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P31362 (PO2F3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Epoc-1
Octamer-binding protein 11
Short name=Oct-11
Octamer-binding transcription factor 11
Short name=OTF-11
Gene names
Name:Pou2f3
Synonyms:Epoc1, Oct11, Otf-11, Otf11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').

Subcellular location

Nucleus.

Tissue specificity

Skin, thymus, stomach and testis.

Developmental stage

During embryogenesis and in adults.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431POU domain, class 2, transcription factor 3
PRO_0000100718

Regions

Domain176 – 25075POU-specific
DNA binding274 – 33360Homeobox
Compositional bias347 – 42074Ser-rich

Experimental info

Sequence conflict1391R → A in CAA79222. Ref.1
Sequence conflict2491P → A in CAA79222. Ref.1
Sequence conflict396 – 43136PTASQ…PTYLH → SQVWALLT in CAA79222. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P31362 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 7E283E797EA8D3FA

FASTA43147,071
        10         20         30         40         50         60 
MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL GDSLQQTLSH 

        70         80         90        100        110        120 
RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV SQFLLSQTPP GQQGLQPNLL 

       130        140        150        160        170        180 
SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD 

       190        200        210        220        230        240 
LEELEKFAKT FKQRRIKLGF TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP 

       250        260        270        280        290        300 
LLEKWLNDPE SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS 

       310        320        330        340        350        360 
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV SPSGSLGPLS 

       370        380        390        400        410        420 
VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ NNSKAAMNSS SSSSFNSSGS 

       430 
WYRWNHPTYL H 

« Hide

References

[1]"Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11."
Goldsborough A.S., Healy L.E., Copeland N.G., Gilbert D.J., Jenkins N.A., Willison K.R., Ashworth A.
Nucleic Acids Res. 21:127-134(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[2]"Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells."
Yukawa K., Yasui T., Yamamoto A., Shiku H., Kishimoto T., Kikutani H.
Gene 133:163-169(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18537 mRNA. Translation: CAA79222.1.
L14677 mRNA. Translation: AAA16855.1.
CCDSCCDS40596.1.
PIRS35541.
UniGeneMm.436650.

3D structure databases

ProteinModelPortalP31362.
SMRP31362. Positions 180-333.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP31362.

Proteomic databases

PaxDbP31362.
PRIDEP31362.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:102565. Pou2f3.

Phylogenomic databases

eggNOGNOG267922.
HOGENOMHOG000220842.
HOVERGENHBG052783.
InParanoidP31362.
PhylomeDBP31362.

Gene expression databases

CleanExMM_POU2F3.
GenevestigatorP31362.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP31362.
SOURCESearch...

Entry information

Entry namePO2F3_MOUSE
AccessionPrimary (citable) accession number: P31362
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot