Reviewed, UniProtKB/Swiss-Prot P31327 (CPSM_HUMAN)

Names and origin

Protein names

Recommended name:
    Carbamoyl-phosphate synthase [ammonia], mitochondrial
    EC=6.3.4.16
Alternative name(s):
    Carbamoyl-phosphate synthetase I
      Short name=CPSase I

Gene names

Name:

CPS1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Catalytic activity	2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate.
Enzyme regulation	Requires N-acetylglutamate as an allosteric activator.
Subcellular location	Mitochondrion.
Tissue specificity	Primarily in the liver and small intestine.
Domain	The type-1 glutamine amidotransferase domain is defective.
Involvement in disease	Defects in CPS1 are the cause of carbamoyl phosphate synthetase 1 deficiency (CPS1D) [MIM:237300]. CPS1D is an autosomal recessive disorder of the urea cycle causing hyperammonemia. Clinical features include protein intolerance, intermittent ataxia, seizures, lethargy, developmental delay and mental retardation. Ref.2 Ref.5 Ref.6 Ref.9 Ref.11 Ref.12 Defects in CPS1 are associated with susceptibility to familial persistent pulmonary hypertension of the newborn [MIM:265380]; also called congenital alveolar capillary dysplasia or CACD. Failure of the transition to a cardiorespiratory circulation at birth results in persistent pulmonary hypertension of the newborn. Characterized by elevated pulmonary vascular resistance with extrapulmonary right-to-left shunting of blood across the patent ductus arteriosus or the foramen ovale, persistent pulmonary hypertension can cause life-threatening hypoxemia in newborn infants. Transitional pulmonary hypertension occurs in 1.9 of every 1000 newborn infants and is associated with a mortality rate of 11 percent.
Sequence similarities	Contains 2 ATP-grasp domains. Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Urea cycle
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	carbamoyl phosphate biosynthetic process Inferred from mutant phenotype. Source: UniProtKB citrulline biosynthetic process Non-traceable author statement. Source: UniProtKB glutamine metabolic process Inferred from electronic annotation. Source: InterPro glycogen catabolic process Ref.2 Inferred from mutant phenotype. Source: UniProtKB nitric oxide metabolic process Inferred from mutant phenotype. Source: UniProtKB positive regulation of vasodilation Inferred from mutant phenotype. Source: UniProtKB response to lipopolysaccharide Inferred from direct assay. Source: UniProtKB triglyceride catabolic process Ref.2 Inferred from mutant phenotype. Source: UniProtKB urea cycle Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	mitochondrial nucleoid Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carbamoyl-phosphate synthase (ammonia) activity Ref.2 Inferred from mutant phenotype. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARAF	P10398	3	EBI-536811,EBI-365961
RAF1	P04049	2	EBI-536811,EBI-365996

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P31327-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P31327-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-451: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 38

38

Mitochondrion By similarity

Chain

39 – 1500

1462

Carbamoyl-phosphate synthase [ammonia], mitochondrial

PRO_0000029897

Regions

Domain

219 – 404

186

Glutamine amidotransferase type-1

Domain

551 – 743

193

ATP-grasp 1

Domain

1093 – 1284

192

ATP-grasp 2

Region

39 – 218

180

Anthranilate phosphoribosyltransferase homolog

Amino acid modifications

Modified residue

55

1

N6-acetyllysine By similarity

Modified residue

119

1

N6-acetyllysine By similarity

Modified residue

287

1

N6-acetyllysine By similarity

Modified residue

527

1

N6-acetyllysine By similarity

Modified residue

841

1

N6-acetyllysine By similarity

Modified residue

892

1

N6-acetyllysine By similarity

Modified residue

898

1

Phosphoserine By similarity

Modified residue

1291

1

N6-acetyllysine By similarity

Natural variations

Alternative sequence

1 – 451

451

Missing in isoform 2.

