Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31365

- P3F2A_XENLA

UniProt

P31365 - P3F2A_XENLA

Protein

POU domain, class 3, transcription factor 2-A

Gene

pou3f2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that may be implicated in patterning of the central nervous system during early development.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi293 – 35260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 2-A
    Alternative name(s):
    Transcription factor POU3-A
    Short name:
    XlPOU3A
    Gene namesi
    Name:pou3f2-a
    Synonyms:pou3, pou3a, pou3f2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254215. pou3f2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382POU domain, class 3, transcription factor 2-APRO_0000100725Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.1 Publication

    Developmental stagei

    First expressed at the neurula stage.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini201 – 27575POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi185 – 1928Gln-rich

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG053120.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTASNHYN LLGSGSSIVH ADPGGMQQAQ SYRDAQTLVQ SDYTLQSNGH    50
    PLSHAHQWIT ALSHGDGAPW ATSPLGQQDI KPTVQSSRDE LHVSGTLQHQ 100
    SRAPHLVHPA HGNHHGPGAW RSTGSTHLSS MASSNGQGLL YSQPSFTVNG 150
    MINPGSGQGI HHHGLRDSHD DHHGDHGHQQ VSQAQQQHSQ LQGGHQDHSD 200
    EDTPTSDDLE QFAKQFKQRR IKLGFTQADV GLALGTLYGN VFSQTTICRF 250
    EALQLSFKNM CKLKPLLNKW LEEADSSSGS PTSIDKIAAQ GRKRKKRTSI 300
    EVSVKGALES HFLKCPKPSA PEITSLADSL QLEKEVVRVW FCNRRQKEKR 350
    MTPPGGTIPG AEDIYGASRD TPPHLGVQTS VQ 382
    Length:382
    Mass (Da):41,587
    Last modified:November 24, 2009 - v2
    Checksum:i30197A0BCAF74881
    GO

    Sequence cautioni

    The sequence AAH41298.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541P → T in AAH41298. 1 PublicationCurated
    Sequence conflicti341 – 3411F → C in CAA46047. (PubMed:1579504)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64835 mRNA. Translation: CAA46047.1.
    BC041298 mRNA. Translation: AAH41298.1. Different initiation.
    BC170064 mRNA. Translation: AAI70064.1.
    BC170066 mRNA. Translation: AAI70066.1.
    PIRiS22652.
    RefSeqiNP_001095225.1. NM_001101755.1.
    UniGeneiXl.7054.

    Genome annotation databases

    GeneIDi394422.
    KEGGixla:394422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64835 mRNA. Translation: CAA46047.1 .
    BC041298 mRNA. Translation: AAH41298.1 . Different initiation.
    BC170064 mRNA. Translation: AAI70064.1 .
    BC170066 mRNA. Translation: AAI70066.1 .
    PIRi S22652.
    RefSeqi NP_001095225.1. NM_001101755.1.
    UniGenei Xl.7054.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394422.
    KEGGi xla:394422.

    Organism-specific databases

    CTDi 394422.
    Xenbasei XB-GENE-6254215. pou3f2.

    Phylogenomic databases

    HOVERGENi HBG053120.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of XLPOU3 cDNA, a member of the POU domain gene family expressed in Xenopus laevis embryos."
      Baltzinger M., Payen E., Remy P.
      Nucleic Acids Res. 20:1993-1993(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Neurula.
    2. "Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis."
      Baltzinger M., Relaix F., Remy P.
      Mech. Dev. 58:103-114(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula and Tail bud.

    Entry informationi

    Entry nameiP3F2A_XENLA
    AccessioniPrimary (citable) accession number: P31365
    Secondary accession number(s): B7ZR71, Q8AVS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3