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P31273 (HXC8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C8
Alternative name(s):
Homeobox protein Hox-3A
Gene names
Name:HOXC8
Synonyms:HOX3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subunit structure

Interacts with SMAD1 and HOMEZ. Ref.7

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Homeobox protein Hox-C8
PRO_0000200180

Regions

DNA binding149 – 20860Homeobox
Motif138 – 1436Antp-type hexapeptide

Experimental info

Sequence conflict1651E → Q in CAA67997. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P31273 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 30C1FD06228833FC

FASTA24227,755
        10         20         30         40         50         60 
MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF 

        70         80         90        100        110        120 
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT 

       130        140        150        160        170        180 
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI 

       190        200        210        220        230        240 
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN 


KD 

« Hide

References

« Hide 'large scale' references
[1]"Complete mutation analysis panel of the 39 human HOX genes."
Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K., Tomita M., McGinnis W., Matsuo N.
Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]"Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-114 AND 147-195.
[6]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-214.
[7]"Homez, a homeobox leucine zipper gene specific to the vertebrate lineage."
Bayarsaihan D., Enkhmandakh B., Makeyev A., Greally J.M., Leckman J.F., Ruddle F.H.
Proc. Natl. Acad. Sci. U.S.A. 100:10358-10363(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HOMEZ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY014300, AY014299 Genomic DNA. Translation: AAG42146.1.
AK290959 mRNA. Translation: BAF83648.1.
CH471054 Genomic DNA. Translation: EAW96743.1.
BC053898 mRNA. Translation: AAH53898.1.
X99680 mRNA. Translation: CAA67996.1.
X99681 mRNA. Translation: CAA67997.1.
CCDSCCDS8870.1.
PIRS15534.
RefSeqNP_073149.1. NM_022658.3.
UniGeneHs.664500.

3D structure databases

ProteinModelPortalP31273.
SMRP31273. Positions 153-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109464. 8 interactions.
DIPDIP-52312N.
IntActP31273. 6 interactions.
MINTMINT-2802457.
STRING9606.ENSP00000040584.

PTM databases

PhosphoSiteP31273.

Polymorphism databases

DMDM13124745.

Proteomic databases

MaxQBP31273.
PaxDbP31273.
PRIDEP31273.

Protocols and materials databases

DNASU3224.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000040584; ENSP00000040584; ENSG00000037965.
GeneID3224.
KEGGhsa:3224.
UCSCuc001ser.3. human.

Organism-specific databases

CTD3224.
GeneCardsGC12P054402.
HGNCHGNC:5129. HOXC8.
HPACAB037020.
HPA028911.
MIM142970. gene.
neXtProtNX_P31273.
PharmGKBPA29404.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314669.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP31273.
KOK09308.
OMAHHGTSSI.
OrthoDBEOG780RP4.
PhylomeDBP31273.
TreeFamTF316310.

Enzyme and pathway databases

SignaLinkP31273.

Gene expression databases

BgeeP31273.
CleanExHS_HOXC8.
GenevestigatorP31273.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHOXC8. human.
GeneWikiHOXC8.
GenomeRNAi3224.
NextBio12831.
PROP31273.
SOURCESearch...

Entry information

Entry nameHXC8_HUMAN
AccessionPrimary (citable) accession number: P31273
Secondary accession number(s): A8K4J4, O15221, O15362
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 21, 2001
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries