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Protein

Homeobox protein Hox-C12

Gene

HOXC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi214 – 273HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3F
Gene namesi
Name:HOXC12
Synonyms:HOC3F, HOX3F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123407.3.
HGNCiHGNC:5124. HOXC12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3228.
OpenTargetsiENSG00000123407.
PharmGKBiPA29399.

Polymorphism and mutation databases

BioMutaiHOXC12.
DMDMi20141538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001941 – 282Homeobox protein Hox-C12Add BLAST282

Proteomic databases

PaxDbiP31275.
PeptideAtlasiP31275.
PRIDEiP31275.

PTM databases

iPTMnetiP31275.
PhosphoSitePlusiP31275.

Expressioni

Gene expression databases

BgeeiENSG00000123407.
CleanExiHS_HOXC12.
GenevisibleiP31275. HS.

Organism-specific databases

HPAiHPA055632.

Structurei

3D structure databases

ProteinModelPortaliP31275.
SMRiP31275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP31275.
KOiK09297.
OMAiEPCNGYS.
OrthoDBiEOG091G0HNN.
PhylomeDBiP31275.
TreeFamiTF351604.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P31275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG
160 170 180 190 200
GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL
210 220 230 240 250
SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR
260 270 280
LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
Length:282
Mass (Da):30,171
Last modified:January 23, 2002 - v2
Checksum:i493C53C511054A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328962, AF328963 Genomic DNA. Translation: AAK16717.1.
CCDSiCCDS8866.1.
PIRiS14933.
RefSeqiNP_776272.1. NM_173860.2.
UniGeneiHs.381267.
Hs.587727.

Genome annotation databases

EnsembliENST00000243103; ENSP00000243103; ENSG00000123407.
GeneIDi3228.
KEGGihsa:3228.
UCSCiuc010soq.3. human.

Similar proteinsi

Entry informationi

Entry nameiHXC12_HUMAN
AccessioniPrimary (citable) accession number: P31275
Secondary accession number(s): Q9BXJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: September 27, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families