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Protein

Homeobox protein Hox-A11

Gene

Hoxa11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi241 – 300HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: MGI
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • bone development Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cartilage development involved in endochondral bone morphogenesis Source: MGI
  • developmental growth Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • male gonad development Source: MGI
  • mesodermal cell fate specification Source: UniProtKB
  • metanephros development Source: MGI
  • multicellular organism development Source: MGI
  • organ induction Source: MGI
  • positive regulation of cell development Source: MGI
  • positive regulation of chondrocyte differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • proximal/distal pattern formation Source: MGI
  • regulation of chondrocyte differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • single fertilization Source: MGI
  • skeletal system development Source: MGI
  • spermatogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • uterus development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A11
Alternative name(s):
Homeobox protein Hox-1.9
Gene namesi
Name:Hoxa11
Synonyms:Hox-1.9, Hoxa-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96172 Hoxa11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000961 – 313Homeobox protein Hox-A11Add BLAST313

Proteomic databases

PaxDbiP31311
PRIDEiP31311

PTM databases

iPTMnetiP31311
PhosphoSitePlusiP31311

Expressioni

Gene expression databases

BgeeiENSMUSG00000038210
CleanExiMM_HOXA11
GenevisibleiP31311 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GmnnO885132EBI-445941,EBI-445922

Protein-protein interaction databases

BioGridi200364, 8 interactors
IntActiP31311, 2 interactors
STRINGi10090.ENSMUSP00000040920

Structurei

3D structure databases

ProteinModelPortaliP31311
SMRiP31311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 175Poly-Ala4
Compositional biasi178 – 185Poly-Ala8
Compositional biasi196 – 201Poly-Gly6
Compositional biasi212 – 215Poly-Arg4
Compositional biasi218 – 221Poly-Ser4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231898
HOVERGENiHBG052048
InParanoidiP31311
KOiK21951
OMAiFGKNTAN
OrthoDBiEOG091G0DZB
PhylomeDBiP31311
TreeFamiTF350668

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS
60 70 80 90 100
NLPQVQPVRE VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA
110 120 130 140 150
AGVPGDVLAK SSANVYHHPT PAVSSNFYST VGRNGVLPQA FDQFFETAYG
160 170 180 190 200
TPENLASSDY PGDKNAEKGP QAAAATSAAA VAAAATGAPA TSSSDGGGGG
210 220 230 240 250
GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR TRKKRCPYTK
260 270 280 290 300
YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN
310
RDRLQYYSAN PLL
Length:313
Mass (Da):34,484
Last modified:October 1, 1996 - v2
Checksum:i07BE80F8E2225B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20371 Genomic DNA Translation: AAA85711.1
U20370 mRNA Translation: AAA85710.1
AK133481 mRNA Translation: BAE21679.1
BC119302 mRNA Translation: AAI19303.1
CCDSiCCDS20148.1
PIRiG37290
RefSeqiNP_034580.1, NM_010450.3
UniGeneiMm.26954

Genome annotation databases

EnsembliENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210
GeneIDi15396
KEGGimmu:15396
UCSCiuc009byn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHXA11_MOUSE
AccessioniPrimary (citable) accession number: P31311
Secondary accession number(s): Q3V026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health