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P31367 (PO6F1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
POU domain protein C
Short name=POU[C]
Short name=ZfPOU[C]
Gene names
Name:pou6f1
Synonyms:pou[c], pouc
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds with high affinity to the motif 5'-TAATGARAT-3'. Ref.1

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitously expressed during embryogenesis. Ref.1

Sequence similarities

Belongs to the POU transcription factor family. Class-6 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610POU domain, class 6, transcription factor 1
PRO_0000100770

Regions

Domain448 – 52275POU-specific
DNA binding543 – 60260Homeobox

Sequences

Sequence LengthMass (Da)Tools
P31367 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 51D7140A6F16DD66

FASTA61063,124
        10         20         30         40         50         60 
MDTEDLPANN APLTVNEQLL GSCTLKFPAQ DAQVIVMSGQ ETIRVLEVEV DTALSSAGAA 

        70         80         90        100        110        120 
ESGGDEEGSG QSLEATEEAQ LDGPVTTSST TAVTVEVSAP VVQTVVSKAA ISVSPAQQTS 

       130        140        150        160        170        180 
VPITVQACPQ VLTQDGLASL MTGMLAQQSS LGQPLLIPLS MAGSVGGQGG LAVLTLPTAT 

       190        200        210        220        230        240 
VATLPGLAAA SPAGGLLKLP FAGLQAATVL NSVQTQLQAP AQAVLQPQMS ALQAMQQTQT 

       250        260        270        280        290        300 
TAATTASIVQ KASEPSVSVA TLQTAGLSIN PAIISAASLG AQPQFISSLT TTPIITSAMS 

       310        320        330        340        350        360 
NVAGLTSQLI TNAQGQVIGT LPLLVNPASL AGAAAASALP AQGLQVQTVA PQLLLNSQGQ 

       370        380        390        400        410        420 
IIATIGNGPT AAIPSTASVL PKATVPLTLT KTTTQGPVGK VAPSKVIIAP QPSVVKPVTS 

       430        440        450        460        470        480 
LTAAGVIACG EMPTVGQLVN KPSAVKDEEA INLEEIREFA KNFKIRRLSL GLTQTQVGQA 

       490        500        510        520        530        540 
LTATEGPAYS QSAICRFEKL DITPKSAQKL KPVLERWLAE AELWNQKGQQ NLMEFVGGEP 

       550        560        570        580        590        600 
SKKRKRRTSF TPQAIEVLNT YFEKNSLPTG QEITEIAKEL NYDREVVRVW FCNRRQTLKN 

       610 
TSKINVFQSQ 

« Hide

References

« Hide 'large scale' references
[1]"Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis."
Johansen T., Moens U., Holm T., Fjose A., Krauss S.
Nucleic Acids Res. 21:475-483(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: NC-1.
Tissue: Embryonic liver.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68432 mRNA. Translation: CAA48481.1.
BC162134 mRNA. Translation: AAI62134.1.
BC162146 mRNA. Translation: AAI62146.1.
PIRS30234.
RefSeqNP_571188.1. NM_131113.1.
UniGeneDr.75078.

3D structure databases

ProteinModelPortalP31367.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000011925; ENSDARP00000003648; ENSDARG00000011570.
ENSDART00000130338; ENSDARP00000111302; ENSDARG00000011570.
GeneID30334.
KEGGdre:30334.

Organism-specific databases

CTD5463.
ZFINZDB-GENE-980526-530. pou6f1.

Phylogenomic databases

eggNOGNOG241882.
GeneTreeENSGT00750000117373.
HOGENOMHOG000063659.
InParanoidP31367.
KOK09368.
OMASYFEKNA.
OrthoDBEOG7353Z3.
PhylomeDBP31367.
TreeFamTF350705.

Gene expression databases

BgeeP31367.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806766.
PROP31367.

Entry information

Entry namePO6F1_DANRE
AccessionPrimary (citable) accession number: P31367
Secondary accession number(s): B3DFR1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families