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Protein

Carbamoyl-phosphate synthase [ammonia], mitochondrial

Gene

CPS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Catalytic activityi

2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate.

Enzyme regulationi

Requires N-acetyl-L-glutamate (NAG) as an allosteric activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1391 – 13911Allosteric activatorCurated
Binding sitei1394 – 13941Allosteric activatorCurated
Binding sitei1410 – 14101Allosteric activatorCurated
Binding sitei1437 – 14371Allosteric activatorCurated
Binding sitei1440 – 14401Allosteric activatorCurated
Binding sitei1449 – 14491Allosteric activatorCurated

GO - Molecular functioni

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  • anion homeostasis Source: Ensembl
  • arginine biosynthetic process Source: GO_Central
  • carbamoyl phosphate biosynthetic process Source: UniProtKB
  • cellular nitrogen compound metabolic process Source: Reactome
  • cellular response to cAMP Source: Ensembl
  • cellular response to fibroblast growth factor stimulus Source: Ensembl
  • cellular response to glucagon stimulus Source: Ensembl
  • cellular response to oleic acid Source: Ensembl
  • citrulline biosynthetic process Source: BHF-UCL
  • glutamine metabolic process Source: InterPro
  • glycogen catabolic process Source: BHF-UCL
  • hepatocyte differentiation Source: Ensembl
  • homocysteine metabolic process Source: UniProtKB
  • midgut development Source: Ensembl
  • nitric oxide metabolic process Source: BHF-UCL
  • positive regulation of vasodilation Source: BHF-UCL
  • response to amine Source: Ensembl
  • response to amino acid Source: Ensembl
  • response to dexamethasone Source: Ensembl
  • response to drug Source: Ensembl
  • response to food Source: Ensembl
  • response to growth hormone Source: Ensembl
  • response to lipopolysaccharide Source: UniProtKB
  • response to starvation Source: Ensembl
  • response to toxic substance Source: Ensembl
  • response to zinc ion Source: Ensembl
  • small molecule metabolic process Source: Reactome
  • triglyceride catabolic process Source: BHF-UCL
  • urea cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS00415-MONOMER.
BRENDAi6.3.4.16. 2681.
ReactomeiREACT_847. Urea cycle.
SABIO-RKP31327.

Protein family/group databases

MEROPSiC26.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC:6.3.4.16)
Alternative name(s):
Carbamoyl-phosphate synthetase I
Short name:
CPSase I
Gene namesi
Name:CPS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2323. CPS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Involvement in diseasei

Carbamoyl phosphate synthetase 1 deficiency (CPS1D)11 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder of the urea cycle causing hyperammonemia. It can present as a devastating metabolic disease dominated by severe hyperammonemia in neonates or as a more insidious late-onset condition, generally manifesting as life-threatening hyperammonemic crises under catabolic situations. Clinical features include protein intolerance, intermittent ataxia, seizures, lethargy, developmental delay and mental retardation.

