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Protein

Homeobox protein Hox-C9

Gene

HOXC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system morphogenesis Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3B
Gene namesi
Name:HOXC9
Synonyms:HOX3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5130. HOXC9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Homeobox protein Hox-C9PRO_0000200184Add
BLAST

Proteomic databases

MaxQBiP31274.
PaxDbiP31274.
PRIDEiP31274.

Expressioni

Gene expression databases

BgeeiP31274.
CleanExiHS_HOXC9.
ExpressionAtlasiP31274. baseline and differential.
GenevestigatoriP31274.

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.1 Publication

Protein-protein interaction databases

BioGridi109465. 19 interactions.
IntActiP31274. 3 interactions.
MINTiMINT-2802481.
STRINGi9606.ENSP00000302836.

Structurei

Secondary structure

1
260
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi194 – 1963Combined sources
Helixi201 – 21313Combined sources
Helixi219 – 22810Combined sources
Helixi233 – 24816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LP0NMR-A192-251[»]
ProteinModelPortaliP31274.
SMRiP31274. Positions 192-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG288226.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG016849.
InParanoidiP31274.
KOiK09294.
OMAiECADYPS.
OrthoDBiEOG7JX34T.
PhylomeDBiP31274.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31274-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,248
Last modified:January 23, 2002 - v3
Checksum:i0B278FF94945BC1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471C → R in AK000445. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871G → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1.
CH471054 Genomic DNA. Translation: EAW96741.1.
BC053894 mRNA. Translation: AAH53894.1.
CCDSiCCDS8869.1.
PIRiS15532.
RefSeqiNP_008828.1. NM_006897.1.
UniGeneiHs.658823.

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
ENST00000508190; ENSP00000423861; ENSG00000180806.
GeneIDi3225.
KEGGihsa:3225.
UCSCiuc001seq.3. human.

Polymorphism databases

DMDMi20141537.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1.
CH471054 Genomic DNA. Translation: EAW96741.1.
BC053894 mRNA. Translation: AAH53894.1.
CCDSiCCDS8869.1.
PIRiS15532.
RefSeqiNP_008828.1. NM_006897.1.
UniGeneiHs.658823.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LP0NMR-A192-251[»]
ProteinModelPortaliP31274.
SMRiP31274. Positions 192-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109465. 19 interactions.
IntActiP31274. 3 interactions.
MINTiMINT-2802481.
STRINGi9606.ENSP00000302836.

Polymorphism databases

DMDMi20141537.

Proteomic databases

MaxQBiP31274.
PaxDbiP31274.
PRIDEiP31274.

Protocols and materials databases

DNASUi3225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
ENST00000508190; ENSP00000423861; ENSG00000180806.
GeneIDi3225.
KEGGihsa:3225.
UCSCiuc001seq.3. human.

Organism-specific databases

CTDi3225.
GeneCardsiGC12P054388.
HGNCiHGNC:5130. HOXC9.
MIMi142971. gene.
neXtProtiNX_P31274.
PharmGKBiPA29405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288226.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG016849.
InParanoidiP31274.
KOiK09294.
OMAiECADYPS.
OrthoDBiEOG7JX34T.
PhylomeDBiP31274.
TreeFamiTF317819.

Miscellaneous databases

ChiTaRSiHOXC9. human.
GeneWikiiHOXC9.
GenomeRNAii3225.
NextBioi12835.
PROiP31274.
SOURCEiSearch...

Gene expression databases

BgeeiP31274.
CleanExiHS_HOXC9.
ExpressionAtlasiP31274. baseline and differential.
GenevestigatoriP31274.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR017112. Homeobox_Hox9.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-257.
  6. "Structural basis for homeodomain recognition by the cell-cycle regulator Geminin."
    Zhou B., Liu C., Xu Z., Zhu G.
    Proc. Natl. Acad. Sci. U.S.A. 109:8931-8936(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 192-251 IN COMPLEX WITH GMNN, INTERACTION WITH GMNN.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-87.

Entry informationi

Entry nameiHXC9_HUMAN
AccessioniPrimary (citable) accession number: P31274
Secondary accession number(s): B2RCN7, Q9H1I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: February 4, 2015
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.