VSP_009332

Natural variant

337

1

H → R in CPS1D. dbSNP rs28940283. Ref.9

VAR_014077

Natural variant

344

1

T → A: dbSNP rs1047883. Ref.2 Ref.3

VAR_006834

Natural variant

457

1

V → G in CPS1D. Ref.5

VAR_017562

Natural variant

544

1

T → M in CPS1D. Ref.2

VAR_006835

Natural variant

810

1

Q → R in CPS1D. Ref.5

VAR_017563

Natural variant

843

1

L → S in CPS1D. Ref.6 Ref.12

VAR_017564

Natural variant

850

1

R → H in CPS1D. Ref.11

VAR_030675

Natural variant

875

1

K → E in CPS1D. Ref.6 Ref.12

VAR_017565

Natural variant

918

1

S → P in CPS1D. Ref.11

VAR_030676

Natural variant

1266

1

F → S: dbSNP rs1047886. Ref.1

VAR_017566

Natural variant

1283

1

M → L: dbSNP rs1047887. Ref.1

VAR_017567

Natural variant

1376

1

G → S Ref.3

VAR_017568

Natural variant

1406

1

T → N 30-40% higher activity; risk factor for persistent pulmonary hypertension of the newborn. dbSNP rs1047891. Ref.5 Ref.3 Ref.1 Ref.10

VAR_017569

Experimental info

Sequence conflict

111

1

A → S in BAA14328. Ref.1

Sequence conflict

279

1

R → Q in BAA14328. Ref.1

Sequence conflict

338

1

G → C in BAA14328. Ref.1

Sequence conflict

718 – 722

5

RLSRS → KMSPN in BAA14328. Ref.1

Sequence conflict

729

1

A → T in BAA14328. Ref.1

Sequence conflict

749

1

E → G in BAA14328. Ref.1

Sequence conflict

912

1

F → L in CAE45707. Ref.6

Sequence conflict

1161 – 1162

2

EH → AT in BAA14328. Ref.1

Sequence conflict

1204 – 1205

2

GD → EN in BAA14328. Ref.1

Sequence conflict

1254

1

I → N in BAA14328. Ref.1

Sequence conflict

1303

1

A → V in BAA14328. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1500

Helix Strand Turn

Details...