See also OMIM:237300
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431A → V in CPS1D. 1 Publication
VAR_066171
Natural varianti58 – 581G → D in CPS1D. 1 Publication
VAR_066172
Natural varianti65 – 651S → F in CPS1D. 1 Publication
VAR_066173
Natural varianti71 – 711V → G in CPS1D. 1 Publication
VAR_066174
Natural varianti79 – 791G → E in CPS1D. 1 Publication
VAR_063560
Natural varianti87 – 871P → S in CPS1D. 1 Publication
VAR_066175
Natural varianti89 – 891Y → D in CPS1D. 1 Publication
VAR_066176
Natural varianti123 – 1231S → F in CPS1D; modestly decreases enzyme activity. 1 Publication
VAR_064062
Natural varianti165 – 1651D → G in CPS1D. 1 Publication
VAR_066177
Natural varianti212 – 2121Y → N in CPS1D. 1 Publication
VAR_063561
Natural varianti224 – 2241D → V in CPS1D. 1 Publication
VAR_066178
Natural varianti233 – 2331R → C in CPS1D. 1 Publication
VAR_066179
Natural varianti243 – 2431H → P in CPS1D. 1 Publication
VAR_066180
Natural varianti258 – 2581G → E in CPS1D. 1 Publication
VAR_066181
Natural varianti263 – 2631G → E in CPS1D. 1 Publication
VAR_066182
Natural varianti280 – 2801K → N in CPS1D. 1 Publication
VAR_063562
Natural varianti301 – 3011G → E in CPS1D. 1 Publication
VAR_066104
Natural varianti304 – 3041A → V in CPS1D; associated with T-986. 1 Publication
VAR_066183
Natural varianti317 – 3171G → E in CPS1D. 1 Publication
VAR_066184
Natural varianti337 – 3371H → R in CPS1D; modestly decreases enzyme activity. 2 Publications
Corresponds to variant rs28940283 [ dbSNP | Ensembl ].
VAR_014077
Natural varianti358 – 3581D → H in CPS1D. 1 Publication
VAR_066185
Natural varianti382 – 3821P → L in CPS1D. 1 Publication
VAR_066186
Natural varianti389 – 3891Y → C in CPS1D. 1 Publication
VAR_066105
Natural varianti390 – 3901L → R in CPS1D. 1 Publication
VAR_066106
Natural varianti401 – 4011G → R in CPS1D. 1 Publication
VAR_066187
Natural varianti431 – 4311G → R in CPS1D. 1 Publication
VAR_066188
Natural varianti432 – 4321G → V in CPS1D. 1 Publication
VAR_066189
Natural varianti438 – 4381A → P in CPS1D. 1 Publication
VAR_063563
Natural varianti438 – 4381A → T in CPS1D. 1 Publication
VAR_066190
Natural varianti450 – 4501K → E in CPS1D. 1 Publication
VAR_066191
Natural varianti457 – 4571V → G in CPS1D. 1 Publication
VAR_017562
Natural varianti471 – 4711T → N in CPS1D. 1 Publication
VAR_064063
Natural varianti498 – 4981A → P in CPS1D. 1 Publication
VAR_066192
Natural varianti531 – 5311V → E in CPS1D. 1 Publication
VAR_066193
Natural varianti531 – 5311V → G in CPS1D. 1 Publication
VAR_066194
Natural varianti544 – 5441T → M in CPS1D. 2 Publications
VAR_006835
Natural varianti587 – 5871R → C in CPS1D. 1 Publication
VAR_066195
Natural varianti587 – 5871R → H in CPS1D. 2 Publications
VAR_063564
Natural varianti587 – 5871R → L in CPS1D. 1 Publication
VAR_066196
Natural varianti589 – 5891A → T in CPS1D. 1 Publication
VAR_066142
Natural varianti593 – 5931G → R in CPS1D. 1 Publication
VAR_063565
Natural varianti597 – 5971S → L in CPS1D. 1 Publication
VAR_066197
Natural varianti622 – 6221V → M in CPS1D. 1 Publication
VAR_066198
Natural varianti628 – 6281G → D in CPS1D. 1 Publication
VAR_066199
Natural varianti632 – 6321I → R in CPS1D. 1 Publication
VAR_066200
Natural varianti638 – 6381R → P in CPS1D. 1 Publication
VAR_066201
Natural varianti640 – 6401A → S in CPS1D. 1 Publication
Corresponds to variant rs142693704 [ dbSNP | Ensembl ].
VAR_066143
Natural varianti648 – 6481C → Y in CPS1D. 1 Publication
VAR_066202
