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P31363

- P3F1A_XENLA

UniProt

P31363 - P3F1A_XENLA

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Protein

POU domain, class 3, transcription factor 1-A

Gene

pou3f1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in neuronal differentiation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi286 – 34560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. nervous system development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1-A
Alternative name(s):
Homeotic protein NRL-22
Short name:
XlNRL-22
Transcription factor POU1
Short name:
XlPOU 1
Short name:
XlPOU1
Gene namesi
Name:pou3f1-a
Synonyms:nrl-22, pou1, pou50
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254450. pou3f1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375POU domain, class 3, transcription factor 1-APRO_0000100764Add
BLAST

Expressioni

Tissue specificityi

In embryos at the neural fold stage, localized primarily in the anterior neural plate, and localized mostly in the anterior region of the nerve cord of neurula stage embryos. In tailbud stages, expressed predominantly in the eye and brain, with weak expression along the length of the nerve cord. In adults, expressed in skin and brain.1 Publication

Developmental stagei

Embryonic expression begins at the neural plate stage and continues throughout development to adulthood.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 26875POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 19192His-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31363-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT
60 70 80 90 100
NAGHHMSLTP HQWLPNPASD WGSGSHLGVQ AEHAKSGVQS NREDLSSGFH
110 120 130 140 150
HHRSHLVHQQ SPSSHAWAQS GGHHLAPMSP SSNSHQPLIY SQSSYTNLNG
160 170 180 190 200
MLGPQASSLH HSMRDPLHDD PGVHDTQVDS PPQHLGHHQD HSDEDAPSSD
210 220 230 240 250
DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF
260 270 280 290 300
KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA
310 320 330 340 350
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP
360 370
HPPMEDVYSQ AETPPLHHTL QTSVQ
Length:375
Mass (Da):41,846
Last modified:December 15, 2009 - v2
Checksum:i55E494F7ECC86EAA
GO

Sequence cautioni

The sequence AAH43847.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA41782.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 104YLPR → LLPW in CAA41782. (PubMed:1717323)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043847 mRNA. Translation: AAH43847.1. Different initiation.
X59056 mRNA. Translation: CAA41782.1. Different initiation.
X54682 mRNA. Translation: CAA38496.1.
PIRiS12183.
S23248.
RefSeqiNP_001158054.1. NM_001164582.1.
UniGeneiXl.1274.
Xl.21449.

Genome annotation databases

GeneIDi394338.
KEGGixla:394338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043847 mRNA. Translation: AAH43847.1 . Different initiation.
X59056 mRNA. Translation: CAA41782.1 . Different initiation.
X54682 mRNA. Translation: CAA38496.1 .
PIRi S12183.
S23248.
RefSeqi NP_001158054.1. NM_001164582.1.
UniGenei Xl.1274.
Xl.21449.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 394338.
KEGGi xla:394338.

Organism-specific databases

CTDi 394338.
Xenbasei XB-GENE-6254450. pou3f1.

Phylogenomic databases

HOVERGENi HBG053120.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neurula.
  2. "XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos."
    Agarwal V.R., Sato S.M.
    Dev. Biol. 147:363-373(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-375, PUTATIVE FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Brain.
  3. "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula embryos."
    Baltzinger M., Stiegler P., Remy P.
    Nucleic Acids Res. 18:6131-6131(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
    Tissue: Neurula.

Entry informationi

Entry nameiP3F1A_XENLA
AccessioniPrimary (citable) accession number: P31363
Secondary accession number(s): P20915, Q7ZYC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3