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Protein

Phosphomannomutase

Gene

PMM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (PMI1)
  2. Phosphomannomutase (PMM1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16NucleophileBy similarity1
Active sitei18Proton donor/acceptorSequence analysis1
Binding sitei25SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei145SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1

GO - Molecular functioni

  • phosphomannomutase activity Source: CGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:PMM1
Ordered Locus Names:CAALFM_C102480WA
ORF Names:CaO19.10454, CaO19.2937
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000183926. PMM1.

Subcellular locationi

GO - Cellular componenti

  • biofilm matrix Source: CGD
  • cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997011 – 252PhosphomannomutaseAdd BLAST252

Proteomic databases

PRIDEiP31353.

2D gel databases

COMPLUYEAST-2DPAGEiP31353.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 17Combined sources7
Turni18 – 20Combined sources3
Beta strandi24 – 26Combined sources3
Helixi30 – 42Combined sources13
Beta strandi43 – 48Combined sources6
Helixi53 – 60Combined sources8
Helixi64 – 66Combined sources3
Beta strandi69 – 73Combined sources5
Helixi74 – 76Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi84 – 88Combined sources5
Helixi91 – 95Combined sources5
Helixi97 – 113Combined sources17
Beta strandi124 – 126Combined sources3
Beta strandi131 – 133Combined sources3
Helixi142 – 155Combined sources14
Helixi157 – 168Combined sources12
Beta strandi174 – 179Combined sources6
Turni180 – 182Combined sources3
Beta strandi183 – 188Combined sources6
Helixi193 – 199Combined sources7
Helixi201 – 203Combined sources3
Beta strandi206 – 213Combined sources8
Helixi222 – 225Combined sources4
Beta strandi231 – 234Combined sources4
Helixi238 – 248Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UE7X-ray1.95A/B1-252[»]
ProteinModelPortaliP31353.
SMRiP31353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

InParanoidiP31353.
KOiK17497.
OrthoDBiEOG092C4IV8.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SFLDiSFLDG01143. C2.B.3:_Phosphomannomutase_Lik. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

P31353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG
60 70 80 90 100
SDLSKQVEQL GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY
110 120 130 140 150
NKLVKFILRY LSDIDLPIRR GTFIEFRNGM INVSPIGRNA STQERNDYEK
160 170 180 190 200
FDKQHHIRET MVEALKKEFP DFGLTYSIGG QISFDVFPTG WDKTYCLQHV
210 220 230 240 250
EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD TIRILNETFK

LQ
Length:252
Mass (Da):29,019
Last modified:July 1, 1993 - v1
Checksum:i25455FC315D85212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
CP017623 Genomic DNA. Translation: AOW25932.1.
RefSeqiXP_721436.1. XM_716343.1.

Genome annotation databases

GeneIDi3636852.
KEGGical:CAALFM_C102480WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPMM_CANAL
AccessioniPrimary (citable) accession number: P31353
Secondary accession number(s): A0A1D8PCR5, Q5AIB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 7, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families