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Protein

Homeobox protein Hox-A10

Gene

Hoxa10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi342 – 401HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • male gonad development Source: MGI
  • multicellular organism development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of gene expression Source: MGI
  • single fertilization Source: MGI
  • skeletal system development Source: MGI
  • spermatogenesis Source: MGI
  • uterus development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A10
Alternative name(s):
Homeobox protein Hox-1.8
Gene namesi
Name:Hoxa10
Synonyms:Hox-1.8, Hoxa-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96171 Hoxa10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000911 – 416Homeobox protein Hox-A10Add BLAST416

Proteomic databases

MaxQBiP31310
PaxDbiP31310
PRIDEiP31310

PTM databases

PhosphoSitePlusiP31310

Expressioni

Tissue specificityi

Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis. Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle.

Developmental stagei

Embryonic expression increases from day 9 to day 12 and then declines to day 15.

Gene expression databases

BgeeiENSMUSG00000000938
CleanExiMM_HOXA10
GenevisibleiP31310 MM

Interactioni

Subunit structurei

Interacts with SIRT2; the interaction is direct.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200363, 6 interactors
IntActiP31310, 3 interactors
STRINGi10090.ENSMUSP00000120276

Structurei

3D structure databases

ProteinModelPortaliP31310
SMRiP31310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 55Gly-richAdd BLAST13
Compositional biasi94 – 107Poly-GlyAdd BLAST14
Compositional biasi130 – 161Gln/Pro-richAdd BLAST32
Compositional biasi232 – 239Poly-Gly8
Compositional biasi288 – 291Poly-Gly4

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiP31310
KOiK17443
OMAiCRMEPPE
OrthoDBiEOG091G0DAN
PhylomeDBiP31310
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31310-1) [UniParc]FASTAAdd to basket
Also known as: a10-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG
60 70 80 90 100
GGGGGYYAHG GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG
110 120 130 140 150
SGGLGPGTHG YAPAPLDLWL DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP
160 170 180 190 200
PPPQPPQPQP QATSCSFAQN IKEESSYCLY DAADKCPKGS AAADLAPFPR
210 220 230 240 250
GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT QQLASPFPAQ
260 270 280 290 300
PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA
310 320 330 340 350
SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT
360 370 380 390 400
KHQTLELEKE FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM
410
NRENRIRELT ANFNFS
Length:416
Mass (Da):43,292
Last modified:April 20, 2010 - v4
Checksum:iA088014205877F3E
GO
Isoform 2 (identifier: P31310-2) [UniParc]FASTAAdd to basket
Also known as: a10-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-322: Missing.
     323-325: DSL → MSQ

Show »
Length:94
Mass (Da):11,409
Checksum:i045A4859DBED931E
GO

Sequence cautioni

The sequence AAA67125 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH50839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44V → G in AAH50839 (PubMed:15489334).Curated1
Sequence conflicti241Q → E in AAA67125 (PubMed:7862151).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023861 – 322Missing in isoform 2. 1 PublicationAdd BLAST322
Alternative sequenceiVSP_002387323 – 325DSL → MSQ in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08757 mRNA Translation: AAA67125.1 Different initiation.
L08758 mRNA Translation: AAD15230.1
BC050839 mRNA Translation: AAH50839.1 Different initiation.
M81659 Genomic DNA Translation: AAA63312.1
CCDSiCCDS20147.2 [P31310-1]
CCDS51775.1 [P31310-2]
PIRiI49754
RefSeqiNP_001116422.1, NM_001122950.2 [P31310-2]
NP_032289.2, NM_008263.3 [P31310-1]
UniGeneiMm.5

Genome annotation databases

EnsembliENSMUST00000121043; ENSMUSP00000112872; ENSMUSG00000000938 [P31310-2]
ENSMUST00000125581; ENSMUSP00000120276; ENSMUSG00000000938 [P31310-1]
GeneIDi15395
KEGGimmu:15395
UCSCiuc009bym.1 mouse [P31310-1]
uc012ema.1 mouse [P31310-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHXA10_MOUSE
AccessioniPrimary (citable) accession number: P31310
Secondary accession number(s): Q80Y22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 157 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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