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P31367

- PO6F1_DANRE

UniProt

P31367 - PO6F1_DANRE

Protein

POU domain, class 6, transcription factor 1

Gene

pou6f1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Transcription factor that binds with high affinity to the motif 5'-TAATGARAT-3'.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi543 – 60260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 6, transcription factor 1
    Alternative name(s):
    POU domain protein C
    Short name:
    POU[C]
    Short name:
    ZfPOU[C]
    Gene namesi
    Name:pou6f1
    Synonyms:pou[c], pouc
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 23

    Organism-specific databases

    ZFINiZDB-GENE-980526-530. pou6f1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610POU domain, class 6, transcription factor 1PRO_0000100770Add
    BLAST

    Expressioni

    Tissue specificityi

    Ubiquitously expressed during embryogenesis.1 Publication

    Gene expression databases

    BgeeiP31367.

    Structurei

    3D structure databases

    ProteinModelPortaliP31367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini448 – 52275POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241882.
    GeneTreeiENSGT00750000117373.
    HOGENOMiHOG000063659.
    InParanoidiP31367.
    KOiK09368.
    OMAiSYFEKNA.
    OrthoDBiEOG7353Z3.
    PhylomeDBiP31367.
    TreeFamiTF350705.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31367-1 [UniParc]FASTAAdd to Basket

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    MDTEDLPANN APLTVNEQLL GSCTLKFPAQ DAQVIVMSGQ ETIRVLEVEV    50
    DTALSSAGAA ESGGDEEGSG QSLEATEEAQ LDGPVTTSST TAVTVEVSAP 100
    VVQTVVSKAA ISVSPAQQTS VPITVQACPQ VLTQDGLASL MTGMLAQQSS 150
    LGQPLLIPLS MAGSVGGQGG LAVLTLPTAT VATLPGLAAA SPAGGLLKLP 200
    FAGLQAATVL NSVQTQLQAP AQAVLQPQMS ALQAMQQTQT TAATTASIVQ 250
    KASEPSVSVA TLQTAGLSIN PAIISAASLG AQPQFISSLT TTPIITSAMS 300
    NVAGLTSQLI TNAQGQVIGT LPLLVNPASL AGAAAASALP AQGLQVQTVA 350
    PQLLLNSQGQ IIATIGNGPT AAIPSTASVL PKATVPLTLT KTTTQGPVGK 400
    VAPSKVIIAP QPSVVKPVTS LTAAGVIACG EMPTVGQLVN KPSAVKDEEA 450
    INLEEIREFA KNFKIRRLSL GLTQTQVGQA LTATEGPAYS QSAICRFEKL 500
    DITPKSAQKL KPVLERWLAE AELWNQKGQQ NLMEFVGGEP SKKRKRRTSF 550
    TPQAIEVLNT YFEKNSLPTG QEITEIAKEL NYDREVVRVW FCNRRQTLKN 600
    TSKINVFQSQ 610
    Length:610
    Mass (Da):63,124
    Last modified:July 1, 1993 - v1
    Checksum:i51D7140A6F16DD66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68432 mRNA. Translation: CAA48481.1.
    BC162134 mRNA. Translation: AAI62134.1.
    BC162146 mRNA. Translation: AAI62146.1.
    PIRiS30234.
    RefSeqiNP_571188.1. NM_131113.1.
    UniGeneiDr.75078.

    Genome annotation databases

    EnsembliENSDART00000011925; ENSDARP00000003648; ENSDARG00000011570.
    ENSDART00000130338; ENSDARP00000111302; ENSDARG00000011570.
    GeneIDi30334.
    KEGGidre:30334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68432 mRNA. Translation: CAA48481.1 .
    BC162134 mRNA. Translation: AAI62134.1 .
    BC162146 mRNA. Translation: AAI62146.1 .
    PIRi S30234.
    RefSeqi NP_571188.1. NM_131113.1.
    UniGenei Dr.75078.

    3D structure databases

    ProteinModelPortali P31367.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000011925 ; ENSDARP00000003648 ; ENSDARG00000011570 .
    ENSDART00000130338 ; ENSDARP00000111302 ; ENSDARG00000011570 .
    GeneIDi 30334.
    KEGGi dre:30334.

    Organism-specific databases

    CTDi 5463.
    ZFINi ZDB-GENE-980526-530. pou6f1.

    Phylogenomic databases

    eggNOGi NOG241882.
    GeneTreei ENSGT00750000117373.
    HOGENOMi HOG000063659.
    InParanoidi P31367.
    KOi K09368.
    OMAi SYFEKNA.
    OrthoDBi EOG7353Z3.
    PhylomeDBi P31367.
    TreeFami TF350705.

    Miscellaneous databases

    NextBioi 20806766.
    PROi P31367.

    Gene expression databases

    Bgeei P31367.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis."
      Johansen T., Moens U., Holm T., Fjose A., Krauss S.
      Nucleic Acids Res. 21:475-483(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: NC-1.
      Tissue: Embryonic liver.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPO6F1_DANRE
    AccessioniPrimary (citable) accession number: P31367
    Secondary accession number(s): B3DFR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3