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Protein

POU domain, class 3, transcription factor 4-A

Gene

pou3f4-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi278 – 337HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 4-A
Alternative name(s):
Transcription factor POU2
Short name:
XlPOU 2
Short name:
XlPOU2
Gene namesi
Name:pou3f4-a
Synonyms:pou2, pou3f4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865294 pou3f4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007651 – 361POU domain, class 3, transcription factor 4-AAdd BLAST361

Proteomic databases

PRIDEiP31364

Expressioni

Tissue specificityi

From embryonic stage 10, expressed in the Spemann's organizer. During gastrulation, expressed in both the involuting mesoderm and the overlying neuroectoderm. During the neural plate and neural fold stages, expressed in the entire neuroectoderm with expression in discrete regions of the developing nervous system persisting at later stages. Transiently expressed in the pronephros from stages 24-32. In adults, expressed in the kidney and brain.2 Publications

Developmental stagei

First expressed at embryonic stage 9, with expression increasing at neurula stage and again at the tailbud stage. Expression persists through development to adulthood.2 Publications

Inductioni

By nog, zic1 and zic3.2 Publications

Structurei

3D structure databases

ProteinModelPortaliP31364
SMRiP31364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 260POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120
KOiK09365

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR016362 TF_POU_3
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PIRSFiPIRSF002629 Transcription_factor_POU, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

P31364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASNPYS ILSSSSLVHA DSAVMQQGSP FRNPQKLLQS DYLQGVPCNG
60 70 80 90 100
HPLGHHWVTS LSDANPWSSS LASSPLDQQD IKPGREDLQL GAIIHHRSPH
110 120 130 140 150
VNHHSPHTNH PNAWGASPAH NSSLTSSGQP INIYSQPSFT VSGMLDHGEL
160 170 180 190 200
TPPLPAGTTQ SLHPVLREPN DHVDLGSHHC QDHSDEETPT SDELEQFAKQ
210 220 230 240 250
FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP
260 270 280 290 300
LLNKWLEEAD SSTGNPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC
310 320 330 340 350
PKPAALEITS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DPQQHEVYSH
360
SVKTDTSCNE L
Length:361
Mass (Da):39,838
Last modified:December 15, 2009 - v2
Checksum:i6F6BE1D6AC844F81
GO

Sequence cautioni

The sequence CAA41781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127S → G in CAA41781 (PubMed:1717323).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17654 mRNA Translation: AAA92684.1
BC076747 mRNA Translation: AAH76747.1
X59055 mRNA Translation: CAA41781.1 Different initiation.
RefSeqiNP_001094393.1, NM_001100923.1
UniGeneiXl.1023

Genome annotation databases

GeneIDi397929
KEGGixla:397929

Similar proteinsi

Entry informationi

Entry nameiP3F4A_XENLA
AccessioniPrimary (citable) accession number: P31364
Secondary accession number(s): Q6DFJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 2009
Last modified: May 23, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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