P31358 (CD52_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CAMPATH-1 antigen

Alternative name(s):
CDw52
Cambridge pathology 1 antigen
Epididymal secretory protein E5
Human epididymis-specific protein 5
Short name=He5
CD_antigen=CD52

Gene names

Name:	CD52
Synonyms:	CDW52, HE5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Ref.5.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from direct assay PubMed 8223854. Source: UniProtKB respiratory burst Non-traceable author statement PubMed 8223854. Source: UniProtKB
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.1
	Peptide	25 – 36	12	CAMPATH-1 antigen		PRO_0000020904
	Propeptide	37 – 61	25	Removed in mature form Potential		PRO_0000020905
Amino acid modifications
	Lipidation	36	1	GPI-anchor amidated serine Ref.5
	Glycosylation	27	1	N-linked (GlcNAc...)
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	40 – 41	2	NI → SM.		VAR_005130
	Natural variant	40	1	N → S. Corresponds to variant rs1071849 [ dbSNP | Ensembl ].		VAR_050775
	Natural variant	41	1	I → M. Corresponds to variant rs17645 [ dbSNP | Ensembl ].		VAR_014838

Sequences

	Sequence		Length	Mass (Da)
	P31358 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 4AE2A056682BEEA6	FASTA	61	6,614
	10 20 30 40 50 60 MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone." Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H. Eur. J. Immunol. 21:1677-1684(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35. Tissue: Spleen.
[2]	"A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone." Kirchhoff C., Krull N., Pera I., Ivell R. Mol. Reprod. Dev. 34:8-15(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis." Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L., Waldmann H. Biochem. J. 293:633-640(1993) [PubMed] [Europe PMC] [Abstract] Cited for: GPI-ANCHOR AT SER-36.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62466 mRNA. Translation: CAA44323.1. X67699 mRNA. Translation: CAA47929.1. AL451139 Genomic DNA. Translation: CAI15846.1. BC000644 mRNA. Translation: AAH00644.1.
IPI	IPI00306137.
PIR	S18766.
RefSeq	NP_001794.2. NM_001803.2.
UniGene	Hs.276770.
3D structure databases
ProteinModelPortal	P31358.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363330.
Proteomic databases
PRIDE	P31358.
Protocols and materials databases
DNASU	1043.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374213; ENSP00000363330; ENSG00000169442.
GeneID	1043.
KEGG	hsa:1043.
UCSC	uc001bmc.3. human.
Organism-specific databases
CTD	1043.
GeneCards	GC01P026644.
HGNC	HGNC:1804. CD52.
MIM	114280. gene.
neXtProt	NX_P31358.
PharmGKB	PA26350.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278089.
HOGENOM	HOG000111488.
HOVERGEN	HBG001036.
InParanoid	P31358.
KO	K06488.
OMA	IQIQTGV.
OrthoDB	EOG4WSWCD.
Gene expression databases
Bgee	P31358.
CleanEx	HS_CD52.
Genevestigator	P31358.
GermOnline	ENSG00000169442. Homo sapiens.
Family and domain databases
InterPro	IPR026643. CAMPATH-1. [Graphical view]
PANTHER	PTHR15029. PTHR15029. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL1912.
ChiTaRS	CD52. human.
DrugBank	DB00087. Alemtuzumab.
GenomeRNAi	1043.
NextBio	4373.
SOURCE	Search...

Entry information

Entry name

CD52_HUMAN

Accession

Primary (citable) accession number: P31358
Secondary accession number(s): Q5T138, Q9BW46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.