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Protein

Phosphomannomutase

Gene

PMM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (PMI1), Mannose-6-phosphate isomerase (PMI1)
  2. Phosphomannomutase (PMM1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16NucleophileBy similarity1
Active sitei18Proton donor/acceptorSequence analysis1
Binding sitei25SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei145SubstrateBy similarity1
Binding sitei183SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1

GO - Molecular functioni

  • phosphomannomutase activity Source: CGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:PMM1
ORF Names:CaO19.10454, CaO19.2937
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000183926. PMM1.

Subcellular locationi

GO - Cellular componenti

  • biofilm matrix Source: CGD
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997011 – 252PhosphomannomutaseAdd BLAST252

Proteomic databases

PRIDEiP31353.

2D gel databases

COMPLUYEAST-2DPAGEP31353.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP31353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

InParanoidiP31353.
KOiK17497.
OrthoDBiEOG092C4IV8.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

P31353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG
60 70 80 90 100
SDLSKQVEQL GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY
110 120 130 140 150
NKLVKFILRY LSDIDLPIRR GTFIEFRNGM INVSPIGRNA STQERNDYEK
160 170 180 190 200
FDKQHHIRET MVEALKKEFP DFGLTYSIGG QISFDVFPTG WDKTYCLQHV
210 220 230 240 250
EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD TIRILNETFK

LQ
Length:252
Mass (Da):29,019
Last modified:July 1, 1993 - v1
Checksum:i25455FC315D85212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
AACQ01000017 Genomic DNA. Translation: EAL02356.1.
AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeqiXP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

Genome annotation databases

EnsemblFungiiEAL02356; EAL02356; CaO19.10454.
EAL02637; EAL02637; CaO19.2937.
GeneIDi3636852.
3637067.
KEGGical:CaO19.10454.
cal:CaO19.2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
AACQ01000017 Genomic DNA. Translation: EAL02356.1.
AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeqiXP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

3D structure databases

ProteinModelPortaliP31353.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEP31353.

Proteomic databases

PRIDEiP31353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL02356; EAL02356; CaO19.10454.
EAL02637; EAL02637; CaO19.2937.
GeneIDi3636852.
3637067.
KEGGical:CaO19.10454.
cal:CaO19.2937.

Organism-specific databases

CGDiCAL0000183926. PMM1.

Phylogenomic databases

InParanoidiP31353.
KOiK17497.
OrthoDBiEOG092C4IV8.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMM_CANAL
AccessioniPrimary (citable) accession number: P31353
Secondary accession number(s): Q5AIB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.