Helix

1344 – 1350

7

Beta strand

1360 – 1365

6

Helix

1368 – 1370

3

Helix

1371 – 1382

12

Turn

1383 – 1385

3

Beta strand

1387 – 1391

5

Helix

1392 – 1400

9

Beta strand

1406 – 1408

3

Helix

1411 – 1413

3

Helix

1423 – 1428

6

Beta strand

1434 – 1437

4

Helix

1443 – 1445

3

Helix

1446 – 1458

13

Helix

1467 – 1475

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: E53A22D77563961D	FASTA	1,500	164,939
	10 20 30 40 50 60 MTRILTAFKV VRTLKTGFGF TNVTAHQKWK FSRPGIRLLS VKAQTAHIVL EDGTKMKGYS 70 80 90 100 110 120 FGHPSSVAGE VVFNTGLGGY PEAITDPAYK GQILTMANPI IGNGGAPDTT ALDELGLSKY 130 140 150 160 170 180 LESNGIKVSG LLVLDYSKDY NHWLATKSLG QWLQEEKVPA IYGVDTRMLT KIIRDKGTML 190 200 210 220 230 240 GKIEFEGQPV DFVDPNKQNL IAEVSTKDVK VYGKGNPTKV VAVDCGIKNN VIRLLVKRGA 250 260 270 280 290 300 EVHLVPWNHD FTKMEYDGIL IAGGPGNPAL AEPLIQNVRK ILESDRKEPL FGISTGNLIT 310 320 330 340 350 360 GLAAGAKTYK MSMANRGQNQ PVLNITNKQA FITAQNHGYA LDNTLPAGWK PLFVNVNDQT 370 380 390 400 410 420 NEGIMHESKP FFAVQFHPEV TPGPIDTEYL FDSFFSLIKK GKATTITSVL PKPALVASRV 430 440 450 460 470 480 EVSKVLILGS GGLSIGQAGE FDYSGSQAVK AMKEENVKTV LMNPNIASVQ TNEVGLKQAD 490 500 510 520 530 540 TVYFLPITPQ FVTEVIKAEQ PDGLILGMGG QTALNCGVEL FKRGVLKEYG VKVLGTSVES 550 560 570 580 590 600 IMATEDRQLF SDKLNEINEK IAPSFAVESI EDALKAADTI GYPVMIRSAY ALGGLGSGIC 610 620 630 640 650 660 PNRETLMDLS TKAFAMTNQI LVEKSVTGWK EIEYEVVRDA DDNCVTVCNM ENVDAMGVHT 670 680 690 700 710 720 GDSVVVAPAQ TLSNAEFQML RRTSINVVRH LGIVGECNIQ FALHPTSMEY CIIEVNARLS 730 740 750 760 770 780 RSSALASKAT GYPLAFIAAK IALGIPLPEI KNVVSGKTSA CFEPSLDYMV TKIPRWDLDR 790 800 810 820 830 840 FHGTSSRIGS SMKSVGEVMA IGRTFEESFQ KALRMCHPSI EGFTPRLPMN KEWPSNLDLR 850 860 870 880 890 900 KELSEPSSTR IYAIAKAIDD NMSLDEIEKL TYIDKWFLYK MRDILNMEKT LKGLNSESMT 910 920 930 940 950 960 EETLKRAKEI GFSDKQISKC LGLTEAQTRE LRLKKNIHPW VKQIDTLAAE YPSVTNYLYV 970 980 990 1000 1010 1020 TYNGQEHDVN FDDHGMMVLG CGPYHIGSSV EFDWCAVSSI RTLRQLGKKT VVVNCNPETV 1030 1040 1050 1060 1070 1080 STDFDECDKL YFEELSLERI LDIYHQEACG GCIISVGGQI PNNLAVPLYK NGVKIMGTSP 1090 1100 1110 1120 1130 1140 LQIDRAEDRS IFSAVLDELK VAQAPWKAVN TLNEALEFAK SVDYPCLLRP SYVLSGSAMN 1150 1160 1170 1180 1190 1200 VVFSEDEMKK FLEEATRVSQ EHPVVLTKFV EGAREVEMDA VGKDGRVISH AISEHVEDAG 1210 1220 1230 1240 1250 1260 VHSGDATLML PTQTISQGAI EKVKDATRKI AKAFAISGPF NVQFLVKGND VLVIECNLRA 1270 1280 1290 1300 1310 1320 SRSFPFVSKT LGVDFIDVAT KVMIGENVDE KHLPTLDHPI IPADYVAIKA PMFSWPRLRD 1330 1340 1350 1360 1370 1380 ADPILRCEMA STGEVACFGE GIHTAFLKAM LSTGFKIPQK GILIGIQQSF RPRFLGVAEQ 1390 1400 1410 1420 1430 1440 LHNEGFKLFA TEATSDWLNA NNVPATPVAW PSQEGQNPSL SSIRKLIRDG SIDLVINLPN 1450 1460 1470 1480 1490 1500 NNTKFVHDNY VIRRTAVDSG IPLLTNFQVT KLFAEAVQKS RKVDSKSLFH YRQYSAGKAA
	Isoform 2. Checksum: 74C9ABBFABAD2AD2	FASTA	1,049	116,038
	10 20 30 40 50 60 MKEENVKTVL MNPNIASVQT NEVGLKQADT VYFLPITPQF VTEVIKAEQP DGLILGMGGQ 70 80 90 100 110 120 TALNCGVELF KRGVLKEYGV KVLGTSVESI MATEDRQLFS DKLNEINEKI APSFAVESIE 130 140 150 160 170 180 DALKAADTIG YPVMIRSAYA LGGLGSGICP NRETLMDLST KAFAMTNQIL VEKSVTGWKE 190 200 210 220 230 240 IEYEVVRDAD DNCVTVCNME NVDAMGVHTG DSVVVAPAQT LSNAEFQMLR RTSINVVRHL 250 260 270 280 290 300 GIVGECNIQF ALHPTSMEYC IIEVNARLSR SSALASKATG YPLAFIAAKI ALGIPLPEIK 310 320 330 340 350 360 NVVSGKTSAC FEPSLDYMVT KIPRWDLDRF HGTSSRIGSS MKSVGEVMAI GRTFEESFQK 370 380 390 400 410 420 ALRMCHPSIE GFTPRLPMNK EWPSNLDLRK ELSEPSSTRI YAIAKAIDDN MSLDEIEKLT 430 440 450 460 470 480 YIDKWFLYKM RDILNMEKTL KGLNSESMTE ETLKRAKEIG FSDKQISKCL GLTEAQTREL 490 500 510 520 530 540 RLKKNIHPWV KQIDTLAAEY PSVTNYLYVT YNGQEHDVNF DDHGMMVLGC GPYHIGSSVE 550 560 570 580 590 600 FDWCAVSSIR TLRQLGKKTV VVNCNPETVS TDFDECDKLY FEELSLERIL DIYHQEACGG 610 620 630 640 650 660 CIISVGGQIP NNLAVPLYKN GVKIMGTSPL QIDRAEDRSI FSAVLDELKV AQAPWKAVNT 670 680 690 