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P31364

- P3F4A_XENLA

UniProt

P31364 - P3F4A_XENLA

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Protein

POU domain, class 3, transcription factor 4-A

Gene
pou3f4-a, pou2, pou3f4
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi278 – 33760HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 4-A
Alternative name(s):
Transcription factor POU2
Short name:
XlPOU 2
Short name:
XlPOU2
Gene namesi
Name:pou3f4-a
Synonyms:pou2, pou3f4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865294. pou3f4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361POU domain, class 3, transcription factor 4-APRO_0000100765Add
BLAST

Expressioni

Tissue specificityi

From embryonic stage 10, expressed in the Spemann's organizer. During gastrulation, expressed in both the involuting mesoderm and the overlying neuroectoderm. During the neural plate and neural fold stages, expressed in the entire neuroectoderm with expression in discrete regions of the developing nervous system persisting at later stages. Transiently expressed in the pronephros from stages 24-32. In adults, expressed in the kidney and brain.2 Publications

Developmental stagei

First expressed at embryonic stage 9, with expression increasing at neurula stage and again at the tailbud stage. Expression persists through development to adulthood.2 Publications

Inductioni

By nog, zic1 and zic3.2 Publications

Structurei

3D structure databases

ProteinModelPortaliP31364.
SMRiP31364. Positions 192-338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 26075POU-specificAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.
KOiK09365.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31364-1 [UniParc]FASTAAdd to Basket

« Hide

MATAASNPYS ILSSSSLVHA DSAVMQQGSP FRNPQKLLQS DYLQGVPCNG    50
HPLGHHWVTS LSDANPWSSS LASSPLDQQD IKPGREDLQL GAIIHHRSPH 100
VNHHSPHTNH PNAWGASPAH NSSLTSSGQP INIYSQPSFT VSGMLDHGEL 150
TPPLPAGTTQ SLHPVLREPN DHVDLGSHHC QDHSDEETPT SDELEQFAKQ 200
FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP 250
LLNKWLEEAD SSTGNPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 300
PKPAALEITS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DPQQHEVYSH 350
SVKTDTSCNE L 361
Length:361
Mass (Da):39,838
Last modified:December 15, 2009 - v2
Checksum:i6F6BE1D6AC844F81
GO

Sequence cautioni

The sequence CAA41781.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271S → G in CAA41781. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17654 mRNA. Translation: AAA92684.1.
BC076747 mRNA. Translation: AAH76747.1.
X59055 mRNA. Translation: CAA41781.1. Different initiation.
RefSeqiNP_001094393.1. NM_001100923.1.
UniGeneiXl.1023.

Genome annotation databases

GeneIDi397929.
KEGGixla:397929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17654 mRNA. Translation: AAA92684.1 .
BC076747 mRNA. Translation: AAH76747.1 .
X59055 mRNA. Translation: CAA41781.1 . Different initiation.
RefSeqi NP_001094393.1. NM_001100923.1.
UniGenei Xl.1023.

3D structure databases

ProteinModelPortali P31364.
SMRi P31364. Positions 192-338.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397929.
KEGGi xla:397929.

Organism-specific databases

CTDi 5456.
Xenbasei XB-GENE-865294. pou3f4.

Phylogenomic databases

HOVERGENi HBG053120.
KOi K09365.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "XLPOU 2, a noggin-inducible gene, has direct neuralizing activity."
    Witta S.E., Agarwal V.R., Sato S.M.
    Development 121:721-730(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Tissue: Brain.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos."
    Agarwal V.R., Sato S.M.
    Dev. Biol. 147:363-373(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-361, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Brain.
  4. "The POU domain gene, XlPOU 2 is an essential downstream determinant of neural induction."
    Matsuo-Takasaki M., Lim J.H., Sato S.M.
    Mech. Dev. 89:75-85(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiP3F4A_XENLA
AccessioniPrimary (citable) accession number: P31364
Secondary accession number(s): Q6DFJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 2009
Last modified: February 19, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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