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Protein

POU domain, class 6, transcription factor 1

Gene

pou6f1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds with high affinity to the motif 5'-TAATGARAT-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi543 – 60260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 6, transcription factor 1
Alternative name(s):
POU domain protein C
Short name:
POU[C]
Short name:
ZfPOU[C]
Gene namesi
Name:pou6f1
Synonyms:pou[c], pouc
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-980526-530. pou6f1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610POU domain, class 6, transcription factor 1PRO_0000100770Add
BLAST

Expressioni

Tissue specificityi

Ubiquitously expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiP31367.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111302.

Structurei

3D structure databases

ProteinModelPortaliP31367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 52275POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241882.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000063659.
InParanoidiP31367.
KOiK09368.
OMAiFNPGIIS.
OrthoDBiEOG7353Z3.
PhylomeDBiP31367.
TreeFamiTF350705.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTEDLPANN APLTVNEQLL GSCTLKFPAQ DAQVIVMSGQ ETIRVLEVEV
60 70 80 90 100
DTALSSAGAA ESGGDEEGSG QSLEATEEAQ LDGPVTTSST TAVTVEVSAP
110 120 130 140 150
VVQTVVSKAA ISVSPAQQTS VPITVQACPQ VLTQDGLASL MTGMLAQQSS
160 170 180 190 200
LGQPLLIPLS MAGSVGGQGG LAVLTLPTAT VATLPGLAAA SPAGGLLKLP
210 220 230 240 250
FAGLQAATVL NSVQTQLQAP AQAVLQPQMS ALQAMQQTQT TAATTASIVQ
260 270 280 290 300
KASEPSVSVA TLQTAGLSIN PAIISAASLG AQPQFISSLT TTPIITSAMS
310 320 330 340 350
NVAGLTSQLI TNAQGQVIGT LPLLVNPASL AGAAAASALP AQGLQVQTVA
360 370 380 390 400
PQLLLNSQGQ IIATIGNGPT AAIPSTASVL PKATVPLTLT KTTTQGPVGK
410 420 430 440 450
VAPSKVIIAP QPSVVKPVTS LTAAGVIACG EMPTVGQLVN KPSAVKDEEA
460 470 480 490 500
INLEEIREFA KNFKIRRLSL GLTQTQVGQA LTATEGPAYS QSAICRFEKL
510 520 530 540 550
DITPKSAQKL KPVLERWLAE AELWNQKGQQ NLMEFVGGEP SKKRKRRTSF
560 570 580 590 600
TPQAIEVLNT YFEKNSLPTG QEITEIAKEL NYDREVVRVW FCNRRQTLKN
610
TSKINVFQSQ
Length:610
Mass (Da):63,124
Last modified:July 1, 1993 - v1
Checksum:i51D7140A6F16DD66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68432 mRNA. Translation: CAA48481.1.
BC162134 mRNA. Translation: AAI62134.1.
BC162146 mRNA. Translation: AAI62146.1.
PIRiS30234.
RefSeqiNP_571188.1. NM_131113.1.
UniGeneiDr.75078.

Genome annotation databases

EnsembliENSDART00000011925; ENSDARP00000003648; ENSDARG00000011570.
ENSDART00000130338; ENSDARP00000111302; ENSDARG00000011570.
GeneIDi30334.
KEGGidre:30334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68432 mRNA. Translation: CAA48481.1.
BC162134 mRNA. Translation: AAI62134.1.
BC162146 mRNA. Translation: AAI62146.1.
PIRiS30234.
RefSeqiNP_571188.1. NM_131113.1.
UniGeneiDr.75078.

3D structure databases

ProteinModelPortaliP31367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000111302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000011925; ENSDARP00000003648; ENSDARG00000011570.
ENSDART00000130338; ENSDARP00000111302; ENSDARG00000011570.
GeneIDi30334.
KEGGidre:30334.

Organism-specific databases

CTDi5463.
ZFINiZDB-GENE-980526-530. pou6f1.

Phylogenomic databases

eggNOGiNOG241882.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000063659.
InParanoidiP31367.
KOiK09368.
OMAiFNPGIIS.
OrthoDBiEOG7353Z3.
PhylomeDBiP31367.
TreeFamiTF350705.

Miscellaneous databases

NextBioi20806766.
PROiP31367.

Gene expression databases

BgeeiP31367.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis."
    Johansen T., Moens U., Holm T., Fjose A., Krauss S.
    Nucleic Acids Res. 21:475-483(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: NC-1.
    Tissue: Embryonic liver.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPO6F1_DANRE
AccessioniPrimary (citable) accession number: P31367
Secondary accession number(s): B3DFR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.