Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31274

- HXC9_HUMAN

UniProt

P31274 - HXC9_HUMAN

Protein

Homeobox protein Hox-C9

Gene

HOXC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (23 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system morphogenesis Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C9
    Alternative name(s):
    Homeobox protein Hox-3B
    Gene namesi
    Name:HOXC9
    Synonyms:HOX3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5130. HOXC9.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29405.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Homeobox protein Hox-C9PRO_0000200184Add
    BLAST

    Proteomic databases

    MaxQBiP31274.
    PaxDbiP31274.
    PRIDEiP31274.

    Expressioni

    Gene expression databases

    BgeeiP31274.
    CleanExiHS_HOXC9.
    GenevestigatoriP31274.

    Interactioni

    Subunit structurei

    Interacts with Geminin/GMNN, which inhibits transcriptional activity.1 Publication

    Protein-protein interaction databases

    BioGridi109465. 14 interactions.
    IntActiP31274. 3 interactions.
    MINTiMINT-2802481.
    STRINGi9606.ENSP00000302836.

    Structurei

    Secondary structure

    1
    260
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi194 – 1963
    Helixi201 – 21313
    Helixi219 – 22810
    Helixi233 – 24816

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LP0NMR-A192-251[»]
    ProteinModelPortaliP31274.
    SMRiP31274. Positions 192-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG288226.
    HOVERGENiHBG016849.
    InParanoidiP31274.
    KOiK09294.
    OMAiSGPISNY.
    OrthoDBiEOG7JX34T.
    PhylomeDBiP31274.
    TreeFamiTF317819.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31274-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF    50
    PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL 100
    SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR 150
    DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT 200
    KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM 250
    NKEKTDKEQS 260
    Length:260
    Mass (Da):29,248
    Last modified:January 23, 2002 - v3
    Checksum:i0B278FF94945BC1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471C → R in AK000445. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871G → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036267

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
    AK000445 mRNA. No translation available.
    AK315194 mRNA. Translation: BAG37634.1.
    CH471054 Genomic DNA. Translation: EAW96741.1.
    BC053894 mRNA. Translation: AAH53894.1.
    CCDSiCCDS8869.1.
    PIRiS15532.
    RefSeqiNP_008828.1. NM_006897.1.
    UniGeneiHs.658823.

    Genome annotation databases

    EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
    ENST00000508190; ENSP00000423861; ENSG00000180806.
    GeneIDi3225.
    KEGGihsa:3225.
    UCSCiuc001seq.3. human.

    Polymorphism databases

    DMDMi20141537.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014302 , AY014301 Genomic DNA. Translation: AAG42151.1 .
    AK000445 mRNA. No translation available.
    AK315194 mRNA. Translation: BAG37634.1 .
    CH471054 Genomic DNA. Translation: EAW96741.1 .
    BC053894 mRNA. Translation: AAH53894.1 .
    CCDSi CCDS8869.1.
    PIRi S15532.
    RefSeqi NP_008828.1. NM_006897.1.
    UniGenei Hs.658823.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LP0 NMR - A 192-251 [» ]
    ProteinModelPortali P31274.
    SMRi P31274. Positions 192-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109465. 14 interactions.
    IntActi P31274. 3 interactions.
    MINTi MINT-2802481.
    STRINGi 9606.ENSP00000302836.

    Polymorphism databases

    DMDMi 20141537.

    Proteomic databases

    MaxQBi P31274.
    PaxDbi P31274.
    PRIDEi P31274.

    Protocols and materials databases

    DNASUi 3225.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303450 ; ENSP00000302836 ; ENSG00000180806 .
    ENST00000508190 ; ENSP00000423861 ; ENSG00000180806 .
    GeneIDi 3225.
    KEGGi hsa:3225.
    UCSCi uc001seq.3. human.

    Organism-specific databases

    CTDi 3225.
    GeneCardsi GC12P054388.
    HGNCi HGNC:5130. HOXC9.
    MIMi 142971. gene.
    neXtProti NX_P31274.
    PharmGKBi PA29405.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288226.
    HOVERGENi HBG016849.
    InParanoidi P31274.
    KOi K09294.
    OMAi SGPISNY.
    OrthoDBi EOG7JX34T.
    PhylomeDBi P31274.
    TreeFami TF317819.

    Miscellaneous databases

    GeneWikii HOXC9.
    GenomeRNAii 3225.
    NextBioi 12835.
    PROi P31274.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31274.
    CleanExi HS_HOXC9.
    Genevestigatori P31274.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR017112. Homeobox_Hox9.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR006711. Hox9_activation_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF04617. Hox9_act. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovium.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    5. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-257.
    6. "Structural basis for homeodomain recognition by the cell-cycle regulator Geminin."
      Zhou B., Liu C., Xu Z., Zhu G.
      Proc. Natl. Acad. Sci. U.S.A. 109:8931-8936(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 192-251 IN COMPLEX WITH GMNN, INTERACTION WITH GMNN.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-87.

    Entry informationi

    Entry nameiHXC9_HUMAN
    AccessioniPrimary (citable) accession number: P31274
    Secondary accession number(s): B2RCN7, Q9H1I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3