Natural varianti651 – 6511E → K in CPS1D. 1 Publication
VAR_063566
Natural varianti654 – 6541D → V in CPS1D. 1 Publication
VAR_066203
Natural varianti674 – 6741N → I in CPS1D. 1 Publication
VAR_063567
Natural varianti674 – 6741N → K in CPS1D. 1 Publication
VAR_066204
Natural varianti678 – 6781Q → P in CPS1D; results in a poor enzyme expression and solubility; hampers correct enzyme folding. 1 Publication
VAR_064064
Natural varianti698 – 6981N → S in CPS1D. 1 Publication
VAR_066205
Natural varianti716 – 7161N → K in CPS1D. 1 Publication
VAR_066144
Natural varianti718 – 7181R → K in CPS1D. 1 Publication
VAR_066107
Natural varianti721 – 7211R → Q in CPS1D. 1 Publication
VAR_066108
Natural varianti724 – 7241A → P in CPS1D. 1 Publication
VAR_066109
Natural varianti726 – 7261A → T in CPS1D. 1 Publication
VAR_066110
Natural varianti767 – 7671D → V in CPS1D. 1 Publication
VAR_066111
Natural varianti774 – 7741P → L in CPS1D; the enzyme is inactive. 1 Publication
VAR_064065
Natural varianti780 – 7801R → H in CPS1D. 2 Publications
VAR_063568
Natural varianti792 – 7921M → I in CPS1D. 1 Publication
VAR_066112
Natural varianti803 – 8031R → C in CPS1D. 1 Publication
VAR_066145
Natural varianti803 – 8031R → G in CPS1D. 1 Publication
VAR_066146
Natural varianti803 – 8031R → S in CPS1D. 1 Publication
VAR_066147
Natural varianti805 – 8051F → L in CPS1D. 1 Publication
VAR_066148
Natural varianti805 – 8051F → S in CPS1D. 1 Publication
VAR_066149
Natural varianti810 – 8101Q → R in CPS1D. 1 Publication
VAR_017563
Natural varianti814 – 8141R → W in CPS1D. 1 Publication
VAR_066150
Natural varianti816 – 8161C → R in CPS1D. 1 Publication
VAR_066151
Natural varianti843 – 8431L → S in CPS1D. 2 Publications
VAR_017564
Natural varianti850 – 8501R → C in CPS1D. 1 Publication
VAR_063569
Natural varianti850 – 8501R → H in CPS1D. 2 Publications
VAR_030675
Natural varianti875 – 8751K → E in CPS1D. 2 Publications
Corresponds to variant rs147062907 [ dbSNP | Ensembl ].
VAR_017565
Natural varianti911 – 9111G → E in CPS1D. 1 Publication
VAR_066152
Natural varianti911 – 9111G → V in CPS1D. 1 Publication
VAR_066153
Natural varianti913 – 9131S → L in CPS1D. 1 Publication
VAR_066154
Natural varianti914 – 9141D → G in CPS1D. 1 Publication
VAR_066155
Natural varianti914 – 9141D → H in CPS1D. 1 Publication
VAR_066156
Natural varianti918 – 9181S → P in CPS1D. 1 Publication
VAR_030676
Natural varianti932 – 9321R → T in CPS1D. 1 Publication
VAR_066157
Natural varianti949 – 9491A → T in CPS1D. 1 Publication
VAR_066158
Natural varianti958 – 9581L → P in CPS1D. 1 Publication
VAR_066159
Natural varianti959 – 9591Y → C in CPS1D. 1 Publication
VAR_066160
Natural varianti962 – 9621Y → C in CPS1D. 1 Publication
VAR_066161
Natural varianti978 – 9781V → E in CPS1D. 1 Publication
VAR_066113
Natural varianti982 – 9821G → D in CPS1D. 1 Publication
VAR_063570
Natural varianti982 – 9821G → S in CPS1D. 1 Publication
VAR_066162
Natural varianti982 – 9821G → V in CPS1D. 1 Publication
VAR_066114
Natural varianti984 – 9841Y → H in CPS1D. 1 Publication
VAR_066115
Natural varianti986 – 9861I → T in CPS1D; associated with V-304. 1 Publication
VAR_066116
Natural varianti987 – 9871G → C in CPS1D; may affect splicing. 1 Publication
VAR_066117
Natural varianti992 – 9921F → S in CPS1D. 1 Publication
VAR_066118
Natural varianti998 – 9981S → F in CPS1D. 1 Publication
VAR_066163
Natural varianti1016 – 10161N → S in CPS1D. 1 Publication
VAR_066119
