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P31358

- CD52_HUMAN

UniProt

P31358 - CD52_HUMAN

Protein

CAMPATH-1 antigen

Gene

CD52

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

    GO - Biological processi

    1. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    2. respiratory burst Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CAMPATH-1 antigen
    Alternative name(s):
    CDw52
    Cambridge pathology 1 antigen
    Epididymal secretory protein E5
    Human epididymis-specific protein 5
    Short name:
    He5
    CD_antigen: CD52
    Gene namesi
    Name:CD52
    Synonyms:CDW52, HE5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1804. CD52.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26350.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Peptidei25 – 3612CAMPATH-1 antigenPRO_0000020904Add
    BLAST
    Propeptidei37 – 6125Removed in mature formSequence AnalysisPRO_0000020905Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)
    Lipidationi36 – 361GPI-anchor amidated serine1 Publication
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiP31358.

    Expressioni

    Gene expression databases

    BgeeiP31358.
    CleanExiHS_CD52.
    GenevestigatoriP31358.

    Interactioni

    Protein-protein interaction databases

    BioGridi107473. 1 interaction.
    STRINGi9606.ENSP00000363330.

    Structurei

    3D structure databases

    ProteinModelPortaliP31358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG278089.
    HOGENOMiHOG000111488.
    HOVERGENiHBG001036.
    InParanoidiP31358.
    KOiK06488.
    OMAiTTFCIAV.
    OrthoDBiEOG7KH9P9.
    PhylomeDBiP31358.
    TreeFamiTF338573.

    Family and domain databases

    InterProiIPR026643. CAMPATH-1.
    [Graphical view]
    PANTHERiPTHR15029. PTHR15029. 1 hit.
    PfamiPF15116. CD52. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31358-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV   50
    ANAIIHLFCF S 61
    Length:61
    Mass (Da):6,614
    Last modified:July 1, 1993 - v1
    Checksum:i4AE2A056682BEEA6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 412NI → SM.
    VAR_005130
    Natural varianti40 – 401N → S.
    Corresponds to variant rs1071849 [ dbSNP | Ensembl ].
    VAR_050775
    Natural varianti41 – 411I → M.
    Corresponds to variant rs17645 [ dbSNP | Ensembl ].
    VAR_014838

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62466 mRNA. Translation: CAA44323.1.
    X67699 mRNA. Translation: CAA47929.1.
    AL451139 Genomic DNA. Translation: CAI15846.1.
    BC000644 mRNA. Translation: AAH00644.1.
    CCDSiCCDS30647.1.
    PIRiS18766.
    RefSeqiNP_001794.2. NM_001803.2.
    UniGeneiHs.276770.

    Genome annotation databases

    EnsembliENST00000374213; ENSP00000363330; ENSG00000169442.
    GeneIDi1043.
    KEGGihsa:1043.
    UCSCiuc001bmc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62466 mRNA. Translation: CAA44323.1 .
    X67699 mRNA. Translation: CAA47929.1 .
    AL451139 Genomic DNA. Translation: CAI15846.1 .
    BC000644 mRNA. Translation: AAH00644.1 .
    CCDSi CCDS30647.1.
    PIRi S18766.
    RefSeqi NP_001794.2. NM_001803.2.
    UniGenei Hs.276770.

    3D structure databases

    ProteinModelPortali P31358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107473. 1 interaction.
    STRINGi 9606.ENSP00000363330.

    Chemistry

    ChEMBLi CHEMBL1912.
    DrugBanki DB00087. Alemtuzumab.
    GuidetoPHARMACOLOGYi 2602.

    Proteomic databases

    PRIDEi P31358.

    Protocols and materials databases

    DNASUi 1043.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374213 ; ENSP00000363330 ; ENSG00000169442 .
    GeneIDi 1043.
    KEGGi hsa:1043.
    UCSCi uc001bmc.3. human.

    Organism-specific databases

    CTDi 1043.
    GeneCardsi GC01P026644.
    HGNCi HGNC:1804. CD52.
    MIMi 114280. gene.
    neXtProti NX_P31358.
    PharmGKBi PA26350.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278089.
    HOGENOMi HOG000111488.
    HOVERGENi HBG001036.
    InParanoidi P31358.
    KOi K06488.
    OMAi TTFCIAV.
    OrthoDBi EOG7KH9P9.
    PhylomeDBi P31358.
    TreeFami TF338573.

    Miscellaneous databases

    ChiTaRSi CD52. human.
    GeneWikii CD52.
    GenomeRNAii 1043.
    NextBioi 4373.
    PROi P31358.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31358.
    CleanExi HS_CD52.
    Genevestigatori P31358.

    Family and domain databases

    InterProi IPR026643. CAMPATH-1.
    [Graphical view ]
    PANTHERi PTHR15029. PTHR15029. 1 hit.
    Pfami PF15116. CD52. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone."
      Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H.
      Eur. J. Immunol. 21:1677-1684(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-35.
      Tissue: Spleen.
    2. "A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone."
      Kirchhoff C., Krull N., Pera I., Ivell R.
      Mol. Reprod. Dev. 34:8-15(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Epididymis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. "Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis."
      Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L., Waldmann H.
      Biochem. J. 293:633-640(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: GPI-ANCHOR AT SER-36.

    Entry informationi

    Entry nameiCD52_HUMAN
    AccessioniPrimary (citable) accession number: P31358
    Secondary accession number(s): Q5T138, Q9BW46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3