Reviewed, UniProtKB/Swiss-Prot P31314 (TLX1_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell leukemia homeobox protein 1
Alternative name(s):
    Homeobox protein Hox-11
    T-cell leukemia/lymphoma protein 3
    Proto-oncogene TCL-3

Gene names

Name:	TLX1
Synonyms:	HOX11, TCL3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Subcellular location	Nucleus Probable.
Involvement in disease	A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.
Miscellaneous	TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	T-cell leukemia homeobox protein 1		PRO_0000049333
Regions
	DNA binding	201 – 260	60	Homeobox
Experimental info
	Sequence conflict	71	1	A → T in CAA08834. Ref.5
	Sequence conflict	276	1	L → R in AAB19293. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P31314-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 09A518FB5271F7ED	FASTA	330	34,365
	10 20 30 40 50 60 MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG 70 80 90 100 110 120 GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS 130 140 150 160 170 180 GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN 190 200 210 220 230 240 RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM 250 260 270 280 290 300 TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN 310 320 330 SSLFALQNLQ PWSDDSTKIT SVTSVASACE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24." Kennedy M.A., Gonzalez-Sarmiento R., Kees U.R., Lampert F., Dear T.N., Boehm T., Rabbitts T.H. Proc. Natl. Acad. Sci. U.S.A. 88:8900-8904(1991) [PubMed: 1681546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein." Lu M., Gong Z., Shen W., Ho A.D. EMBO J. 10:2905-2910(1991) [PubMed: 1717256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia." Hatano M., Roberts C.W., Minden M., Crist W.M., Korsmeyer S.J. Science 253:79-82(1991) [PubMed: 1676542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells." Lu M., Zhang N., Ho A.D. Oncogene 7:1325-1330(1992) [PubMed: 1352396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line." Watt P.M., Ranford P.R., Kees U.R. Gene 234:169-176(1999) [PubMed: 10393251] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Multiple negative elements contribute to repression of the HOX11 proto-oncogene." Brake R.L., Kees U.R., Watt P.M. Oncogene 17:1787-1795(1998) [PubMed: 9778044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
[9]	"A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene." Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., Bellgard M.I. Gene 391:223-232(2007) [PubMed: 17303350] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M75952 mRNA. Translation: AAA58662.1. M62626 mRNA. Translation: AAA36719.1. S38742 mRNA. Translation: AAB19293.1. AJ009794 Genomic DNA. Translation: CAA08834.1. AL357395 Genomic DNA. Translation: CAH72448.1. CH471066 Genomic DNA. Translation: EAW49778.1. AF067443 Genomic DNA. Translation: AAG10096.1.
IPI	IPI00011051.
PIR	A40855.
RefSeq	NP_005512.1.
UniGene	Hs.89583
3D structure databases
HSSP	HSSP built from PDB template 1IG7 based on UniProtKB P13297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:155N.
Proteomic databases
PRIDE	P31314.
Genome annotation databases
Ensembl	ENSG00000107807. Homo sapiens. [Contig view]
GeneID	3195.
KEGG	hsa:3195.
Organism-specific databases
GeneCards	GC10P102880.
HGNC	HGNC:5056. TLX1.
MIM	186770. gene+phenotype.
Orphanet	513. Leukemia, lymphoblastic, acute.
PharmGKB	PA35095.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P31314.
HOVERGEN	P31314.
OMA	P31314. NVNMALA.
Gene expression databases
ArrayExpress	P31314.
Bgee	P31314.
CleanEx	HS_TLX1.
GermOnline	ENSG00000107807. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	12708.
SOURCE	Search...

Entry information

Entry name

TLX1_HUMAN

Accession

Primary (citable) accession number: P31314
Secondary accession number(s): O75699, Q5VXP2, Q9HCA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)