POU domain, class 3, transcription factor 2

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Reviewed, UniProtKB/Swiss-Prot P31360 (PO3F2_MOUSE)

Last modified June 16, 2009. Version 80. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    POU domain, class 3, transcription factor 2
Alternative name(s):
    Nervous system-specific octamer-binding transcription factor N-Oct-3
    Brain-specific homeobox/POU domain protein 2
      Short name=Brain-2
      Short name=Protein Brn-2

Gene names

Name:	Pou3f2
Synonyms:	Brn-2, Brn2, Otf7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters By similarity.
Subunit structure	Interacts with PQBP1 By similarity.
Subcellular location	Nucleus.
Tissue specificity	Expressed specifically in the neuroectodermal cell lineage.
Sequence similarities	Belongs to the POU transcription factor family. Class-3 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	astrocyte development Inferred from mutant phenotype. Source: MGI cerebral cortex radially oriented cell migration Inferred from genetic interaction. Source: MGI epidermis development Inferred from mutant phenotype. Source: MGI forebrain ventricular zone progenitor cell division Inferred from genetic interaction. Source: MGI hypothalamus cell differentiation Inferred from mutant phenotype. Source: MGI myelination in the peripheral nervous system Inferred from genetic interaction. Source: MGI neurohypophysis development Inferred from mutant phenotype. Source: MGI neuron differentiation Inferred from direct assay. Source: MGI positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI regulation of axonogenesis Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 445

445

POU domain, class 3, transcription factor 2

PRO_0000100723

Regions

Domain

264 – 338

POU-specific

DNA binding

356 – 415

Homeobox

Compositional bias

68 – 90

Poly-Gly

Compositional bias

125 – 149

Poly-Gln

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Sequences

Sequence

Length

Mass (Da)

Tools

P31360-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 1A47F10950EECE8A
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FASTA

445

47,149

        10         20         30         40         50         60 
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ 

        70         80         90        100        110        120 
WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG 

       130        140        150        160        170        180 
PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ QRPPHLVHHA ANHHPGPGAW RSAAAAAHLP 

       190        200        210        220        230        240 
PSMGASNGGL LYSQPSFTVN GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ 

       250        260        270        280        290        300 
PPPPPPPQGP PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 

       310        320        330        340        350        360 
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR 

       370        380        390        400        410        420 
TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT 

       430        440 
LPGAEDVYGG SRDTPPHHGV QTPVQ

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References

[1]	"Structure and evolution of four POU domain genes expressed in mouse brain." Hara Y., Rovescalli C., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed: 1565620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M88300 Genomic DNA. Translation: AAA39961.1.
IPI	IPI00133441.
PIR	S31224.
RefSeq	NP_032925.1.
UniGene	Mm.129387 Mm.389520 Mm.393532
3D structure databases
HSSP	HSSP built from PDB template 1OCT based on UniProtKB P14859.
SMR	P31360. Positions 270-416.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000052621. Mus musculus. [Contig view]
GeneID	18992.
KEGG	mmu:18992.
Organism-specific databases
MGI	MGI:101895. Pou3f2.
Phylogenomic databases
HOGENOM	P31360.
HOVERGEN	P31360.
OMA	P31360. SASIVHA.
Gene expression databases
ArrayExpress	P31360.
Bgee	P31360.
CleanEx	MM_POU3F2.
GermOnline	ENSMUSG00000052621. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR013847. POU. IPR000327. POU_specific. IPR016362. Transcription_factor_POU. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PIRSF	PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTS	PR00028. POUDOMAIN.
ProDom	PD000010. Homeobox. 1 hit. PD000583. POU. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295386.
SOURCE	Search...

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Entry information

Entry name

PO3F2_MOUSE

Accession

Primary (citable) accession number: P31360

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents