P31277 (HXD11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D11

Alternative name(s):
Homeobox protein Hox-4F

Gene names

Name:	HOXD11
Synonyms:	HOX4F

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB cartilage development involved in endochondral bone morphogenesis Inferred from electronic annotation. Source: Compara developmental growth Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from sequence or structural similarity. Source: UniProtKB embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal joint morphogenesis Inferred from electronic annotation. Source: Compara metanephros development Inferred from electronic annotation. Source: Compara organ induction Inferred from electronic annotation. Source: Compara positive regulation of cell development Inferred from electronic annotation. Source: Compara positive regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara proximal/distal pattern formation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Homeobox protein Hox-D11		PRO_0000200231
Regions
	DNA binding	266 – 325	60	Homeobox
	Compositional bias	90 – 102	13	Poly-Gly
	Compositional bias	108 – 120	13	Poly-Ala
Natural variations
	Natural variant	245	1	G → D. Ref.4		VAR_031647
Experimental info
	Sequence conflict	196 – 205	10	PPPPAPPQPE → RRHPRRHSPM in AAF79045. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P31277 [UniParc]. Last modified February 10, 2009. Version 3. Checksum: 2960C3C983EA9A6A	FASTA	338	35,197
	10 20 30 40 50 60 MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE 70 80 90 100 110 120 VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA 130 140 150 160 170 180 EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ 190 200 210 220 230 240 FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG 250 260 270 280 290 300 SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS 310 320 330 RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra type." Miwa N., Yoshiura K., Kantaputra P.K., Soeda E., Niikawa N. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-331.
[4]	"Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome." Zhao X., Sun M., Zhao J., Leyva J.A., Zhu H., Yang W., Zeng X., Ao Y., Liu Q., Liu G., Lo W.H.Y., Jabs E.W., Amzel L.M., Shan X., Zhang X. Am. J. Hum. Genet. 80:361-371(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ASP-245.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF154915 Genomic DNA. Translation: AAF79045.1. AC009336 Genomic DNA. No translation available.
IPI	IPI00305856.
PIR	S14938.
RefSeq	NP_067015.2. NM_021192.2.
UniGene	Hs.421136.
3D structure databases
ProteinModelPortal	P31277.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000249504.
Polymorphism databases
DMDM	223590220.
Proteomic databases
PaxDb	P31277.
PRIDE	P31277.
Protocols and materials databases
DNASU	3237.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249504; ENSP00000249504; ENSG00000128713.
GeneID	3237.
KEGG	hsa:3237.
UCSC	uc002uki.3. human.
Organism-specific databases
CTD	3237.
GeneCards	GC02P176936.
HGNC	HGNC:5134. HOXD11.
MIM	142986. gene.
neXtProt	NX_P31277.
PharmGKB	PA29408.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305087.
HOGENOM	HOG000231898.
HOVERGEN	HBG052048.
KO	K09296.
OMA	SPCTKAT.
OrthoDB	EOG4KKZ3X.
Gene expression databases
Bgee	P31277.
CleanEx	HS_HOXD11.
Genevestigator	P31277.
GermOnline	ENSG00000128713. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR021918. DUF3528. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF12045. DUF3528. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3237.
NextBio	12883.
SOURCE	Search...

Entry information

Entry name

HXD11_HUMAN

Accession

Primary (citable) accession number: P31277
Secondary accession number(s): A6NIS4, Q9NS02

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 120 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.