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Reviewed, UniProtKB/Swiss-Prot P31335 (PUR9_CHICK)

Last modified June 16, 2009. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Bifunctional purine biosynthesis protein PURH
Including the following 2 domains:
    1- Recommended name:
            Phosphoribosylaminoimidazolecarboxamide formyltransferase
              EC=2.1.2.3
        Alternative name(s):
            5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
            AICAR transformylase
    2- Recommended name:
            IMP cyclohydrolase
              EC=3.5.4.10
        Alternative name(s):
            Inosinicase
            IMP synthetase
            ATIC
Gene names
Name: ATIC
Synonyms: PURH
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Subunit structure

Homodimer (Possible).

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.

Sequence similarities

Belongs to the purH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Bifunctional purine biosynthesis protein PURH
PRO_0000192155

Secondary structure

1 ........................................................................................................... 593
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P31335-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: BD1A34F03D96A136

FASTA59364,415
        10         20         30         40         50         60 
MAARQQLALL SVSEKAGLVE FARSLNALGL GLIASGGTAT ALRDAGLPVR DVSDLTGFPE 

        70         80         90        100        110        120 
MLGGRVKTLH PAVHAGILAR NIPEDNADMN KQDFSLVRVV VCNLYPFVKT VSSPGVTVPE 

       130        140        150        160        170        180 
AVEKIDIGGV ALLRAAAKNH ARVTVVCDPA DYSSVAKEMA ASKDKDTSVE TRRHLALKAF 

       190        200        210        220        230        240 
THTAQYDAAI SDYFRKEYSK GVSQLPLRYG MNPHQSPAQL YTTRPKLPLT VVNGSPGFIN 

       250        260        270        280        290        300 
LCDALNAWQL VKELKQALGI PAAASFKHVS PAGAAVGIPL SEEEAQVCMV HDLHKTLTPL 

       310        320        330        340        350        360 
ASAYARSRGA DRMSSFGDFI ALSDICDVPT AKIISREVSD GVVAPGYEEE ALKILSKKKN 

       370        380        390        400        410        420 
GGYCVLQMDP NYEPDDNEIR TLYGLQLMQK RNNAVIDRSL FKNIVTKNKT LPESAVRDLI 

       430        440        450        460        470        480 
VASIAVKYTQ SNSVCYAKDG QVIGIGAGQQ SRIHCTRLAG DKANSWWLRH HPRVLSMKFK 

       490        500        510        520        530        540 
AGVKRAEVSN AIDQYVTGTI GEDEDLVKWQ AMFEEVPAQL TEAEKKQWIA KLTAVSLSSD 

       550        560        570        580        590 
AFFPFRDNVD RAKRIGVQFI VAPSGSAADE VVIEACNELG ITLIHTNLRL FHH

« Hide

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References

[1]"De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase."
Ni L., Guan K., Zalkin H., Dixon J.E.
Gene 106:197-205(1991) [PubMed: 1937050] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

S64492 mRNA. Translation: AAB20309.1.
IPIIPI00600106.
PIRDTCHPH. JQ1281.
RefSeqNP_990509.1.
UniGeneGga.4556

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1G8MX-ray1.75A/B1-593[»]
1M9NX-ray1.93A/B1-593[»]
1OZ0X-ray2.50A/B1-593[»]
1THZX-ray1.80A/B1-593[»]
2B1GX-ray2.10A/B/C/D1-593[»]
2B1IX-ray2.02A/B1-593[»]
2IU0X-ray2.53A/B1-593[»]
2IU3X-ray2.90A/B1-593[»]
ModBaseSearch...

Genome annotation databases

EnsemblENSGALG00000003570. Gallus gallus. [Contig view]
GeneID396091.
KEGGgga:396091.

Phylogenomic databases

HOGENOMP31335.
HOVERGENP31335.

Enzyme and pathway databases

BRENDA2.1.2.3. 4.
3.5.4.10. 4.

Family and domain databases

InterProIPR002695. AICARFT_IMPCHas.
IPR013982. AICARFT_IMPCHas_formly.
IPR011607. MGS.
[Graphical view]
PANTHERPTHR11692. AICARFT_IMPCHas. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
[Graphical view]
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

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Entry information

Entry namePUR9_CHICK
AccessionPrimary (citable) accession number: P31335
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents