Reviewed,
UniProtKB/Swiss-Prot P31314 (TLX1_HUMAN)
Last modified
June 16, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: T-cell leukemia homeobox protein 1 Alternative name(s): Homeobox protein Hox-11 T-cell leukemia/lymphoma protein 3 Proto-oncogene TCL-3 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 330 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. |
| Subcellular location | Nucleus Probable. |
| Involvement in disease | A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. |
| Miscellaneous | TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity. |
| Sequence similarities | Contains 1 homeobox DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24." Kennedy M.A., Gonzalez-Sarmiento R., Kees U.R., Lampert F., Dear T.N., Boehm T., Rabbitts T.H. Proc. Natl. Acad. Sci. U.S.A. 88:8900-8904(1991) [PubMed: 1681546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein." Lu M., Gong Z., Shen W., Ho A.D. EMBO J. 10:2905-2910(1991) [PubMed: 1717256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia." Hatano M., Roberts C.W., Minden M., Crist W.M., Korsmeyer S.J. Science 253:79-82(1991) [PubMed: 1676542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells." Lu M., Zhang N., Ho A.D. Oncogene 7:1325-1330(1992) [PubMed: 1352396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line." Watt P.M., Ranford P.R., Kees U.R. Gene 234:169-176(1999) [PubMed: 10393251] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [6] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "Multiple negative elements contribute to repression of the HOX11 proto-oncogene." Brake R.L., Kees U.R., Watt P.M. Oncogene 17:1787-1795(1998) [PubMed: 9778044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64. |
| [9] | "A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene." Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., Bellgard M.I. Gene 391:223-232(2007) [PubMed: 17303350] [Abstract] Cited for: IDENTIFICATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M75952 mRNA. Translation: AAA58662.1. M62626 mRNA. Translation: AAA36719.1. S38742 mRNA. Translation: AAB19293.1. AJ009794 Genomic DNA. Translation: CAA08834.1. AL357395 Genomic DNA. Translation: CAH72448.1. CH471066 Genomic DNA. Translation: EAW49778.1. AF067443 Genomic DNA. Translation: AAG10096.1. | |
| IPI | IPI00011051. |
| PIR | A40855. |
| RefSeq | NP_005512.1. |
| UniGene | Hs.89583 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IG7 based on UniProtKB P13297. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:155N. |
Proteomic databases | |
| PRIDE | P31314. |
Genome annotation databases | |
| Ensembl | ENSG00000107807. Homo sapiens. [Contig view] |
| GeneID | 3195. |
| KEGG | hsa:3195. |
Organism-specific databases | |
| GeneCards | GC10P102880. |
| HGNC | HGNC:5056. TLX1. |
| MIM | 186770. gene+phenotype. |
| Orphanet | 513. Leukemia, lymphoblastic, acute. |
| PharmGKB | PA35095. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P31314. |
| HOVERGEN | P31314. |
| OMA | P31314. NVNMALA. |
Gene expression databases | |
| ArrayExpress | P31314. |
| Bgee | P31314. |
| CleanEx | HS_TLX1. |
| GermOnline | ENSG00000107807. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 12708. |
| SOURCE | Search... |
Entry information
| Entry name | TLX1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31314 Secondary accession number(s): O75699, Q5VXP2, Q9HCA0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


