P31353 (PMM_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphomannomutase
Short name=PMM
EC=5.4.2.8

Gene names

Name:	PMM1
ORF Names:	CaO19.10454, CaO19.2937

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the eukaryotic PMM family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GDP-mannose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway mannose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphomannomutase activity Inferred from genetic interaction Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Phosphomannomutase		PRO_0000199701
Sites
	Active site	16	1	Nucleophile By similarity
	Active site	18	1	By similarity
	Active site	51	1	By similarity
	Active site	193	1	By similarity
	Binding site	25	1	Substrate By similarity
	Binding site	127	1	Substrate By similarity
	Binding site	138	1	Substrate By similarity
	Binding site	145	1	Substrate By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	185	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P31353 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 25455FC315D85212	FASTA	252	29,019
	10 20 30 40 50 60 MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG SDLSKQVEQL 70 80 90 100 110 120 GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY NKLVKFILRY LSDIDLPIRR 130 140 150 160 170 180 GTFIEFRNGM INVSPIGRNA STQERNDYEK FDKQHHIRET MVEALKKEFP DFGLTYSIGG 190 200 210 220 230 240 QISFDVFPTG WDKTYCLQHV EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD 250 TIRILNETFK LQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Candida albicans PMM1 gene encoding phosphomannomutase complements a Saccharomyces cerevisiae sec 53-6 mutation." Smith D.J., Cooper M., De Tiani M., Losberger C., Payton M.A. Curr. Genet. 22:501-503(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M96770 Genomic DNA. Translation: AAA34356.1. AACQ01000017 Genomic DNA. Translation: EAL02356.1. AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeq	XP_721164.1. XM_716071.1. XP_721436.1. XM_716343.1.
3D structure databases
ProteinModelPortal	P31353.
SMR	P31353. Positions 10-245.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0006021.
2D gel databases
COMPLUYEAST-2DPAGE	P31353.
Proteomic databases
PRIDE	P31353.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3636852. 3637067.
KEGG	cal:CaO19.10454. cal:CaO19.2937.
Organism-specific databases
CGD	CAL0006021. PMM1.
Phylogenomic databases
eggNOG	COG0561.
KO	K01840.
Enzyme and pathway databases
UniPathway	UPA00126; UER00424.
Family and domain databases
Gene3D	3.40.50.1000. 2 hits.
InterPro	IPR023214. HAD-like_dom. IPR006379. HAD-SF_hydro_IIB. IPR005002. PMM. [Graphical view]
PANTHER	PTHR10466. PTHR10466. 1 hit.
Pfam	PF03332. PMM. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PMM_CANAL

Accession

Primary (citable) accession number: P31353
Secondary accession number(s): Q5AIB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program