Natural varianti1017 – 10171P → L in CPS1D. 1 Publication
VAR_066120
Natural varianti1022 – 10221T → I in CPS1D. 1 Publication
VAR_066121
Natural varianti1034 – 10341E → G in CPS1D. 1 Publication
VAR_066122
Natural varianti1045 – 10451H → R in CPS1D. 1 Publication
VAR_066123
Natural varianti1054 – 10541I → R in CPS1D. 1 Publication
VAR_066164
Natural varianti1059 – 10591Q → R in CPS1D. 1 Publication
VAR_066124
Natural varianti1065 – 10651A → E in CPS1D. 1 Publication
VAR_066125
Natural varianti1089 – 10891R → C in CPS1D. 1 Publication
VAR_066126
Natural varianti1089 – 10891R → L in CPS1D. 1 Publication
VAR_066165
Natural varianti1103 – 11031Q → R in CPS1D. 1 Publication
VAR_063571
Natural varianti1141 – 11411V → G in CPS1D. 1 Publication
VAR_063572
Natural varianti1155 – 11551A → E in CPS1D. 1 Publication
VAR_066127
Natural varianti1155 – 11551A → V in CPS1D. 1 Publication
VAR_066128
Natural varianti1195 – 11951H → P in CPS1D. 1 Publication
VAR_063573
Natural varianti1203 – 12031S → L in CPS1D. 1 Publication
VAR_066129
Natural varianti1203 – 12031S → P in CPS1D. 1 Publication
VAR_066166
Natural varianti1205 – 12051D → N in CPS1D. 1 Publication
VAR_066167
Natural varianti1215 – 12151I → V in CPS1D. 1 Publication
Corresponds to variant rs141373204 [ dbSNP | Ensembl ].
VAR_063574
Natural varianti1228 – 12281R → Q in CPS1D. 1 Publication
VAR_066130
Natural varianti1241 – 12411N → K in CPS1D. 1 Publication
VAR_063575
Natural varianti1255 – 12551E → D in CPS1D. 1 Publication
VAR_066131
Natural varianti1262 – 12621R → P in CPS1D. 1 Publication
VAR_066132
Natural varianti1262 – 12621R → Q in CPS1D. 1 Publication
VAR_066133
Natural varianti1274 – 12741D → H in CPS1D. 1 Publication
VAR_066134
Natural varianti1327 – 13271C → R in CPS1D. 1 Publication
VAR_066135
Natural varianti1331 – 13311S → P in CPS1D. 1 Publication
VAR_066168
Natural varianti1333 – 13331G → E in CPS1D. 1 Publication
VAR_066136
Natural varianti1371 – 13711R → L in CPS1D. 1 Publication
VAR_066137
Natural varianti1378 – 13781A → T in CPS1D. 1 Publication
VAR_066169
Natural varianti1391 – 13911T → M in CPS1D. 1 Publication
VAR_066138
Natural varianti1398 – 13981L → V in CPS1D. 1 Publication
VAR_066139
Natural varianti1411 – 14111P → L in CPS1D; modestly decreases enzyme activity. 2 Publications
VAR_064066
Natural varianti1439 – 14391P → L in CPS1D. 1 Publication
VAR_066140
Natural varianti1443 – 14431T → A in CPS1D. 1 Publication
VAR_066170
Natural varianti1453 – 14531R → Q in CPS1D; the enzyme is inactive. 1 Publication
VAR_064067
Natural varianti1453 – 14531R → W in CPS1D; the enzyme is inactive. 2 Publications
VAR_064068
Natural varianti1462 – 14621P → R in CPS1D. 1 Publication
VAR_066141
Natural varianti1491 – 14911Y → H in CPS1D; triggers a large decrease in the apparent affinity for N-acetyl-L-glutamate (NAG). 1 Publication
VAR_064069
Pulmonary hypertension, neonatal (PHN)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. CPS1 variants influence the availability of precursors for nitric oxide (NO) synthesis and play a role in clinical situations where endogenous NO production is critically important, such as neonatal pulmonary hypertension, increased pulmonary artery pressure following surgical repair of congenital heart defects or hepatovenocclusive disease following bone marrow transplantation. Infants with neonatal pulmonary hypertension homozygous for Thr-1406 have lower L-arginine concentrations than neonates homozygous for Asn-1406 (PubMed:11407344).