700 710 720 LNEALEFAKS VDYPCLLRPS YVLSGSAMNV VFSEDEMKKF LEEATRVSQE HPVVLTKFVE 730 740 750 760 770 780 GAREVEMDAV GKDGRVISHA ISEHVEDAGV HSGDATLMLP TQTISQGAIE KVKDATRKIA 790 800 810 820 830 840 KAFAISGPFN VQFLVKGNDV LVIECNLRAS RSFPFVSKTL GVDFIDVATK VMIGENVDEK 850 860 870 880 890 900 HLPTLDHPII PADYVAIKAP MFSWPRLRDA DPILRCEMAS TGEVACFGEG IHTAFLKAML 910 920 930 940 950 960 STGFKIPQKG ILIGIQQSFR PRFLGVAEQL HNEGFKLFAT EATSDWLNAN NVPATPVAWP 970 980 990 1000 1010 1020 SQEGQNPSLS SIRKLIRDGS IDLVINLPNN NTKFVHDNYV IRRTAVDSGI PLLTNFQVTK 1030 1040 LFAEAVQKSR KVDSKSLFHY RQYSAGKAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperammonemia." Haraguchi Y., Uchino T., Takiguchi M., Endo F., Mori M., Matsuda I. Gene 107:335-340(1991) [PubMed: 1840546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-1266; LEU-1283 AND ASN-1406. Tissue: Liver.
[2]	"Prenatal diagnosis of carbamoyl phosphate synthetase I deficiency by identification of a missense mutation in CPS1." Finckh U., Kohlschuetter A., Schaefer H., Sperhake K., Colombo J.-P., Gal A. Hum. Mutat. 12:206-211(1998) [PubMed: 9711878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CPS1D MET-544, VARIANT ALA-344. Tissue: Liver.
[3]	"Characterization of genomic structure and polymorphisms in the human carbamyl phosphate synthetase I gene." Summar M.L., Hall L.D., Eeds A.M., Hutcheson H.B., Kuo A.N., Willis A.S., Rubio V., Arvin M.K., Schofield J.P., Dawson E.P. Gene 311:51-57(2003) [PubMed: 12853138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-344; SER-1376 AND ASN-1406.
[4]	"Cloning of an isoform of CPS1 gene related to spermatogenesis." Huo R., Zhu H., Huang X.Y., Xu Z.Y., Lu L., Xu M., Yin L.L., Li J.M., Zhou Z.M., Sha J.H. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[5]	"Structural organization of the human carbamyl phosphate synthetase I gene (CPS1) and identification of two novel genetic lesions." Funghini S., Donati M.A., Pasquini E., Zammarchi E., Morrone A. Hum. Mutat. 22:340-341(2003) [PubMed: 12955727] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS CPS1D GLY-457 AND ARG-810, VARIANT ASN-1406.
[6]	"Gene structure of human carbamylphosphate synthetase 1 and novel mutations in patients with neonatal onset." Haeberle J., Schmidt E., Pauli S., Rapp B., Christensen E., Wermuth B., Koch H.G. Hum. Mutat. 21:444-444(2003) [PubMed: 12655559] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS CPS1D SER-843 AND GLU-875.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 795-1500. Tissue: Small intestine.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	"Novel mutations (H337R and 238-362del) in the CPS1 gene cause carbamoyl phosphate synthetase I deficiency." Aoshima T., Kajita M., Sekido Y., Kikuchi S., Yasuda I., Saheki T., Watanabe K., Shimokata K., Niwa T. Hum. Hered. 52:99-101(2001) [PubMed: 11474210] [Abstract] Cited for: VARIANT CPS1D ARG-337.
[10]	"Neonatal pulmonary hypertension -- urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function." Pearson D.L., Dawling S., Walsh W.F., Haines J.L., Christman B.W., Bazyk A., Scott N., Summar M.L. N. Engl. J. Med. 344:1832-1838(2001) [PubMed: 11407344] [Abstract] Cited for: VARIANT ASN-1406.
[11]	"Mutational analysis of carbamoylphosphate synthetase I deficiency in three Japanese patients." Wakutani Y., Nakayasu H., Takeshima T., Adachi M., Kawataki M., Kihira K., Sawada H., Bonno M., Yamamoto H., Nakashima K. J. Inherit. Metab. Dis. 27:787-788(2004) [PubMed: 15617192] [Abstract] Cited for: VARIANTS CPS1D HIS-850 AND PRO-918.
[12]	"Genetic approach to prenatal diagnosis in urea cycle defects." Haeberle J., Koch H.G. Prenat. Diagn. 24:378-383(2004) [PubMed: 15164414] [Abstract] Cited for: VARIANTS CPS1D SER-843 AND GLU-875.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBLGenBankDDBJ

