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P31314 (TLX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox protein Hox-11
Proto-oncogene TCL-3
T-cell leukemia/lymphoma protein 3
Gene names
Name:TLX1
Synonyms:HOX11, TCL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Subunit structure

Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3. Ref.13

Subcellular location

Nucleus Probable.

Involvement in disease

A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

Miscellaneous

TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P31314-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P31314-2)

The sequence of this isoform differs from the canonical sequence as follows:
     258-330: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330T-cell leukemia homeobox protein 1
PRO_0000049333

Regions

DNA binding201 – 26060Homeobox

Amino acid modifications

Modified residue2361N6-acetyllysine Ref.12

Natural variations

Alternative sequence258 – 33073Missing in isoform 2.
VSP_043068

Experimental info

Sequence conflict711A → T in CAA08834. Ref.5
Sequence conflict2761L → R in AAB19293. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 09A518FB5271F7ED

FASTA33034,365
        10         20         30         40         50         60 
MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG 

        70         80         90        100        110        120 
GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS 

       130        140        150        160        170        180 
GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN 

       190        200        210        220        230        240 
RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM 

       250        260        270        280        290        300 
TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN 

       310        320        330 
SSLFALQNLQ PWSDDSTKIT SVTSVASACE 

« Hide

Isoform 2 [UniParc].

Checksum: A8072D76E4FC6CC7
Show »

FASTA25726,245

References

« Hide 'large scale' references
[1]"The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein."
Lu M., Gong Z., Shen W., Ho A.D.
EMBO J. 10:2905-2910(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[2]"HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24."
Kennedy M.A., Gonzalez-Sarmiento R., Kees U.R., Lampert F., Dear T.N., Boehm T., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 88:8900-8904(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[3]"Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia."
Hatano M., Roberts C.W., Minden M., Crist W.M., Korsmeyer S.J.
Science 253:79-82(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells."
Lu M., Zhang N., Ho A.D.
Oncogene 7:1325-1330(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line."
Watt P.M., Ranford P.R., Kees U.R.
Gene 234:169-176(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[9]"Multiple negative elements contribute to repression of the HOX11 proto-oncogene."
Brake R.L., Kees U.R., Watt P.M.
Oncogene 17:1787-1795(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
[10]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-247 (ISOFORM 1/2).
Tissue: Bone marrow.
[11]"A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene."
Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., Bellgard M.I.
Gene 391:223-232(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[12]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"MEIS proteins as partners of the TLX1/HOX11 oncoprotein."
Milech N., Gottardo N.G., Ford J., D'Souza D., Greene W.K., Kees U.R., Watt P.M.
Leuk. Res. 34:358-363(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEIS1; MEIS2; PBX1; PBX2 AND PBX3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62626 mRNA. Translation: AAA36719.1.
M75952 mRNA. Translation: AAA58662.1.
S38742 mRNA. Translation: AAB19293.1.
AJ009794 Genomic DNA. Translation: CAA08834.1.
AL357395 Genomic DNA. Translation: CAH72448.1.
CH471066 Genomic DNA. Translation: EAW49778.1.
BC130530 mRNA. Translation: AAI30531.1.
AF067443 Genomic DNA. Translation: AAG10096.1.
PIRA40855.
RefSeqNP_001182446.1. NM_001195517.1.
NP_005512.1. NM_005521.3.
UniGeneHs.89583.

3D structure databases

ProteinModelPortalP31314.
SMRP31314. Positions 187-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109435. 4 interactions.
DIPDIP-155N.
IntActP31314. 9 interactions.
STRING9606.ENSP00000359215.

PTM databases

PhosphoSiteP31314.

Polymorphism databases

DMDM399982.

Proteomic databases

PaxDbP31314.
PRIDEP31314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370196; ENSP00000359215; ENSG00000107807. [P31314-1]
ENST00000467928; ENSP00000434914; ENSG00000107807. [P31314-2]
GeneID3195.
KEGGhsa:3195.
UCSCuc001ksw.3. human. [P31314-1]

Organism-specific databases

CTD3195.
GeneCardsGC10P102889.
HGNCHGNC:5056. TLX1.
MIM186770. gene+phenotype.
neXtProtNX_P31314.
Orphanet99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBPA35095.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314631.
HOGENOMHOG000116280.
HOVERGENHBG036206.
InParanoidP31314.
KOK09340.
OMAGEYGLGC.
OrthoDBEOG7Q5HFW.
PhylomeDBP31314.
TreeFamTF325347.

Enzyme and pathway databases

SignaLinkP31314.

Gene expression databases

BgeeP31314.
CleanExHS_TLX1.
GenevestigatorP31314.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTLX1.
GenomeRNAi3195.
NextBio12708.
PROP31314.
SOURCESearch...

Entry information

Entry nameTLX1_HUMAN
AccessionPrimary (citable) accession number: P31314
Secondary accession number(s): A1L4G3 expand/collapse secondary AC list , O75699, Q5VXP2, Q9HCA0, Q9UD59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM