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P31360

- PO3F2_MOUSE

UniProt

P31360 - PO3F2_MOUSE

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Protein

POU domain, class 3, transcription factor 2

Gene
Pou3f2, Brn-2, Brn2, Otf7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi356 – 41560HomeoboxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II transcription coactivator activity Source: UniProtKB
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. astrocyte development Source: MGI
  2. cellular response to organic substance Source: MGI
  3. cerebral cortex radially oriented cell migration Source: MGI
  4. epidermis development Source: MGI
  5. forebrain ventricular zone progenitor cell division Source: MGI
  6. hypothalamus cell differentiation Source: MGI
  7. myelination in peripheral nervous system Source: MGI
  8. neurohypophysis development Source: MGI
  9. neuron differentiation Source: MGI
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of multicellular organism growth Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. regulation of axonogenesis Source: MGI
  14. regulation of cell differentiation Source: MGI
  15. regulation of transcription from RNA polymerase II promoter Source: MGI
  16. Schwann cell development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 2
Alternative name(s):
Brain-specific homeobox/POU domain protein 2
Short name:
Brain-2
Short name:
Brn-2
Nervous system-specific octamer-binding transcription factor N-Oct-3
Octamer-binding protein 7
Short name:
Oct-7
Octamer-binding transcription factor 7
Short name:
OTF-7
Gene namesi
Name:Pou3f2
Synonyms:Brn-2, Brn2, Otf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:101895. Pou3f2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445POU domain, class 3, transcription factor 2PRO_0000100723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP31360.

PTM databases

PhosphoSiteiP31360.

Expressioni

Tissue specificityi

Expressed specifically in the neuroectodermal cell lineage.

Gene expression databases

BgeeiP31360.
CleanExiMM_POU3F2.
GenevestigatoriP31360.

Interactioni

Subunit structurei

Interacts with PQBP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP31360.
SMRiP31360. Positions 267-416.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 33875POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 9023Poly-GlyAdd
BLAST
Compositional biasi125 – 14925Poly-GlnAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00730000110809.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiA2AJY1.
KOiK09365.
OMAiMHNSSNN.
OrthoDBiEOG7DJSMG.
PhylomeDBiP31360.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31360-1 [UniParc]FASTAAdd to Basket

« Hide

MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS    50
NGHPLSHAHQ WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ 100
PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ 150
QRPPHLVHHA ANHHPGPGAW RSAAAAAHLP PSMGASNGGL LYSQPSFTVN 200
GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ PPPPPPPQGP 250
PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 300
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI 350
AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV 400
RVWFCNRRQK EKRMTPPGGT LPGAEDVYGG SRDTPPHHGV QTPVQ 445
Length:445
Mass (Da):47,149
Last modified:July 1, 1993 - v1
Checksum:i1A47F10950EECE8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88300 Genomic DNA. Translation: AAA39961.1.
AL772230 Genomic DNA. Translation: CAM22634.1.
CCDSiCCDS18005.1.
PIRiS31224.
RefSeqiNP_032925.1. NM_008899.2.
UniGeneiMm.129387.
Mm.389520.
Mm.487875.

Genome annotation databases

EnsembliENSMUST00000178174; ENSMUSP00000136147; ENSMUSG00000095139.
GeneIDi18992.
KEGGimmu:18992.
UCSCiuc008sdp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88300 Genomic DNA. Translation: AAA39961.1 .
AL772230 Genomic DNA. Translation: CAM22634.1 .
CCDSi CCDS18005.1.
PIRi S31224.
RefSeqi NP_032925.1. NM_008899.2.
UniGenei Mm.129387.
Mm.389520.
Mm.487875.

3D structure databases

ProteinModelPortali P31360.
SMRi P31360. Positions 267-416.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P31360.

Proteomic databases

PRIDEi P31360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000178174 ; ENSMUSP00000136147 ; ENSMUSG00000095139 .
GeneIDi 18992.
KEGGi mmu:18992.
UCSCi uc008sdp.2. mouse.

Organism-specific databases

CTDi 5454.
MGIi MGI:101895. Pou3f2.

Phylogenomic databases

eggNOGi NOG261729.
GeneTreei ENSGT00730000110809.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi A2AJY1.
KOi K09365.
OMAi MHNSSNN.
OrthoDBi EOG7DJSMG.
PhylomeDBi P31360.
TreeFami TF316413.

Miscellaneous databases

NextBioi 295386.
PROi P31360.
SOURCEi Search...

Gene expression databases

Bgeei P31360.
CleanExi MM_POU3F2.
Genevestigatori P31360.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and evolution of four POU domain genes expressed in mouse brain."
    Hara Y., Rovescalli C., Kim Y., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPO3F2_MOUSE
AccessioniPrimary (citable) accession number: P31360
Secondary accession number(s): A2AJY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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