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P31362

- PO2F3_MOUSE

UniProt

P31362 - PO2F3_MOUSE

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Protein

POU domain, class 2, transcription factor 3

Gene

Pou2f3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi274 – 33360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein dimerization activity Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. epidermis development Source: MGI
  2. keratinocyte differentiation Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 3
Alternative name(s):
Epoc-1
Octamer-binding protein 11
Short name:
Oct-11
Octamer-binding transcription factor 11
Short name:
OTF-11
Gene namesi
Name:Pou2f3
Synonyms:Epoc1, Oct11, Otf-11, Otf11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:102565. Pou2f3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431POU domain, class 2, transcription factor 3PRO_0000100718Add
BLAST

Proteomic databases

PaxDbiP31362.
PRIDEiP31362.

PTM databases

PhosphoSiteiP31362.

Expressioni

Tissue specificityi

Skin, thymus, stomach and testis.

Developmental stagei

During embryogenesis and in adults.

Gene expression databases

CleanExiMM_POU2F3.
GenevestigatoriP31362.

Structurei

3D structure databases

ProteinModelPortaliP31362.
SMRiP31362. Positions 180-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 25075POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 42074Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOGENOMiHOG000220842.
HOVERGENiHBG052783.
InParanoidiP31362.
PhylomeDBiP31362.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31362-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL
60 70 80 90 100
GDSLQQTLSH RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV
110 120 130 140 150
SQFLLSQTPP GQQGLQPNLL SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG
160 170 180 190 200
SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD LEELEKFAKT FKQRRIKLGF
210 220 230 240 250
TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP LLEKWLNDPE
260 270 280 290 300
SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS
310 320 330 340 350
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV
360 370 380 390 400
SPSGSLGPLS VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ
410 420 430
NNSKAAMNSS SSSSFNSSGS WYRWNHPTYL H
Length:431
Mass (Da):47,071
Last modified:November 1, 1997 - v2
Checksum:i7E283E797EA8D3FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391R → A in CAA79222. (PubMed:8441607)Curated
Sequence conflicti249 – 2491P → A in CAA79222. (PubMed:8441607)Curated
Sequence conflicti396 – 43136PTASQ…PTYLH → SQVWALLT in CAA79222. (PubMed:8441607)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA. Translation: CAA79222.1.
L14677 mRNA. Translation: AAA16855.1.
CCDSiCCDS40596.1.
PIRiS35541.
UniGeneiMm.436650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18537 mRNA. Translation: CAA79222.1 .
L14677 mRNA. Translation: AAA16855.1 .
CCDSi CCDS40596.1.
PIRi S35541.
UniGenei Mm.436650.

3D structure databases

ProteinModelPortali P31362.
SMRi P31362. Positions 180-333.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P31362.

Proteomic databases

PaxDbi P31362.
PRIDEi P31362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:102565. Pou2f3.

Phylogenomic databases

eggNOGi NOG267922.
HOGENOMi HOG000220842.
HOVERGENi HBG052783.
InParanoidi P31362.
PhylomeDBi P31362.

Miscellaneous databases

PROi P31362.
SOURCEi Search...

Gene expression databases

CleanExi MM_POU2F3.
Genevestigatori P31362.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11."
    Goldsborough A.S., Healy L.E., Copeland N.G., Gilbert D.J., Jenkins N.A., Willison K.R., Ashworth A.
    Nucleic Acids Res. 21:127-134(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells."
    Yukawa K., Yasui T., Yamamoto A., Shiku H., Kishimoto T., Kikutani H.
    Gene 133:163-169(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Thymus.

Entry informationi

Entry nameiPO2F3_MOUSE
AccessioniPrimary (citable) accession number: P31362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3