D90282 mRNA. Translation: BAA14328.1.
Y15793 mRNA. Translation: CAA75785.1.
AF154830 mRNA. Translation: AAD38072.1.
AY317138 mRNA. Translation: AAP84318.1.
AY167007 , AY166970, AY166971, AY166972, AY166973, AY166974, AY166975, AY166976, AY166977, AY166978, AY166979, AY166980, AY166981, AY166982, AY166983, AY166984, AY166985, AY166986, AY166987, AY166988, AY166989, AY166990, AY166991, AY166992, AY166993, AY166994, AY166995, AY166996, AY166997, AY166998, AY166999, AY167000, AY167001, AY167002, AY167003, AY167004, AY167005, AY167006 Genomic DNA. Translation: AAO31763.1.
AF536523 Genomic DNA. Translation: AAN77181.1.
BX640601 mRNA. Translation: CAE45707.1.

IPI

IPI00011062.
IPI00397498.

PIR

JQ1348.

RefSeq

NP_001116105.1.
NP_001116106.1.
NP_001866.2.

UniGene

Hs.149252

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YVQ	X-ray	1.98	A	1343-1478	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P31327. 2 interactions.

Protein family/group databases

MEROPS

C26.951.

PTM databases

PhosphoSite

P31327.

Proteomic databases

PRIDE

P31327.

Genome annotation databases

Ensembl

ENSG00000021826. Homo sapiens. [Contig view]

GeneID

1373.

KEGG

hsa:1373.

UCSC

uc002vee.2. human.
uc010fus.1. human.

Organism-specific databases

GeneCards

GC02P211050.

HGNC

HGNC:2323. CPS1.

HPA

CAB003781.

MIM

237300. phenotype.
265380. phenotype.
608307. gene.

Orphanet

147. Carbamoylphosphate synthetase deficiency.

PharmGKB

PA26840.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P31327.

OMA

P31327. MDLSTKA.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-11364.

BRENDA

6.3.4.16. 247.

Reactome

REACT_13. Metabolism of amino acids.

Gene expression databases

ArrayExpress

P31327.

Bgee

P31327.

CleanEx

HS_CPS1.

GermOnline

ENSG00000021826. Homo sapiens.

Family and domain databases

InterPro

IPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR001317. CarbamoylP_synth_GATase.
IPR005483. CarbamoylP_synth_lsu.
IPR005479. CarbamoylP_synth_lsu_ATP-bd.
IPR006275. CarbamoylP_synth_lsu_Gln-dep.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
IPR000991. GATase_class1_C.
IPR011607. MGS.
IPR013817. Pre-ATP_grasp.
[Graphical view]

Gene3D

G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 2 hits.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.

Pfam

PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]

PRINTS

PR00098. CPSASE.
PR00099. CPSGATASE.

TIGRFAMs

TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.

PROSITE

PS50975. ATP_GRASP. 2 hits.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

5565.

SOURCE

Search...

Entry information

Entry name

CPSM_HUMAN

Accession

Primary (citable) accession number: P31327
Secondary accession number(s): O43774, Q7Z5I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	December 15, 1998
Last modified:	July 7, 2009
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)