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Protein

Homeobox protein Hox-C12

Gene

HOXC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi214 – 27360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3F
Gene namesi
Name:HOXC12
Synonyms:HOC3F, HOX3F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5124. HOXC12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29399.

Polymorphism and mutation databases

BioMutaiHOXC12.
DMDMi20141538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Homeobox protein Hox-C12PRO_0000200194Add
BLAST

Proteomic databases

PaxDbiP31275.
PeptideAtlasiP31275.
PRIDEiP31275.

PTM databases

iPTMnetiP31275.

Expressioni

Gene expression databases

CleanExiHS_HOXC12.
GenevisibleiP31275. HS.

Organism-specific databases

HPAiHPA055632.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000243103.

Structurei

3D structure databases

ProteinModelPortaliP31275.
SMRiP31275. Positions 214-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP31275.
KOiK09297.
OMAiVSINPSF.
OrthoDBiEOG7FV3R4.
PhylomeDBiP31275.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLSWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGRDPGAGP GAALLPLEPS GPPALGFKYD YAAGGGGGDG
160 170 180 190 200
GGGAGPPHDP PSCQSLESDS SSSLLNEGNK GAGAGDPGSL VSPLNPGGGL
210 220 230 240 250
SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT RQRRRELSDR
260 270 280
LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF
Length:282
Mass (Da):30,171
Last modified:January 23, 2002 - v2
Checksum:i493C53C511054A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328962, AF328963 Genomic DNA. Translation: AAK16717.1.
CCDSiCCDS8866.1.
PIRiS14933.
RefSeqiNP_776272.1. NM_173860.1.
UniGeneiHs.381267.
Hs.587727.

Genome annotation databases

EnsembliENST00000243103; ENSP00000243103; ENSG00000123407.
GeneIDi3228.
KEGGihsa:3228.
UCSCiuc010soq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328962, AF328963 Genomic DNA. Translation: AAK16717.1.
CCDSiCCDS8866.1.
PIRiS14933.
RefSeqiNP_776272.1. NM_173860.1.
UniGeneiHs.381267.
Hs.587727.

3D structure databases

ProteinModelPortaliP31275.
SMRiP31275. Positions 214-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243103.

PTM databases

iPTMnetiP31275.

Polymorphism and mutation databases

BioMutaiHOXC12.
DMDMi20141538.

Proteomic databases

PaxDbiP31275.
PeptideAtlasiP31275.
PRIDEiP31275.

Protocols and materials databases

DNASUi3228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243103; ENSP00000243103; ENSG00000123407.
GeneIDi3228.
KEGGihsa:3228.
UCSCiuc010soq.3. human.

Organism-specific databases

CTDi3228.
GeneCardsiHOXC12.
HGNCiHGNC:5124. HOXC12.
HPAiHPA055632.
MIMi142975. gene.
neXtProtiNX_P31275.
PharmGKBiPA29399.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP31275.
KOiK09297.
OMAiVSINPSF.
OrthoDBiEOG7FV3R4.
PhylomeDBiP31275.
TreeFamiTF351604.

Miscellaneous databases

GeneWikiiHOXC12.
GenomeRNAii3228.
PROiP31275.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HOXC12.
GenevisibleiP31275. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-279.

Entry informationi

Entry nameiHXC12_HUMAN
AccessioniPrimary (citable) accession number: P31275
Secondary accession number(s): Q9BXJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: July 6, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.