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P31353

- PMM_CANAL

UniProt

P31353 - PMM_CANAL

Protein

Phosphomannomutase

Gene

PMM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei16 – 161NucleophileBy similarity
    Active sitei18 – 181Proton donor/acceptorSequence Analysis
    Binding sitei25 – 251SubstrateBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei138 – 1381SubstrateBy similarity
    Binding sitei145 – 1451SubstrateBy similarity
    Binding sitei183 – 1831SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: CGD

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:PMM1
    ORF Names:CaO19.10454, CaO19.2937
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0006021. PMM1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252PhosphomannomutasePRO_0000199701Add
    BLAST

    Proteomic databases

    PRIDEiP31353.

    2D gel databases

    COMPLUYEAST-2DPAGEP31353.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0006021.

    Structurei

    3D structure databases

    ProteinModelPortaliP31353.
    SMRiP31353. Positions 10-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    eggNOGiCOG0561.
    KOiK17497.
    OrthoDBiEOG7X3R31.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P31353-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFANKQDPK TLVLFDVDGT LTPARLTISE EMKKTLEKLR EKVVIGFVGG    50
    SDLSKQVEQL GPNVLNDFDY CFSENGLTAY KLGKELASQS FINWIGNEKY 100
    NKLVKFILRY LSDIDLPIRR GTFIEFRNGM INVSPIGRNA STQERNDYEK 150
    FDKQHHIRET MVEALKKEFP DFGLTYSIGG QISFDVFPTG WDKTYCLQHV 200
    EDEHFENIHF FGDKSYKGGN DYEIYNDPRT IGHAVNSPDD TIRILNETFK 250
    LQ 252
    Length:252
    Mass (Da):29,019
    Last modified:July 1, 1993 - v1
    Checksum:i25455FC315D85212
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96770 Genomic DNA. Translation: AAA34356.1.
    AACQ01000017 Genomic DNA. Translation: EAL02356.1.
    AACQ01000015 Genomic DNA. Translation: EAL02637.1.
    RefSeqiXP_721164.1. XM_716071.1.
    XP_721436.1. XM_716343.1.

    Genome annotation databases

    GeneIDi3636852.
    3637067.
    KEGGical:CaO19.10454.
    cal:CaO19.2937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96770 Genomic DNA. Translation: AAA34356.1 .
    AACQ01000017 Genomic DNA. Translation: EAL02356.1 .
    AACQ01000015 Genomic DNA. Translation: EAL02637.1 .
    RefSeqi XP_721164.1. XM_716071.1.
    XP_721436.1. XM_716343.1.

    3D structure databases

    ProteinModelPortali P31353.
    SMRi P31353. Positions 10-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0006021.

    2D gel databases

    COMPLUYEAST-2DPAGE P31353.

    Proteomic databases

    PRIDEi P31353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3636852.
    3637067.
    KEGGi cal:CaO19.10454.
    cal:CaO19.2937.

    Organism-specific databases

    CGDi CAL0006021. PMM1.

    Phylogenomic databases

    eggNOGi COG0561.
    KOi K17497.
    OrthoDBi EOG7X3R31.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Candida albicans PMM1 gene encoding phosphomannomutase complements a Saccharomyces cerevisiae sec 53-6 mutation."
      Smith D.J., Cooper M., De Tiani M., Losberger C., Payton M.A.
      Curr. Genet. 22:501-503(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPMM_CANAL
    AccessioniPrimary (citable) accession number: P31353
    Secondary accession number(s): Q5AIB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3