Disease descriptionA disease characterized by elevated pulmonary artery pressure. Pulmonary hypertension in the neonate is associated with multiple underlying problems such as respiratory distress syndrome, meconium aspiration syndrome, congenital diaphragmatic hernia, bronchopulmonary dysplasia, sepsis, or congenital heart disease.

See also OMIM:615371
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti530 – 5301G → V Found in a patient with VACTERL syndrome and postsurgical PHN; variant of unknown pathological significance. 1 Publication
VAR_070211
Natural varianti1406 – 14061T → N Associated with PHN susceptibility; 30-40% higher activity; also highly associated with hepatocellular carcinoma (HCC) progression. 7 Publications
Corresponds to variant rs1047891 [ dbSNP | Ensembl ].
VAR_017569

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi237300. phenotype.
615371. phenotype.
Orphaneti147. Carbamoyl-phosphate synthase deficiency.
PharmGKBiPA26840.

Chemistry

DrugBankiDB06775. Carglumic Acid.

Polymorphism and mutation databases

BioMutaiCPS1.
DMDMi4033707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionBy similarityAdd
BLAST
Chaini39 – 15001462Carbamoyl-phosphate synthase [ammonia], mitochondrialPRO_0000029897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551N6-acetyllysine; alternateBy similarity
Modified residuei55 – 551N6-glutaryllysine1 Publication
Modified residuei55 – 551N6-succinyllysine; alternateBy similarity
Modified residuei57 – 571N6-acetyllysine; alternateBy similarity
Modified residuei57 – 571N6-succinyllysine; alternateBy similarity
Modified residuei119 – 1191N6-acetyllysine; alternateBy similarity
Modified residuei119 – 1191N6-succinyllysine; alternateBy similarity
Modified residuei148 – 1481Phosphoserine1 Publication
Modified residuei157 – 1571N6-acetyllysine; alternateBy similarity
Modified residuei157 – 1571N6-succinyllysine; alternateBy similarity
Modified residuei171 – 1711N6-acetyllysineBy similarity
Modified residuei171 – 1711N6-glutaryllysine1 Publication
Modified residuei176 – 1761N6-glutaryllysine1 Publication
Modified residuei182 – 1821N6-acetyllysineBy similarity
Modified residuei197 – 1971N6-acetyllysineBy similarity
Modified residuei207 – 2071N6-acetyllysine; alternateBy similarity
Modified residuei207 – 2071N6-glutaryllysine1 Publication
Modified residuei207 – 2071N6-succinyllysine; alternateBy similarity
Modified residuei210 – 2101N6-acetyllysineBy similarity
Modified residuei210 – 2101N6-glutaryllysine1 Publication
Modified residuei214 – 2141N6-acetyllysine; alternateBy similarity
Modified residuei214 – 2141N6-glutaryllysine1 Publication
Modified residuei214 – 2141N6-succinyllysine; alternateBy similarity
Modified residuei219 – 2191N6-acetyllysineBy similarity
Modified residuei219 – 2191N6-glutaryllysine1 Publication
Modified residuei228 – 2281N6-acetyllysineBy similarity
Modified residuei228 – 2281N6-glutaryllysine1 Publication
Modified residuei237 – 2371N6-glutaryllysine1 Publication
Modified residuei280 – 2801N6-acetyllysineBy similarity
Modified residuei280 – 2801N6-glutaryllysine1 Publication
Modified residuei287 – 2871N6-acetyllysine; alternateBy similarity
Modified residuei287 – 2871N6-succinyllysine; alternateBy similarity
Modified residuei307 – 3071N6-acetyllysine; alternateBy similarity
Modified residuei307 – 3071N6-glutaryllysine1 Publication
Modified residuei307 – 3071N6-succinyllysine; alternateBy similarity
Modified residuei310 – 3101N6-acetyllysineBy similarity
Modified residuei310 – 3101N6-glutaryllysine1 Publication
Modified residuei400 – 4001N6-succinyllysineBy similarity
Modified residuei402 – 4021N6-glutaryllysine1 Publication
Modified residuei402 – 4021N6-succinyllysineBy similarity
Modified residuei412 – 4121N6-acetyllysine; alternateBy similarity
Modified residuei412 – 4121N6-glutaryllysine1 Publication
Modified residuei412 – 4121N6-succinyllysine; alternateBy similarity
Modified residuei453 – 4531N6-acetyllysineBy similarity
Modified residuei453 – 4531N6-glutaryllysine1 Publication
Modified residuei458 – 4581N6-acetyllysine; alternateBy similarity
Modified residuei458 – 4581N6-glutaryllysine1 Publication
Modified residuei458 – 4581N6-succinyllysine; alternateBy similarity
