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P31365 (P3F2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 2-A
Alternative name(s):
Transcription factor POU3-A
Short name=XlPOU3A
Gene names
Name:pou3f2-a
Synonyms:pou3, pou3a, pou3f2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that may be implicated in patterning of the central nervous system during early development By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain. Ref.2

Developmental stage

First expressed at the neurula stage. Ref.2

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence caution

The sequence AAH41298.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382POU domain, class 3, transcription factor 2-A
PRO_0000100725

Regions

Domain201 – 27575POU-specific
DNA binding293 – 35260Homeobox
Compositional bias185 – 1928Gln-rich

Experimental info

Sequence conflict1541P → T in AAH41298. Ref.3
Sequence conflict3411F → C in CAA46047. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P31365 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: 30197A0BCAF74881

FASTA38241,587
        10         20         30         40         50         60 
MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH PLSHAHQWIT 

        70         80         90        100        110        120 
ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHVSGTLQHQ SRAPHLVHPA HGNHHGPGAW 

       130        140        150        160        170        180 
RSTGSTHLSS MASSNGQGLL YSQPSFTVNG MINPGSGQGI HHHGLRDSHD DHHGDHGHQQ 

       190        200        210        220        230        240 
VSQAQQQHSQ LQGGHQDHSD EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN 

       250        260        270        280        290        300 
VFSQTTICRF EALQLSFKNM CKLKPLLNKW LEEADSSSGS PTSIDKIAAQ GRKRKKRTSI 

       310        320        330        340        350        360 
EVSVKGALES HFLKCPKPSA PEITSLADSL QLEKEVVRVW FCNRRQKEKR MTPPGGTIPG 

       370        380 
AEDIYGASRD TPPHLGVQTS VQ 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of XLPOU3 cDNA, a member of the POU domain gene family expressed in Xenopus laevis embryos."
Baltzinger M., Payen E., Remy P.
Nucleic Acids Res. 20:1993-1993(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Neurula.
[2]"Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis."
Baltzinger M., Relaix F., Remy P.
Mech. Dev. 58:103-114(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula and Tail bud.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64835 mRNA. Translation: CAA46047.1.
BC041298 mRNA. Translation: AAH41298.1. Different initiation.
BC170064 mRNA. Translation: AAI70064.1.
BC170066 mRNA. Translation: AAI70066.1.
PIRS22652.
RefSeqNP_001095225.1. NM_001101755.1.
UniGeneXl.7054.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394422.
KEGGxla:394422.

Organism-specific databases

CTD394422.
XenbaseXB-GENE-6254215. pou3f2.

Phylogenomic databases

HOVERGENHBG053120.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP3F2A_XENLA
AccessionPrimary (citable) accession number: P31365
Secondary accession number(s): B7ZR71, Q8AVS5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 24, 2009
Last modified: February 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families