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P31314 (TLX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox protein Hox-11
Proto-oncogene TCL-3
T-cell leukemia/lymphoma protein 3
Gene names
Name:TLX1
Synonyms:HOX11, TCL3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Subcellular location

Nucleus Probable.

Involvement in disease

Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

Miscellaneous

TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityChromosomal rearrangement
   DiseaseProto-oncogene
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330T-cell leukemia homeobox protein 1
PRO_0000049333

Regions

DNA binding201 – 26060Homeobox

Amino acid modifications

Modified residue2361N6-acetyllysine Ref.11

Experimental info

Sequence conflict711A → T in CAA08834. Ref.5
Sequence conflict2761L → R in AAB19293. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P31314 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 09A518FB5271F7ED

FASTA33034,365
        10         20         30         40         50         60 
MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG 

        70         80         90        100        110        120 
GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS 

       130        140        150        160        170        180 
GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN 

       190        200        210        220        230        240 
RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM 

       250        260        270        280        290        300 
TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN 

       310        320        330 
SSLFALQNLQ PWSDDSTKIT SVTSVASACE

« Hide

References

« Hide 'large scale' references
[1]"The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein."
Lu M., Gong Z., Shen W., Ho A.D.
EMBO J. 10:2905-2910(1991) [PubMed: 1717256] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[2]"HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24."
Kennedy M.A., Gonzalez-Sarmiento R., Kees U.R., Lampert F., Dear T.N., Boehm T., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 88:8900-8904(1991) [PubMed: 1681546] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[3]"Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia."
Hatano M., Roberts C.W., Minden M., Crist W.M., Korsmeyer S.J.
Science 253:79-82(1991) [PubMed: 1676542] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells."
Lu M., Zhang N., Ho A.D.
Oncogene 7:1325-1330(1992) [PubMed: 1352396] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line."
Watt P.M., Ranford P.R., Kees U.R.
Gene 234:169-176(1999) [PubMed: 10393251] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"Multiple negative elements contribute to repression of the HOX11 proto-oncogene."
Brake R.L., Kees U.R., Watt P.M.
Oncogene 17:1787-1795(1998) [PubMed: 9778044] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
[9]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed: 7518789] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-247.
Tissue: Bone marrow.
[10]"A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene."
Greene W.K., Sontani Y., Sharp M.A., Dunn D.S., Kees U.R., Bellgard M.I.
Gene 391:223-232(2007) [PubMed: 17303350] [Abstract]
Cited for: IDENTIFICATION.
[11]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-236, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M62626 mRNA. Translation: AAA36719.1.
M75952 mRNA. Translation: AAA58662.1.
S38742 mRNA. Translation: AAB19293.1.
AJ009794 Genomic DNA. Translation: CAA08834.1.
AL357395 Genomic DNA. Translation: CAH72448.1.
CH471066 Genomic DNA. Translation: EAW49778.1.
AF067443 Genomic DNA. Translation: AAG10096.1.
IPIIPI00011051.
PIRA40855.
RefSeqNP_005512.1. NM_005521.3.
UniGeneHs.89583.

3D structure databases

ProteinModelPortalP31314.
SMRP31314. Positions 187-263.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-155N.
IntActP31314. 2 interactions.
STRINGP31314.

PTM databases

PhosphoSiteP31314.

Polymorphism databases

DMDM399982.

Proteomic databases

PRIDEP31314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370196; ENSP00000359215; ENSG00000107807.
GeneID3195.
KEGGhsa:3195.
UCSCuc001ksw.1. human.

Organism-specific databases

CTD3195.
GeneCardsGC10P102880.
H-InvDBHIX0035425.
HGNCHGNC:5056. TLX1.
MIM186770. gene+phenotype.
neXtProtNX_P31314.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00590000082900.
HOGENOMHBG714799.
HOVERGENHBG036206.
InParanoidP31314.
OMANVNMALA.
OrthoDBEOG49GKHR.
PhylomeDBP31314.

Gene expression databases

ArrayExpressP31314.
BgeeP31314.
CleanExHS_TLX1.
GenevestigatorP31314.
GermOnlineENSG00000107807. Homo sapiens.

Family and domain databases

InterProIPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KOK09340.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio12708.
SOURCESearch...

Entry information

Entry nameTLX1_HUMAN
AccessionPrimary (citable) accession number: P31314
Secondary accession number(s): O75699 expand/collapse secondary AC list , Q5VXP2, Q9HCA0, Q9UD59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents