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P31310 (HXA10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A10
Alternative name(s):
Homeobox protein Hox-1.8
Gene names
Name:Hoxa10
Synonyms:Hox-1.8, Hoxa-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis. Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle.

Developmental stage

Embryonic expression increases from day 9 to day 12 and then declines to day 15.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA67125.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH50839.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from genetic interaction PubMed 12869760. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 12869760. Source: MGI

male gonad development

Inferred from genetic interaction PubMed 23760953. Source: MGI

multicellular organismal development

Inferred from direct assay PubMed 11900456. Source: MGI

proximal/distal pattern formation

Inferred from genetic interaction PubMed 12869760. Source: MGI

regulation of gene expression

Inferred from genetic interaction PubMed 23760953. Source: MGI

single fertilization

Inferred from genetic interaction PubMed 23760953. Source: MGI

skeletal system development

Inferred from genetic interaction PubMed 12869760. Source: MGI

spermatogenesis

Inferred from genetic interaction PubMed 23760953. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

uterus development

Inferred from genetic interaction PubMed 23760953. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from direct assay PubMed 9343407. Source: MGI

   Molecular_functionDNA binding

Traceable author statement PubMed 11900456. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P31310-1)

Also known as: a10-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P31310-2)

Also known as: a10-2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-322: Missing.
     323-325: DSL → MSQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Homeobox protein Hox-A10
PRO_0000200091

Regions

DNA binding342 – 40160Homeobox
Compositional bias43 – 5513Gly-rich
Compositional bias94 – 10714Poly-Gly
Compositional bias130 – 16132Gln/Pro-rich
Compositional bias232 – 2398Poly-Gly
Compositional bias288 – 2914Poly-Gly

Natural variations

Alternative sequence1 – 322322Missing in isoform 2.
VSP_002386
Alternative sequence323 – 3253DSL → MSQ in isoform 2.
VSP_002387

Experimental info

Sequence conflict441V → G in AAH50839. Ref.2
Sequence conflict2411Q → E in AAA67125. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (a10-1) [UniParc].

Last modified April 20, 2010. Version 4.
Checksum: A088014205877F3E

FASTA41643,292
        10         20         30         40         50         60 
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG GGGGGYYAHG 

        70         80         90        100        110        120 
GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG SGGLGPGTHG YAPAPLDLWL 

       130        140        150        160        170        180 
DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP PPPQPPQPQP QATSCSFAQN IKEESSYCLY 

       190        200        210        220        230        240 
DAADKCPKGS AAADLAPFPR GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT 

       250        260        270        280        290        300 
QQLASPFPAQ PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA 

       310        320        330        340        350        360 
SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT KHQTLELEKE 

       370        380        390        400        410 
FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM NRENRIRELT ANFNFS 

« Hide

Isoform 2 (a10-2) [UniParc].

Checksum: 045A4859DBED931E
Show »

FASTA9411,409

References

« Hide 'large scale' references
[1]"The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes."
Benson G.V., Nguyen T.-H.E., Maas R.L.
Mol. Cell. Biol. 15:1591-1601(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: CD-1.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-416 (ISOFORM 1).
Tissue: Limb.
[3]"Identification of 10 murine homeobox genes."
Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G., Potter S.S.
Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 342-401.
[4]"Detection of homeobox genes in development and evolution."
Murtha M.T., Leckman J.F., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-387.
Strain: C57BL/6.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08757 mRNA. Translation: AAA67125.1. Different initiation.
L08758 mRNA. Translation: AAD15230.1.
BC050839 mRNA. Translation: AAH50839.1. Different initiation.
M81659 Genomic DNA. Translation: AAA63312.1.
PIRI49754.
RefSeqNP_001116422.1. NM_001122950.2.
NP_032289.2. NM_008263.3.
UniGeneMm.5.

3D structure databases

ProteinModelPortalP31310.
SMRP31310. Positions 343-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200363. 6 interactions.
IntActP31310. 3 interactions.
MINTMINT-1172417.
STRING10090.ENSMUSP00000120276.

PTM databases

PhosphoSiteP31310.

Proteomic databases

PRIDEP31310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000121043; ENSMUSP00000112872; ENSMUSG00000000938. [P31310-2]
ENSMUST00000125581; ENSMUSP00000120276; ENSMUSG00000000938. [P31310-1]
GeneID15395.
KEGGmmu:15395.
UCSCuc009bym.1. mouse. [P31310-1]
uc012ema.1. mouse. [P31310-2]

Organism-specific databases

CTD3206.
MGIMGI:96171. Hoxa10.

Phylogenomic databases

eggNOGNOG248153.
GeneTreeENSGT00750000117229.
HOGENOMHOG000231182.
HOVERGENHBG052934.
InParanoidP31310.
KOK17443.
OMACRMEPPE.
OrthoDBEOG72JWGM.
PhylomeDBP31310.
TreeFamTF317819.

Gene expression databases

BgeeP31310.
CleanExMM_HOXA10.
GenevestigatorP31310.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288076.
PROP31310.
SOURCESearch...

Entry information

Entry nameHXA10_MOUSE
AccessionPrimary (citable) accession number: P31310
Secondary accession number(s): Q80Y22
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries