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Protein

Homeobox protein Hox-D11

Gene

HOXD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP31277

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Alternative name(s):
Homeobox protein Hox-4F
Gene namesi
Name:HOXD11
Synonyms:HOX4F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128713.12
HGNCiHGNC:5134 HOXD11
MIMi142986 gene
neXtProtiNX_P31277

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3237
OpenTargetsiENSG00000128713
PharmGKBiPA29408

Polymorphism and mutation databases

BioMutaiHOXD11
DMDMi223590220

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002311 – 338Homeobox protein Hox-D11Add BLAST338

Proteomic databases

PaxDbiP31277
PeptideAtlasiP31277
PRIDEiP31277

PTM databases

iPTMnetiP31277
PhosphoSitePlusiP31277

Expressioni

Gene expression databases

BgeeiENSG00000128713
CleanExiHS_HOXD11
GenevisibleiP31277 HS

Organism-specific databases

HPAiHPA055155

Interactioni

Protein-protein interaction databases

BioGridi109477, 1 interactor
STRINGi9606.ENSP00000249504

Structurei

3D structure databases

ProteinModelPortaliP31277
SMRiP31277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 102Poly-GlyAdd BLAST13
Compositional biasi108 – 120Poly-AlaAdd BLAST13

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231898
HOVERGENiHBG052048
InParanoidiP31277
KOiK09296
OMAiCAYYVSP
OrthoDBiEOG091G12E6
PhylomeDBiP31277
TreeFamiTF350668

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 2 hits
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN
60 70 80 90 100
LAPHVQPVRE VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA
110 120 130 140 150
GGYAPYYAAA AAAAAAAAAA EEAAMQRELL PPAGRRPDVL FKAPEPVCAA
160 170 180 190 200
PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ FYEAAPGPPF AGPQPPPPPA
210 220 230 240 250
PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG SGGDGEGPPG
260 270 280 290 300
EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS
310 320 330
RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF
Length:338
Mass (Da):35,197
Last modified:February 10, 2009 - v3
Checksum:i2960C3C983EA9A6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196 – 205PPPPAPPQPE → RRHPRRHSPM in AAF79045 (Ref. 1) Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031647245G → D1 PublicationCorresponds to variant dbSNP:rs376305712Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154915 Genomic DNA Translation: AAF79045.1
AC009336 Genomic DNA No translation available.
CCDSiCCDS2265.1
PIRiS14938
RefSeqiNP_067015.2, NM_021192.2
UniGeneiHs.421136

Genome annotation databases

EnsembliENST00000249504; ENSP00000249504; ENSG00000128713
GeneIDi3237
KEGGihsa:3237
UCSCiuc002uki.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXD11_HUMAN
AccessioniPrimary (citable) accession number: P31277
Secondary accession number(s): A6NIS4, Q9NS02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health