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P31353

- PMM_CANAL

UniProt

P31353 - PMM_CANAL

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Protein
Phosphomannomutase
Gene
PMM1, CaO19.10454, CaO19.2937
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei16 – 161Nucleophile By similarity
Active sitei18 – 181Proton donor/acceptor Reviewed prediction
Binding sitei25 – 251Substrate By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei145 – 1451Substrate By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei185 – 1851Substrate By similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: CGD

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:PMM1
ORF Names:CaO19.10454, CaO19.2937
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0006021. PMM1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Phosphomannomutase
PRO_0000199701Add
BLAST

Proteomic databases

PRIDEiP31353.

2D gel databases

COMPLUYEAST-2DPAGEP31353.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5476.CAL0006021.

Structurei

3D structure databases

ProteinModelPortaliP31353.
SMRiP31353. Positions 10-245.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.

Phylogenomic databases

eggNOGiCOG0561.
KOiK17497.
OrthoDBiEOG7X3R31.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

P31353-1 [UniParc]FASTAAdd to Basket

« Hide

MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG    50
SDLSKQVEQL GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY 100
NKLVKFILRY LSDIDLPIRR GTFIEFRNGM INVSPIGRNA STQERNDYEK 150
FDKQHHIRET MVEALKKEFP DFGLTYSIGG QISFDVFPTG WDKTYCLQHV 200
EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD TIRILNETFK 250
LQ 252
Length:252
Mass (Da):29,019
Last modified:July 1, 1993 - v1
Checksum:i25455FC315D85212
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
AACQ01000017 Genomic DNA. Translation: EAL02356.1.
AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeqiXP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

Genome annotation databases

GeneIDi3636852.
3637067.
KEGGical:CaO19.10454.
cal:CaO19.2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1 .
AACQ01000017 Genomic DNA. Translation: EAL02356.1 .
AACQ01000015 Genomic DNA. Translation: EAL02637.1 .
RefSeqi XP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

3D structure databases

ProteinModelPortali P31353.
SMRi P31353. Positions 10-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0006021.

2D gel databases

COMPLUYEAST-2DPAGE P31353.

Proteomic databases

PRIDEi P31353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3636852.
3637067.
KEGGi cal:CaO19.10454.
cal:CaO19.2937.

Organism-specific databases

CGDi CAL0006021. PMM1.

Phylogenomic databases

eggNOGi COG0561.
KOi K17497.
OrthoDBi EOG7X3R31.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Candida albicans PMM1 gene encoding phosphomannomutase complements a Saccharomyces cerevisiae sec 53-6 mutation."
    Smith D.J., Cooper M., De Tiani M., Losberger C., Payton M.A.
    Curr. Genet. 22:501-503(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPMM_CANAL
AccessioniPrimary (citable) accession number: P31353
Secondary accession number(s): Q5AIB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: December 11, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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