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P31363 (P3F1A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1-A
Alternative name(s):
Homeotic protein NRL-22
Short name=XlNRL-22
Transcription factor POU1
Short name=XlPOU 1
Short name=XlPOU1
Gene names
Name:pou3f1-a
Synonyms:nrl-22, pou1, pou50
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in neuronal differentiation. Ref.2

Subcellular location

Nucleus By similarity.

Tissue specificity

In embryos at the neural fold stage, localized primarily in the anterior neural plate, and localized mostly in the anterior region of the nerve cord of neurula stage embryos. In tailbud stages, expressed predominantly in the eye and brain, with weak expression along the length of the nerve cord. In adults, expressed in skin and brain. Ref.2

Developmental stage

Embryonic expression begins at the neural plate stage and continues throughout development to adulthood. Ref.2

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence caution

The sequence AAH43847.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA41782.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNeurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375POU domain, class 3, transcription factor 1-A
PRO_0000100764

Regions

Domain194 – 26875POU-specific
DNA binding286 – 34560Homeobox
Compositional bias100 – 19192His-rich

Experimental info

Sequence conflict7 – 104YLPR → LLPW in CAA41782. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P31363 [UniParc].

Last modified December 15, 2009. Version 2.
Checksum: 55E494F7ECC86EAA

FASTA37541,846
        10         20         30         40         50         60 
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT NAGHHMSLTP 

        70         80         90        100        110        120 
HQWLPNPASD WGSGSHLGVQ AEHAKSGVQS NREDLSSGFH HHRSHLVHQQ SPSSHAWAQS 

       130        140        150        160        170        180 
GGHHLAPMSP SSNSHQPLIY SQSSYTNLNG MLGPQASSLH HSMRDPLHDD PGVHDTQVDS 

       190        200        210        220        230        240 
PPQHLGHHQD HSDEDAPSSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI 

       250        260        270        280        290        300 
CRFEALQLSF KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA 

       310        320        330        340        350        360 
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP HPPMEDVYSQ 

       370 
AETPPLHHTL QTSVQ 

« Hide

References

« Hide 'large scale' references
[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neurula.
[2]"XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos."
Agarwal V.R., Sato S.M.
Dev. Biol. 147:363-373(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-375, PUTATIVE FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Brain.
[3]"Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula embryos."
Baltzinger M., Stiegler P., Remy P.
Nucleic Acids Res. 18:6131-6131(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 220-324.
Tissue: Neurula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC043847 mRNA. Translation: AAH43847.1. Different initiation.
X59056 mRNA. Translation: CAA41782.1. Different initiation.
X54682 mRNA. Translation: CAA38496.1.
PIRS12183.
S23248.
RefSeqNP_001158054.1. NM_001164582.1.
UniGeneXl.1274.
Xl.21449.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID394338.
KEGGxla:394338.

Organism-specific databases

CTD394338.
XenbaseXB-GENE-6254450. pou3f1.

Phylogenomic databases

HOVERGENHBG053120.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP3F1A_XENLA
AccessionPrimary (citable) accession number: P31363
Secondary accession number(s): P20915, Q7ZYC6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 15, 2009
Last modified: February 19, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families