Reviewed, UniProtKB/Swiss-Prot P31358 (CD52_HUMAN)

Names and origin

Protein names

Recommended name:
    CAMPATH-1 antigen
Alternative name(s):
    Cambridge pathology 1 antigen
    Epididymal secretory protein E5
    CDw52
    CD_antigen=CD52

Gene names

Name:	CD52
Synonyms:	CDW52, HE5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Ref.5.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	elevation of cytosolic calcium ion concentration Inferred from direct assay. Source: UniProtKB respiratory burst Non-traceable author statement. Source: UniProtKB
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc membrane fraction Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.1
	Peptide	25 – 36	12	CAMPATH-1 antigen		PRO_0000020904
	Propeptide	37 – 61	25	Removed in mature form Potential		PRO_0000020905
Amino acid modifications
	Lipidation	36	1	GPI-anchor amidated serine
	Glycosylation	27	1	N-linked (GlcNAc...)
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	40 – 41	2	NI → SM		VAR_005130
	Natural variant	40	1	N → S: dbSNP rs1071849.		VAR_050775
	Natural variant	41	1	I → M: dbSNP rs17645.		VAR_014838

Sequences

	Sequence		Length	Mass (Da)
	P31358-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 4AE2A056682BEEA6	FASTA	61	6,614
	10 20 30 40 50 60 MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone." Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H. Eur. J. Immunol. 21:1677-1684(1991) [PubMed: 1711975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35. Tissue: Spleen.
[2]	"A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone." Kirchhoff C., Krull N., Pera I., Ivell R. Mol. Reprod. Dev. 34:8-15(1993) [PubMed: 8418821] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis." Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L., Waldmann H. Biochem. J. 293:633-640(1993) [PubMed: 7688956] [Abstract] Cited for: GPI-ANCHOR AT SER-36.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62466 mRNA. Translation: CAA44323.1. X67699 mRNA. Translation: CAA47929.1. AL451139 Genomic DNA. Translation: CAI15846.1. BC000644 mRNA. Translation: AAH00644.1.
IPI	IPI00306137.
PIR	S18766.
RefSeq	NP_001794.2.
UniGene	Hs.276770
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P31358.
Genome annotation databases
Ensembl	ENST00000374213; ENSP00000363330; ENSG00000169442; Homo sapiens. [Genome view]
GeneID	1043.
KEGG	hsa:1043.
UCSC	uc001bmc.1. human.
Organism-specific databases
CTD	1043.
GeneCards	GC01P026516.
H-InvDB	HIX0021604.
HGNC	HGNC:1804. CD52.
MIM	114280. gene.
PharmGKB	PA26350.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P31358.
InParanoid	P31358.
OMA	IQIQTGV.
OrthoDB	EOG9JQ6M6.
Gene expression databases
ArrayExpress	P31358.
Bgee	P31358.
CleanEx	HS_CD52.
Genevestigator	P31358.
GermOnline	ENSG00000169442. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
DrugBank	DB00087. Alemtuzumab.
NextBio	4373.
SOURCE	Search...

Entry information

Entry name

CD52_HUMAN

Accession

Primary (citable) accession number: P31358
Secondary accession number(s): Q5T138, Q9BW46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	December 15, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.