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Protein

POU domain, class 3, transcription factor 2-A

Gene

pou3f2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that may be implicated in patterning of the central nervous system during early development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi293 – 35260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 2-A
Alternative name(s):
Transcription factor POU3-A
Short name:
XlPOU3A
Gene namesi
Name:pou3f2-a
Synonyms:pou3, pou3a, pou3f2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254215. pou3f2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382POU domain, class 3, transcription factor 2-APRO_0000100725Add
BLAST

Expressioni

Tissue specificityi

Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.1 Publication

Developmental stagei

First expressed at the neurula stage.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 27575POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1928Gln-rich

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. TF_POU_3.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH
60 70 80 90 100
PLSHAHQWIT ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHVSGTLQHQ
110 120 130 140 150
SRAPHLVHPA HGNHHGPGAW RSTGSTHLSS MASSNGQGLL YSQPSFTVNG
160 170 180 190 200
MINPGSGQGI HHHGLRDSHD DHHGDHGHQQ VSQAQQQHSQ LQGGHQDHSD
210 220 230 240 250
EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN VFSQTTICRF
260 270 280 290 300
EALQLSFKNM CKLKPLLNKW LEEADSSSGS PTSIDKIAAQ GRKRKKRTSI
310 320 330 340 350
EVSVKGALES HFLKCPKPSA PEITSLADSL QLEKEVVRVW FCNRRQKEKR
360 370 380
MTPPGGTIPG AEDIYGASRD TPPHLGVQTS VQ
Length:382
Mass (Da):41,587
Last modified:November 24, 2009 - v2
Checksum:i30197A0BCAF74881
GO

Sequence cautioni

The sequence AAH41298.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541P → T in AAH41298 (Ref. 3) Curated
Sequence conflicti341 – 3411F → C in CAA46047 (PubMed:1579504).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64835 mRNA. Translation: CAA46047.1.
BC041298 mRNA. Translation: AAH41298.1. Different initiation.
BC170064 mRNA. Translation: AAI70064.1.
BC170066 mRNA. Translation: AAI70066.1.
PIRiS22652.
RefSeqiNP_001095225.1. NM_001101755.1.
UniGeneiXl.7054.

Genome annotation databases

GeneIDi394422.
KEGGixla:394422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64835 mRNA. Translation: CAA46047.1.
BC041298 mRNA. Translation: AAH41298.1. Different initiation.
BC170064 mRNA. Translation: AAI70064.1.
BC170066 mRNA. Translation: AAI70066.1.
PIRiS22652.
RefSeqiNP_001095225.1. NM_001101755.1.
UniGeneiXl.7054.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394422.
KEGGixla:394422.

Organism-specific databases

CTDi394422.
XenbaseiXB-GENE-6254215. pou3f2.

Phylogenomic databases

HOVERGENiHBG053120.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. TF_POU_3.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of XLPOU3 cDNA, a member of the POU domain gene family expressed in Xenopus laevis embryos."
    Baltzinger M., Payen E., Remy P.
    Nucleic Acids Res. 20:1993-1993(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neurula.
  2. "Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis."
    Baltzinger M., Relaix F., Remy P.
    Mech. Dev. 58:103-114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula and Tail bud.

Entry informationi

Entry nameiP3F2A_XENLA
AccessioniPrimary (citable) accession number: P31365
Secondary accession number(s): B7ZR71, Q8AVS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 24, 2009
Last modified: April 1, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.