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P31360

- PO3F2_MOUSE

UniProt

P31360 - PO3F2_MOUSE

Protein

POU domain, class 3, transcription factor 2

Gene

Pou3f2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi356 – 41560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II transcription coactivator activity Source: UniProtKB
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. astrocyte development Source: MGI
    2. cellular response to organic substance Source: MGI
    3. cerebral cortex radially oriented cell migration Source: MGI
    4. epidermis development Source: MGI
    5. forebrain ventricular zone progenitor cell division Source: MGI
    6. hypothalamus cell differentiation Source: MGI
    7. myelination in peripheral nervous system Source: MGI
    8. neurohypophysis development Source: MGI
    9. neuron differentiation Source: MGI
    10. positive regulation of cell proliferation Source: MGI
    11. positive regulation of multicellular organism growth Source: MGI
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. regulation of axonogenesis Source: MGI
    14. regulation of cell differentiation Source: MGI
    15. regulation of transcription from RNA polymerase II promoter Source: MGI
    16. Schwann cell development Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 2
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 2
    Short name:
    Brain-2
    Short name:
    Brn-2
    Nervous system-specific octamer-binding transcription factor N-Oct-3
    Octamer-binding protein 7
    Short name:
    Oct-7
    Octamer-binding transcription factor 7
    Short name:
    OTF-7
    Gene namesi
    Name:Pou3f2
    Synonyms:Brn-2, Brn2, Otf7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:101895. Pou3f2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445POU domain, class 3, transcription factor 2PRO_0000100723Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei343 – 3431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP31360.

    PTM databases

    PhosphoSiteiP31360.

    Expressioni

    Tissue specificityi

    Expressed specifically in the neuroectodermal cell lineage.

    Gene expression databases

    BgeeiP31360.
    CleanExiMM_POU3F2.
    GenevestigatoriP31360.

    Interactioni

    Subunit structurei

    Interacts with PQBP1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP31360.
    SMRiP31360. Positions 267-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini264 – 33875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi68 – 9023Poly-GlyAdd
    BLAST
    Compositional biasi125 – 14925Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiA2AJY1.
    KOiK09365.
    OMAiMHNSSNN.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP31360.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31360-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS    50
    NGHPLSHAHQ WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ 100
    PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ 150
    QRPPHLVHHA ANHHPGPGAW RSAAAAAHLP PSMGASNGGL LYSQPSFTVN 200
    GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ PPPPPPPQGP 250
    PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 300
    YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI 350
    AAQGRKRKKR TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV 400
    RVWFCNRRQK EKRMTPPGGT LPGAEDVYGG SRDTPPHHGV QTPVQ 445
    Length:445
    Mass (Da):47,149
    Last modified:July 1, 1993 - v1
    Checksum:i1A47F10950EECE8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88300 Genomic DNA. Translation: AAA39961.1.
    AL772230 Genomic DNA. Translation: CAM22634.1.
    CCDSiCCDS18005.1.
    PIRiS31224.
    RefSeqiNP_032925.1. NM_008899.2.
    UniGeneiMm.129387.
    Mm.389520.
    Mm.487875.

    Genome annotation databases

    EnsembliENSMUST00000178174; ENSMUSP00000136147; ENSMUSG00000095139.
    GeneIDi18992.
    KEGGimmu:18992.
    UCSCiuc008sdp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88300 Genomic DNA. Translation: AAA39961.1 .
    AL772230 Genomic DNA. Translation: CAM22634.1 .
    CCDSi CCDS18005.1.
    PIRi S31224.
    RefSeqi NP_032925.1. NM_008899.2.
    UniGenei Mm.129387.
    Mm.389520.
    Mm.487875.

    3D structure databases

    ProteinModelPortali P31360.
    SMRi P31360. Positions 267-416.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P31360.

    Proteomic databases

    PRIDEi P31360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000178174 ; ENSMUSP00000136147 ; ENSMUSG00000095139 .
    GeneIDi 18992.
    KEGGi mmu:18992.
    UCSCi uc008sdp.2. mouse.

    Organism-specific databases

    CTDi 5454.
    MGIi MGI:101895. Pou3f2.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi A2AJY1.
    KOi K09365.
    OMAi MHNSSNN.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P31360.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295386.
    PROi P31360.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31360.
    CleanExi MM_POU3F2.
    Genevestigatori P31360.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and evolution of four POU domain genes expressed in mouse brain."
      Hara Y., Rovescalli C., Kim Y., Nirenberg M.
      Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPO3F2_MOUSE
    AccessioniPrimary (citable) accession number: P31360
    Secondary accession number(s): A2AJY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3