 | PRO_0000008973 | |||||||||||||||||||||||||||||||||||||||||||||
| Chain | 4 – 208 | 205 | Glia-activating factor | PRO_0000008974 | ||||||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 79 | 1 | N-linked (GlcNAc...) | |||||||||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 94 | 1 | I → V: dbSNP rs12427696. Ref.2 | VAR_020944 | ||||||||||||||||||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 24 – 26 | 3 | VLP → SLL AA sequence Ref.7 | |||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 34 | 1 | S → A AA sequence Ref.7 | |||||||||||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 53 – 60 | 8 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 63 – 68 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 73 – 76 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 82 – 87 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 91 – 93 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 95 – 101 | 7 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 104 – 109 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Turn | 110 – 112 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 115 – 118 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 124 – 129 | 6 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 132 – 134 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 136 – 142 | 7 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 145 – 154 | 10 | ||||||||||||||||||||||||||||||||||||||||||||||
| Turn | 156 – 158 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 161 – 163 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 175 – 177 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 183 – 185 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 187 – 190 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 194 – 196 | 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 200 – 203 | 4 | ||||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property." Miyamoto M., Naruo K., Seko C., Matsumoto S., Kondo T., Kurokawa T. Mol. Cell. Biol. 13:4251-4259(1993) [PubMed: 8321227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Foreskin. |
| [2] | NIEHS SNPs program Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-94. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [4] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties." Naruo K., Seko C., Kuroshima K., Matsutani E., Sasada R., Kondo T., Kurokawa T. J. Biol. Chem. 268:2857-2864(1993) [PubMed: 8428960] [Abstract] Cited for: PROTEIN SEQUENCE OF 4-26 AND 34-54. Tissue: Glial tumor. |
| [8] | "Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces." Hecht H.J., Adar R., Hofmann B., Bogin O., Weich H., Yayon A. Acta Crystallogr. D 57:378-384(2001) [PubMed: 11223514] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | D14838 mRNA. Translation: BAA03572.1. AY682094 Genomic DNA. Translation: AAT74624.1. AK290792 mRNA. Translation: BAF83481.1. AL139378 Genomic DNA. Translation: CAC17692.1. CH471075 Genomic DNA. Translation: EAX08316.1. BC069692 mRNA. Translation: AAH69692.1. BC103978 mRNA. Translation: AAI03979.1. BC103979 mRNA. Translation: AAI03980.1. | ||||||||||||||||||
| IPI | IPI00011172. | ||||||||||||||||||
| PIR | A48137. | ||||||||||||||||||
| RefSeq | NP_002001.1. | ||||||||||||||||||
| UniGene | Hs.111 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-6036N. | ||||||||||||||||||
| STRING | P31371. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P31371. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000382353; ENSP00000371790; ENSG00000102678; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 2254. | ||||||||||||||||||
| KEGG | hsa:2254. | ||||||||||||||||||
| UCSC | uc001uog.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 2254. | ||||||||||||||||||
| GeneCards | GC13P021144. | ||||||||||||||||||
| H-InvDB | HIX0037350. | ||||||||||||||||||
| HGNC | HGNC:3687. FGF9. | ||||||||||||||||||
| HPA | CAB004392. | ||||||||||||||||||
| MIM | 600921. gene. | ||||||||||||||||||
| Orphanet | 3237. Multiple synostoses. | ||||||||||||||||||
| PharmGKB | PA28126. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG15138. | ||||||||||||||||||
| HOGENOM | HBG715603. | ||||||||||||||||||
| HOVERGEN | P31371. | ||||||||||||||||||
| InParanoid | P31371. | ||||||||||||||||||
| OMA | YLAMNNK. | ||||||||||||||||||
| OrthoDB | EOG9N5ZG3. | ||||||||||||||||||
| PhylomeDB | P31371. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Pathway_Interaction_DB | fgf_pathway. FGF signaling pathway. | ||||||||||||||||||
| Reactome | REACT_9470. Signaling by FGFR. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P31371. | ||||||||||||||||||
| Bgee | P31371. | ||||||||||||||||||
| CleanEx | HS_FGF9. | ||||||||||||||||||
| Genevestigator | P31371. | ||||||||||||||||||
| GermOnline | ENSG00000102678. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. | ||||||||||||||||||
| Pfam | PF00167. FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. | ||||||||||||||||||
| SMART | SM00442. FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 9131. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | FGF9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31371 Secondary accession number(s): A8K427, Q3SY32 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


