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P31363

- P3F1A_XENLA

UniProt

P31363 - P3F1A_XENLA

Protein

POU domain, class 3, transcription factor 1-A

Gene

pou3f1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    May play a role in neuronal differentiation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi286 – 34560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. nervous system development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 1-A
    Alternative name(s):
    Homeotic protein NRL-22
    Short name:
    XlNRL-22
    Transcription factor POU1
    Short name:
    XlPOU 1
    Short name:
    XlPOU1
    Gene namesi
    Name:pou3f1-a
    Synonyms:nrl-22, pou1, pou50
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254450. pou3f1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375POU domain, class 3, transcription factor 1-APRO_0000100764Add
    BLAST

    Expressioni

    Tissue specificityi

    In embryos at the neural fold stage, localized primarily in the anterior neural plate, and localized mostly in the anterior region of the nerve cord of neurula stage embryos. In tailbud stages, expressed predominantly in the eye and brain, with weak expression along the length of the nerve cord. In adults, expressed in skin and brain.1 Publication

    Developmental stagei

    Embryonic expression begins at the neural plate stage and continues throughout development to adulthood.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini194 – 26875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 19192His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG053120.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31363-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT    50
    NAGHHMSLTP HQWLPNPASD WGSGSHLGVQ AEHAKSGVQS NREDLSSGFH 100
    HHRSHLVHQQ SPSSHAWAQS GGHHLAPMSP SSNSHQPLIY SQSSYTNLNG 150
    MLGPQASSLH HSMRDPLHDD PGVHDTQVDS PPQHLGHHQD HSDEDAPSSD 200
    DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF 250
    KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA 300
    LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP 350
    HPPMEDVYSQ AETPPLHHTL QTSVQ 375
    Length:375
    Mass (Da):41,846
    Last modified:December 15, 2009 - v2
    Checksum:i55E494F7ECC86EAA
    GO

    Sequence cautioni

    The sequence AAH43847.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA41782.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 104YLPR → LLPW in CAA41782. (PubMed:1717323)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043847 mRNA. Translation: AAH43847.1. Different initiation.
    X59056 mRNA. Translation: CAA41782.1. Different initiation.
    X54682 mRNA. Translation: CAA38496.1.
    PIRiS12183.
    S23248.
    RefSeqiNP_001158054.1. NM_001164582.1.
    UniGeneiXl.1274.
    Xl.21449.

    Genome annotation databases

    GeneIDi394338.
    KEGGixla:394338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043847 mRNA. Translation: AAH43847.1 . Different initiation.
    X59056 mRNA. Translation: CAA41782.1 . Different initiation.
    X54682 mRNA. Translation: CAA38496.1 .
    PIRi S12183.
    S23248.
    RefSeqi NP_001158054.1. NM_001164582.1.
    UniGenei Xl.1274.
    Xl.21449.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 394338.
    KEGGi xla:394338.

    Organism-specific databases

    CTDi 394338.
    Xenbasei XB-GENE-6254450. pou3f1.

    Phylogenomic databases

    HOVERGENi HBG053120.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neurula.
    2. "XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos."
      Agarwal V.R., Sato S.M.
      Dev. Biol. 147:363-373(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-375, PUTATIVE FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Brain.
    3. "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula embryos."
      Baltzinger M., Stiegler P., Remy P.
      Nucleic Acids Res. 18:6131-6131(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
      Tissue: Neurula.

    Entry informationi

    Entry nameiP3F1A_XENLA
    AccessioniPrimary (citable) accession number: P31363
    Secondary accession number(s): P20915, Q7ZYC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3