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Protein

GS homeobox 1

Gene

Gsx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi146 – 20560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adenohypophysis development Source: MGI
  • hypothalamus development Source: MGI
  • neuron fate commitment Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • spinal cord association neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GS homeobox 1
Alternative name(s):
Homeobox protein GSH-1
Gene namesi
Name:Gsx1
Synonyms:Gsh-1, Gsh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95842. Gsx1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261GS homeobox 1PRO_0000048895Add
BLAST

Proteomic databases

PaxDbiP31315.
PRIDEiP31315.

PTM databases

iPTMnetiP31315.
PhosphoSiteiP31315.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053129.
CleanExiMM_GSX1.
ExpressionAtlasiP31315. baseline.
GenevisibleiP31315. MM.

Interactioni

Protein-protein interaction databases

BioGridi200085. 1 interaction.
STRINGi10090.ENSMUSP00000069728.

Structurei

3D structure databases

ProteinModelPortaliP31315.
SMRiP31315. Positions 148-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi110 – 1178Poly-Ala

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000010106.
HOVERGENiHBG003555.
InParanoidiP31315.
KOiK09310.
OMAiHNCKCSS.
OrthoDBiEOG091G0HAO.
PhylomeDBiP31315.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVDSL VLREASDKKA PEGSPPPLFP YAVPPPHALH GLSPGACHAR
60 70 80 90 100
KAGLLCVCPL CVTASQLHGP PGPPALPLLK ASFPPFGSQY CHAPLGRQHS
110 120 130 140 150
VSPGVAHGPA AAAAAAALYQ TSYPLPDPRQ FHCISVDSSS NQLPSSKRMR
160 170 180 190 200
TAFTSTQLLE LEREFASNMY LSRLRRIEIA TYLNLSEKQV KIWFQNRRVK
210 220 230 240 250
HKKEGKGSNH RGGAGAGAGG GAPQGCKCSS LSSAKCSEDD DELPMSPSSS
260
GKDDRDLTVT P
Length:261
Mass (Da):27,728
Last modified:October 1, 1996 - v2
Checksum:iBA9D6B94359E4FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21224 mRNA. Translation: AAA96814.1.
CCDSiCCDS19877.1.
PIRiS63604.
RefSeqiNP_032204.1. NM_008178.2.
UniGeneiMm.4797.

Genome annotation databases

EnsembliENSMUST00000065382; ENSMUSP00000069728; ENSMUSG00000053129.
GeneIDi14842.
KEGGimmu:14842.
UCSCiuc009anw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21224 mRNA. Translation: AAA96814.1.
CCDSiCCDS19877.1.
PIRiS63604.
RefSeqiNP_032204.1. NM_008178.2.
UniGeneiMm.4797.

3D structure databases

ProteinModelPortaliP31315.
SMRiP31315. Positions 148-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200085. 1 interaction.
STRINGi10090.ENSMUSP00000069728.

PTM databases

iPTMnetiP31315.
PhosphoSiteiP31315.

Proteomic databases

PaxDbiP31315.
PRIDEiP31315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065382; ENSMUSP00000069728; ENSMUSG00000053129.
GeneIDi14842.
KEGGimmu:14842.
UCSCiuc009anw.1. mouse.

Organism-specific databases

CTDi219409.
MGIiMGI:95842. Gsx1.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000010106.
HOVERGENiHBG003555.
InParanoidiP31315.
KOiK09310.
OMAiHNCKCSS.
OrthoDBiEOG091G0HAO.
PhylomeDBiP31315.
TreeFamiTF315938.

Miscellaneous databases

PROiP31315.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053129.
CleanExiMM_GSX1.
ExpressionAtlasiP31315. baseline.
GenevisibleiP31315. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSX1_MOUSE
AccessioniPrimary (citable) accession number: P31315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.