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Protein

CAMPATH-1 antigen

Gene

CD52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

GO - Biological processi

  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • respiratory burst Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CAMPATH-1 antigen
Alternative name(s):
CDw52
Cambridge pathology 1 antigen
Epididymal secretory protein E5
Human epididymis-specific protein 5
Short name:
He5
CD_antigen: CD52
Gene namesi
Name:CD52
Synonyms:CDW52, HE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1804. CD52.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26350.

Chemistry

ChEMBLiCHEMBL1912.
DrugBankiDB00087. Alemtuzumab.

Polymorphism and mutation databases

BioMutaiCD52.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Peptidei25 – 3612CAMPATH-1 antigenPRO_0000020904Add
BLAST
Propeptidei37 – 6125Removed in mature formSequence analysisPRO_0000020905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)
Lipidationi36 – 361GPI-anchor amidated serine1 Publication
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP31358.
PRIDEiP31358.

Expressioni

Gene expression databases

BgeeiENSG00000169442.
CleanExiHS_CD52.
ExpressionAtlasiP31358. baseline and differential.
GenevisibleiP31358. HS.

Interactioni

Protein-protein interaction databases

BioGridi107473. 1 interaction.
STRINGi9606.ENSP00000363330.

Structurei

3D structure databases

ProteinModelPortaliP31358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KC6Z. Eukaryota.
ENOG4110P9R. LUCA.
GeneTreeiENSGT00730000112116.
HOGENOMiHOG000111488.
HOVERGENiHBG001036.
InParanoidiP31358.
KOiK06488.
OMAiIQIQTGV.
PhylomeDBiP31358.
TreeFamiTF338573.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV
60
ANAIIHLFCF S
Length:61
Mass (Da):6,614
Last modified:July 1, 1993 - v1
Checksum:i4AE2A056682BEEA6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 412NI → SM.
VAR_005130
Natural varianti40 – 401N → S.
Corresponds to variant rs1071849 [ dbSNP | Ensembl ].
VAR_050775
Natural varianti41 – 411I → M.
Corresponds to variant rs17645 [ dbSNP | Ensembl ].
VAR_014838

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62466 mRNA. Translation: CAA44323.1.
X67699 mRNA. Translation: CAA47929.1.
AL451139 Genomic DNA. Translation: CAI15846.1.
BC000644 mRNA. Translation: AAH00644.1.
CCDSiCCDS30647.1.
PIRiS18766.
RefSeqiNP_001794.2. NM_001803.2.
UniGeneiHs.276770.

Genome annotation databases

EnsembliENST00000374213; ENSP00000363330; ENSG00000169442.
GeneIDi1043.
KEGGihsa:1043.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62466 mRNA. Translation: CAA44323.1.
X67699 mRNA. Translation: CAA47929.1.
AL451139 Genomic DNA. Translation: CAI15846.1.
BC000644 mRNA. Translation: AAH00644.1.
CCDSiCCDS30647.1.
PIRiS18766.
RefSeqiNP_001794.2. NM_001803.2.
UniGeneiHs.276770.

3D structure databases

ProteinModelPortaliP31358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107473. 1 interaction.
STRINGi9606.ENSP00000363330.

Chemistry

ChEMBLiCHEMBL1912.
DrugBankiDB00087. Alemtuzumab.

Polymorphism and mutation databases

BioMutaiCD52.

Proteomic databases

PaxDbiP31358.
PRIDEiP31358.

Protocols and materials databases

DNASUi1043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374213; ENSP00000363330; ENSG00000169442.
GeneIDi1043.
KEGGihsa:1043.

Organism-specific databases

CTDi1043.
GeneCardsiCD52.
HGNCiHGNC:1804. CD52.
MIMi114280. gene.
neXtProtiNX_P31358.
PharmGKBiPA26350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC6Z. Eukaryota.
ENOG4110P9R. LUCA.
GeneTreeiENSGT00730000112116.
HOGENOMiHOG000111488.
HOVERGENiHBG001036.
InParanoidiP31358.
KOiK06488.
OMAiIQIQTGV.
PhylomeDBiP31358.
TreeFamiTF338573.

Miscellaneous databases

ChiTaRSiCD52. human.
GeneWikiiCD52.
GenomeRNAii1043.
PROiP31358.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169442.
CleanExiHS_CD52.
ExpressionAtlasiP31358. baseline and differential.
GenevisibleiP31358. HS.

Family and domain databases

InterProiIPR026643. CAMPATH-1.
[Graphical view]
PANTHERiPTHR15029. PTHR15029. 1 hit.
PfamiPF15116. CD52. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD52_HUMAN
AccessioniPrimary (citable) accession number: P31358
Secondary accession number(s): Q5T138, Q9BW46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.