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P31358

- CD52_HUMAN

UniProt

P31358 - CD52_HUMAN

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Protein

CAMPATH-1 antigen

Gene
CD52, CDW52, HE5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

GO - Biological processi

  1. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  2. respiratory burst Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CAMPATH-1 antigen
Alternative name(s):
CDw52
Cambridge pathology 1 antigen
Epididymal secretory protein E5
Human epididymis-specific protein 5
Short name:
He5
CD_antigen: CD52
Gene namesi
Name:CD52
Synonyms:CDW52, HE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1804. CD52.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Peptidei25 – 3612CAMPATH-1 antigenPRO_0000020904Add
BLAST
Propeptidei37 – 6125Removed in mature form Reviewed predictionPRO_0000020905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)
Lipidationi36 – 361GPI-anchor amidated serine1 Publication
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiP31358.

Expressioni

Gene expression databases

BgeeiP31358.
CleanExiHS_CD52.
GenevestigatoriP31358.

Interactioni

Protein-protein interaction databases

BioGridi107473. 1 interaction.
STRINGi9606.ENSP00000363330.

Structurei

3D structure databases

ProteinModelPortaliP31358.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278089.
HOGENOMiHOG000111488.
HOVERGENiHBG001036.
InParanoidiP31358.
KOiK06488.
OMAiTTFCIAV.
OrthoDBiEOG7KH9P9.
PhylomeDBiP31358.
TreeFamiTF338573.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31358-1 [UniParc]FASTAAdd to Basket

« Hide

MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV   50
ANAIIHLFCF S 61
Length:61
Mass (Da):6,614
Last modified:July 1, 1993 - v1
Checksum:i4AE2A056682BEEA6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 412NI → SM.
VAR_005130
Natural varianti40 – 401N → S.
Corresponds to variant rs1071849 [ dbSNP | Ensembl ].
VAR_050775
Natural varianti41 – 411I → M.
Corresponds to variant rs17645 [ dbSNP | Ensembl ].
VAR_014838

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62466 mRNA. Translation: CAA44323.1.
X67699 mRNA. Translation: CAA47929.1.
AL451139 Genomic DNA. Translation: CAI15846.1.
BC000644 mRNA. Translation: AAH00644.1.
CCDSiCCDS30647.1.
PIRiS18766.
RefSeqiNP_001794.2. NM_001803.2.
UniGeneiHs.276770.

Genome annotation databases

EnsembliENST00000374213; ENSP00000363330; ENSG00000169442.
GeneIDi1043.
KEGGihsa:1043.
UCSCiuc001bmc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62466 mRNA. Translation: CAA44323.1 .
X67699 mRNA. Translation: CAA47929.1 .
AL451139 Genomic DNA. Translation: CAI15846.1 .
BC000644 mRNA. Translation: AAH00644.1 .
CCDSi CCDS30647.1.
PIRi S18766.
RefSeqi NP_001794.2. NM_001803.2.
UniGenei Hs.276770.

3D structure databases

ProteinModelPortali P31358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107473. 1 interaction.
STRINGi 9606.ENSP00000363330.

Chemistry

ChEMBLi CHEMBL1912.
DrugBanki DB00087. Alemtuzumab.
GuidetoPHARMACOLOGYi 2602.

Proteomic databases

PRIDEi P31358.

Protocols and materials databases

DNASUi 1043.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374213 ; ENSP00000363330 ; ENSG00000169442 .
GeneIDi 1043.
KEGGi hsa:1043.
UCSCi uc001bmc.3. human.

Organism-specific databases

CTDi 1043.
GeneCardsi GC01P026644.
HGNCi HGNC:1804. CD52.
MIMi 114280. gene.
neXtProti NX_P31358.
PharmGKBi PA26350.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278089.
HOGENOMi HOG000111488.
HOVERGENi HBG001036.
InParanoidi P31358.
KOi K06488.
OMAi TTFCIAV.
OrthoDBi EOG7KH9P9.
PhylomeDBi P31358.
TreeFami TF338573.

Miscellaneous databases

ChiTaRSi CD52. human.
GeneWikii CD52.
GenomeRNAii 1043.
NextBioi 4373.
PROi P31358.
SOURCEi Search...

Gene expression databases

Bgeei P31358.
CleanExi HS_CD52.
Genevestigatori P31358.

Family and domain databases

InterProi IPR026643. CAMPATH-1.
[Graphical view ]
PANTHERi PTHR15029. PTHR15029. 1 hit.
Pfami PF15116. CD52. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone."
    Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H.
    Eur. J. Immunol. 21:1677-1684(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35.
    Tissue: Spleen.
  2. "A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone."
    Kirchhoff C., Krull N., Pera I., Ivell R.
    Mol. Reprod. Dev. 34:8-15(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. "Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis."
    Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L., Waldmann H.
    Biochem. J. 293:633-640(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR AT SER-36.

Entry informationi

Entry nameiCD52_HUMAN
AccessioniPrimary (citable) accession number: P31358
Secondary accession number(s): Q5T138, Q9BW46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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