P31275 (HXC12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C12

Alternative name(s):
Homeobox protein Hox-3F

Gene names

Name:	HOXC12
Synonyms:	HOC3F, HOX3F

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Homeobox protein Hox-C12		PRO_0000200194
Regions
	DNA binding	214 – 273	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P31275 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 493C53C511054A4D	FASTA	282	30,171
	10 20 30 40 50 60 MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP 70 80 90 100 110 120 CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP 130 140 150 160 170 180 GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK 190 200 210 220 230 240 GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT 250 260 270 280 RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF

References

[1]	"Complete mutation analysis panel of the 39 human HOX genes." Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K., Tomita M., McGinnis W., Matsuo N. Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-279.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF328962, AF328963 Genomic DNA. Translation: AAK16717.1.
IPI	IPI00010758.
PIR	S14933.
RefSeq	NP_776272.1. NM_173860.1.
UniGene	Hs.381267. Hs.587727.
3D structure databases
ProteinModelPortal	P31275.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000243103.
Polymorphism databases
DMDM	20141538.
Proteomic databases
PaxDb	P31275.
PRIDE	P31275.
Protocols and materials databases
DNASU	3228.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243103; ENSP00000243103; ENSG00000123407.
GeneID	3228.
KEGG	hsa:3228.
UCSC	uc010soq.2. human.
Organism-specific databases
CTD	3228.
GeneCards	GC12P054349.
HGNC	HGNC:5124. HOXC12.
MIM	142975. gene.
neXtProt	NX_P31275.
PharmGKB	PA29399.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG239684.
HOGENOM	HOG000231177.
HOVERGEN	HBG052050.
InParanoid	P31275.
KO	K09297.
OMA	EPCNGYS.
OrthoDB	EOG4BP1CK.
PhylomeDB	P31275.
Gene expression databases
CleanEx	HS_HOXC12.
Genevestigator	P31275.
GermOnline	ENSG00000123407. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3228.
NextBio	12847.
SOURCE	Search...

Entry information

Entry name

HXC12_HUMAN

Accession

Primary (citable) accession number: P31275
Secondary accession number(s): Q9BXJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.