Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphomannomutase

Gene

PMM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei16 – 161NucleophileBy similarity
Active sitei18 – 181Proton donor/acceptorSequence Analysis
Binding sitei25 – 251SubstrateBy similarity
Binding sitei127 – 1271SubstrateBy similarity
Binding sitei138 – 1381SubstrateBy similarity
Binding sitei145 – 1451SubstrateBy similarity
Binding sitei183 – 1831SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: CGD

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:PMM1
ORF Names:CaO19.10454, CaO19.2937
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0006021. PMM1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252PhosphomannomutasePRO_0000199701Add
BLAST

Proteomic databases

PRIDEiP31353.

2D gel databases

COMPLUYEAST-2DPAGEP31353.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0006021.

Structurei

3D structure databases

ProteinModelPortaliP31353.
SMRiP31353. Positions 10-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
InParanoidiP31353.
KOiK17497.
OrthoDBiEOG7X3R31.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

P31353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG
60 70 80 90 100
SDLSKQVEQL GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY
110 120 130 140 150
NKLVKFILRY LSDIDLPIRR GTFIEFRNGM INVSPIGRNA STQERNDYEK
160 170 180 190 200
FDKQHHIRET MVEALKKEFP DFGLTYSIGG QISFDVFPTG WDKTYCLQHV
210 220 230 240 250
EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD TIRILNETFK

LQ
Length:252
Mass (Da):29,019
Last modified:June 30, 1993 - v1
Checksum:i25455FC315D85212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
AACQ01000017 Genomic DNA. Translation: EAL02356.1.
AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeqiXP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

Genome annotation databases

GeneIDi3636852.
3637067.
KEGGical:CaO19.10454.
cal:CaO19.2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96770 Genomic DNA. Translation: AAA34356.1.
AACQ01000017 Genomic DNA. Translation: EAL02356.1.
AACQ01000015 Genomic DNA. Translation: EAL02637.1.
RefSeqiXP_721164.1. XM_716071.1.
XP_721436.1. XM_716343.1.

3D structure databases

ProteinModelPortaliP31353.
SMRiP31353. Positions 10-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0006021.

2D gel databases

COMPLUYEAST-2DPAGEP31353.

Proteomic databases

PRIDEiP31353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3636852.
3637067.
KEGGical:CaO19.10454.
cal:CaO19.2937.

Organism-specific databases

CGDiCAL0006021. PMM1.

Phylogenomic databases

eggNOGiCOG0561.
InParanoidiP31353.
KOiK17497.
OrthoDBiEOG7X3R31.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Candida albicans PMM1 gene encoding phosphomannomutase complements a Saccharomyces cerevisiae sec 53-6 mutation."
    Smith D.J., Cooper M., De Tiani M., Losberger C., Payton M.A.
    Curr. Genet. 22:501-503(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPMM_CANAL
AccessioniPrimary (citable) accession number: P31353
Secondary accession number(s): Q5AIB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1993
Last sequence update: June 30, 1993
Last modified: January 6, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.