ID   HXA10_MOUSE             Reviewed;         416 AA.
AC   P31310; Q80Y22;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 4.
DT   24-JAN-2024, entry version 186.
DE   RecName: Full=Homeobox protein Hox-A10;
DE   AltName: Full=Homeobox protein Hox-1.8;
GN   Name=Hoxa10; Synonyms=Hox-1.8, Hoxa-10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=CD-1; TISSUE=Kidney;
RX   PubMed=7862151; DOI=10.1128/mcb.15.3.1591;
RA   Benson G.V., Nguyen T.-H.E., Maas R.L.;
RT   "The expression pattern of the murine Hoxa-10 gene and the sequence
RT   recognition of its homeodomain reveal specific properties of Abdominal B-
RT   like genes.";
RL   Mol. Cell. Biol. 15:1591-1601(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-416 (ISOFORM 1).
RC   TISSUE=Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 342-401.
RX   PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA   Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA   Potter S.S.;
RT   "Identification of 10 murine homeobox genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-387.
RC   STRAIN=C57BL/6J; TISSUE=Spleen;
RX   PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA   Murtha M.T., Leckman J.F., Ruddle F.H.;
RT   "Detection of homeobox genes in development and evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds to the DNA
CC       sequence 5'-AA[AT]TTTTATTAC-3'.
CC   -!- SUBUNIT: Interacts with SIRT2; the interaction is direct.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=a10-1;
CC         IsoId=P31310-1; Sequence=Displayed;
CC       Name=2; Synonyms=a10-2;
CC         IsoId=P31310-2; Sequence=VSP_002386, VSP_002387;
CC   -!- TISSUE SPECIFICITY: Expressed in the developing limb bud where it is
CC       restricted to the mesenchyme along the proximal-distal axis. Also found
CC       in developing gut and urogenital tract. In adult tissue, both forms
CC       found in kidney but only isoform 1 is expressed in skeletal muscle.
CC   -!- DEVELOPMENTAL STAGE: Embryonic expression increases from day 9 to day
CC       12 and then declines to day 15.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA67125.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH50839.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L08757; AAA67125.1; ALT_INIT; mRNA.
DR   EMBL; L08758; AAD15230.1; -; mRNA.
DR   EMBL; BC050839; AAH50839.1; ALT_INIT; mRNA.
DR   EMBL; M81659; AAA63312.1; -; Genomic_DNA.
DR   CCDS; CCDS20147.2; -. [P31310-1]
DR   CCDS; CCDS51775.1; -. [P31310-2]
DR   PIR; I49754; I49754.
DR   RefSeq; NP_001116422.1; NM_001122950.2. [P31310-2]
DR   RefSeq; NP_032289.2; NM_008263.3. [P31310-1]
DR   AlphaFoldDB; P31310; -.
DR   SMR; P31310; -.
DR   BioGRID; 200363; 20.
DR   IntAct; P31310; 7.
DR   STRING; 10090.ENSMUSP00000120276; -.
DR   iPTMnet; P31310; -.
DR   PhosphoSitePlus; P31310; -.
DR   jPOST; P31310; -.
DR   MaxQB; P31310; -.
DR   PaxDb; 10090-ENSMUSP00000120276; -.
DR   ProteomicsDB; 267179; -. [P31310-1]
DR   ProteomicsDB; 267180; -. [P31310-2]
DR   Antibodypedia; 48441; 289 antibodies from 26 providers.
DR   DNASU; 15395; -.
DR   Ensembl; ENSMUST00000121043.2; ENSMUSP00000112872.2; ENSMUSG00000000938.12. [P31310-2]
DR   Ensembl; ENSMUST00000125581.2; ENSMUSP00000120276.2; ENSMUSG00000000938.12. [P31310-1]
DR   GeneID; 15395; -.
DR   KEGG; mmu:15395; -.
DR   UCSC; uc009bym.1; mouse. [P31310-1]
DR   UCSC; uc012ema.1; mouse. [P31310-2]
DR   AGR; MGI:96171; -.
DR   CTD; 3206; -.
DR   MGI; MGI:96171; Hoxa10.
DR   VEuPathDB; HostDB:ENSMUSG00000000938; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000162440; -.
DR   HOGENOM; CLU_057871_0_0_1; -.
DR   InParanoid; P31310; -.
DR   OMA; YYPHYLP; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P31310; -.
DR   TreeFam; TF317819; -.
DR   BioGRID-ORCS; 15395; 2 hits in 75 CRISPR screens.
DR   ChiTaRS; Hoxa10; mouse.
DR   PRO; PR:P31310; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P31310; Protein.
DR   Bgee; ENSMUSG00000000938; Expressed in gastrula and 152 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR   GO; GO:0003677; F:DNA binding; TAS:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR   GO; GO:0008584; P:male gonad development; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0030850; P:prostate gland development; IEA:Ensembl.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR   GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR   GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR   GO; GO:0007338; P:single fertilization; IGI:MGI.
DR   GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR   GO; GO:0007283; P:spermatogenesis; IGI:MGI.
DR   GO; GO:0060065; P:uterus development; IGI:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; HOMEOBOX PROTEIN ABDOMINAL-B; 1.
DR   PANTHER; PTHR45874:SF1; HOMEOBOX PROTEIN HOX-A10; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P31310; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..416
FT                   /note="Homeobox protein Hox-A10"
FT                   /id="PRO_0000200091"
FT   DNA_BIND        342..401
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          40..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..160
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..322
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7862151"
FT                   /id="VSP_002386"
FT   VAR_SEQ         323..325
FT                   /note="DSL -> MSQ (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7862151"
FT                   /id="VSP_002387"
FT   CONFLICT        44
FT                   /note="V -> G (in Ref. 2; AAH50839)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241
FT                   /note="Q -> E (in Ref. 1; AAA67125)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   416 AA;  43292 MW;  A088014205877F3E CRC64;
     MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG GGGGGYYAHG
     GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG SGGLGPGTHG YAPAPLDLWL
     DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP PPPQPPQPQP QATSCSFAQN IKEESSYCLY
     DAADKCPKGS AAADLAPFPR GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT
     QQLASPFPAQ PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA
     SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT KHQTLELEKE
     FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM NRENRIRELT ANFNFS
//