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P31277

- HXD11_HUMAN

UniProt

P31277 - HXD11_HUMAN

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Protein

Homeobox protein Hox-D11

Gene

HOXD11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi266 – 32560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. branching involved in ureteric bud morphogenesis Source: UniProtKB
  3. cartilage development involved in endochondral bone morphogenesis Source: Ensembl
  4. developmental growth Source: Ensembl
  5. dorsal/ventral pattern formation Source: UniProtKB
  6. embryonic digit morphogenesis Source: Ensembl
  7. embryonic forelimb morphogenesis Source: Ensembl
  8. embryonic skeletal joint morphogenesis Source: Ensembl
  9. metanephros development Source: Ensembl
  10. organ induction Source: Ensembl
  11. positive regulation of cell development Source: Ensembl
  12. positive regulation of chondrocyte differentiation Source: Ensembl
  13. proximal/distal pattern formation Source: Ensembl
  14. regulation of transcription, DNA-templated Source: UniProtKB-KW
  15. single fertilization Source: Ensembl
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Alternative name(s):
Homeobox protein Hox-4F
Gene namesi
Name:HOXD11
Synonyms:HOX4F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:5134. HOXD11.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Homeobox protein Hox-D11PRO_0000200231Add
BLAST

Proteomic databases

PaxDbiP31277.
PRIDEiP31277.

Expressioni

Gene expression databases

BgeeiP31277.
CleanExiHS_HOXD11.
GenevestigatoriP31277.

Interactioni

Protein-protein interaction databases

BioGridi109477. 1 interaction.
STRINGi9606.ENSP00000249504.

Structurei

3D structure databases

ProteinModelPortaliP31277.
SMRiP31277. Positions 266-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 10213Poly-GlyAdd
BLAST
Compositional biasi108 – 12013Poly-AlaAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305087.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiP31277.
KOiK09296.
OMAiFYETAPG.
OrthoDBiEOG7ZWD2F.
PhylomeDBiP31277.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31277-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN
60 70 80 90 100
LAPHVQPVRE VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA
110 120 130 140 150
GGYAPYYAAA AAAAAAAAAA EEAAMQRELL PPAGRRPDVL FKAPEPVCAA
160 170 180 190 200
PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ FYEAAPGPPF AGPQPPPPPA
210 220 230 240 250
PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG SGGDGEGPPG
260 270 280 290 300
EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS
310 320 330
RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF
Length:338
Mass (Da):35,197
Last modified:February 10, 2009 - v3
Checksum:i2960C3C983EA9A6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 20510PPPPAPPQPE → RRHPRRHSPM in AAF79045. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451G → D.1 Publication
VAR_031647

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154915 Genomic DNA. Translation: AAF79045.1.
AC009336 Genomic DNA. No translation available.
CCDSiCCDS2265.1.
PIRiS14938.
RefSeqiNP_067015.2. NM_021192.2.
UniGeneiHs.421136.

Genome annotation databases

EnsembliENST00000249504; ENSP00000249504; ENSG00000128713.
GeneIDi3237.
KEGGihsa:3237.
UCSCiuc002uki.3. human.

Polymorphism databases

DMDMi223590220.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154915 Genomic DNA. Translation: AAF79045.1 .
AC009336 Genomic DNA. No translation available.
CCDSi CCDS2265.1.
PIRi S14938.
RefSeqi NP_067015.2. NM_021192.2.
UniGenei Hs.421136.

3D structure databases

ProteinModelPortali P31277.
SMRi P31277. Positions 266-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109477. 1 interaction.
STRINGi 9606.ENSP00000249504.

Polymorphism databases

DMDMi 223590220.

Proteomic databases

PaxDbi P31277.
PRIDEi P31277.

Protocols and materials databases

DNASUi 3237.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249504 ; ENSP00000249504 ; ENSG00000128713 .
GeneIDi 3237.
KEGGi hsa:3237.
UCSCi uc002uki.3. human.

Organism-specific databases

CTDi 3237.
GeneCardsi GC02P176936.
HGNCi HGNC:5134. HOXD11.
MIMi 142986. gene.
neXtProti NX_P31277.
PharmGKBi PA29408.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305087.
GeneTreei ENSGT00760000118834.
HOGENOMi HOG000231898.
HOVERGENi HBG052048.
InParanoidi P31277.
KOi K09296.
OMAi FYETAPG.
OrthoDBi EOG7ZWD2F.
PhylomeDBi P31277.
TreeFami TF350668.

Miscellaneous databases

ChiTaRSi HOXD11. human.
GeneWikii HOXD11.
GenomeRNAii 3237.
NextBioi 12883.
PROi P31277.
SOURCEi Search...

Gene expression databases

Bgeei P31277.
CleanExi HS_HOXD11.
Genevestigatori P31277.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra type."
    Miwa N., Yoshiura K., Kantaputra P.K., Soeda E., Niikawa N.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-331.
  4. "Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome."
    Zhao X., Sun M., Zhao J., Leyva J.A., Zhu H., Yang W., Zeng X., Ao Y., Liu Q., Liu G., Lo W.H.Y., Jabs E.W., Amzel L.M., Shan X., Zhang X.
    Am. J. Hum. Genet. 80:361-371(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-245.

Entry informationi

Entry nameiHXD11_HUMAN
AccessioniPrimary (citable) accession number: P31277
Secondary accession number(s): A6NIS4, Q9NS02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3