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P31311

- HXA11_MOUSE

UniProt

P31311 - HXA11_MOUSE

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Protein

Homeobox protein Hox-A11

Gene

Hoxa11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi241 – 30060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. branching involved in ureteric bud morphogenesis Source: MGI
  3. cartilage development involved in endochondral bone morphogenesis Source: MGI
  4. developmental growth Source: MGI
  5. dorsal/ventral pattern formation Source: MGI
  6. embryonic digit morphogenesis Source: MGI
  7. embryonic forelimb morphogenesis Source: MGI
  8. embryonic limb morphogenesis Source: MGI
  9. embryonic skeletal joint morphogenesis Source: MGI
  10. male gonad development Source: MGI
  11. mesodermal cell fate specification Source: UniProtKB
  12. metanephros development Source: MGI
  13. multicellular organismal development Source: MGI
  14. organ induction Source: MGI
  15. positive regulation of cell development Source: MGI
  16. positive regulation of chondrocyte differentiation Source: MGI
  17. positive regulation of transcription, DNA-templated Source: UniProtKB
  18. proximal/distal pattern formation Source: MGI
  19. regulation of chondrocyte differentiation Source: MGI
  20. regulation of gene expression Source: MGI
  21. single fertilization Source: MGI
  22. skeletal system development Source: MGI
  23. spermatogenesis Source: MGI
  24. transcription, DNA-templated Source: UniProtKB-KW
  25. uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A11
Alternative name(s):
Homeobox protein Hox-1.9
Gene namesi
Name:Hoxa11
Synonyms:Hox-1.9, Hoxa-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96172. Hoxa11.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. protein complex Source: UniProtKB
  3. protein-DNA complex Source: UniProtKB
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Homeobox protein Hox-A11PRO_0000200096Add
BLAST

Proteomic databases

PRIDEiP31311.

PTM databases

PhosphoSiteiP31311.

Expressioni

Gene expression databases

BgeeiP31311.
CleanExiMM_HOXA11.
GenevestigatoriP31311.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GmnnO885132EBI-445941,EBI-445922

Protein-protein interaction databases

BioGridi200364. 8 interactions.
IntActiP31311. 2 interactions.
MINTiMINT-1172550.
STRINGi10090.ENSMUSP00000040920.

Structurei

3D structure databases

ProteinModelPortaliP31311.
SMRiP31311. Positions 241-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 1754Poly-Ala
Compositional biasi178 – 1858Poly-Ala
Compositional biasi196 – 2016Poly-Gly
Compositional biasi212 – 2154Poly-Arg
Compositional biasi218 – 2214Poly-Ser

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG274734.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31311.
KOiK09296.
OMAiLQYYSAN.
OrthoDBiEOG7ZWD2F.
PhylomeDBiP31311.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31311-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS
60 70 80 90 100
NLPQVQPVRE VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA
110 120 130 140 150
AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG
160 170 180 190 200
TPENLASSDY PGDKNAEKGP QAAAATSAAA VAAAATGAPA TSSSDGGGGG
210 220 230 240 250
GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR TRKKRCPYTK
260 270 280 290 300
YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN
310
RDRLQYYSAN PLL
Length:313
Mass (Da):34,484
Last modified:October 1, 1996 - v2
Checksum:i07BE80F8E2225B3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20371 Genomic DNA. Translation: AAA85711.1.
U20370 mRNA. Translation: AAA85710.1.
AK133481 mRNA. Translation: BAE21679.1.
BC119302 mRNA. Translation: AAI19303.1.
CCDSiCCDS20148.1.
PIRiG37290.
RefSeqiNP_034580.1. NM_010450.3.
UniGeneiMm.26954.

Genome annotation databases

EnsembliENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210.
GeneIDi15396.
KEGGimmu:15396.
UCSCiuc009byn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20371 Genomic DNA. Translation: AAA85711.1 .
U20370 mRNA. Translation: AAA85710.1 .
AK133481 mRNA. Translation: BAE21679.1 .
BC119302 mRNA. Translation: AAI19303.1 .
CCDSi CCDS20148.1.
PIRi G37290.
RefSeqi NP_034580.1. NM_010450.3.
UniGenei Mm.26954.

3D structure databases

ProteinModelPortali P31311.
SMRi P31311. Positions 241-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200364. 8 interactions.
IntActi P31311. 2 interactions.
MINTi MINT-1172550.
STRINGi 10090.ENSMUSP00000040920.

PTM databases

PhosphoSitei P31311.

Proteomic databases

PRIDEi P31311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048026 ; ENSMUSP00000040920 ; ENSMUSG00000038210 .
GeneIDi 15396.
KEGGi mmu:15396.
UCSCi uc009byn.1. mouse.

Organism-specific databases

CTDi 3207.
MGIi MGI:96172. Hoxa11.

Phylogenomic databases

eggNOGi NOG274734.
GeneTreei ENSGT00760000118834.
HOGENOMi HOG000231898.
HOVERGENi HBG052048.
InParanoidi P31311.
KOi K09296.
OMAi LQYYSAN.
OrthoDBi EOG7ZWD2F.
PhylomeDBi P31311.
TreeFami TF350668.

Miscellaneous databases

NextBioi 288080.
PROi P31311.
SOURCEi Search...

Gene expression databases

Bgeei P31311.
CleanExi MM_HOXA11.
Genevestigatori P31311.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility."
    Hsieh-Li H.M., Witte D.P., Weinstein M., Branford W., Li H., Small K., Potter S.S.
    Development 121:1373-1385(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-300.

Entry informationi

Entry nameiHXA11_MOUSE
AccessioniPrimary (citable) accession number: P31311
Secondary accession number(s): Q3V026
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3