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Protein

Homeobox protein Hox-C11

Gene

Hoxc11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi232 – 291HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • metanephros development Source: MGI
  • organ induction Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • proximal/distal pattern formation Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C11
Alternative name(s):
Homeobox protein Hox-3.7
Gene namesi
Name:Hoxc11
Synonyms:Hox-3.7, Hoxc-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96193. Hoxc11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001951 – 304Homeobox protein Hox-C11Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP31313.
PRIDEiP31313.

PTM databases

PhosphoSitePlusiP31313.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001656.
CleanExiMM_HOXC11.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001701.

Structurei

3D structure databases

ProteinModelPortaliP31313.
SMRiP31313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31313.
KOiK09296.
OMAiEEHTNSG.
OrthoDBiEOG091G0CZ4.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNSVNLGNF CSPSRKERGA DFGERGSCTS NLYLPSCTYY VPEFSTVSSF
60 70 80 90 100
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM
110 120 130 140 150
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HAAPAGFYSS VNKNSVLPQA
160 170 180 190 200
FDRFFDNAYC GGGDAPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE
210 220 230 240 250
AEEENTNPSS SGSSHSATKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE
260 270 280 290 300
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG

NPLL
Length:304
Mass (Da):33,708
Last modified:October 3, 2012 - v3
Checksum:iCD91F6D2212751F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160979 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL03950.1.
BC139233 mRNA. Translation: AAI39234.1.
BC139269 mRNA. Translation: AAI39270.1.
CCDSiCCDS27892.1.
PIRiI37290.
RefSeqiNP_001020013.1. NM_001024842.1.
UniGeneiMm.37692.

Genome annotation databases

EnsembliENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656.
GeneIDi109663.
KEGGimmu:109663.
UCSCiuc007xwy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160979 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL03950.1.
BC139233 mRNA. Translation: AAI39234.1.
BC139269 mRNA. Translation: AAI39270.1.
CCDSiCCDS27892.1.
PIRiI37290.
RefSeqiNP_001020013.1. NM_001024842.1.
UniGeneiMm.37692.

3D structure databases

ProteinModelPortaliP31313.
SMRiP31313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001701.

PTM databases

PhosphoSitePlusiP31313.

Proteomic databases

PaxDbiP31313.
PRIDEiP31313.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001701; ENSMUSP00000001701; ENSMUSG00000001656.
GeneIDi109663.
KEGGimmu:109663.
UCSCiuc007xwy.1. mouse.

Organism-specific databases

CTDi3227.
MGIiMGI:96193. Hoxc11.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31313.
KOiK09296.
OMAiEEHTNSG.
OrthoDBiEOG091G0CZ4.
TreeFamiTF350668.

Miscellaneous databases

PROiP31313.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001656.
CleanExiMM_HOXC11.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXC11_MOUSE
AccessioniPrimary (citable) accession number: P31313
Secondary accession number(s): B9EI74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.