Homeobox protein Hox-A10 - Mus musculus (Mouse)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Experimental info

Preferred order of sections

Molecule processing

Regions

Natural variations

Experimental info

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

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P31310 (HXA10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Homeobox protein Hox-A10

Alternative name(s):
Homeobox protein Hox-1.8

Gene names

Name:	Hoxa10
Synonyms:	Hox-1.8, Hoxa-10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Subcellular location	Nucleus.
Tissue specificity	Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis. Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle.
Developmental stage	Embryonic expression increases from day 9 to day 12 and then declines to day 15.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence AAA67125.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH50839.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from genetic interaction PubMed 12869760. Source: MGI embryonic limb morphogenesis Inferred from genetic interaction PubMed 12869760. Source: MGI proximal/distal pattern formation Inferred from genetic interaction PubMed 12869760. Source: MGI skeletal system development Inferred from genetic interaction PubMed 12869760. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from direct assay PubMed 9343407. Source: MGI
Molecular_function	DNA binding Traceable author statement PubMed 11900456. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 416

416

Homeobox protein Hox-A10

PRO_0000200091

DNA binding

342 – 401

Homeobox

Compositional bias

43 – 55

Gly-rich

Compositional bias

94 – 107

Poly-Gly

Compositional bias

130 – 161

Gln/Pro-rich

Compositional bias

232 – 239

Poly-Gly

Compositional bias

288 – 291

Poly-Gly

Alternative sequence

1 – 322

322

Missing in isoform 2.

VSP_002386

Alternative sequence

323 – 325

DSL → MSQ in isoform 2.

VSP_002387

Sequence conflict

V → G in AAH50839. Ref.2

Sequence conflict

241

Q → E in AAA67125. Ref.1

Sequence		Length	Mass (Da)
Isoform 1 (a10-1) [UniParc]. Last modified April 20, 2010. Version 4. Checksum: A088014205877F3E Show »	FASTA	416	43,292
10 20 30 40 50 60 MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG GGGGGYYAHG 70 80 90 100 110 120 GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG SGGLGPGTHG YAPAPLDLWL 130 140 150 160 170 180 DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP PPPQPPQPQP QATSCSFAQN IKEESSYCLY 190 200 210 220 230 240 DAADKCPKGS AAADLAPFPR GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT 250 260 270 280 290 300 QQLASPFPAQ PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA 310 320 330 340 350 360 SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT KHQTLELEKE 370 380 390 400 410 FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM NRENRIRELT ANFNFS « Hide
Isoform 2 (a10-2) [UniParc]. Checksum: 045A4859DBED931E Show »	FASTA	94	11,409
10 20 30 40 50 60 MSQGSSKGEN AANWLTAKSG RKKRCPYTKH QTLELEKEFL FNMYLTRERR LEISRSVHLT 70 80 90 DRQVKIWFQN RRMKLKKMNR ENRIRELTAN FNFS « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes." Benson G.V., Nguyen T.-H.E., Maas R.L. Mol. Cell. Biol. 15:1591-1601(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: CD-1. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-416 (ISOFORM 1). Tissue: Limb.
[3]	"Identification of 10 murine homeobox genes." Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S. Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 342-401.
[4]	"Detection of homeobox genes in development and evolution." Murtha M.T., Leckman J.F., Ruddle F.H. Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-387. Strain: C57BL/6. Tissue: Spleen.
+	Additional computationally mapped references.

Sequence databases
EMBL GenBank DDBJ	L08757 mRNA. Translation: AAA67125.1. Different initiation. L08758 mRNA. Translation: AAD15230.1. BC050839 mRNA. Translation: AAH50839.1. Different initiation. M81659 Genomic DNA. Translation: AAA63312.1.
IPI	IPI00133247. IPI00228049.
PIR	I49754.
RefSeq	NP_001116422.1. NM_001122950.2. NP_032289.2. NM_008263.3.
UniGene	Mm.5.
3D structure databases
ProteinModelPortal	P31310.
SMR	P31310. Positions 343-401.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31310. 3 interactions.
MINT	MINT-1172417.
STRING	10090.ENSMUSP00000120276.
PTM databases
PhosphoSite	P31310.
Proteomic databases
PRIDE	P31310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000121043; ENSMUSP00000112872; ENSMUSG00000000938. ENSMUST00000125581; ENSMUSP00000120276; ENSMUSG00000000938.
GeneID	15395.
KEGG	mmu:15395.
UCSC	uc009bym.1. mouse. uc012ema.1. mouse.
Organism-specific databases
CTD	3206.
MGI	MGI:96171. Hoxa10.
Phylogenomic databases
eggNOG	NOG248153.
GeneTree	ENSGT00700000104054.
HOGENOM	HOG000231182.
HOVERGEN	HBG052934.
InParanoid	P31310.
KO	K09295.
OMA	CRMEPPD.
OrthoDB	EOG4VX26S.
Gene expression databases
ArrayExpress	P31310.
Bgee	P31310.
CleanEx	MM_HOXA10.
Genevestigator	P31310.
GermOnline	ENSMUSG00000000938. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288076.
SOURCE	Search...

Entry name

HXA10_MOUSE

Accession

Primary (citable) accession number: P31310
Secondary accession number(s): Q80Y22

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 119 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P31310-1)

Also known as: a10-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P31310-2)

Also known as: a10-2;

The sequence of this isoform differs from the canonical sequence as follows:
1-322: Missing.
323-325: DSL → MSQ