Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P31360 (PO3F2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 2
Alternative name(s):
Brain-specific homeobox/POU domain protein 2
Short name=Brain-2
Short name=Brn-2
Nervous system-specific octamer-binding transcription factor N-Oct-3
Octamer-binding protein 7
Short name=Oct-7
Octamer-binding transcription factor 7
Short name=OTF-7
Gene names
Name:Pou3f2
Synonyms:Brn-2, Brn2, Otf7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters By similarity.

Subunit structure

Interacts with PQBP1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed specifically in the neuroectodermal cell lineage.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSchwann cell development

Inferred from genetic interaction PubMed 12782656. Source: MGI

astrocyte development

Inferred from mutant phenotype PubMed 8543156. Source: MGI

cellular response to organic substance

Inferred from direct assay PubMed 18794345. Source: MGI

cerebral cortex radially oriented cell migration

Inferred from genetic interaction PubMed 12130536. Source: MGI

epidermis development

Inferred from mutant phenotype PubMed 8543156. Source: MGI

forebrain ventricular zone progenitor cell division

Inferred from genetic interaction PubMed 12130536. Source: MGI

hypothalamus cell differentiation

Inferred from mutant phenotype PubMed 8543156. Source: MGI

myelination in peripheral nervous system

Inferred from genetic interaction PubMed 12782656. Source: MGI

neurohypophysis development

Inferred from mutant phenotype PubMed 8543156. Source: MGI

neuron differentiation

Inferred from direct assay PubMed 17141158. Source: MGI

positive regulation of cell proliferation

Inferred from sequence orthology PubMed 15024079. Source: MGI

positive regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 8543156. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 17141158. Source: MGI

regulation of axonogenesis

Inferred from mutant phenotype PubMed 8543156. Source: MGI

regulation of cell differentiation

Inferred from mutant phenotype PubMed 8593698. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15465489. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 12782656. Source: MGI

transcription factor complex

Inferred from direct assay PubMed 12782656. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12782656PubMed 15465489. Source: MGI

RNA polymerase II transcription coactivator activity

Inferred from direct assay PubMed 18505825. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 17141158. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445POU domain, class 3, transcription factor 2
PRO_0000100723

Regions

Domain264 – 33875POU-specific
DNA binding356 – 41560Homeobox
Compositional bias68 – 9023Poly-Gly
Compositional bias125 – 14925Poly-Gln

Amino acid modifications

Modified residue3431Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P31360 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 1A47F10950EECE8A

FASTA44547,149
        10         20         30         40         50         60 
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ 

        70         80         90        100        110        120 
WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG 

       130        140        150        160        170        180 
PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQQ QRPPHLVHHA ANHHPGPGAW RSAAAAAHLP 

       190        200        210        220        230        240 
PSMGASNGGL LYSQPSFTVN GMLGAGGQPA GLHHHGLRDA HDEPHHADHH PHPHSHPHQQ 

       250        260        270        280        290        300 
PPPPPPPQGP PGHPGAHHDP HSDEDTPTSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL 

       310        320        330        340        350        360 
YGNVFSQTTI CRFEALQLSF KNMCKLKPLL NKWLEEADSS SGSPTSIDKI AAQGRKRKKR 

       370        380        390        400        410        420 
TSIEVSVKGA LESHFLKCPK PSAQEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPPGGT 

       430        440 
LPGAEDVYGG SRDTPPHHGV QTPVQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88300 Genomic DNA. Translation: AAA39961.1.
AL772230 Genomic DNA. Translation: CAM22634.1.
PIRS31224.
RefSeqNP_032925.1. NM_008899.2.
UniGeneMm.129387.
Mm.389520.
Mm.487875.

3D structure databases

ProteinModelPortalP31360.
SMRP31360. Positions 267-416.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP31360.

Proteomic databases

PRIDEP31360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000178174; ENSMUSP00000136147; ENSMUSG00000095139.
GeneID18992.
KEGGmmu:18992.
UCSCuc008sdp.2. mouse.

Organism-specific databases

CTD5454.
MGIMGI:101895. Pou3f2.

Phylogenomic databases

eggNOGNOG261729.
GeneTreeENSGT00730000110809.
HOGENOMHOG000116303.
HOVERGENHBG053120.
InParanoidA2AJY1.
KOK09365.
OMAMHNSSNN.
OrthoDBEOG7DJSMG.
PhylomeDBP31360.
TreeFamTF316413.

Gene expression databases

BgeeP31360.
CleanExMM_POU3F2.
GenevestigatorP31360.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295386.
PROP31360.
SOURCESearch...

Entry information

Entry namePO3F2_MOUSE
AccessionPrimary (citable) accession number: P31360
Secondary accession number(s): A2AJY1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot