Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P31314

- TLX1_HUMAN

UniProt

P31314 - TLX1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

T-cell leukemia homeobox protein 1

Gene

TLX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi201 – 26060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. central nervous system development Source: Ensembl
  3. neuron differentiation Source: Ensembl
  4. organ formation Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. spleen development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP31314.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox protein Hox-11
Proto-oncogene TCL-3
T-cell leukemia/lymphoma protein 3
Gene namesi
Name:TLX1
Synonyms:HOX11, TCL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:5056. TLX1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi186770. gene+phenotype.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA35095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330T-cell leukemia homeobox protein 1PRO_0000049333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP31314.
PRIDEiP31314.

PTM databases

PhosphoSiteiP31314.

Expressioni

Gene expression databases

BgeeiP31314.
CleanExiHS_TLX1.
GenevestigatoriP31314.

Interactioni

Subunit structurei

Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ets1P275772EBI-2820655,EBI-4289053From a different organism.
MEIS1O004704EBI-2820655,EBI-1210694
MEIS2O14770-24EBI-2820655,EBI-6390216
PBX1P40424-22EBI-2820655,EBI-6390251

Protein-protein interaction databases

BioGridi109435. 4 interactions.
DIPiDIP-155N.
IntActiP31314. 9 interactions.
STRINGi9606.ENSP00000359215.

Structurei

3D structure databases

ProteinModelPortaliP31314.
SMRiP31314. Positions 187-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314631.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiP31314.
KOiK09340.
OMAiGEYGLGC.
OrthoDBiEOG7Q5HFW.
PhylomeDBiP31314.
TreeFamiTF325347.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P31314-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL
60 70 80 90 100
VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS
110 120 130 140 150
YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL
160 170 180 190 200
ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG HPYQNRTPPK
210 220 230 240 250
KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM TDAQVKTWFQ
260 270 280 290 300
NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN
310 320 330
SSLFALQNLQ PWSDDSTKIT SVTSVASACE
Length:330
Mass (Da):34,365
Last modified:July 1, 1993 - v1
Checksum:i09A518FB5271F7ED
GO
Isoform 2 (identifier: P31314-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-330: Missing.

Note: No experimental confirmation available.

Show »
Length:257
Mass (Da):26,245
Checksum:iA8072D76E4FC6CC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → T in CAA08834. (PubMed:10393251)Curated
Sequence conflicti276 – 2761L → R in AAB19293. (PubMed:1676542)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 33073Missing in isoform 2. 1 PublicationVSP_043068Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62626 mRNA. Translation: AAA36719.1.
M75952 mRNA. Translation: AAA58662.1.
S38742 mRNA. Translation: AAB19293.1.
AJ009794 Genomic DNA. Translation: CAA08834.1.
AL357395 Genomic DNA. Translation: CAH72448.1.
CH471066 Genomic DNA. Translation: EAW49778.1.
BC130530 mRNA. Translation: AAI30531.1.
AF067443 Genomic DNA. Translation: AAG10096.1.
CCDSiCCDS55725.1. [P31314-2]
CCDS7510.1. [P31314-1]
PIRiA40855.
RefSeqiNP_001182446.1. NM_001195517.1. [P31314-2]
NP_005512.1. NM_005521.3. [P31314-1]
UniGeneiHs.89583.

Genome annotation databases

EnsembliENST00000370196; ENSP00000359215; ENSG00000107807. [P31314-1]
ENST00000467928; ENSP00000434914; ENSG00000107807. [P31314-2]
GeneIDi3195.
KEGGihsa:3195.
UCSCiuc001ksw.3. human. [P31314-1]

Polymorphism databases

DMDMi399982.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62626 mRNA. Translation: AAA36719.1 .
M75952 mRNA. Translation: AAA58662.1 .
S38742 mRNA. Translation: AAB19293.1 .
AJ009794 Genomic DNA. Translation: CAA08834.1 .
AL357395 Genomic DNA. Translation: CAH72448.1 .
CH471066 Genomic DNA. Translation: EAW49778.1 .
BC130530 mRNA. Translation: AAI30531.1 .
AF067443 Genomic DNA. Translation: AAG10096.1 .
CCDSi CCDS55725.1. [P31314-2 ]
CCDS7510.1. [P31314-1 ]
PIRi A40855.
RefSeqi NP_001182446.1. NM_001195517.1. [P31314-2 ]
NP_005512.1. NM_005521.3. [P31314-1 ]
UniGenei Hs.89583.

3D structure databases

ProteinModelPortali P31314.
SMRi P31314. Positions 187-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109435. 4 interactions.
DIPi DIP-155N.
IntActi P31314. 9 interactions.
STRINGi 9606.ENSP00000359215.

PTM databases

PhosphoSitei P31314.

Polymorphism databases

DMDMi 399982.

Proteomic databases

PaxDbi P31314.
PRIDEi P31314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370196 ; ENSP00000359215 ; ENSG00000107807 . [P31314-1 ]
ENST00000467928 ; ENSP00000434914 ; ENSG00000107807 . [P31314-2 ]
GeneIDi 3195.
KEGGi hsa:3195.
UCSCi uc001ksw.3. human. [P31314-1 ]

Organism-specific databases

CTDi 3195.
GeneCardsi GC10P102889.
HGNCi HGNC:5056. TLX1.
MIMi 186770. gene+phenotype.
neXtProti NX_P31314.
Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBi PA35095.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314631.
GeneTreei ENSGT00760000118779.
HOGENOMi HOG000116280.
HOVERGENi HBG036206.
InParanoidi P31314.
KOi K09340.
OMAi GEYGLGC.
OrthoDBi EOG7Q5HFW.
PhylomeDBi P31314.
TreeFami TF325347.

Enzyme and pathway databases

SignaLinki P31314.

Miscellaneous databases

GeneWikii TLX1.
GenomeRNAii 3195.
NextBioi 12708.
PROi P31314.
SOURCEi Search...

Gene expression databases

Bgeei P31314.
CleanExi HS_TLX1.
Genevestigatori P31314.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein."
    Lu M., Gong Z., Shen W., Ho A.D.
    EMBO J. 10:2905-2910(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  3. "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia."
    Hatano M., Roberts C.W., Minden M., Crist W.M., Korsmeyer S.J.
    Science 253:79-82(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells."
    Lu M., Zhang N., Ho A.D.
    Oncogene 7:1325-1330(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line."
    Watt P.M., Ranford P.R., Kees U.R.
    Gene 234:169-176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  9. "Multiple negative elements contribute to repression of the HOX11 proto-oncogene."
    Brake R.L., Kees U.R., Watt P.M.
    Oncogene 17:1787-1795(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
  10. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
    Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
    Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-247 (ISOFORM 1/2).
    Tissue: Bone marrow.
  11. "A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene."
    Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., Bellgard M.I.
    Gene 391:223-232(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-236, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: INTERACTION WITH MEIS1; MEIS2; PBX1; PBX2 AND PBX3.

Entry informationi

Entry nameiTLX1_HUMAN
AccessioniPrimary (citable) accession number: P31314
Secondary accession number(s): A1L4G3
, O75699, Q5VXP2, Q9HCA0, Q9UD59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3