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P31311 (HXA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A11
Alternative name(s):
Homeobox protein Hox-1.9
Gene names
Name:Hoxa11
Synonyms:Hox-1.9, Hoxa-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from genetic interaction PubMed 12869760. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from genetic interaction PubMed 11493536. Source: MGI

cartilage development involved in endochondral bone morphogenesis

Inferred from genetic interaction PubMed 14668414. Source: MGI

developmental growth

Inferred from genetic interaction PubMed 14668414. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction PubMed 11493536. Source: MGI

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 12869760. Source: MGI

embryonic forelimb morphogenesis

Inferred from genetic interaction PubMed 22916278. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 14668414. Source: MGI

embryonic skeletal joint morphogenesis

Inferred from genetic interaction PubMed 20978074. Source: MGI

male gonad development

Inferred from genetic interaction PubMed 23760953. Source: MGI

mesodermal cell fate specification

Inferred from direct assay PubMed 17785448. Source: UniProtKB

metanephros development

Inferred from genetic interaction PubMed 12050119. Source: MGI

multicellular organismal development

Inferred from direct assay PubMed 11900456. Source: MGI

organ induction

Inferred from genetic interaction PubMed 12050119. Source: MGI

positive regulation of cell development

Inferred from genetic interaction PubMed 14668414. Source: MGI

positive regulation of chondrocyte differentiation

Inferred from genetic interaction PubMed 14668414. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 17785448. Source: UniProtKB

proximal/distal pattern formation

Inferred from genetic interaction PubMed 12869760. Source: MGI

regulation of chondrocyte differentiation

Inferred from genetic interaction PubMed 22916278. Source: MGI

regulation of gene expression

Inferred from genetic interaction PubMed 23760953. Source: MGI

single fertilization

Inferred from genetic interaction PubMed 23760953. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 7596412. Source: MGI

spermatogenesis

Inferred from genetic interaction PubMed 23760953. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

uterus development

Inferred from genetic interaction PubMed 23760953. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleolus

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from direct assay PubMed 17785448. Source: UniProtKB

protein-DNA complex

Inferred from direct assay PubMed 17785448. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 9343407. Source: MGI

   Molecular_functionDNA binding

Traceable author statement PubMed 11900456. Source: MGI

protein binding

Inferred from physical interaction PubMed 14973489. Source: IntAct

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GmnnO885132EBI-445941,EBI-445922

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Homeobox protein Hox-A11
PRO_0000200096

Regions

DNA binding241 – 30060Homeobox
Compositional bias172 – 1754Poly-Ala
Compositional bias178 – 1858Poly-Ala
Compositional bias196 – 2016Poly-Gly
Compositional bias212 – 2154Poly-Arg
Compositional bias218 – 2214Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
P31311 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 07BE80F8E2225B3E

FASTA31334,484
        10         20         30         40         50         60 
MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS NLPQVQPVRE 

        70         80         90        100        110        120 
VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA AGVPGDVLAK SSANVYHHPT 

       130        140        150        160        170        180 
PAVSSNFYST VGRNGVLPQA FDQFFETAYG TPENLASSDY PGDKNAEKGP QAAAATSAAA 

       190        200        210        220        230        240 
VAAAATGAPA TSSSDGGGGG GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR 

       250        260        270        280        290        300 
TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN 

       310 
RDRLQYYSAN PLL 

« Hide

References

« Hide 'large scale' references
[1]"Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility."
Hsieh-Li H.M., Witte D.P., Weinstein M., Branford W., Li H., Small K., Potter S.S.
Development 121:1373-1385(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Identification of 10 murine homeobox genes."
Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S.
Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-300.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20371 Genomic DNA. Translation: AAA85711.1.
U20370 mRNA. Translation: AAA85710.1.
AK133481 mRNA. Translation: BAE21679.1.
BC119302 mRNA. Translation: AAI19303.1.
CCDSCCDS20148.1.
PIRG37290.
RefSeqNP_034580.1. NM_010450.3.
UniGeneMm.26954.

3D structure databases

ProteinModelPortalP31311.
SMRP31311. Positions 241-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200364. 8 interactions.
IntActP31311. 2 interactions.
MINTMINT-1172550.
STRING10090.ENSMUSP00000040920.

PTM databases

PhosphoSiteP31311.

Proteomic databases

PRIDEP31311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210.
GeneID15396.
KEGGmmu:15396.
UCSCuc009byn.1. mouse.

Organism-specific databases

CTD3207.
MGIMGI:96172. Hoxa11.

Phylogenomic databases

eggNOGNOG274734.
GeneTreeENSGT00750000117432.
HOGENOMHOG000231898.
HOVERGENHBG052048.
InParanoidP31311.
KOK09296.
OMALQYYSAN.
OrthoDBEOG7ZWD2F.
PhylomeDBP31311.
TreeFamTF350668.

Gene expression databases

BgeeP31311.
CleanExMM_HOXA11.
GenevestigatorP31311.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288080.
PROP31311.
SOURCESearch...

Entry information

Entry nameHXA11_MOUSE
AccessionPrimary (citable) accession number: P31311
Secondary accession number(s): Q3V026
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries