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Protein

T-cell leukemia homeobox protein 1

Gene

TLX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi201 – 260HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107807-MONOMER.
SignaLinkiP31314.
SIGNORiP31314.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox protein Hox-11
Proto-oncogene TCL-3
T-cell leukemia/lymphoma protein 3
Gene namesi
Name:TLX1
Synonyms:HOX11, TCL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:5056. TLX1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3195.
MalaCardsiTLX1.
MIMi186770. gene+phenotype.
OpenTargetsiENSG00000107807.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA35095.

Polymorphism and mutation databases

BioMutaiTLX1.
DMDMi399982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493331 – 330T-cell leukemia homeobox protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP31314.
PeptideAtlasiP31314.
PRIDEiP31314.

PTM databases

iPTMnetiP31314.
PhosphoSitePlusiP31314.

Expressioni

Gene expression databases

BgeeiENSG00000107807.
CleanExiHS_TLX1.
ExpressionAtlasiP31314. baseline and differential.
GenevisibleiP31314. HS.

Interactioni

Subunit structurei

Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ets1P275772EBI-2820655,EBI-4289053From a different organism.
MEIS1O004704EBI-2820655,EBI-1210694
MEIS2O14770-24EBI-2820655,EBI-6390216
PBX1P40424-22EBI-2820655,EBI-6390251

Protein-protein interaction databases

BioGridi109435. 4 interactors.
DIPiDIP-155N.
IntActiP31314. 9 interactors.
STRINGi9606.ENSP00000359215.

Structurei

3D structure databases

ProteinModelPortaliP31314.
SMRiP31314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiP31314.
KOiK09340.
OMAiGEYGLGC.
OrthoDBiEOG091G0RNV.
PhylomeDBiP31314.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31314-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL
60 70 80 90 100
VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS
110 120 130 140 150
YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL
160 170 180 190 200
ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG HPYQNRTPPK
210 220 230 240 250
KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM TDAQVKTWFQ
260 270 280 290 300
NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN
310 320 330
SSLFALQNLQ PWSDDSTKIT SVTSVASACE
Length:330
Mass (Da):34,365
Last modified:July 1, 1993 - v1
Checksum:i09A518FB5271F7ED
GO
Isoform 2 (identifier: P31314-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-330: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):26,245
Checksum:iA8072D76E4FC6CC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71A → T in CAA08834 (PubMed:10393251).Curated1
Sequence conflicti276L → R in AAB19293 (PubMed:1676542).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043068258 – 330Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62626 mRNA. Translation: AAA36719.1.
M75952 mRNA. Translation: AAA58662.1.
S38742 mRNA. Translation: AAB19293.1.
AJ009794 Genomic DNA. Translation: CAA08834.1.
AL357395 Genomic DNA. Translation: CAH72448.1.
CH471066 Genomic DNA. Translation: EAW49778.1.
BC130530 mRNA. Translation: AAI30531.1.
AF067443 Genomic DNA. Translation: AAG10096.1.
CCDSiCCDS55725.1. [P31314-2]
CCDS7510.1. [P31314-1]
PIRiA40855.
RefSeqiNP_001182446.1. NM_001195517.1. [P31314-2]
NP_005512.1. NM_005521.3. [P31314-1]
UniGeneiHs.89583.

Genome annotation databases

EnsembliENST00000370196; ENSP00000359215; ENSG00000107807. [P31314-1]
ENST00000467928; ENSP00000434914; ENSG00000107807. [P31314-2]
GeneIDi3195.
KEGGihsa:3195.
UCSCiuc001ksw.4. human. [P31314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62626 mRNA. Translation: AAA36719.1.
M75952 mRNA. Translation: AAA58662.1.
S38742 mRNA. Translation: AAB19293.1.
AJ009794 Genomic DNA. Translation: CAA08834.1.
AL357395 Genomic DNA. Translation: CAH72448.1.
CH471066 Genomic DNA. Translation: EAW49778.1.
BC130530 mRNA. Translation: AAI30531.1.
AF067443 Genomic DNA. Translation: AAG10096.1.
CCDSiCCDS55725.1. [P31314-2]
CCDS7510.1. [P31314-1]
PIRiA40855.
RefSeqiNP_001182446.1. NM_001195517.1. [P31314-2]
NP_005512.1. NM_005521.3. [P31314-1]
UniGeneiHs.89583.

3D structure databases

ProteinModelPortaliP31314.
SMRiP31314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109435. 4 interactors.
DIPiDIP-155N.
IntActiP31314. 9 interactors.
STRINGi9606.ENSP00000359215.

PTM databases

iPTMnetiP31314.
PhosphoSitePlusiP31314.

Polymorphism and mutation databases

BioMutaiTLX1.
DMDMi399982.

Proteomic databases

PaxDbiP31314.
PeptideAtlasiP31314.
PRIDEiP31314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370196; ENSP00000359215; ENSG00000107807. [P31314-1]
ENST00000467928; ENSP00000434914; ENSG00000107807. [P31314-2]
GeneIDi3195.
KEGGihsa:3195.
UCSCiuc001ksw.4. human. [P31314-1]

Organism-specific databases

CTDi3195.
DisGeNETi3195.
GeneCardsiTLX1.
HGNCiHGNC:5056. TLX1.
MalaCardsiTLX1.
MIMi186770. gene+phenotype.
neXtProtiNX_P31314.
OpenTargetsiENSG00000107807.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA35095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00860000133665.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiP31314.
KOiK09340.
OMAiGEYGLGC.
OrthoDBiEOG091G0RNV.
PhylomeDBiP31314.
TreeFamiTF325347.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107807-MONOMER.
SignaLinkiP31314.
SIGNORiP31314.

Miscellaneous databases

GeneWikiiTLX1.
GenomeRNAii3195.
PROiP31314.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107807.
CleanExiHS_TLX1.
ExpressionAtlasiP31314. baseline and differential.
GenevisibleiP31314. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX1_HUMAN
AccessioniPrimary (citable) accession number: P31314
Secondary accession number(s): A1L4G3
, O75699, Q5VXP2, Q9HCA0, Q9UD59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.