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P31368

- PDM1_DROME

UniProt

P31368 - PDM1_DROME

Protein

Protein nubbin

Gene

nub

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi523 – 58260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
    2. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. dendrite morphogenesis Source: FlyBase
    2. ganglion mother cell fate determination Source: FlyBase
    3. limb joint morphogenesis Source: FlyBase
    4. pattern specification process Source: FlyBase
    5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
    6. ventral cord development Source: FlyBase
    7. wing disc development Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    SignaLinkiP31368.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein nubbin
    Alternative name(s):
    POU domain protein 1
    Short name:
    PDM-1
    Protein twain
    dOCT1
    dPOU-19
    Gene namesi
    Name:nub
    Synonyms:OCT1, pdm-1, POU-19, TWN
    ORF Names:CG34395
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0085424. nub.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Protein nubbinPRO_0000100777Add
    BLAST

    Proteomic databases

    PaxDbiP31368.
    PRIDEiP31368.

    Expressioni

    Tissue specificityi

    Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.2 Publications

    Developmental stagei

    Expressed both maternally and zygotically.3 Publications

    Gene expression databases

    BgeeiP31368.

    Interactioni

    Protein-protein interaction databases

    BioGridi60715. 27 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP31368.
    SMRiP31368. Positions 425-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini421 – 49575POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi104 – 1074Poly-His
    Compositional biasi191 – 20111Poly-AlaAdd
    BLAST
    Compositional biasi359 – 3646Poly-His
    Compositional biasi407 – 4159Poly-Ala

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    GeneTreeiENSGT00750000117373.
    InParanoidiP31368.
    KOiK09364.
    OrthoDBiEOG7DJSMG.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVMSELRWHT ASPEDNKNSL KRDLLKSTPT SAREAAVHIM QNRYISRLSR    50
    SPSPLQSNAS DCDDNNSSVG TSSDRCRSPL SPALSLSHQQ AKRQLMSLQP 100
    HPAHHHHNPH HLNHLNHHQY KQEEDYDDAN GGALNLTSDN SRHSTQSPSN 150
    SVKSATASPV PVISVPSPVP PMISPVLAPS GCGSTTPNSM AAAAAAAAAV 200
    ASTMGSGISP LLALPGMSSP QAQLAAAGLG MNNPLLTGSL SPQDFAQFHQ 250
    LLQQRQVALT QQFNSYMELL RSGSLGLAQD DPALTAQVAA AQFLMQSQLQ 300
    ALSQASQQLQ ALQKQQQRQV DEPLQLNHKM TQQPRSSTPH SIRSPIAIRS 350
    PASSPQQLHH HHHHPLQITP PSSAASLKLS GMLTPSTPTS GTQMSQGTTT 400
    PQPKTVASAA AARAAGEPSP EETTDLEELE QFAKTFKQRR IKLGFTQGDV 450
    GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLQKW LDDADRTIQA 500
    TGGVFDPAAL QATVSTPEII GRRRKKRTSI ETTIRGALEK AFLANQKPTS 550
    EEITQLADRL SMEKEVVRVW FCNRRQKEKR INPSLDSPTG ADDDESSYMM 600
    H 601
    Length:601
    Mass (Da):65,202
    Last modified:July 1, 1993 - v1
    Checksum:i8FFCD7B3C162D2B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti420 – 4201P → R in AAB21409. (PubMed:1685891)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81957 mRNA. Translation: AAA28829.1.
    S80561 mRNA. Translation: AAB21409.1.
    M65015 mRNA. Translation: AAA28480.1.
    AE014134 Genomic DNA. Translation: AAF53205.2.
    AY118387 mRNA. Translation: AAM48416.1.
    PIRiB56564.
    RefSeqiNP_476659.1. NM_057311.4.
    UniGeneiDm.4744.

    Genome annotation databases

    EnsemblMetazoaiFBtr0112643; FBpp0111555; FBgn0085424.
    GeneIDi34669.
    KEGGidme:Dmel_CG34395.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81957 mRNA. Translation: AAA28829.1 .
    S80561 mRNA. Translation: AAB21409.1 .
    M65015 mRNA. Translation: AAA28480.1 .
    AE014134 Genomic DNA. Translation: AAF53205.2 .
    AY118387 mRNA. Translation: AAM48416.1 .
    PIRi B56564.
    RefSeqi NP_476659.1. NM_057311.4.
    UniGenei Dm.4744.

    3D structure databases

    ProteinModelPortali P31368.
    SMRi P31368. Positions 425-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60715. 27 interactions.

    Proteomic databases

    PaxDbi P31368.
    PRIDEi P31368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0112643 ; FBpp0111555 ; FBgn0085424 .
    GeneIDi 34669.
    KEGGi dme:Dmel_CG34395.

    Organism-specific databases

    CTDi 34669.
    FlyBasei FBgn0085424. nub.

    Phylogenomic databases

    eggNOGi NOG267922.
    GeneTreei ENSGT00750000117373.
    InParanoidi P31368.
    KOi K09364.
    OrthoDBi EOG7DJSMG.

    Enzyme and pathway databases

    Reactomei REACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    SignaLinki P31368.

    Miscellaneous databases

    GenomeRNAii 34669.
    NextBioi 789610.

    Gene expression databases

    Bgeei P31368.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a family of Drosophila POU domain genes expressed in early development."
      Billin A.N., Cockerill K.A., Poole S.J.
      Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
      Strain: Oregon-R.
      Tissue: Embryo.
    2. "Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns."
      Lloyd A., Sakonju S.
      Mech. Dev. 36:87-102(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements."
      Dick T., Yang X., Yeo S., Chia W.
      Proc. Natl. Acad. Sci. U.S.A. 88:7645-7649(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    4. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    5. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPDM1_DROME
    AccessioniPrimary (citable) accession number: P31368
    Secondary accession number(s): Q9VK74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3