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P31368

- PDM1_DROME

UniProt

P31368 - PDM1_DROME

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Protein

Protein nubbin

Gene
nub, OCT1, pdm-1, POU-19, TWN, CG34395
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. Repressed directly or indirectly by the BX-C homeotic proteins.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi523 – 58260HomeoboxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. dendrite morphogenesis Source: FlyBase
  2. ganglion mother cell fate determination Source: FlyBase
  3. limb joint morphogenesis Source: FlyBase
  4. pattern specification process Source: FlyBase
  5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  6. ventral cord development Source: FlyBase
  7. wing disc development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
SignaLinkiP31368.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein nubbin
Alternative name(s):
POU domain protein 1
Short name:
PDM-1
Protein twain
dOCT1
dPOU-19
Gene namesi
Name:nub
Synonyms:OCT1, pdm-1, POU-19, TWN
ORF Names:CG34395
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0085424. nub.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Protein nubbinPRO_0000100777Add
BLAST

Proteomic databases

PaxDbiP31368.
PRIDEiP31368.

Expressioni

Tissue specificityi

Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.2 Publications

Developmental stagei

Expressed both maternally and zygotically.3 Publications

Gene expression databases

BgeeiP31368.

Interactioni

Protein-protein interaction databases

BioGridi60715. 27 interactions.

Structurei

3D structure databases

ProteinModelPortaliP31368.
SMRiP31368. Positions 425-583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini421 – 49575POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-His
Compositional biasi191 – 20111Poly-AlaAdd
BLAST
Compositional biasi359 – 3646Poly-His
Compositional biasi407 – 4159Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
GeneTreeiENSGT00750000117373.
InParanoidiP31368.
KOiK09364.
OrthoDBiEOG7DJSMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31368-1 [UniParc]FASTAAdd to Basket

« Hide

MVMSELRWHT ASPEDNKNSL KRDLLKSTPT SAREAAVHIM QNRYISRLSR    50
SPSPLQSNAS DCDDNNSSVG TSSDRCRSPL SPALSLSHQQ AKRQLMSLQP 100
HPAHHHHNPH HLNHLNHHQY KQEEDYDDAN GGALNLTSDN SRHSTQSPSN 150
SVKSATASPV PVISVPSPVP PMISPVLAPS GCGSTTPNSM AAAAAAAAAV 200
ASTMGSGISP LLALPGMSSP QAQLAAAGLG MNNPLLTGSL SPQDFAQFHQ 250
LLQQRQVALT QQFNSYMELL RSGSLGLAQD DPALTAQVAA AQFLMQSQLQ 300
ALSQASQQLQ ALQKQQQRQV DEPLQLNHKM TQQPRSSTPH SIRSPIAIRS 350
PASSPQQLHH HHHHPLQITP PSSAASLKLS GMLTPSTPTS GTQMSQGTTT 400
PQPKTVASAA AARAAGEPSP EETTDLEELE QFAKTFKQRR IKLGFTQGDV 450
GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLQKW LDDADRTIQA 500
TGGVFDPAAL QATVSTPEII GRRRKKRTSI ETTIRGALEK AFLANQKPTS 550
EEITQLADRL SMEKEVVRVW FCNRRQKEKR INPSLDSPTG ADDDESSYMM 600
H 601
Length:601
Mass (Da):65,202
Last modified:July 1, 1993 - v1
Checksum:i8FFCD7B3C162D2B2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti420 – 4201P → R in AAB21409. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81957 mRNA. Translation: AAA28829.1.
S80561 mRNA. Translation: AAB21409.1.
M65015 mRNA. Translation: AAA28480.1.
AE014134 Genomic DNA. Translation: AAF53205.2.
AY118387 mRNA. Translation: AAM48416.1.
PIRiB56564.
RefSeqiNP_476659.1. NM_057311.4.
UniGeneiDm.4744.

Genome annotation databases

EnsemblMetazoaiFBtr0112643; FBpp0111555; FBgn0085424.
GeneIDi34669.
KEGGidme:Dmel_CG34395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81957 mRNA. Translation: AAA28829.1 .
S80561 mRNA. Translation: AAB21409.1 .
M65015 mRNA. Translation: AAA28480.1 .
AE014134 Genomic DNA. Translation: AAF53205.2 .
AY118387 mRNA. Translation: AAM48416.1 .
PIRi B56564.
RefSeqi NP_476659.1. NM_057311.4.
UniGenei Dm.4744.

3D structure databases

ProteinModelPortali P31368.
SMRi P31368. Positions 425-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60715. 27 interactions.

Proteomic databases

PaxDbi P31368.
PRIDEi P31368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0112643 ; FBpp0111555 ; FBgn0085424 .
GeneIDi 34669.
KEGGi dme:Dmel_CG34395.

Organism-specific databases

CTDi 34669.
FlyBasei FBgn0085424. nub.

Phylogenomic databases

eggNOGi NOG267922.
GeneTreei ENSGT00750000117373.
InParanoidi P31368.
KOi K09364.
OrthoDBi EOG7DJSMG.

Enzyme and pathway databases

Reactomei REACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
SignaLinki P31368.

Miscellaneous databases

GenomeRNAii 34669.
NextBioi 789610.

Gene expression databases

Bgeei P31368.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a family of Drosophila POU domain genes expressed in early development."
    Billin A.N., Cockerill K.A., Poole S.J.
    Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
    Tissue: Embryo.
  2. "Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns."
    Lloyd A., Sakonju S.
    Mech. Dev. 36:87-102(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements."
    Dick T., Yang X., Yeo S., Chia W.
    Proc. Natl. Acad. Sci. U.S.A. 88:7645-7649(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiPDM1_DROME
AccessioniPrimary (citable) accession number: P31368
Secondary accession number(s): Q9VK74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi