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Protein

Homeobox protein Hox-C9

Gene

HOXC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 251HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C9
Alternative name(s):
Homeobox protein Hox-3B
Gene namesi
Name:HOXC9
Synonyms:HOX3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5130. HOXC9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3225.
OpenTargetsiENSG00000180806.
PharmGKBiPA29405.

Polymorphism and mutation databases

BioMutaiHOXC9.
DMDMi20141537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001841 – 260Homeobox protein Hox-C9Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP31274.
PaxDbiP31274.
PeptideAtlasiP31274.
PRIDEiP31274.

PTM databases

iPTMnetiP31274.
PhosphoSitePlusiP31274.

Expressioni

Gene expression databases

BgeeiENSG00000180806.
CleanExiHS_HOXC9.
ExpressionAtlasiP31274. baseline and differential.
GenevisibleiP31274. HS.

Interactioni

Subunit structurei

Interacts with Geminin/GMNN, which inhibits transcriptional activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LPXNO607115EBI-1779423,EBI-744222

Protein-protein interaction databases

BioGridi109465. 22 interactors.
IntActiP31274. 10 interactors.
MINTiMINT-2802481.
STRINGi9606.ENSP00000302836.

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi186 – 188Combined sources3
Beta strandi194 – 196Combined sources3
Helixi201 – 213Combined sources13
Helixi219 – 228Combined sources10
Helixi233 – 248Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LP0NMR-A192-251[»]
2MSYNMR-A184-251[»]
ProteinModelPortaliP31274.
SMRiP31274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG016849.
InParanoidiP31274.
KOiK09294.
OMAiSGPISNY.
OrthoDBiEOG091G0ECO.
PhylomeDBiP31274.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF
60 70 80 90 100
PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL
110 120 130 140 150
SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR
160 170 180 190 200
DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT
210 220 230 240 250
KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM
260
NKEKTDKEQS
Length:260
Mass (Da):29,248
Last modified:January 23, 2002 - v3
Checksum:i0B278FF94945BC1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47C → R in AK000445 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03626787G → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1.
CH471054 Genomic DNA. Translation: EAW96741.1.
BC053894 mRNA. Translation: AAH53894.1.
CCDSiCCDS8869.1.
PIRiS15532.
RefSeqiNP_008828.1. NM_006897.2.
UniGeneiHs.658823.

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
ENST00000508190; ENSP00000423861; ENSG00000180806.
GeneIDi3225.
KEGGihsa:3225.
UCSCiuc001seq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014302, AY014301 Genomic DNA. Translation: AAG42151.1.
AK000445 mRNA. No translation available.
AK315194 mRNA. Translation: BAG37634.1.
CH471054 Genomic DNA. Translation: EAW96741.1.
BC053894 mRNA. Translation: AAH53894.1.
CCDSiCCDS8869.1.
PIRiS15532.
RefSeqiNP_008828.1. NM_006897.2.
UniGeneiHs.658823.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LP0NMR-A192-251[»]
2MSYNMR-A184-251[»]
ProteinModelPortaliP31274.
SMRiP31274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109465. 22 interactors.
IntActiP31274. 10 interactors.
MINTiMINT-2802481.
STRINGi9606.ENSP00000302836.

PTM databases

iPTMnetiP31274.
PhosphoSitePlusiP31274.

Polymorphism and mutation databases

BioMutaiHOXC9.
DMDMi20141537.

Proteomic databases

MaxQBiP31274.
PaxDbiP31274.
PeptideAtlasiP31274.
PRIDEiP31274.

Protocols and materials databases

DNASUi3225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303450; ENSP00000302836; ENSG00000180806.
ENST00000508190; ENSP00000423861; ENSG00000180806.
GeneIDi3225.
KEGGihsa:3225.
UCSCiuc001seq.4. human.

Organism-specific databases

CTDi3225.
DisGeNETi3225.
GeneCardsiHOXC9.
HGNCiHGNC:5130. HOXC9.
MIMi142971. gene.
neXtProtiNX_P31274.
OpenTargetsiENSG00000180806.
PharmGKBiPA29405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG016849.
InParanoidiP31274.
KOiK09294.
OMAiSGPISNY.
OrthoDBiEOG091G0ECO.
PhylomeDBiP31274.
TreeFamiTF317819.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180806-MONOMER.

Miscellaneous databases

ChiTaRSiHOXC9. human.
GeneWikiiHOXC9.
GenomeRNAii3225.
PROiP31274.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180806.
CleanExiHS_HOXC9.
ExpressionAtlasiP31274. baseline and differential.
GenevisibleiP31274. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXC9_HUMAN
AccessioniPrimary (citable) accession number: P31274
Secondary accession number(s): B2RCN7, Q9H1I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2002
Last modified: November 30, 2016
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.