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P31358 (CD52_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CAMPATH-1 antigen
Alternative name(s):
CDw52
Cambridge pathology 1 antigen
Epididymal secretory protein E5
Human epididymis-specific protein 5
Short name=He5
CD_antigen=CD52
Gene names
Name:CD52
Synonyms:CDW52, HE5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Ref.5.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.1
Peptide25 – 3612CAMPATH-1 antigen
PRO_0000020904
Propeptide37 – 6125Removed in mature form Potential
PRO_0000020905

Amino acid modifications

Lipidation361GPI-anchor amidated serine Ref.5
Glycosylation271N-linked (GlcNAc...)
Glycosylation401N-linked (GlcNAc...) Potential

Natural variations

Natural variant40 – 412NI → SM.
VAR_005130
Natural variant401N → S.
Corresponds to variant rs1071849 [ dbSNP | Ensembl ].
VAR_050775
Natural variant411I → M.
Corresponds to variant rs17645 [ dbSNP | Ensembl ].
VAR_014838

Sequences

Sequence LengthMass (Da)Tools
P31358 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 4AE2A056682BEEA6

FASTA616,614
        10         20         30         40         50         60 
MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF 


S 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone."
Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H.
Eur. J. Immunol. 21:1677-1684(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35.
Tissue: Spleen.
[2]"A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone."
Kirchhoff C., Krull N., Pera I., Ivell R.
Mol. Reprod. Dev. 34:8-15(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epididymis.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[5]"Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis."
Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L., Waldmann H.
Biochem. J. 293:633-640(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: GPI-ANCHOR AT SER-36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62466 mRNA. Translation: CAA44323.1.
X67699 mRNA. Translation: CAA47929.1.
AL451139 Genomic DNA. Translation: CAI15846.1.
BC000644 mRNA. Translation: AAH00644.1.
CCDSCCDS30647.1.
PIRS18766.
RefSeqNP_001794.2. NM_001803.2.
UniGeneHs.276770.

3D structure databases

ProteinModelPortalP31358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107473. 1 interaction.
STRING9606.ENSP00000363330.

Chemistry

ChEMBLCHEMBL1912.
DrugBankDB00087. Alemtuzumab.
GuidetoPHARMACOLOGY2602.

Proteomic databases

PRIDEP31358.

Protocols and materials databases

DNASU1043.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374213; ENSP00000363330; ENSG00000169442.
GeneID1043.
KEGGhsa:1043.
UCSCuc001bmc.3. human.

Organism-specific databases

CTD1043.
GeneCardsGC01P026644.
HGNCHGNC:1804. CD52.
MIM114280. gene.
neXtProtNX_P31358.
PharmGKBPA26350.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278089.
HOGENOMHOG000111488.
HOVERGENHBG001036.
InParanoidP31358.
KOK06488.
OMATTFCIAV.
OrthoDBEOG7KH9P9.
PhylomeDBP31358.
TreeFamTF338573.

Gene expression databases

BgeeP31358.
CleanExHS_CD52.
GenevestigatorP31358.

Family and domain databases

InterProIPR026643. CAMPATH-1.
[Graphical view]
PANTHERPTHR15029. PTHR15029. 1 hit.
PfamPF15116. CD52. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCD52. human.
GeneWikiCD52.
GenomeRNAi1043.
NextBio4373.
PROP31358.
SOURCESearch...

Entry information

Entry nameCD52_HUMAN
AccessionPrimary (citable) accession number: P31358
Secondary accession number(s): Q5T138, Q9BW46
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries