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Protein

Homeobox protein Hox-A9

Gene

HOXA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi206 – 265HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • endothelial cell activation Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • negative regulation of myeloid cell differentiation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP31269.
SIGNORiP31269.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A9
Alternative name(s):
Homeobox protein Hox-1G
Gene namesi
Name:HOXA9
Synonyms:HOX1G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000078399.15.
HGNCiHGNC:5109. HOXA9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.
A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi140R → A: Results in loss of methylation. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei163 – 164Breakpoint for translocation to form MSI2/HOXA9 fusion protein2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3205.
OpenTargetsiENSG00000078399.
PharmGKBiPA29386.

Polymorphism and mutation databases

BioMutaiHOXA9.
DMDMi6166219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000811 – 272Homeobox protein Hox-A9Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140Symmetric dimethylarginine1 Publication1

Post-translational modificationi

Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

EPDiP31269.
MaxQBiP31269.
PaxDbiP31269.
PeptideAtlasiP31269.
PRIDEiP31269.

PTM databases

iPTMnetiP31269.
PhosphoSitePlusiP31269.

Expressioni

Gene expression databases

BgeeiENSG00000078399.
CleanExiHS_HOXA9.
ExpressionAtlasiP31269. baseline and differential.
GenevisibleiP31269. HS.

Organism-specific databases

HPAiHPA061982.

Interactioni

Subunit structurei

Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109445. 16 interactors.
CORUMiP31269.
IntActiP31269. 8 interactors.
MINTiMINT-2802430.
STRINGi9606.ENSP00000343619.

Structurei

3D structure databases

ProteinModelPortaliP31269.
SMRiP31269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00900000140792.
HOGENOMiHOG000231180.
HOVERGENiHBG016849.
InParanoidiP31269.
KOiK21950.
OMAiWSHVPAQ.
OrthoDBiEOG091G0IP5.
PhylomeDBiP31269.
TreeFamiTF317819.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR006711. Hox9_activation_N.
IPR017112. HXA9/HXB9/HXC9.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
PIRSFiPIRSF037109. Homeobox_Hox9. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P31269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTGALGNY YVDSFLLGAD AADELSVGRY APGTLGQPPR QAATLAEHPD
60 70 80 90 100
FSPCSFQSKA TVFGASWNPV HAAGANAVPA AVYHHHHHHP YVHPQAPVAA
110 120 130 140 150
AAPDGRYMRS WLEPTPGALS FAGLPSSRPY GIKPEPLSAR RGDCPTLDTH
160 170 180 190 200
TLSLTDYACG SPPVDREKQP SEGAFSENNA ENESGGDKPP IDPNNPAANW
210 220 230 240 250
LHARSTRKKR CPYTKHQTLE LEKEFLFNMY LTRDRRYEVA RLLNLTERQV
260 270
KIWFQNRRMK MKKINKDRAK DE
Length:272
Mass (Da):30,172
Last modified:July 15, 1999 - v4
Checksum:i823A1A22BB07A881
GO

Sequence cautioni

P31269: The sequence AAC50364 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64G → V in AAB40867 (Ref. 1) Curated1
Sequence conflicti67W → R in AAD08713 (PubMed:9880515).Curated1
Sequence conflicti80Missing in AAB40867 (Ref. 1) Curated1
Sequence conflicti243L → F in AAB40867 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82759 mRNA. Translation: AAB40867.1.
AF010258 Genomic DNA. Translation: AAD08713.1.
BT006990 mRNA. Translation: AAP35636.1.
AC004080 Genomic DNA. No translation available.
BC006537 mRNA. Translation: AAH06537.1.
BC010023 mRNA. Translation: AAH10023.1.
U41813 mRNA. Translation: AAC50364.1. Different initiation.
CCDSiCCDS5409.1.
PIRiS14929.
RefSeqiNP_689952.1. NM_152739.3.
UniGeneiHs.659350.

Genome annotation databases

EnsembliENST00000343483; ENSP00000343619; ENSG00000078399.
GeneIDi3205.
KEGGihsa:3205.
UCSCiuc003syt.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiHXA9_HUMAN
AccessioniPrimary (citable) accession number: P31269
Secondary accession number(s): O43369, O43429, Q99820
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1999
Last modified: October 25, 2017
This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families