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P31274

- HXC9_HUMAN

UniProt

P31274 - HXC9_HUMAN

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Protein

Homeobox protein Hox-C9

Gene

HOXC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3B
Gene namesi
Name:HOXC9
Synonyms:HOX3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5130. HOXC9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Homeobox protein Hox-C9PRO_0000200184Add
BLAST

Proteomic databases

MaxQBiP31274.
PaxDbiP31274.
PRIDEiP31274.

Expressioni

Gene expression databases

BgeeiP31274.
CleanExiHS_HOXC9.
GenevestigatoriP31274.

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.1 Publication

Protein-protein interaction databases

BioGridi109465. 18 interactions.
IntActiP31274. 3 interactions.
MINTiMINT-2802481.
STRINGi9606.ENSP00000302836.

Structurei

Secondary structure

1
260
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi194 – 1963
Helixi201 – 21313
Helixi219 – 22810
Helixi233 – 24816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LP0NMR-A192-251[»]
ProteinModelPortaliP31274.
SMRiP31274. Positions 192-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG288226.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG016849.
InParanoidiP31274.
KOiK09294.
OMAiSGPISNY.
OrthoDBiEOG7JX34T.
PhylomeDBiP31274.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31274-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,248
Last modified:January 23, 2002 - v3
Checksum:i0B278FF94945BC1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471C → R in AK000445. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871G → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036267

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1.
CH471054 Genomic DNA. Translation: EAW96741.1.
BC053894 mRNA. Translation: AAH53894.1.
CCDSiCCDS8869.1.
PIRiS15532.
RefSeqiNP_008828.1. NM_006897.1.
UniGeneiHs.658823.

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
ENST00000508190; ENSP00000423861; ENSG00000180806.
GeneIDi3225.
KEGGihsa:3225.
UCSCiuc001seq.3. human.

Polymorphism databases

DMDMi20141537.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY014302 , AY014301 Genomic DNA. Translation: AAG42151.1 .
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1 .
CH471054 Genomic DNA. Translation: EAW96741.1 .
BC053894 mRNA. Translation: AAH53894.1 .
CCDSi CCDS8869.1.
PIRi S15532.
RefSeqi NP_008828.1. NM_006897.1.
UniGenei Hs.658823.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LP0 NMR - A 192-251 [» ]
ProteinModelPortali P31274.
SMRi P31274. Positions 192-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109465. 18 interactions.
IntActi P31274. 3 interactions.
MINTi MINT-2802481.
STRINGi 9606.ENSP00000302836.

Polymorphism databases

DMDMi 20141537.

Proteomic databases

MaxQBi P31274.
PaxDbi P31274.
PRIDEi P31274.

Protocols and materials databases

DNASUi 3225.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303450 ; ENSP00000302836 ; ENSG00000180806 .
ENST00000508190 ; ENSP00000423861 ; ENSG00000180806 .
GeneIDi 3225.
KEGGi hsa:3225.
UCSCi uc001seq.3. human.

Organism-specific databases

CTDi 3225.
GeneCardsi GC12P054388.
HGNCi HGNC:5130. HOXC9.
MIMi 142971. gene.
neXtProti NX_P31274.
PharmGKBi PA29405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288226.
GeneTreei ENSGT00760000118834.
HOVERGENi HBG016849.
InParanoidi P31274.
KOi K09294.
OMAi SGPISNY.
OrthoDBi EOG7JX34T.
PhylomeDBi P31274.
TreeFami TF317819.

Miscellaneous databases

GeneWikii HOXC9.
GenomeRNAii 3225.
NextBioi 12835.
PROi P31274.
SOURCEi Search...

Gene expression databases

Bgeei P31274.
CleanExi HS_HOXC9.
Genevestigatori P31274.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view ]
PIRSFi PIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-257.
  6. "Structural basis for homeodomain recognition by the cell-cycle regulator Geminin."
    Zhou B., Liu C., Xu Z., Zhu G.
    Proc. Natl. Acad. Sci. U.S.A. 109:8931-8936(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 192-251 IN COMPLEX WITH GMNN, INTERACTION WITH GMNN.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-87.

Entry informationi

Entry nameiHXC9_HUMAN
AccessioniPrimary (citable) accession number: P31274
Secondary accession number(s): B2RCN7, Q9H1I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: October 29, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3