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Protein

POU domain, class 2, transcription factor 3

Gene

Pou2f3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi274 – 333HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: MGI
  • keratinocyte differentiation Source: MGI
  • negative regulation by host of viral transcription Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • wound healing Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Epoc-1
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Gene namesi
Name:Pou2f3
Synonyms:Epoc1, Oct11, Otf-11, Otf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:102565. Pou2f3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor complex Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007181 – 431POU domain, class 2, transcription factor 3Add BLAST431

Proteomic databases

MaxQBiP31362.
PaxDbiP31362.
PRIDEiP31362.

PTM databases

iPTMnetiP31362.
PhosphoSitePlusiP31362.

Expressioni

Tissue specificityi

Skin, thymus, stomach and testis.

Developmental stagei

During embryogenesis and in adults.

Gene expression databases

CleanExiMM_POU2F3.

Interactioni

GO - Molecular functioni

  • protein dimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135115.

Structurei

3D structure databases

ProteinModelPortaliP31362.
SMRiP31362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 250POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 420Ser-richAdd BLAST74

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
HOGENOMiHOG000220842.
HOVERGENiHBG052783.
InParanoidiP31362.
PhylomeDBiP31362.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR000972. TF_octamer.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P31362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
GDSLQQTLSH RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV
110 120 130 140 150
SQFLLSQTPP GQQGLQPNLL SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG
160 170 180 190 200
SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD LEELEKFAKT FKQRRIKLGF
210 220 230 240 250
TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP LLEKWLNDPE
260 270 280 290 300
SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS
310 320 330 340 350
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV
360 370 380 390 400
SPSGSLGPLS VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ
410 420 430
NNSKAAMNSS SSSSFNSSGS WYRWNHPTYL H
Length:431
Mass (Da):47,071
Last modified:November 1, 1997 - v2
Checksum:i7E283E797EA8D3FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139R → A in CAA79222 (PubMed:8441607).Curated1
Sequence conflicti249P → A in CAA79222 (PubMed:8441607).Curated1
Sequence conflicti396 – 431PTASQ…PTYLH → SQVWALLT in CAA79222 (PubMed:8441607).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA. Translation: CAA79222.1.
L14677 mRNA. Translation: AAA16855.1.
CCDSiCCDS40596.1.
PIRiS35541.
UniGeneiMm.436650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA. Translation: CAA79222.1.
L14677 mRNA. Translation: AAA16855.1.
CCDSiCCDS40596.1.
PIRiS35541.
UniGeneiMm.436650.

3D structure databases

ProteinModelPortaliP31362.
SMRiP31362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135115.

PTM databases

iPTMnetiP31362.
PhosphoSitePlusiP31362.

Proteomic databases

MaxQBiP31362.
PaxDbiP31362.
PRIDEiP31362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102565. Pou2f3.

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
HOGENOMiHOG000220842.
HOVERGENiHBG052783.
InParanoidiP31362.
PhylomeDBiP31362.

Miscellaneous databases

PROiP31362.
SOURCEiSearch...

Gene expression databases

CleanExiMM_POU2F3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR000972. TF_octamer.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPO2F3_MOUSE
AccessioniPrimary (citable) accession number: P31362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: February 15, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.