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P31311

- HXA11_MOUSE

UniProt

P31311 - HXA11_MOUSE

Protein

Homeobox protein Hox-A11

Gene

Hoxa11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi241 – 30060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. branching involved in ureteric bud morphogenesis Source: MGI
    3. cartilage development involved in endochondral bone morphogenesis Source: MGI
    4. developmental growth Source: MGI
    5. dorsal/ventral pattern formation Source: MGI
    6. embryonic digit morphogenesis Source: MGI
    7. embryonic forelimb morphogenesis Source: MGI
    8. embryonic limb morphogenesis Source: MGI
    9. embryonic skeletal joint morphogenesis Source: MGI
    10. male gonad development Source: MGI
    11. mesodermal cell fate specification Source: UniProtKB
    12. metanephros development Source: MGI
    13. multicellular organismal development Source: MGI
    14. organ induction Source: MGI
    15. positive regulation of cell development Source: MGI
    16. positive regulation of chondrocyte differentiation Source: MGI
    17. positive regulation of transcription, DNA-templated Source: UniProtKB
    18. proximal/distal pattern formation Source: MGI
    19. regulation of chondrocyte differentiation Source: MGI
    20. regulation of gene expression Source: MGI
    21. single fertilization Source: MGI
    22. skeletal system development Source: MGI
    23. spermatogenesis Source: MGI
    24. transcription, DNA-templated Source: UniProtKB-KW
    25. uterus development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A11
    Alternative name(s):
    Homeobox protein Hox-1.9
    Gene namesi
    Name:Hoxa11
    Synonyms:Hox-1.9, Hoxa-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96172. Hoxa11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleolus Source: Ensembl
    3. protein complex Source: UniProtKB
    4. protein-DNA complex Source: UniProtKB
    5. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Homeobox protein Hox-A11PRO_0000200096Add
    BLAST

    Proteomic databases

    PRIDEiP31311.

    PTM databases

    PhosphoSiteiP31311.

    Expressioni

    Gene expression databases

    BgeeiP31311.
    CleanExiMM_HOXA11.
    GenevestigatoriP31311.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GmnnO885132EBI-445941,EBI-445922

    Protein-protein interaction databases

    BioGridi200364. 8 interactions.
    IntActiP31311. 2 interactions.
    MINTiMINT-1172550.
    STRINGi10090.ENSMUSP00000040920.

    Structurei

    3D structure databases

    ProteinModelPortaliP31311.
    SMRiP31311. Positions 241-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi172 – 1754Poly-Ala
    Compositional biasi178 – 1858Poly-Ala
    Compositional biasi196 – 2016Poly-Gly
    Compositional biasi212 – 2154Poly-Arg
    Compositional biasi218 – 2214Poly-Ser

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG274734.
    GeneTreeiENSGT00750000117432.
    HOGENOMiHOG000231898.
    HOVERGENiHBG052048.
    InParanoidiP31311.
    KOiK09296.
    OMAiLQYYSAN.
    OrthoDBiEOG7ZWD2F.
    PhylomeDBiP31311.
    TreeFamiTF350668.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR021918. DUF3528.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF12045. DUF3528. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS    50
    NLPQVQPVRE VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA 100
    AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG 150
    TPENLASSDY PGDKNAEKGP QAAAATSAAA VAAAATGAPA TSSSDGGGGG 200
    GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR TRKKRCPYTK 250
    YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN 300
    RDRLQYYSAN PLL 313
    Length:313
    Mass (Da):34,484
    Last modified:October 1, 1996 - v2
    Checksum:i07BE80F8E2225B3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20371 Genomic DNA. Translation: AAA85711.1.
    U20370 mRNA. Translation: AAA85710.1.
    AK133481 mRNA. Translation: BAE21679.1.
    BC119302 mRNA. Translation: AAI19303.1.
    CCDSiCCDS20148.1.
    PIRiG37290.
    RefSeqiNP_034580.1. NM_010450.3.
    UniGeneiMm.26954.

    Genome annotation databases

    EnsembliENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210.
    GeneIDi15396.
    KEGGimmu:15396.
    UCSCiuc009byn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20371 Genomic DNA. Translation: AAA85711.1 .
    U20370 mRNA. Translation: AAA85710.1 .
    AK133481 mRNA. Translation: BAE21679.1 .
    BC119302 mRNA. Translation: AAI19303.1 .
    CCDSi CCDS20148.1.
    PIRi G37290.
    RefSeqi NP_034580.1. NM_010450.3.
    UniGenei Mm.26954.

    3D structure databases

    ProteinModelPortali P31311.
    SMRi P31311. Positions 241-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200364. 8 interactions.
    IntActi P31311. 2 interactions.
    MINTi MINT-1172550.
    STRINGi 10090.ENSMUSP00000040920.

    PTM databases

    PhosphoSitei P31311.

    Proteomic databases

    PRIDEi P31311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048026 ; ENSMUSP00000040920 ; ENSMUSG00000038210 .
    GeneIDi 15396.
    KEGGi mmu:15396.
    UCSCi uc009byn.1. mouse.

    Organism-specific databases

    CTDi 3207.
    MGIi MGI:96172. Hoxa11.

    Phylogenomic databases

    eggNOGi NOG274734.
    GeneTreei ENSGT00750000117432.
    HOGENOMi HOG000231898.
    HOVERGENi HBG052048.
    InParanoidi P31311.
    KOi K09296.
    OMAi LQYYSAN.
    OrthoDBi EOG7ZWD2F.
    PhylomeDBi P31311.
    TreeFami TF350668.

    Miscellaneous databases

    NextBioi 288080.
    PROi P31311.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31311.
    CleanExi MM_HOXA11.
    Genevestigatori P31311.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR021918. DUF3528.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF12045. DUF3528. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility."
      Hsieh-Li H.M., Witte D.P., Weinstein M., Branford W., Li H., Small K., Potter S.S.
      Development 121:1373-1385(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-300.

    Entry informationi

    Entry nameiHXA11_MOUSE
    AccessioniPrimary (citable) accession number: P31311
    Secondary accession number(s): Q3V026
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3