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Protein

Homeobox protein Hox-C8

Gene

HOXC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. neuron differentiation Source: Ensembl
  4. skeletal system morphogenesis Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP31273.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3A
Gene namesi
Name:HOXC8
Synonyms:HOX3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5129. HOXC8.

Subcellular locationi

GO - Cellular componenti

  1. microtubule cytoskeleton Source: HPA
  2. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Homeobox protein Hox-C8PRO_0000200180Add
BLAST

Proteomic databases

MaxQBiP31273.
PaxDbiP31273.
PRIDEiP31273.

PTM databases

PhosphoSiteiP31273.

Expressioni

Gene expression databases

BgeeiP31273.
CleanExiHS_HOXC8.
GenevestigatoriP31273.

Organism-specific databases

HPAiCAB037020.
HPA028911.

Interactioni

Subunit structurei

Interacts with SMAD1 and HOMEZ.1 Publication

Protein-protein interaction databases

BioGridi109464. 9 interactions.
DIPiDIP-52312N.
IntActiP31273. 6 interactions.
MINTiMINT-2802457.
STRINGi9606.ENSP00000040584.

Structurei

3D structure databases

ProteinModelPortaliP31273.
SMRiP31273. Positions 153-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi138 – 1436Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP31273.
KOiK09308.
OMAiHHGTSSI.
OrthoDBiEOG780RP4.
PhylomeDBiP31273.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ
60 70 80 90 100
HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY
110 120 130 140 150
GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR
160 170 180 190 200
SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR
210 220 230 240
RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
Length:242
Mass (Da):27,755
Last modified:February 21, 2001 - v2
Checksum:i30C1FD06228833FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651E → Q in CAA67997 (PubMed:2576652).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014300, AY014299 Genomic DNA. Translation: AAG42146.1.
AK290959 mRNA. Translation: BAF83648.1.
CH471054 Genomic DNA. Translation: EAW96743.1.
BC053898 mRNA. Translation: AAH53898.1.
X99680 mRNA. Translation: CAA67996.1.
X99681 mRNA. Translation: CAA67997.1.
CCDSiCCDS8870.1.
PIRiS15534.
RefSeqiNP_073149.1. NM_022658.3.
UniGeneiHs.664500.

Genome annotation databases

EnsembliENST00000040584; ENSP00000040584; ENSG00000037965.
GeneIDi3224.
KEGGihsa:3224.
UCSCiuc001ser.3. human.

Polymorphism databases

DMDMi13124745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014300, AY014299 Genomic DNA. Translation: AAG42146.1.
AK290959 mRNA. Translation: BAF83648.1.
CH471054 Genomic DNA. Translation: EAW96743.1.
BC053898 mRNA. Translation: AAH53898.1.
X99680 mRNA. Translation: CAA67996.1.
X99681 mRNA. Translation: CAA67997.1.
CCDSiCCDS8870.1.
PIRiS15534.
RefSeqiNP_073149.1. NM_022658.3.
UniGeneiHs.664500.

3D structure databases

ProteinModelPortaliP31273.
SMRiP31273. Positions 153-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109464. 9 interactions.
DIPiDIP-52312N.
IntActiP31273. 6 interactions.
MINTiMINT-2802457.
STRINGi9606.ENSP00000040584.

PTM databases

PhosphoSiteiP31273.

Polymorphism databases

DMDMi13124745.

Proteomic databases

MaxQBiP31273.
PaxDbiP31273.
PRIDEiP31273.

Protocols and materials databases

DNASUi3224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000040584; ENSP00000040584; ENSG00000037965.
GeneIDi3224.
KEGGihsa:3224.
UCSCiuc001ser.3. human.

Organism-specific databases

CTDi3224.
GeneCardsiGC12P054402.
HGNCiHGNC:5129. HOXC8.
HPAiCAB037020.
HPA028911.
MIMi142970. gene.
neXtProtiNX_P31273.
PharmGKBiPA29404.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG314669.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP31273.
KOiK09308.
OMAiHHGTSSI.
OrthoDBiEOG780RP4.
PhylomeDBiP31273.
TreeFamiTF316310.

Enzyme and pathway databases

SignaLinkiP31273.

Miscellaneous databases

ChiTaRSiHOXC8. human.
GeneWikiiHOXC8.
GenomeRNAii3224.
NextBioi12831.
PROiP31273.
SOURCEiSearch...

Gene expression databases

BgeeiP31273.
CleanExiHS_HOXC8.
GenevestigatoriP31273.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
    Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
    FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-114 AND 147-195.
  6. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-214.
  7. Cited for: INTERACTION WITH HOMEZ.

Entry informationi

Entry nameiHXC8_HUMAN
AccessioniPrimary (citable) accession number: P31273
Secondary accession number(s): A8K4J4, O15221, O15362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 21, 2001
Last modified: February 4, 2015
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.