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P31273

- HXC8_HUMAN

UniProt

P31273 - HXC8_HUMAN

Protein

Homeobox protein Hox-C8

Gene

HOXC8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi149 – 20860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. neuron differentiation Source: Ensembl
    4. skeletal system morphogenesis Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP31273.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C8
    Alternative name(s):
    Homeobox protein Hox-3A
    Gene namesi
    Name:HOXC8
    Synonyms:HOX3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5129. HOXC8.

    Subcellular locationi

    GO - Cellular componenti

    1. microtubule cytoskeleton Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29404.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Homeobox protein Hox-C8PRO_0000200180Add
    BLAST

    Proteomic databases

    MaxQBiP31273.
    PaxDbiP31273.
    PRIDEiP31273.

    PTM databases

    PhosphoSiteiP31273.

    Expressioni

    Gene expression databases

    BgeeiP31273.
    CleanExiHS_HOXC8.
    GenevestigatoriP31273.

    Organism-specific databases

    HPAiCAB037020.
    HPA028911.

    Interactioni

    Subunit structurei

    Interacts with SMAD1 and HOMEZ.1 Publication

    Protein-protein interaction databases

    BioGridi109464. 8 interactions.
    DIPiDIP-52312N.
    IntActiP31273. 6 interactions.
    MINTiMINT-2802457.
    STRINGi9606.ENSP00000040584.

    Structurei

    3D structure databases

    ProteinModelPortaliP31273.
    SMRiP31273. Positions 153-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi138 – 1436Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG314669.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP31273.
    KOiK09308.
    OMAiHHGTSSI.
    OrthoDBiEOG780RP4.
    PhylomeDBiP31273.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ    50
    HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY 100
    GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR 150
    SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR 200
    RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD 242
    Length:242
    Mass (Da):27,755
    Last modified:February 21, 2001 - v2
    Checksum:i30C1FD06228833FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651E → Q in CAA67997. (PubMed:2576652)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014300, AY014299 Genomic DNA. Translation: AAG42146.1.
    AK290959 mRNA. Translation: BAF83648.1.
    CH471054 Genomic DNA. Translation: EAW96743.1.
    BC053898 mRNA. Translation: AAH53898.1.
    X99680 mRNA. Translation: CAA67996.1.
    X99681 mRNA. Translation: CAA67997.1.
    CCDSiCCDS8870.1.
    PIRiS15534.
    RefSeqiNP_073149.1. NM_022658.3.
    UniGeneiHs.664500.

    Genome annotation databases

    EnsembliENST00000040584; ENSP00000040584; ENSG00000037965.
    GeneIDi3224.
    KEGGihsa:3224.
    UCSCiuc001ser.3. human.

    Polymorphism databases

    DMDMi13124745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY014300 , AY014299 Genomic DNA. Translation: AAG42146.1 .
    AK290959 mRNA. Translation: BAF83648.1 .
    CH471054 Genomic DNA. Translation: EAW96743.1 .
    BC053898 mRNA. Translation: AAH53898.1 .
    X99680 mRNA. Translation: CAA67996.1 .
    X99681 mRNA. Translation: CAA67997.1 .
    CCDSi CCDS8870.1.
    PIRi S15534.
    RefSeqi NP_073149.1. NM_022658.3.
    UniGenei Hs.664500.

    3D structure databases

    ProteinModelPortali P31273.
    SMRi P31273. Positions 153-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109464. 8 interactions.
    DIPi DIP-52312N.
    IntActi P31273. 6 interactions.
    MINTi MINT-2802457.
    STRINGi 9606.ENSP00000040584.

    PTM databases

    PhosphoSitei P31273.

    Polymorphism databases

    DMDMi 13124745.

    Proteomic databases

    MaxQBi P31273.
    PaxDbi P31273.
    PRIDEi P31273.

    Protocols and materials databases

    DNASUi 3224.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000040584 ; ENSP00000040584 ; ENSG00000037965 .
    GeneIDi 3224.
    KEGGi hsa:3224.
    UCSCi uc001ser.3. human.

    Organism-specific databases

    CTDi 3224.
    GeneCardsi GC12P054402.
    HGNCi HGNC:5129. HOXC8.
    HPAi CAB037020.
    HPA028911.
    MIMi 142970. gene.
    neXtProti NX_P31273.
    PharmGKBi PA29404.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314669.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P31273.
    KOi K09308.
    OMAi HHGTSSI.
    OrthoDBi EOG780RP4.
    PhylomeDBi P31273.
    TreeFami TF316310.

    Enzyme and pathway databases

    SignaLinki P31273.

    Miscellaneous databases

    ChiTaRSi HOXC8. human.
    GeneWikii HOXC8.
    GenomeRNAii 3224.
    NextBioi 12831.
    PROi P31273.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31273.
    CleanExi HS_HOXC8.
    Genevestigatori P31273.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    5. "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines."
      Flagiello D., Gibaud A., Dutrillaux B., Poupon M.-F., Malfoy B.
      FEBS Lett. 415:263-267(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-114 AND 147-195.
    6. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-214.
    7. Cited for: INTERACTION WITH HOMEZ.

    Entry informationi

    Entry nameiHXC8_HUMAN
    AccessioniPrimary (citable) accession number: P31273
    Secondary accession number(s): A8K4J4, O15221, O15362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3