Modified residuei522 – 5221N6-acetyllysine; alternateBy similarity
Modified residuei522 – 5221N6-succinyllysine; alternateBy similarity
Modified residuei527 – 5271N6-acetyllysine; alternateBy similarity
Modified residuei527 – 5271N6-glutaryllysine1 Publication
Modified residuei527 – 5271N6-succinyllysine; alternateBy similarity
Modified residuei532 – 5321N6-acetyllysineBy similarity
Modified residuei532 – 5321N6-glutaryllysine1 Publication
Modified residuei537 – 5371Phosphoserine; alternateBy similarity
Glycosylationi537 – 5371O-linked (GlcNAc); alternateBy similarity
Modified residuei553 – 5531N6-acetyllysine; alternateBy similarity
Modified residuei553 – 5531N6-glutaryllysine1 Publication
Modified residuei553 – 5531N6-succinyllysine; alternateBy similarity
Modified residuei560 – 5601N6-acetyllysine; alternateBy similarity
Modified residuei560 – 5601N6-succinyllysine; alternateBy similarity
Modified residuei569 – 5691Phosphoserine1 Publication
Modified residuei575 – 5751N6-acetyllysine; alternateBy similarity
Modified residuei575 – 5751N6-succinyllysine; alternateBy similarity
Modified residuei612 – 6121N6-acetyllysine; alternateBy similarity
Modified residuei612 – 6121N6-succinyllysine; alternateBy similarity
Modified residuei630 – 6301N6-acetyllysineBy similarity
Modified residuei728 – 7281N6-glutaryllysine1 Publication
Modified residuei751 – 7511N6-acetyllysine; alternateBy similarity
Modified residuei751 – 7511N6-succinyllysine; alternateBy similarity
Modified residuei757 – 7571N6-acetyllysine; alternateBy similarity
Modified residuei757 – 7571N6-glutaryllysine1 Publication
Modified residuei757 – 7571N6-succinyllysine; alternateBy similarity
Modified residuei772 – 7721N6-acetyllysineBy similarity
Modified residuei772 – 7721N6-glutaryllysine1 Publication
Modified residuei793 – 7931N6-acetyllysine; alternateBy similarity
Modified residuei793 – 7931N6-glutaryllysine1 Publication
Modified residuei793 – 7931N6-succinyllysine; alternateBy similarity
Modified residuei811 – 8111N6-acetyllysineBy similarity
Modified residuei811 – 8111N6-glutaryllysine1 Publication
Modified residuei831 – 8311N6-acetyllysine; alternateBy similarity
Modified residuei831 – 8311N6-succinyllysine; alternateBy similarity
Modified residuei835 – 8351Phosphoserine1 Publication
Modified residuei841 – 8411N6-acetyllysineBy similarity
Modified residuei841 – 8411N6-glutaryllysine1 Publication
Modified residuei856 – 8561N6-acetyllysineBy similarity
Modified residuei856 – 8561N6-glutaryllysine1 Publication
Modified residuei869 – 8691N6-glutaryllysine1 Publication
Modified residuei875 – 8751N6-acetyllysine; alternateBy similarity
Modified residuei875 – 8751N6-glutaryllysine1 Publication
Modified residuei875 – 8751N6-succinyllysine; alternateBy similarity
Modified residuei889 – 8891N6-acetyllysine; alternateBy similarity
Modified residuei889 – 8891N6-glutaryllysine1 Publication
Modified residuei889 – 8891N6-succinyllysine; alternateBy similarity
Modified residuei892 – 8921N6-acetyllysine; alternateBy similarity
Modified residuei892 – 8921N6-glutaryllysine1 Publication
Modified residuei892 – 8921N6-succinyllysine; alternateBy similarity
Modified residuei905 – 9051N6-glutaryllysine1 Publication
Modified residuei908 – 9081N6-acetyllysineBy similarity
Modified residuei908 – 9081N6-glutaryllysine1 Publication
Modified residuei915 – 9151N6-acetyllysine; alternateBy similarity
Modified residuei915 – 9151N6-glutaryllysine1 Publication
Modified residuei915 – 9151N6-succinyllysine; alternateBy similarity
Modified residuei919 – 9191N6-acetyllysine; alternateBy similarity
Modified residuei919 – 9191N6-glutaryllysine1 Publication
Modified residuei919 – 9191N6-succinyllysine; alternateBy similarity
Modified residuei935 – 9351N6-acetyllysineBy similarity
Modified residuei1074 – 10741N6-acetyllysine; alternateBy similarity
Modified residuei1074 – 10741N6-glutaryllysine1 Publication
Modified residuei1074 – 10741N6-succinyllysine; alternateBy similarity
Modified residuei1079 – 10791Phosphoserine1 Publication
Modified residuei1100 – 11001N6-acetyllysine; alternateBy similarity
Modified residuei1100 – 11001N6-succinyllysine; alternateBy similarity
Modified residuei1149 – 11491N6-succinyllysineBy similarity