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P31362

- PO2F3_MOUSE

UniProt

P31362 - PO2F3_MOUSE

Protein

POU domain, class 2, transcription factor 3

Gene

Pou2f3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi274 – 33360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein dimerization activity Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. epidermis development Source: MGI
    2. keratinocyte differentiation Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. wound healing Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 3
    Alternative name(s):
    Epoc-1
    Octamer-binding protein 11
    Short name:
    Oct-11
    Octamer-binding transcription factor 11
    Short name:
    OTF-11
    Gene namesi
    Name:Pou2f3
    Synonyms:Epoc1, Oct11, Otf-11, Otf11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:102565. Pou2f3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431POU domain, class 2, transcription factor 3PRO_0000100718Add
    BLAST

    Proteomic databases

    PaxDbiP31362.
    PRIDEiP31362.

    PTM databases

    PhosphoSiteiP31362.

    Expressioni

    Tissue specificityi

    Skin, thymus, stomach and testis.

    Developmental stagei

    During embryogenesis and in adults.

    Gene expression databases

    CleanExiMM_POU2F3.
    GenevestigatoriP31362.

    Structurei

    3D structure databases

    ProteinModelPortaliP31362.
    SMRiP31362. Positions 180-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 25075POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 42074Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG052783.
    InParanoidiP31362.
    PhylomeDBiP31362.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL    50
    GDSLQQTLSH RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV 100
    SQFLLSQTPP GQQGLQPNLL SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG 150
    SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD LEELEKFAKT FKQRRIKLGF 200
    TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP LLEKWLNDPE 250
    SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS 300
    SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV 350
    SPSGSLGPLS VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ 400
    NNSKAAMNSS SSSSFNSSGS WYRWNHPTYL H 431
    Length:431
    Mass (Da):47,071
    Last modified:November 1, 1997 - v2
    Checksum:i7E283E797EA8D3FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391R → A in CAA79222. (PubMed:8441607)Curated
    Sequence conflicti249 – 2491P → A in CAA79222. (PubMed:8441607)Curated
    Sequence conflicti396 – 43136PTASQ…PTYLH → SQVWALLT in CAA79222. (PubMed:8441607)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18537 mRNA. Translation: CAA79222.1.
    L14677 mRNA. Translation: AAA16855.1.
    CCDSiCCDS40596.1.
    PIRiS35541.
    UniGeneiMm.436650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18537 mRNA. Translation: CAA79222.1 .
    L14677 mRNA. Translation: AAA16855.1 .
    CCDSi CCDS40596.1.
    PIRi S35541.
    UniGenei Mm.436650.

    3D structure databases

    ProteinModelPortali P31362.
    SMRi P31362. Positions 180-333.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P31362.

    Proteomic databases

    PaxDbi P31362.
    PRIDEi P31362.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:102565. Pou2f3.

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG052783.
    InParanoidi P31362.
    PhylomeDBi P31362.

    Miscellaneous databases

    PROi P31362.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_POU2F3.
    Genevestigatori P31362.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11."
      Goldsborough A.S., Healy L.E., Copeland N.G., Gilbert D.J., Jenkins N.A., Willison K.R., Ashworth A.
      Nucleic Acids Res. 21:127-134(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells."
      Yukawa K., Yasui T., Yamamoto A., Shiku H., Kishimoto T., Kikutani H.
      Gene 133:163-169(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Thymus.

    Entry informationi

    Entry nameiPO2F3_MOUSE
    AccessioniPrimary (citable) accession number: P31362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3